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Ribose modified nucleosides and nucleotides as ligands for purine receptors
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Mechanisms of platelet aggregation
CURRENT OPINION IN HEMATOLOGY
Activation of the alpha(2A)-adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro
PLATELETS
Activation of G(i)-coupled receptors releases a tonic state of inhibited platelet aggregation
PLATELETS
The platelet ADP receptors
HAEMATOLOGICA
Discovery and mapping of ten novel G protein-coupled receptor genes
GENE
The ATP-gated P2X(1) ion channel acts as a positive regulator of platelet responses to collagen
THROMBOSIS AND HAEMOSTASIS
ADP receptors of platelets and their inhibition
THROMBOSIS AND HAEMOSTASIS
Platelet shape change evoked by selective activation of P2X(1) purinoceptors with alpha,beta-methylene ATP
THROMBOSIS AND HAEMOSTASIS
Discovery and recognition of purine receptor subtypes on platelets
DRUG DEVELOPMENT RESEARCH
Probing adenosine and P2 receptors: Design of novel purines and nonpurinesas selective ligands
DRUG DEVELOPMENT RESEARCH
Expression of the P2Y(1) nucleotide receptor in chick muscle: Its functional role in the regulation of acetylcholinesterase and acetylcholine receptor
JOURNAL OF NEUROSCIENCE
Extracellular nucleotides differentially regulate interleukin-1 beta signaling in primary human astrocytes: Implications for inflammatory gene expression
JOURNAL OF NEUROSCIENCE
Stimulation of P2 receptors in the ventral tegmental area enhances dopaminergic mechanisms in vivo
NEUROPHARMACOLOGY
Identification of the platelet ADP receptor targeted by antithrombotic drugs
NATURE
Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
MpI ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP
MOLECULAR PHARMACOLOGY
P-2Y1 and P-2Y2 receptor-operated Ca2+ signals in primary cultures of cardiac microvascular endothelial cells
MICROVASCULAR RESEARCH
Agonists of the P2Y(AC)-receptor activate MAP kinase by a ras-independent pathway in rat C6 glioma
JOURNAL OF NEUROCHEMISTRY
[S-35]CTP gamma S autoradiography reveals a wide distribution of G(i/o)-linked ADP receptors in the nervous system: close similarities with the platelet P2Y(ADP) receptor
JOURNAL OF NEUROCHEMISTRY
An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors
JOURNAL OF MOLECULAR BIOLOGY
Docking ligands onto binding site representations derived from proteins built by homology modelling
JOURNAL OF MOLECULAR BIOLOGY
Molecular identification and characterization of the platelet ADP receptortargeted by thienopyridine antithrombotic drugs
JOURNAL OF CLINICAL INVESTIGATION
Identification of a novel human ADP receptor coupled to G(i)
JOURNAL OF BIOLOGICAL CHEMISTRY
ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999
JOURNAL OF BIOLOGICAL CHEMISTRY
Characterisation of P2Y(1)-like receptor in cultured rat pineal glands
EUROPEAN JOURNAL OF PHARMACOLOGY
Inhibition of platelet function by administration of MRS2179, a P2Y(1) receptor antagonist
EUROPEAN JOURNAL OF PHARMACOLOGY
Platelet collagen receptor integrin alpha(2)beta(1) activation involves differential participation of ADP-receptor subtypes P2Y1 and P2Y12 but not intracellular calcium change
EUROPEAN JOURNAL OF BIOCHEMISTRY
Minireview: Insights into G protein-coupled receptor function using molecular models
ENDOCRINOLOGY
Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747
BRITISH JOURNAL OF PHARMACOLOGY
Activity of adenosine diphosphates and triphosphates on a P2Y(T)-type receptor in brain capillary endothelial cells
BRITISH JOURNAL OF PHARMACOLOGY
Novel modified adenosine 5 '-triphosphate analogues pharmacologically characterized in human embryonic kidney 293 cells highly expressing rat brain P2Y(1) receptor: biotinylated analogue potentially suitable for specific P2Y(1) receptor isolation
BIOCHEMICAL PHARMACOLOGY
2-thioether-5 '-O-(1-thiotriphosphate)-adenosine derivatives: New insulin secretagogues acting through P2Y-receptors
ISRAEL MEDICAL ASSOCIATION JOURNAL
The role of heterotrimeric G proteins in platelet activation
BIOLOGICAL CHEMISTRY
Platelets from a patient heterozygous for the defect of P2(CYC) receptors for ADP have a secretion defect despite normal thromboxane A(2) production and normal granule stores - Further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2(CYC) receptors
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Activation of the platelet collagen receptor integrin alpha 2 beta 1 - Itsmechanism and participation in the physiological functions of platelets
TRENDS IN CARDIOVASCULAR MEDICINE
Immunohistochemical localization of the P2Y(1) purinergic receptor in Alzheimer's disease
NEUROREPORT
ADP-induced platelet shape change: an investigation of the signalling pathways involved and their dependence on the method of platelet preparation
PLATELETS
Platelet activation by ADP: the role of ADP antagonists
ANNALS OF MEDICINE
P2-receptor agonists: From molecular recognition studies to potential clinical applications
DRUG DEVELOPMENT RESEARCH
Imagination and reality in the search for the P2Y receptors
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
