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p27-p16 chimera: A superior antiproliferative for the prevention of neointimal hyperplasia
MOLECULAR THERAPY
JAB1/CSN5 and the COP9 signalosome - A complex situation
EMBO REPORTS
p21(cip1) is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal
EMBO REPORTS
Triggering ubiquitination of a CDK inhibitor at origins of DNA replication
NATURE CELL BIOLOGY
The origin of CDK regulation
NATURE CELL BIOLOGY
p27 destruction: Cks1 pulls the trigger
NATURE CELL BIOLOGY
Growth-factor-dependent mitogenesis requires two distinct phases of signalling
NATURE CELL BIOLOGY
The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer
BREAST CANCER RESEARCH
Culture in low levels of oxygen enhances in vitro proliferation potential of satellite cells from old skeletal muscles
CELLULAR AND MOLECULAR LIFE SCIENCES
Overexpression of cyclin E and cyclin-dependent kinase 2 is correlated with development of hepatocellular carcinomas
HEPATOLOGY RESEARCH
Tuberous sclerosis gene products in proliferation control
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Expression and significance of cell cycle-related proteins Cyclin D1, CDK4, p27, E2F-1 and Ets-1 in chondrosarcoma of the jaws
ORAL ONCOLOGY
Overexpressing eukaryotic translation initiation factor 4E stimulates bovine mammary epithelial cell proliferation
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Expression of p21(Waf1), p27(Kip1) and cyclin D1 proteins in breast ductalcarcinoma in situ: Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status
PATHOLOGY INTERNATIONAL
Differential activity of TGF-beta 2 on the expression of p27(Kip1) and Cdk4 in actively cycling and contact inhibited rabbit corneal endothelial cells
MOLECULAR VISION
Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptortyrosine kinase
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Role of Sp1 in the induction of p27 gene expression in vascular smooth muscle cells in vitro and after balloon angioplasty
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Low levels of p27 in association with deregulated p53-pRb protein status enhance tumor proliferation and chromosomal instability in non-small cell lung carcinomas
MOLECULAR MEDICINE
P27(kip1) expression is associated with tumor response to preoperative chemoradiotherapy in rectal cancer
ANNALS OF SURGICAL ONCOLOGY
Prostate cancer: simplicity to complexity
NATURE GENETICS
Becoming glial in the neural retina
DEVELOPMENTAL DYNAMICS
Immunohistochemical analysis of p27 (Kip1) in human pituitary glands and in various types of pituitary adenomas
ENDOCRINE PATHOLOGY
Cyclins D1 and D3 and topoisomerase II alpha in inactive pituitary adenomas
ENDOCRINE PATHOLOGY
12p12-13 deletion in prostate tumors and quantitative expression of CDKNIBand ETV6 candidate genes
GENES CHROMOSOMES & CANCER
Cyclin-dependent kinase inhibitors in the development of the central nervous system
CELL GROWTH & DIFFERENTIATION
Cyclin-dependent kinase (cdk) inhibitors/cdk4/cdk2 complexes in early stages of mouse mammary preneoplasia
CELL GROWTH & DIFFERENTIATION
Low expression of p27(Kip1) in advanced mucoepidermoid carcinomas of head and neck
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Bcl-2, cell cycle regulatory proteins and corticosensitivity in childhood acute lymphoblastic leukaemia
LEUKEMIA & LYMPHOMA
Prognostic implications of p27 and cyclin E protein contents in malignant lymphomas
LEUKEMIA & LYMPHOMA
Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis
PLANT CELL
Predictive value of altered p27(Kip1) and p21(WAF/Cip1) protein expressionfor the clinical prognosis of patients with localized prostate cancer
ONCOLOGY REPORTS
IFN alpha 2b induces apoptosis and proteasome-mediated degradation of p27(Kip1) in a human lung cancer cell line
ONCOLOGY REPORTS
Expression of second class of KIP protein p57(KIP2) in human colorectal carcinoma
INTERNATIONAL JOURNAL OF ONCOLOGY
Loss of p27 expression predicts poor prognosis in patients with Dukes' B stage or proximal colorectal cancer
INTERNATIONAL JOURNAL OF ONCOLOGY
Selective effects of E1B-defective adenoviruses and adenovirus E1A mutantsin deficient mouse primary embryonic fibroblasts
INTERNATIONAL JOURNAL OF ONCOLOGY
Underexpression of cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in serous ovarian carcinomas
INTERNATIONAL JOURNAL OF ONCOLOGY
Low levels of cell cycle inhibitor p27kip1 combined with high levels of Ki-67 predict shortened disease-free survival in T1 and T2 invasive breast carcinomas
INTERNATIONAL JOURNAL OF ONCOLOGY
Insufficient effect of p27(KIP1) to inhibit cyclin D1 in human esophageal cancer in vitro
INTERNATIONAL JOURNAL OF ONCOLOGY
Expression of the G1-S modulators in hepatitis B virus-related hepatocellular carcinoma and dysplastic nodule: Association of cyclin D1 and p53 proteins with the progression of hepatocellular carcinoma
JOURNAL OF KOREAN MEDICAL SCIENCE
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCFSKP2
CURRENT BIOLOGY
Protein destruction: Adapting roles for Cks proteins
CURRENT BIOLOGY
Modulation of the expression of the Cip/Kip family of cyclin-dependent kinase inhibitors in foetal developing lungs of hamsters
CELL PROLIFERATION
Ubiquitin proteasome pathway: implications and advances in cancer therapy
SURGICAL ONCOLOGY-OXFORD
Cell type-specific induction of cyclin D and cyclin-dependent kinase inhibitor p27(kip1) expression by estrogen in rat endometrium
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Region-specific expression of cell cycle inhibitors in the adult brain
NEUROREPORT
Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression
ONCOGENE
BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells
