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La ricerca find articoli where soggetti phrase all words 'O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 126 riferimenti
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    1. Boiardi, A; Silvani, A; Ciusani, E; Watson, A; Margison, G; Berger, E; Lucas, C; Giroux, B
      Fotemustine combined with procarbazine in recurrent malignant gliomas: A phase I study with evaluation of lymphocyte O-6-alkylguanine-DNA alkyltransferase activity

      JOURNAL OF NEURO-ONCOLOGY
    2. Reinard, J; Eichhorn, U; Wiessler, M; Kaina, B
      Inactivation of O-6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors

      INTERNATIONAL JOURNAL OF CANCER
    3. Marchenay, C; Cellarier, E; Levi, F; Rolhion, C; Kwiatkowski, F; Claustrat, B; Madelmont, JC; Chollet, P
      Circadian variation in O-6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects

      INTERNATIONAL JOURNAL OF CANCER
    4. Long, L; Moschel, RC; Dolan, ME
      Debenzylation of O-6-benzyl-8-oxoguanine in human liver: implications for O-6-benzylguanine metabolism

      BIOCHEMICAL PHARMACOLOGY
    5. Engelbergs, J; Thomale, J; Rajewsky, MF
      Role of DNA repair in carcinogen-induced ras mutation

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    6. Schilsky, RL; Dolan, ME; Bertucci, D; Ewesuedo, RB; Vogelzang, NJ; Mani, S; Wilson, LR; Ratain, MJ
      Phase I clinical and pharmacological study of O-6-benzylguanine followed by carmustine in patients with advanced cancer

      CLINICAL CANCER RESEARCH
    7. Kaur, TB; Travaline, JM; Gaughan, JP; Richie, JP; Stellman, SD; Lazarus, P
      Role of polymorphisms in codons 143 and 160 of the O-6-alkylguanine DNA alkyltransferase gene in lung cancer risk

      CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
    8. Xu-Welliver, M; Pegg, AE
      Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O-6-alkylguanine-DNA alkyltransferase insensitive to O-6-benzylguanine

      BIOCHEMICAL JOURNAL
    9. Xu-Welliver, M; Kanugula, S; Loktionova, NA; Crone, TM; Pegg, AE
      Conserved residue lysine(165) is essential for the ability of O-6-alkylguanine-DNA alkyltransferase to react with O-6-benzylguanine

      BIOCHEMICAL JOURNAL
    10. Daniels, DS; Mol, CD; Arvai, AS; Kanugula, S; Pegg, AE; Tainer, JA
      Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

      EMBO JOURNAL
    11. Toft, NJ; Sanson, OJ; Brookes, RA; Arends, MJ; Wood, M; Margison, GP; Winton, DJ; Clarke, AR
      In vivo administration of O-6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but doesinhibit P450-dependent activation of dacarbazine

      CARCINOGENESIS
    12. Thompson, MJ; Abdul-Rahman, S; Baker, TG; Rafferty, JA; Margison, GP; Bibby, MC
      Role of O-6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O-6-alkylating agents

      JOURNAL OF REPRODUCTION AND FERTILITY
    13. D'Atri, S; Graziani, G; Lacal, PM; Nistico, V; Gilberti, S; Faraoni, I; Watson, AJ; Bonmassar, E; Margison, GP
      Attenuation of O-6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    14. Griffin, RJ; Arris, CE; Bleasdale, C; Boyle, FT; Calvert, AH; Curtin, NJ; Dalby, C; Kanugula, S; Lembicz, NK; Newell, DR; Pegg, AE; Golding, BT
      Resistance-modifying agents. 8. Inhibition of O-6-alkylguanine-DNA alkyltransferase by O-6-alkenyl-, O-6-cycloalkenyl-, and O-6-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O-6-(1-cyclopentenylmethyl)guanine

      JOURNAL OF MEDICINAL CHEMISTRY
    15. Middleton, MR; Lee, SM; Arance, A; Wood, M; Thatcher, N; Margison, GP
      O-6-methylguanine formation, repair protein depletion and clinical outcomewith a 4 hr schedule of temozolomide in the treatment of advanced melanoma: Results of phase II study

      INTERNATIONAL JOURNAL OF CANCER
    16. Frosina, G
      Overexpression of enzymes that repair endogenous damage to DNA

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    17. Davis, BM; Koc, ON; Gerson, SL
      Limiting numbers of G156A O-6-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection

      BLOOD
    18. Gerson, SL; Schupp, J; Liu, LL; Pegg, AE; Srinivasen, S
      Leukocyte O-6-akylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O-6-benzylguanine

      CLINICAL CANCER RESEARCH
    19. Reese, JS; Davis, BM; Liu, LL; Gerson, SL
      Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells usingO-6-benzylguanine and temozolomide

      CLINICAL CANCER RESEARCH
    20. Longhurst, SJ; Rafferty, JA; Arrand, JR; Cortez, N; Giraud, C; Berns, KI; Fairbairn, LJ
      Recombinant adeno-associated virus-mediated expression of O-6-alkylguanine-DNA-alkyltransferase protects human epithelial and hematopoietic cells against chloroethylating agent toxicity

      HUMAN GENE THERAPY
    21. Davis, BM; Roth, JC; Liu, LL; Xu-Welliver, M; Pegg, AE; Gerson, SL
      Characterization of the P140K, PVP(138-140)MLK, and G156A O-6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy

      HUMAN GENE THERAPY
    22. Deng, CJ; Xie, DW; Capasso, H; Zhao, YJ; Wang, LD; Hong, JY
      Genetic polymorphism of human O-6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region

      PHARMACOGENETICS
    23. Koc, ON; Reese, JS; Szekely, EM; Gerson, SL
      Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis (2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer

      CANCER GENE THERAPY
    24. Gander, M; Leyvraz, S; Decosterd, L; Bonfanti, M; Marzolini, C; Shen, F; Lienard, D; Perey, L; Colella, G; Biollaz, J; Lejeune, F; Yarosh, D; Belanich, M; D'Incalci, M
      Sequential administration of temozolomide and fotemustine: Depletion of O-6-alkyl guanine-DNA transferase in blood lymphocytes and in tumours

      ANNALS OF ONCOLOGY
    25. Phillips, WP; Gerson, SL
      Acquired resistance to O-6-benzylguanine plus chloroethylnitrosoureas in human breast cancer

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    26. Glassner, BJ; Weeda, G; Allan, JM; Broekhof, JLM; Carls, NHE; Donker, I; Engelward, BP; Hampson, RJ; Hersmus, R; Hickman, MJ; Broth, RB; Warren, HB; Wu, MM; Hoeijmakers, JHJ; Samson, LD
      DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

      MUTAGENESIS
    27. Wali, RK; Skarosi, S; Hart, J; Zhang, YC; Dolan, ME; Moschel, RC; Nguyen, L; Mustafi, R; Brasitus, TA; Bissonnette, M
      Inhibition of O-6-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats

      CARCINOGENESIS
    28. Edara, S; Kanugula, S; Pegg, AE
      Expression of the inactive C145A mutant human O-6-alkylguanine-DNA alkyltransferase in E-coli increases cell killing and mutations by N-methyl-N '-nitro-N-nitrosoguanidine

      CARCINOGENESIS
    29. Xu-Welliver, M; Leitao, J; Kanugula, S; Pegg, AE
      Alteration of the conserved residue tyrosine-158 to histidine renders human O-6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O-6-benzylguanine

      CANCER RESEARCH
    30. Cai, YN; Wu, MH; Ludeman, SM; Grdina, DJ; Dolan, ME
      Role of O-6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity

      CANCER RESEARCH
    31. Spiro, TP; Gerson, SL; Liu, LL; Majka, S; Haaga, J; Hoppel, CL; Ingalls, ST; Pluda, JM; Willson, JKV
      O-6-benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directrd DNA repair

      CANCER RESEARCH
    32. Bibby, MC; Thompson, MJ; Rafferty, JA; Margison, GP; McElhinney, RS
      Influence of O-6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-l-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice

      BRITISH JOURNAL OF CANCER
    33. Xu-Welliver, M; Leitao, J; Kanugula, S; Meehan, WJ; Pegg, AE
      Role of codon 160 in the sensitivity of human O-6-alkylguanine-DNA a alkyltransferase to O-6-benzylguanine

      BIOCHEMICAL PHARMACOLOGY
    34. CHINNASAMY N; FAIRBAIRN LJ; LAHER J; WILLINGTON MA; RAFFERTY JA
      MODULATION OF O-6-ALKYLATING AGENT INDUCED CLASTOGENICITY BY ENHANCEDDNA-REPAIR CAPACITY OF BONE-MARROW CELLS

      Mutation research. Genetic toxicology and environmental mutagenesis
    35. HAYES MT; BARTLEY J; PARSONS PG
      IN-VITRO EVALUATION OF FOTEMUSTINE AS A POTENTIAL AGENT FOR LIMB PERFUSION IN MELANOMA

      Melanoma research
    36. Citti, L; Mariani, L; Capecchi, B; Piras, A; Leuzzi, R; Rainaldi, G
      The sensitization of cells treated with O-6-methylguanine to alkylation damage is affected by the number of O-6-methylguanine-DNA methyltransferase molecules escaped from inactivation

      MUTATION RESEARCH-DNA REPAIR
    37. DOLAN ME; ROY SK; FASANMADE AA; PARAS PR; SCHILSKY RL; RATAIN MJ
      O-6-BENZYLGUANINE IN HUMANS - METABOLIC, PHARMACOKINETIC, AND PHARMACODYNAMIC FINDINGS

      Journal of clinical oncology
    38. JAECKLE KA; EYRE HJ; TOWNSEND JJ; SCHULMAN S; KNUDSON HM; BELANICH M; YAROSH DB; BEARMAN SI; GIROUX DJ; SCHOLD SC
      CORRELATION OF TUMOR O-6 METHYLGUANINE-DNA METHYLTRANSFERASE LEVELS WITH SURVIVAL OF MALIGNANT ASTROCYTOMA PATIENTS TREATED WITH BIS-CHLOROETHYLNITROSOUREA - A SOUTHWEST-ONCOLOGY-GROUP STUDY

      Journal of clinical oncology
    39. KANUGULA S; GOODTZOVA K; PEGG AE
      PROBING OF CONFORMATIONAL-CHANGES IN HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE PROTEIN IN ITS ALKYLATED AND DNA-BOUND STATES BY LIMITED PROTEOLYSIS

      Biochemical journal
    40. CHEN ZP; MCQUILLAN A; MOHR G; PANASCI LC
      EXCISION-REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY GENE-2 EXPRESSION AND CHLOROETHYLNITROSOUREA RESISTANCE IN HUMAN GLIOMA CELL-LINES

      Neurosurgery
    41. KLEIBL K; MARGISON GP
      INCREASING DNA-REPAIR CAPACITY IN BONE-MARROW BY GENE-TRANSFER AS A PROSPECTIVE TOOL IN CANCER-THERAPY

      Neoplasma
    42. ENGELBERGS J; THOMALE J; GALHOFF A; RAJEWSKY MF
      FAST REPAIR OF O-6-ETHYLGUANINE, BUT NOT O-6-METHYLGUANINE, IN TRANSCRIBED GENES PREVENTS MUTATION OF H-RAS IN RAT MAMMARY TUMORIGENESIS INDUCED BY ETHYLNITROSOUREA IN-PLACE OF METHYLNITROSOUREA

      Proceedings of the National Academy of Sciences of the United Statesof America
    43. PEGG AE; KANUGULA S; EDARA S; PAULY GT; MOSCHEL RC; GOODTZOVA K
      REACTION OF O-6-BENZYLGUANINE-RESISTANT MUTANTS OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE WITH O-6-BENZYLGUANINE IN OLIGODEOXYRIBONUCLEOTIDES

      The Journal of biological chemistry
    44. XUWELLIVER M; KANUGULA S; PEGG AE
      ISOLATION OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE MUTANTS HIGHLY RESISTANT TO INACTIVATION BY O-6-BENZYLGUANINE

      Cancer research
    45. ENCELL LP; COATES MM; LOEB LA
      ENGINEERING HUMAN DNA ALKYLTRANSFERASES FOR GENE-THERAPY USING RANDOMSEQUENCE MUTAGENESIS

      Cancer research
    46. GOODTZOVA K; KANUGULA S; EDARA S; PEGG AE
      INVESTIGATION OF THE ROLE OF TYROSINE-114 IN THE ACTIVITY OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANFERASE

      Biochemistry
    47. DOLAN ME; PEGG AE
      O-6-BENZYLGUANINE AND ITS ROLE IN CHEMOTHERAPY

      Clinical cancer research
    48. YULE SM; KEARNS PR; HALL AG
      ALKYLATING AGENT RESISTANCE IN PEDIATRIC ONCOLOGY

      International journal of pediatric hematology/oncology
    49. ISHIBE N; KELSEY KT
      GENETIC SUSCEPTIBILITY TO ENVIRONMENTAL AND OCCUPATIONAL CANCERS

      CCC. Cancer causes & control
    50. BUSER K; JONCOURT F; ALTERMATT HJ; BACCHI M; OBERLI A; CERNY T
      BREAST-CANCER - PRETREATMENT DRUG-RESISTANCE PARAMETERS (GSH-SYSTEM, ATASE, P-GLYCOPROTEIN) IN TUMOR-TISSUE AND THEIR CORRELATION WITH CLINICAL AND PROGNOSTIC CHARACTERISTICS

      Annals of oncology
    51. TONG HH; PARK JH; BRADY T; WEGHORST CM; DAMBROSIO SM
      MOLECULAR CHARACTERIZATION OF MUTATIONS IN THE HPRT GENE OF NORMAL HUMAN SKIN KERATINOCYTES TREATED WITH N-ETHYL-N-NITROSOUREA - INFLUENCE OF O-6-ALKYLGUANINE ALKYLTRANSFERASE

      Environmental and molecular mutagenesis
    52. HAYES RB; KLEIN S; SURUDA A; SCHULTE P; BOENIGER M; STEWART P; LIVINGSTON GK; OESCH F
      O-6-ALKYLGUANINE DNA ALKYLTRANSFERASE ACTIVITY IN STUDENT EMBALMERS

      American journal of industrial medicine
    53. DOLAN ME
      INHIBITION OF DNA-REPAIR AS A MEANS OF INCREASING THE ANTITUMOR-ACTIVITY OF DNA REACTIVE AGENTS

      Advanced drug delivery reviews
    54. RAFFERTY JA; WIBLEY JEA; SPEERS P; HICKSON I; MARGISON GP; MOODY PCE; DOUGLAS KT
      THE POTENTIAL ROLE OF GLYCINE-160 OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN REACTION WITH O-6-BENZYLGUANINE AS DETERMINED BY SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING COMPARISONS

      Biochimica et biophysica acta. Protein structure and molecular enzymology
    55. PIEPER RO
      UNDERSTANDING AND MANIPULATING O-6-METHYLGUANINE-DNA METHYLTRANSFERASE EXPRESSION

      Pharmacology & therapeutics
    56. SAMSON L; HAN S; MARQUIS JC; RASMUSSEN LJ
      MAMMALIAN DNA-REPAIR METHYLTRANSFERASES SHIELD (OMET)-ME-4 FROM NUCLEOTIDE EXCISION-REPAIR

      Carcinogenesis
    57. BUSCHFORT C; MULLER MR; SEEBER S; RAJEWSKY MF; THOMALE J
      DNA EXCISION-REPAIR PROFILES OF NORMAL AND LEUKEMIC HUMAN-LYMPHOCYTES- FUNCTIONAL-ANALYSIS AT THE SINGLE-CELL LEVEL

      Cancer research
    58. KOKKINAKIS DM; AHMED MM; DELGADO R; FRUITWALA MM; MOHIUDDIN M; ALBORESSAAVEDRA J
      ROLE OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE IN THE RESISTANCE OF PANCREATIC TUMORS TO DNA ALKYLATING-AGENTS

      Cancer research
    59. DAVIS BM; REESE JS; KOC ON; LEE K; SCHUPP JE; GERSON SL
      SELECTION FOR G156A O-6-METHYLGUANINE DNA METHYLTRANSFERASE GENE-TRANSDUCED HEMATOPOIETIC PROGENITORS AND PROTECTION FROM LETHALITY IN MICETREATED WITH O-6-BENZYLGUANINE AND 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA

      Cancer research
    60. PHILLIPS WP; WILLSON JKV; MARKOWITZ SD; ZBOROWSKA E; ZAIDI NH; LIU LL; GORDON NH; GERSON SL
      O-6-METHYLGUANINE-DNA METHYLTRANSFERASE (MGMT) TRANSFECTANTS OF A 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA (BCNU)-SENSITIVE COLON-CANCER CELL-LINE SELECTIVELY REPOPULATE HETEROGENEOUS MGMT(+) MGMT(-) XENOGRAFTS AFTER BCNU AND O-6-BENZYLGUANINE PLUS BCNU/

      Cancer research
    61. BECKER K; GREGEL CM; KAINA B
      THE DNA-REPAIR PROTEIN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE PROTECTS AGAINST SKIN TUMOR-FORMATION INDUCED BY ANTINEOPLASTIC CHLOROETHYLNITROSOAREA

