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NO as a signaling molecule: effects on kinases
INTERNATIONAL IMMUNOPHARMACOLOGY
Expression of ras (p21) protein in plasma from exposed workers and from patients with lung disease
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Dimerization of small GTPase Rab5
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Inhibition of the nitrosothiol production of cultured osteoarthritic chondrocytes by rhein, cortisol and diclofenac
OSTEOARTHRITIS AND CARTILAGE
Protein recruitment systems for the analysis of protein +/- protein interactions
METHODS
ELISA-based Ki-ras gene mutation analyses in pancreatic and cholangiocarcinoma cells and tissues
ONCOLOGY REPORTS
Alanine scan mutagenesis of the switch I domain of the Caulobacter crescentus CgtA protein reveals critical amino acids required for in vivo function
MOLECULAR MICROBIOLOGY
Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM-CSF as adjuvant
EXPERIMENTAL DERMATOLOGY
Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes
GLIA
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain
GENES & DEVELOPMENT
Revisiting the structural flexibility of the complex p21(ras)-GTP: The catalytic conformation of the molecular switch II
PROTEINS-STRUCTURE FUNCTION AND GENETICS
Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Ras-farnesyltransferase-inhibitors as promising anti-tumor drugs
BIOORGANIC CHEMISTRY OF BIOLOGICAL SIGNAL TRANSDUCTION
Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines
BIOCHEMICAL JOURNAL
Effects of 12 beticolins, Cercospora beticola toxins, on proliferation of ras-transformed adrenocortical cell
ACTA PHARMACOLOGICA SINICA
Redox regulation of skeletal muscle glucose transport
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
Hyperosmotic stress activates the insulin receptor in CHO cells
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Epithelial proliferation and ras p21 oncoprotein expression in rectal mucosa of patients with ulcerative colitis
DIGESTIVE DISEASES AND SCIENCES
Nonradioactive determination of Ras-GTP levels using activated Ras interaction assay
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT G
Low concentrations of inorganic mercury inhibit Ras activation during T cell receptor-mediated signal transduction
TOXICOLOGY AND APPLIED PHARMACOLOGY
Molecular science of the living organism: The case of G-proteins
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
Dynamic properties of the Ras switch I region and its importance for binding to effectors
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
beta-adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of phosphatidylinositol 3-kinase
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
GTPase stimulation in shrimp Ras(Q(61)K) with geranylgeranyl pyrophosphatebut not mammalian GAP
JOURNAL OF EXPERIMENTAL ZOOLOGY
The importance of structural transitions of the switch II region for the functions of elongation factor Tu on the ribosome
JOURNAL OF BIOLOGICAL CHEMISTRY
Mg2+ is not catalytically required in the intrinsic and kirromycin-stimulated GTPase action of Thermus thermophilus EF-Tu
JOURNAL OF BIOLOGICAL CHEMISTRY
gamma-phosphate protonation and pH-dependent unfolding of the Ras center dot GTP center dot Mg2+ complex - A vibrational spectroscopy study
JOURNAL OF BIOLOGICAL CHEMISTRY
Inhibition by D-limonene of experimental hepatocarcinogenesis is in Sprague-Dawley rats does not involve p21(RAS) plasma membrane association
INTERNATIONAL JOURNAL OF CANCER
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
INTERNATIONAL JOURNAL OF CANCER
Comparison of nitrophenylethyl and hydroxyphenacyl caging groups
BIOPOLYMERS
Molecular dynamics simulations of Gly-12 -> Val mutant of p21(ras): Dynamic inhibition mechanism
BIOPHYSICAL JOURNAL
Aromatic substrate specificity of horseradish peroxidase C studied by a combined fluorescence line narrowing/energy minimization approach: The effectof localized side-chain reorganization
BIOCHEMISTRY
Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic
BIOCHEMISTRY
A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release
BIOCHEMISTRY
DnaA protein Lys-415 is close to the ATP-binding site: ATP-pyridoxal affinity labeling
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Ligation of the alpha M-2* signaling receptor regulates synthesis of cytosolic phospholipase A(2)
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Expression of inducible nitric oxide synthase is increased in acute myeloid leukaemia
ACTA HAEMATOLOGICA
Inhibition of cell growth in human glioblastoma cell lines by farnesyltransferase inhibitor SCH66336
NEURO-ONCOLOGY
Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms
MOLECULAR BIOLOGY OF THE CELL
Molecular biology of esophageal squamous cell carcinoma
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Dexamethasone enhances ras-recision gene expression in cultured murine fetal lungs: role in development
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Structural changes induced in p21(Ras) upon GAP-334 complexation as probedby ESEEM spectroscopy and molecular-dynamics simulation
STRUCTURE
Role of the switch II region in the conformational transition of activation of Ha-ras-p21
PROTEIN SCIENCE
A step toward the prediction of the fluorescence lifetimes of tryptophan residues in proteins based on structural and spectral data
PROTEIN SCIENCE
The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP
CURRENT BIOLOGY
Inhibition of Ras p21 synthesis by antisense undecamers with uniform and specifically arranged phosphorothioate linkages
ANTI-CANCER DRUGS
Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF
ONCOGENE
Structure of the nucleotide-binding domain of Plasmodium falciparum Rab6 in the GDP-bound form
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
ras-p21-induced cell transformation: Unique signal transduction pathways and implications for the design of new chemotherapeutic agents