Platelet P2 receptors: from curiosity to clinical targets
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
The discovery and development of P2 receptor subtypes
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
Adventures in the pharmacological analysis of P2 receptors
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
Molecular pharmacology of P2Y-receptors
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Characterization of contractile P2 receptors in human coronary arteries byuse of the stable pyrimidines uridine 5 '-O-thiodiphosphate and uridine 5 '-O-3-thiotriphosphate
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets
EUROPEAN JOURNAL OF BIOCHEMISTRY
The stable pyrimidines UDP beta S and UTP gamma S discriminate between theP2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery
BRITISH JOURNAL OF PHARMACOLOGY
ADP is not an agonist at P2X(1) receptors: evidence for separate receptorsstimulated by ATP and ADP on human platelets
BRITISH JOURNAL OF PHARMACOLOGY
The P2Y(1) receptor closes the N-type Ca2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists
BRITISH JOURNAL OF PHARMACOLOGY
P-2Y purinoceptor subtypes recruit different Mek activators in astrocytes
BRITISH JOURNAL OF PHARMACOLOGY
The central role of the P-2T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity
BRITISH JOURNAL OF HAEMATOLOGY
ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of G alpha q
BLOOD
Fc gamma RIIA requires a Gi-dependent pathway for an efficient stimulationof phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation
BLOOD
Phosphate-substituted ATP analogs are antagonists at human P2Y(1) purinoceptors
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
ADP receptors and clinical bleeding disorders
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y(1)-deficient mice
NATURE MEDICINE
The P2Y1 receptor is essential for ADP-induced shape change and aggregation in mouse platelets
PLATELETS
ATP does not affect fibrinogen binding to platelet GPIIbIIIa in systems free of signal transduction
PLATELETS
cAMP is an important messenger for ADP-induced platelet aggregation
PLATELETS
Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes
THROMBOSIS AND HAEMOSTASIS
Role of intracellular signaling events in ADP-induced platelet aggregation
THROMBOSIS AND HAEMOSTASIS
Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets - Definition and detection of ticlopidine/clopidogrel effects
THROMBOSIS AND HAEMOSTASIS
Signaling through platelet integrin alpha IIb beta 3: Inside-out, outside-in, and sideways
THROMBOSIS AND HAEMOSTASIS
Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation
THROMBOSIS AND HAEMOSTASIS
Lack of specificity of [S-35]-ATP gamma S and [S-35]-ADP beta S as radioligands for ionotropic and metabotropic P2 receptor binding
DRUG DEVELOPMENT RESEARCH
Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis
NUCLEOTIDES AND THEIR RECEPTORS IN THE NERVOUS SYSTEMS
Molecular recognition of modified adenine nucleotides by the P2Y(1)-receptor. 2. A computational approach
JOURNAL OF MEDICINAL CHEMISTRY
2-thioether 5 '-O-(1-thiotriphosphate)adenosine derivatives as new insulinsecretagogues acting through P2Y-receptors
JOURNAL OF MEDICINAL CHEMISTRY
No requirement of P2X1 purinoceptors for platelet aggregation
EUROPEAN JOURNAL OF PHARMACOLOGY
Relaxant effect of 2-methyl-thio-adenosine diphosphate on rat thoracic aorta: effect of clopidogrel
EUROPEAN JOURNAL OF PHARMACOLOGY
Ticlopidine and clopidogrel
CIRCULATION
Vasodilatation of intrapulmonary arteries to P2-receptor nucleotides in normal and pulmonary hypertensive newborn piglets
BRITISH JOURNAL OF PHARMACOLOGY
Regulation of cyclic AMP by extracellular ATP in cultured brain capillary endothelial cells
BRITISH JOURNAL OF PHARMACOLOGY
Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adenosine 5 '-diphospbate (ADP) in human platelets
BRITISH JOURNAL OF PHARMACOLOGY
A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
BLOOD
REGIONAL DISTRIBUTION OF [S-35] 2'-DEOXY 5'-O-(1-THIO) ATP BINDING-SITES AND THE P2Y(1) MESSENGER-RNA WITHIN THE CHICK BRAIN
Neuroscience
Molecular physiology of platelet ADP receptors
DRUG DEVELOPMENT RESEARCH
Effects of adenosine 3 '-phosphate 5 '-phosphosulfate on P2 receptors in platelets and smooth muscle preparations
DRUG DEVELOPMENT RESEARCH
ROLE OF P2Y1 PURINOCEPTOR IN ADP-INDUCED PLATELET ACTIVATION
FEBS letters
COMPETITIVE AND SELECTIVE ANTAGONISM OF P2Y(1) RECEPTORS BY N-6-METHYL 2'-DEOXYADENOSINE 3',5'-BISPHOSPHATE
British Journal of Pharmacology
MULTIPLE P2 RECEPTOR SUBTYPES ON PLATELETS - A NEW INTERPRETATION OF THEIR FUNCTION
Trends in pharmacological sciences
HEK293 HUMAN EMBRYONIC KIDNEY-CELLS ENDOGENOUSLY EXPRESS THE P2Y(1) AND P2Y(2) RECEPTORS
Neuropharmacology
DISTRIBUTION OF [S-35]DATP-ALPHA-S BINDING SITES IN THE ADULT RAT NEURAXIS
Neuropharmacology
FIDELITY IN FUNCTIONAL COUPLING OF THE RAT P2Y(1) RECEPTOR TO PHOSPHOLIPASE-C
British Journal of Pharmacology
AN EXAMINATION OF DEOXYADENOSINE 5'(ALPHA-THIO)TRIPHOSPHATE AS A LIGAND TO DEFINE P2Y RECEPTORS AND ITS SELECTIVITY AS A LOW POTENCY PARTIAL AGONIST OF THE P2Y(1) RECEPTOR
British Journal of Pharmacology