      Cancer research
    62. CHRISTIANS FC; DAWSON BJ; COATES MM; LOEB LA
      CREATION OF HUMAN ALKYLTRANSFERASES RESISTANT TO O-6-BENZYLGUANINE

      Cancer research
    63. DEBITON E; CUSSACBUCHDHAL C; MOUNETOU E; RAPP M; DUPUY JM; MAURIZIS JC; VEYRE A; MADELMONT JC
      ENHANCEMENT BY O-6-BENZYL-N2-ACETYLGUANOSINE OF OETHYL]-N[2-(METHYLSULPHONYL)ETHYL]-N'-NITROSOUREA THERAPEUTIC INDEX ON NUDE-MICE BEARING RESISTANT HUMAN-MELANOMA

      British Journal of Cancer
    64. HAYES MT; BARTLEY J; PARSONS PG; EAGLESHAM GK; PRAKASH AS
      MECHANISM OF ACTION OF FOTEMUSTINE, A NEW CHLOROETHYLNITROSOUREA ANTICANCER AGENT - EVIDENCE FOR THE FORMATION OF 2 DNA-REACTIVE INTERMEDIATES CONTRIBUTING TO CYTOTOXICITY

      Biochemistry
    65. BIANCHINI F; WEIDERPASS E; KYRTOPOULOS S; SOULIOTIS VL; HENRYAMAR M; WILD CP; BOFFETTA P
      DETECTION OF DNA METHYLATION ADDUCTS IN HODGKINS-DISEASE PATIENTS TREATED WITH PROCARBAZINE

      Biomarkers
    66. SMITH DC; GERSON SL; LIU LL; DONNELLY S; DAY R; TRUMP DL; KIRKWOOD JM
      CARMUSTINE AND STREPTOZOCIN IN REFRACTORY MELANOMA - AN ATTEMPT AT MODULATION OF O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE

      Clinical cancer research
    67. MEMISOGLU A; SAMSON L
      DNA-REPAIR FUNCTIONS IN HETEROLOGOUS CELLS

      Critical reviews in biochemistry and molecular biology
    68. YANAGISAWA T; WATANABE K; MINEURA K; KOWADA M
      MEASUREMENT OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY USINGOLIGONUCLEOTIDES AND RESTRICTION ENZYME IN HUMAN BRAIN-TUMORS

      International journal of oncology
    69. HICKSON I; FAIRBAIRN LJ; CHINNASAMY N; DEXTER TM; MARGISON GP; RAFFERTY JA
      PROTECTION OF MAMMALIAN-CELLS AGAINST CHLOROETHYLATING AGENT TOXICITYBY AN O-6-BENZYLGUANINE-RESISTANT MUTANT OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE

      Gene therapy
    70. HANSSON J; MARTENHED G; EGYHAZI S; TANI E; PLATZ A
      ANALYSIS OF O-6 METHYLGUANINE-DNA METHYLTRANSFERASE MESSENGER-RNA IN FINE-NEEDLE BIOPSIES FROM HUMAN-MELANOMA METASTASES BY REVERSE TRANSCRIPTION AND POLYMERASE CHAIN-REACTION

      European journal of cancer
    71. RAFFERTY JA; CLARKE AR; SELLAPPAN D; KOREF MS; FRAYLING IM; MARGISON GP
      INDUCTION OF MURINE O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE IN RESPONSETO IONIZING-RADIATION IS P53 GENE DOSE-DEPENDENT

      Oncogene
    72. CRONE TM; GOODTZOVA K; PEGG AE
      AMINO-ACID-RESIDUES AFFECTING THE ACTIVITY AND STABILITY OF HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE

      Mutation research. DNA repair
    73. BENDER K; FEDERWISCH M; LOGGEN U; NEHLS P; RAJEWSKY MF
      BINDING AND REPAIR OF O-6-ETHYLGUANINE IN DOUBLE-STRANDED OLIGODEOXYNUCLEOTIDES BY RECOMBINANT HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE DO NOT EXHIBIT SIGNIFICANT DEPENDENCE ON SEQUENCE CONTEXT