CANCER INVESTIGATION
Characterization of epidermal growth factor receptor function in lysophosphatidic acid signaling in PC12 cells
JOURNAL OF CELLULAR BIOCHEMISTRY
Cytoplasmic overexpression of p53 and p21(ras) in megaloblastic anemia
HAEMATOLOGICA
Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway
CANCER CHEMOTHERAPY AND PHARMACOLOGY
RB protein expression in human endometrial carcinomas - An immunohistochemical study
PATHOLOGY RESEARCH AND PRACTICE
p53 protein detection by the Western blotting technique in normal and neoplastic specimens of human endometrium
CANCER LETTERS
Organization of transport from endoplasmic reticulum to Golgi in higher plants
BIOCHEMICAL SOCIETY TRANSACTIONS
Identification, using molecular dynamics, of an effector domain of the ras-binding domain of the raf-p74 protein that is uniquely involved in oncogenic ras-p21 signaling
JOURNAL OF PROTEIN CHEMISTRY
GTPase mechanism and function: new insights from systematic mutational analysis of the phosphate-binding loop residue Ala(30) of Rab5
BIOCHEMICAL JOURNAL
Triphosphate structure of guanylate-binding protein 1 and implications fornucleotide binding and GTPase mechanism
EMBO JOURNAL
Ras farnesyltransferase inhibition: a novel and safe approach for cancer chemotherapy
ACTA PHARMACOLOGICA SINICA
Overexpression of Grb2 in inflammatory lesions and preneoplastic foci and tumors induced by N-nitrosodimethylamine in helicobacter hepaticus-infectedand -noninfected A/J mice
TOXICOLOGIC PATHOLOGY
Treatment of v-Ki-Ras-transformed SVC1 cells with low retinoic acid induces malignancy reversion associated with Ras p21 down-regulation
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Mn2+ as a probe of divalent metal ion binding and function in enzymes and other proteins
METAL IONS IN BIOLOGICAL SYSTEMS, VOL 37
Immunotherapy for colorectal cancer: Potential application in an adjuvant setting
SEMINARS IN ONCOLOGY
Glutathione-S-transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal kinase
ANNALS OF CLINICAL AND LABORATORY SCIENCE
Analysis and identification of protein-protein interactions using protein recruitment systems
APPLICATIONS OF CHIMERIC GENES AND HYBRID PROTEINS, PT C
Measurement of GTPase center dot effector affinities
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT D
Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT D
Bioorganic synthesis of lipid-modified proteins for the study of signal transduction
NATURE
Expression of a dominant-negative mutant of p21(ras) inhibits induction ofnitric oxide synthase and activation of nuclear factor-kappa B in primary astrocytes
JOURNAL OF NEUROCHEMISTRY
Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells
JOURNAL OF NEUROCHEMISTRY
Three-dimensional view of the surface motif associated with the P-loop structure: Cis and trans cases of convergent evolution
JOURNAL OF MOLECULAR BIOLOGY
High-resolution crystal structure of S. cerevisiae Ypt51(Delta C15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis
JOURNAL OF MOLECULAR BIOLOGY
Analysis of farnesyl transferase activity during hormone-induced maturation of Xenopus laevis oocytes
JOURNAL OF EXPERIMENTAL ZOOLOGY
Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein
JOURNAL OF EXPERIMENTAL MEDICINE
Formation of the Ras dimer is essential for Raf-1 activation
JOURNAL OF BIOLOGICAL CHEMISTRY
Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit
JOURNAL OF BIOLOGICAL CHEMISTRY
Kinetics of the interaction of translation factor SelB from Escherichia coli with guanosine nucleotides and selenocysteine insertion sequence RNA
JOURNAL OF BIOLOGICAL CHEMISTRY
The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons
JOURNAL OF BIOLOGICAL CHEMISTRY
Unique in vivo associations with SmgGDS and RhoGDI and different guanine nucleotide exchange activities exhibited by RhoA, dominant negative RhoA(Asn-19) and activated RhoA(Val-14)
JOURNAL OF BIOLOGICAL CHEMISTRY
Extracellular lipid-mediated signaling in tumor-cell activation and pseudopod protrusion
INTERNATIONAL JOURNAL OF CANCER
Substrate binding and enzyme function investigated by infrared spectroscopy
FEBS LETTERS
Application of linear free energy relationships to the serpin-proteinase inhibition mechanism
FEBS LETTERS
Phosphorylation of the p190 RhoGAP N-terminal domain by c-Src results in aloss of GTP binding activity
FEBS LETTERS
ras p21 isoprenylation inhibition induces flat colon tumors in Wistar rats
DISEASES OF THE COLON & RECTUM
Increased mitogen-activated protein kinase activities stimulated with interleukin-1-beta and mechanism(s) of the kinase signaling pathways in rat gastric epithelial cells
DIGESTION
Oxidative stress and S-nitrosylation of proteins in cells
BRITISH JOURNAL OF PHARMACOLOGY
Akt-dependent antiapoptotic action of insulin is sensitive to farnesyltransferase inhibitor
BIOCHEMISTRY
Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras
BIOCHEMISTRY
Structure of the complex of Cdc42Hs with a peptide derived from p-21 activated kinase
BIOCHEMISTRY
Spectroscopic methods for analysis of protein secondary structure
ANALYTICAL BIOCHEMISTRY
Mn2+ sites in the hammerhead ribozyme investigated by EPR and continuous-wave Q-band ENDOR spectroscopies
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
The substrate-assisted general base catalysis model for phosphate monoester hydrolysis: Evaluation using reactivity comparisons
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
A phase I vaccine trial with peptides reflecting ras oncogene mutations ofsolid tumors
JOURNAL OF IMMUNOTHERAPY
Molecular reaction mechanisms of proteins monitored by time-resolved FTIR-spectroscopy
BIOLOGICAL CHEMISTRY
Cytogenetic damage and ras p21 oncoprotein levels from patients with chronic obstructive pulmonary disease (COPD), untreated lung cancer and healthy controls
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS