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Akt takes centre stage in cell-cycle deregulation
NATURE CELL BIOLOGY
Characteristics of antitumour activity of cepharanthin against a human adenosquamous cell carcinoma cell line
ORAL ONCOLOGY
Is G1 arrest in plant seeds induced by a p53-related pathway?
TRENDS IN PLANT SCIENCE
Expression of p21(Waf1), p27(Kip1) and cyclin D1 proteins in breast ductalcarcinoma in situ: Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status
PATHOLOGY INTERNATIONAL
p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity
TOXICOLOGICAL SCIENCES
Tranilast inhibits cardiac allograft vasculopathy in association with p21(Waf1/Cip1) expression on neointimal cells in murine cardiac transplantationmodel
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Growth inhibitory effect of p21 and p53 containing adenoviruses on transitional cell carcinoma cell lines in vitro and in vivo
UROLOGIC ONCOLOGY
Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21(WAF11)
CLINICAL CANCER RESEARCH
The p53 mutational spectrum associated with BRCA1 mutant ovarian cancer
CLINICAL CANCER RESEARCH
Clinical significance and prognostic value of apoptosis relayed proteins in superficial esophageal squamous cell carcinoma
ANNALS OF SURGICAL ONCOLOGY
Dynamic forces in the cell cycle affecting fibroblasts in pressure ulcers
WOUND REPAIR AND REGENERATION
Immunoreactivity of p53, mdm2, and p21(WAF1) in dedifferentiated liposarcoma: Special emphasis on the distinct immunophenotype of the well-differentiated component
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
Overexpressed human RAD50 exhibits cell death in a p21 (WAF1/CIP1)-dependent manner: Its potential utility in local gene therapy of tumor
CELL GROWTH & DIFFERENTIATION
Interleukin-9 (IL-9) induces cell growth arrest associated with sustained signal transducer and activator of transcription activation in lymphoma cells overexpressing the IL-9 receptor
CELL GROWTH & DIFFERENTIATION
Retinoic acid protects against hyperoxia-mediated cell-cycle arrest of lung alveolar epithelial cells by preserving late G1 cyclin activities
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
The cyclin-dependent kinase inhibitor p21 protects the lung from oxidativestress
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Predictive value of altered p27(Kip1) and p21(WAF/Cip1) protein expressionfor the clinical prognosis of patients with localized prostate cancer
ONCOLOGY REPORTS
Expression of DNA mismatch repair proteins hMSH2 and hMLH1 and the cyclin G1 inhibitor, p21(waf1/cip1) in pediatric tumors: Correlation with responseto therapy
ONCOLOGY REPORTS
Prognostic significance of p21(waf1), cyclin D1 and retinoblastoma expression detected by immunohistochemistry in non-small cell lung cancer
ONCOLOGY REPORTS
Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin
INTERNATIONAL JOURNAL OF ONCOLOGY
Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21(WAF1/CIP1) in human hepatocellular and colorectal carcinomacells
INTERNATIONAL JOURNAL OF ONCOLOGY
Expression of G1 cell cycle markers and the effect of adenovirus-mediated overexpression of p21Waf-1 in squamous cell carcinoma of the esophagus
INTERNATIONAL JOURNAL OF ONCOLOGY
Analysis of p53, p21(Waf1/Cip1) and TGF-beta(3) immunohistochemical staining in Bowen's disease
DERMATOLOGY
Induction of apoptosis in p53-deficient human hepatoma cell line by wild-type p53 gene transduction: Inhibition by antioxidant
MOLECULES AND CELLS
Prognostic value of p53, p21/WAF1, Bcl-2, Bax, Bak and Ki-67 immunoreactivity in pT1 G3 urothelial bladder carcinomas
TUMOR BIOLOGY
Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model
ANTI-CANCER DRUGS
RB regulates transcription of the p21/WAF1/CIP1 gene
ONCOGENE
Analysis of p16 and p21(Cip1) expression in tumorigenic human bronchial epithelial cells induced by asbestos
ONCOGENE
p21(waf1/cip1)-null human fibroblasts are deficient in nucleotide excisionrepair downstream the recruitment of PCNA to DNA repair sites
ONCOGENE
Cell cycle-independent upregulation of p27Kip1 by p21Waf1 in K562 cells
ONCOGENE
p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues
ONCOGENE
Activation of the p21(CIP1/WAF1) promoter by bone morphogenetic protein-2 in mouse B lineage cells
ONCOGENE
Change in gene expression subsequent to induction of Pnn/DRS/memA: increase in p21(cip1/waf1)
ONCOGENE
Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid
ONCOGENE
The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect
ONCOGENE
Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1
ONCOGENE
P21/WAF1/Cip1 expression in invasive ductal breast carcinoma: relationshipto p53, proliferation rate, and survival at 5 years
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
Regression of primary hepatocarcinoma in cancer-prone transgenic mice by local interferon-gamma delivery is associated with macrophages recruitment and nitric oxide production
CANCER GENE THERAPY
Apoptosis in raw 264.7 cells exposed to 4-hydroxy-2-nonenal: Dependence oncytochrome c release but not p53 accumulation
FREE RADICAL BIOLOGY AND MEDICINE
Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2
GENES & DEVELOPMENT
p21 gene codon 31 arginine/serine polymorphism: Non-association with endometriosis
JOURNAL OF CLINICAL LABORATORY ANALYSIS
Correlation between TGF-beta 1 and p21 (WAF1/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas
PANCREAS
Protein p21(WAF1/CIP1) is phosphorylated by protein kinase CK2 in vitro and interacts with the amino terminal end of the CK2 beta subunit
JOURNAL OF CELLULAR BIOCHEMISTRY
Cell-cycle arrest in TrkA-expressing NIH3T3 cells involves nitric oxide synthase
JOURNAL OF CELLULAR BIOCHEMISTRY
Osteoclast differentiation is associated with transient upregulation of cyclin-dependent kinase inhibitors p21(WAF1/CIP1) and p27(KIP1)
JOURNAL OF CELLULAR BIOCHEMISTRY
Development of colonic neoplasms and expressions of p53 and p21 proteins in experimental colitis of mice induced by dextran sulfate sodium
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis C virus core protein
MICROBIOLOGY AND IMMUNOLOGY
p21(WAF1/CIP1) expression in colorectal carcinomas: its correlation with p53 mutations and p53 and Ki67 immunohistochemistry.
PATHOLOGIE BIOLOGIE
An immunohistochemical analysis of cyclin D1, p53. and p21(waf1/cip1) proteins in tumors originating from the follicular epithelium of the thyroid gland
PATHOLOGY RESEARCH AND PRACTICE
P21 (WAF1) expression in colorectal cancer: Correlation with P53 and cyclin D1 expression, clinicopathological parameters and prognosis
PATHOLOGY RESEARCH AND PRACTICE
Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27(Kip1) and p57(Kip2) during mouse development
ANATOMY AND EMBRYOLOGY
Malignant peripheral nerve sheath tumours: high Ki67 labelling index is the significant prognostic indicator
HISTOPATHOLOGY
Reduced expression of p21(WAF1) is an indicator of malignant behaviour in anal carcinomas
HISTOPATHOLOGY
Influenza A virus infection of mice induces nuclear accumulation of the tumorsuppressor protein p53 in the lung
ARCHIVES OF VIROLOGY
Nitric oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic guanosine monophosphate
NEUROSCIENCE LETTERS
Exogenous expression of p21(WAF1/CIP1) exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells
CANCER LETTERS
A role for protein kinase C delta in the differential sensitivity of MCF-7and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAF1/CIP1) induction
CANCER LETTERS
Expression of p21(WAF1/CIP1) and p53 proteins in gastric carcinoma: its relationships with cell proliferation activity and prognosis
CANCER LETTERS
Novel bile acid derivatives induce apoptosis via a p53-independent pathwayin human breast carcinoma cells
CANCER LETTERS
Prognostic significance of histopathological grading and immunoreactivity for p53 and p21/WAF1 in grade 2 pTa transitional cell carcinoma of the urinary bladder
EUROPEAN UROLOGY
Arginine form of p21 gene codon 31 is less prominent in patients with calcium oxalate stone
UROLOGICAL RESEARCH
Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells
PROSTATE
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
EMBO JOURNAL
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
EMBO JOURNAL
A degradation signal located in the C-terminus of p21(WAF1/CIP1) is a binding site for the C8 alpha-subunit of the 20S proteasome