      Nucleic acids research
    74. LEE SM; PORTMANN BC; MARGISON GP
      ABNORMAL INTRACELLULAR-DISTRIBUTION OF O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE IN HEPATITIS-B CIRRHOTIC HUMAN LIVER - A POTENTIAL COFACTOR INTHE DEVELOPMENT OF HEPATOCELLULAR-CARCINOMA

      Hepatology
    75. RAFFERTY JA; HICKSON I; CHINNASAMY N; LASHFORD LS; MARGISON GP; DEXTER TM; FAIRBAIRN LJ
      CHEMOPROTECTION OF NORMAL-TISSUES BY TRANSFER OF DRUG-RESISTANCE GENES

      Cancer metastasis reviews
    76. SOULIOTIS VL; VALAVANIS C; BOUSSIOTIS VA; PANGALIS GA; KYRTOPOULOS SA
      COMPARATIVE-STUDY OF THE FORMATION AND REPAIR OF O-6-METHYLGUANINE INHUMANS AND RODENTS TREATED WITH DACARBAZINE

      Carcinogenesis
    77. CITTI L; BOLDRINI L; PREUSS I; KAINA B; MARIANI L; RAINALDI G
      TARGETING OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE (MGMT) ACTIVITY BY ANTI-MESSENGER OLIGONUCLEOTIDE SENSITIZES CHO MEX(+) TRANSFECTED CELLS TO MITOZOLOMIDE/

      Carcinogenesis
    78. KOC ON; ALLAY JA; LEE K; DAVIS BM; REESE JS; GERSON SL
      TRANSFER OF DRUG-RESISTANCE GENES INTO HEMATOPOIETIC PROGENITORS TO IMPROVE CHEMOTHERAPY TOLERANCE

      Seminars in oncology
    79. REESE JS; KOC ON; LEE KM; LIU LL; ALLAY JA; PHILLIPS WP; GERSON SL
      RETROVIRAL TRANSDUCTION OF A MUTANT METHYLGUANINE DNA METHYLTRANSFERASE GENE INTO HUMAN CD34 CELLS CONFERS RESISTANCE TO O-6-BENZYLGUANINE PLUS 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA

      Proceedings of the National Academy of Sciences of the United Statesof America
    80. MARGISON GP; RAFFERTY JA; ELDER RH; KELLY J; WATSON AJ; WILLINGTON MA; LEE SM; HICKSON I; FAIRBAIRN LJ; DEXTER TM; JELINEK J; STOCKING C; BAUM C; OSTERTAG W; EGHYAZI S; HANSSON J; RINGBORG U; DONNELLY D; MCMURRY TBH; MCCORMICK J; MCELHINNEY RS
      MODULATING NITROSOUREA RESPONSE IN TUMORS AND NORMAL TISSUE - APPLICATION TO FOTEMUSTINE

      Medicamentos de actualidad
    81. LACAL PM; DATRI S; ORLANDO L; BONMASSAR E; GRAZIANI G
      IN-VITRO INACTIVATION OF HUMAN O-6-ALKYLGUANINE DNA ALKYLTRANSFERASE BY ANTITUMOR TRIAZENE COMPOUNDS

      The Journal of pharmacology and experimental therapeutics
    82. LIU LL; LEE K; WASAN E; GERSON SL
      DIFFERENTIAL SENSITIVITY OF HUMAN AND MOUSE ALKYLTRANSFERASE TO O-6-BENZYLGUANINE USING A TRANSGENIC MODEL

      Cancer research
    83. LOKTIONOVA NA; PEGG AE
      POINT MUTATIONS IN HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE PREVENT THE SENSITIZATION BY O-6-BENZYLGUANINE TO KILLING BY N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA

      Cancer research
    84. EDARA S; KANUGULA S; GOODTZOVA K; PEGG AE
      RESISTANCE OF THE HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE CONTAINING ARGININE AT CODON-160 TO INACTIVATION BY O-6-BENZYLGUANINE

      Cancer research
    85. LIU LL; MARKOWITZ S; GERSON SL
      MISMATCH REPAIR MUTATIONS OVERRIDE ALKYLTRANSFERASE IN CONFERRING RESISTANCE TO TEMOZOLOMIDE BUT NOT TO 1,3-BIS(2-CHLOROETHYL)NITROSOUREA

      Cancer research
    86. WEDGE SR; PORTEOUS JK; MAY BL; NEWLANDS ES
      POTENTIATION OF TEMOZOLOMIDE AND BCNU CYTOTOXICITY BY O-6-BENZYLGUANINE - A COMPARATIVE-STUDY IN-VITRO