ONCOGENE
Differential effects of transforming growth factor on cell cycle regulatory molecules in human myeloid leukemia cells
ONCOGENE
Cell cycle-independent upregulation of p27Kip1 by p21Waf1 in K562 cells
ONCOGENE
Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells
ONCOGENE
Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase
ONCOGENE
The mechanism of cell cycle regulation by v-Src
ONCOGENE
Ectopic expression of Cdk6 circumvents transforming growth factor-beta mediated growth inhibition
ONCOGENE
Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression
ONCOGENE
Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression
ONCOGENE
Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells
ONCOGENE
Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappa B activation
ONCOGENE
Biochemical differences between SUDHL-1 and KARPAS 299 cells derived from t(2;5)-positive anaplastic large cell lymphoma are responsible for the different sensitivity to the anti proliferative effect of p27(Kip1)
ONCOGENE
Adhesion-regulated G1 cell cycle arrest in epithelial cells requires the downregulation of c-Myc
ONCOGENE
P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells
ONCOGENE
Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27
ONCOGENE
A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT
ONCOGENE
p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis
ONCOGENE
Novel properties of the cyclin encoded by Human Herpesvirus 8 that facilitate exit from quiescence
ONCOGENE
Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention ofp27(Kip1) in the cyclin E-cdk2 complexes
ONCOGENE
Exploitation of a non-apoptotic caspase to regulate the abundance of the cdkI p27(KIP1) in transformed lymphoid cells
ONCOGENE
Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27(kip1) levels
ONCOGENE
Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
ONCOGENE
Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and skp2
ONCOGENE
Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc
ONCOGENE
Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta 1-induced apoptosis in human gastric cancer cells
ONCOGENE
Angiotensin II induces p27(Kip1) expression in renal tubules in vivo: roleof reactive oxygen species
JOURNAL OF MOLECULAR MEDICINE-JMM
Apoptosis, analysed by means of lamin B detection, correlates with grade of astroglial tumours but not with p27(Kip1)/retinoblastoma protein expression
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
Cytokines and cell cycle regulation in the fibrous progression of crescentformation in antiglomerular basement membrane nephritis of WKY rats
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
Expression of cyclin-dependent kinase inhibitors p16(MTS1), p21(WAF1), andp27(KIP1) in HPV-positive and HPV-negative cervical adenocarcinomas
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling
ANNALS OF ONCOLOGY
Cyclin-dependent kinase inhibitors, p21(waf1/cip1) and p27(kip1), are expressed site- and hair cycle-dependently in rat hair follicles
JOURNAL OF DERMATOLOGICAL SCIENCE
Immunohistochemical analysis of cell-cycle- and apoptosis-related factors in lining epithelium of odontogenic keratocysts
JOURNAL OF ORAL PATHOLOGY & MEDICINE
Incidence and effects of Ha-ras codon 12 G -> A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus
MOLECULAR CARCINOGENESIS
Correlation of p27 protein expression with HER-2/neu expression in breast cancer
MOLECULAR CARCINOGENESIS
Promotion of S-Phase entry and cell growth under serum starvation by SAC/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: Association with inhibition of p27 accumulation
MOLECULAR CARCINOGENESIS
Elevated expression of SAG/ROC2/Rbx2/Hrt2 in human colon carcinomas: SAG does not induce neoplastic transformation, but antisense SAG transfection inhibits tumor cell growth
MOLECULAR CARCINOGENESIS
Expression of p27(Kip1) protein in transitional cell carcinoma of the upper urinary tract
MODERN PATHOLOGY
Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: Report of a case and review of the literature
MODERN PATHOLOGY
Applications of molecular diagnostics: Solid tumor genetics can determine clinical treatment protocols
MODERN PATHOLOGY
Deregulated expression of cell cycle-associated proteins in solid pseudopapillary tumor of the pancreas
MODERN PATHOLOGY
Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin A and cyclin B1 in diffuse large B-cell lymphomas
MODERN PATHOLOGY
Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland
MODERN PATHOLOGY
p27(Kip1) immunostaining for the differential diagnosis of small B-cell neoplasms in trephine bone marrow biopsies
MODERN PATHOLOGY
Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, cyclinE, p27(kip1), and Ki-67 in normal placenta and gestational trophoblastic disease
MODERN PATHOLOGY
Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis
FASEB JOURNAL
The growth suppressor p27(Kip1) protects against diet-induced atherosclerosis
FASEB JOURNAL
Hot papers - A dual role for CDK inhibitors - Comment
SCIENTIST
Prostate pathology - Histologic and molecular perspectives
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Comparison of the effects of recombinant adenovirus-mediated expression ofwildtype p53 and p27(Kip1) on cell cycle and apoptosis in SUDHL-1 cells derived from anaplastic large cell lymphoma
LEUKEMIA
Cell cycle regulatory protein expression in fresh acute myeloid leukemia cells and after drug exposure
LEUKEMIA
Expression of p57/Kip2 protein in pancreatic adenocarcinoma
PANCREAS
Role of D-1 and E cyclins in cell cycle progression of human fibroblasts adhering to cementum attachment protein
JOURNAL OF BONE AND MINERAL RESEARCH