EMBO JOURNAL
p53, p21 and p27 protein expression in head and neck cancer and their prognostic value
ANTICANCER RESEARCH
Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Role of transforming growth factor beta in the growth inhibition of human breast cancer cells by basic fibroblast growth factor
BREAST CANCER RESEARCH AND TREATMENT
Cip/Kip cell-cycle inhibitors: A neuro-oncological perspective
JOURNAL OF NEURO-ONCOLOGY
Age-dependent changes of p57(Kip2) and p21(Cip1/Waf1) expression in skeletal muscle and lung of mice
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Action of an HMG CoA reductase inhibitor, lovastatin, on apoptosis of untransformed and ts-SV40 transformed human smooth muscle cells derived from saphenous vein
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Molecular response to ischemia-reperfusion of rat skin: Study of expression of p53, p21(WAF-1), and Bax proteins, and apoptosis
ANNALS OF PLASTIC SURGERY
Inhibitory effects of sodium butyrate on proliferation and invasiveness ofhuman glioma cells
NEUROSURGERY
Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus
GYNECOLOGIC ONCOLOGY
Bcl-2 exerts a pRb-Mediated cell cycle inhibitory function in HEC1B endometrial carcinoma cells
GYNECOLOGIC ONCOLOGY
Regulation of the DNA methylation machinery and its role in cellular transformation
PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 69
Reduced p21(WAF1/CIP1) expression is an early event in gallbladder carcinogenesis and is of prognostic significance for patients with carcinomas of the gallbladder
HUMAN PATHOLOGY
Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: Clinicopathologic correlation and survival analysis
HUMAN PATHOLOGY
p27: A potential main inhibitor of cell proliferation in digestive endocrine tumors but not a marker of benign behavior
HUMAN PATHOLOGY
Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C
VIROLOGY
Cell cycle control and immunosuppression in organ transplantation
TRANSPLANTATION PROCEEDINGS
Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies
MOLECULAR PHARMACOLOGY
Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation
MOLECULAR PHARMACOLOGY
Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma
LABORATORY INVESTIGATION
Editorial: New trends for optimal management of bladder tumors
JOURNAL OF UROLOGY
p21 gene regulation during enterocyte differentiation
JOURNAL OF SURGICAL RESEARCH
Decreased growth inhibitory responses of squamous carcinoma cells to interferon-gamma involve failure to recruit cki proteins into cdk2 complexes
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Role of cyclin kinase inhibitor p21 in systemic autoimmunity
JOURNAL OF IMMUNOLOGY
Induction of anergy in Th1 cells associated with increased levels of cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1)
JOURNAL OF IMMUNOLOGY
Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas
JOURNAL OF CLINICAL PATHOLOGY
Activation of p21(WAF1-Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin - Involvement of protein kinase C
JOURNAL OF BIOLOGICAL CHEMISTRY
Transcriptional activation of mouse sst2 somatostatin receptor promoter bytransforming growth factor-beta - Involvement of Smad4
JOURNAL OF BIOLOGICAL CHEMISTRY
Expression of P21 predicts PSA failure in locally advanced prostate cancertreated by prostatectomy
INTERNATIONAL JOURNAL OF CANCER
Quantitative p21(waf-1)/p53 immunohistochemical analysis defines groups ofprimary invasive breast carcinomas with different prognostic indicators
INTERNATIONAL JOURNAL OF CANCER
Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition
INTERNATIONAL JOURNAL OF CANCER
Activation of HTLV-I long terminal repeat by stress-inducing agents and protection of HTLV-I-Infected T-cells from apoptosis by the viral Tax protein
EXPERIMENTAL CELL RESEARCH
Contrasting roles of p57(KIP2) and p21(WAF1/CIP1/SDI1) transplanted human and bovine adrenocortical cells
EXPERIMENTAL CELL RESEARCH
Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein
EXPERIMENTAL CELL RESEARCH
Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts
EXPERIMENTAL CELL RESEARCH