      British Journal of Cancer
    87. FRIED MG; KANUGULA S; BROMBERG JL; PEGG AE
      DNA-BINDING MECHANISM OF O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE - STOICHIOMETRY AND EFFECTS OF DNA-BASE COMPOSITION AND SECONDARY STRUCTURE ON COMPLEX STABILITY

      Biochemistry
    88. SRIVENUGOPAL KS; YUAN XH; FRIEDMAN HS; ALIOSMAN F
      UBIQUITINATION-DEPENDENT PROTEOLYSIS OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE IN HUMAN AND MURINE TUMOR-CELLS FOLLOWING INACTIVATION WITHO-6-BENZYLGUANINE OR 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA

      Biochemistry
    89. OH HK; TEO AKC; ALI RB; LIM A; AYI TC; YAROSH DB; LI BFL
      CONFORMATIONAL CHANGE IN HUMAN DNA-REPAIR ENZYME O-6-METHYLGUANINE-DNA METHYLTRANSFERASE UPON ALKYLATION OF ITS ACTIVE-SITE BY SN1 (INDIRECT-ACTING) AND SN2 (DIRECT-ACTING) ALKYLATING-AGENTS - BREAKING A SALT-LINK

      Biochemistry
    90. GERSON SL; ALLAY E; VITANTONIO K; DUMENCO LL
      DETERMINANTS OF O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY IN HUMAN COLON-CANCER

      Clinical cancer research
    91. GROMBACHER T; KAINA B
      CONSTITUTIVE EXPRESSION AND INDUCIBILITY OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE AND N-METHYLPURINE-DNA GLYCOSYLASE IN RAT-LIVER CELLS EXHIBITING DIFFERENT STATUS OF DIFFERENTIATION

      Biochimica et biophysica acta. Molecular basis of disease
    92. XIAO W; FONTANIE T
      EXPRESSION OF THE HUMAN MGMT O-6-METHYLGUANINE DNA METHYLTRANSFERASE GENE IN A YEAST ALKYLATION-SENSITIVE MUTANT - ITS EFFECTS ON BOTH EXOGENOUS AND ENDOGENOUS DNA ALKYLATION DAMAGE

      Mutation research. DNA repair
    93. GERSON SL; WILLSON JKV
      O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE - A TARGET FOR THE MODULATION OF DRUG RESISTANCE

      Hematology/oncology clinics of North America
    94. WILLSON JKV; HAAGA JR; TREY JE; STELLATO TA; GORDON NH; GERSON SL
      MODULATION OF O-6-ALKYLGUANINE ALKYLTRANSFERASE DIRECTED DNA-REPAIR IN METASTATIC COLON CANCERS

      Journal of clinical oncology
    95. FAIRBAIRN LJ; WATSON AJ; RAFFERTY JA; ELDER RH; MARGISON GP
      O-6-BENZYLGUANINE INCREASES THE SENSITIVITY OF HUMAN PRIMARY BONE-MARROW CELLS TO THE CYTOTOXIC EFFECTS OF TEMOZOLOMIDE

      Experimental hematology
    96. ALLEMAND I; ANGULO JF
      TRANSGENIC AND KNOCK-OUT MODELS FOR STUDYING DNA-REPAIR

      Biochimie
    97. ZHAO KM; CHEN JM; ZUO HZ; WU Y; ZHANG YP
      MODULATION OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE-MEDIATED NIMUSTINE RESISTANCE IN RECURRENT MALIGNANT GLIOMAS BY STREPTOZOTOCIN - A PRELIMINARY-REPORT

      Anticancer research
    98. MAGULLSELTENREICH A; ZELLER WJ
      SENSITIZATION OF HUMAN COLON-TUMOR CELL-LINES TO CARMUSTINE BY DEPLETION OF O-6 ALKYLGUANINE DNA ALKYLTRANSFERASE

      Journal of cancer research and clinical oncology
    99. YANG J; CHEN JM; ZHANG YP
      TRANSFER AND EXPRESSION OF HUMAN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE CDNA CONFERS RESISTANCE OF MER(-)HELA MR CELLS TO PYRIMIDINYL)METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA

      Carcinogenesis
    100. XIAO W; RATHGEBER L; FONTANIE T; BAWA S
      DNA MISMATCH REPAIR MUTANTS DO NOT INCREASE N-METHYL-N'-NITRO-N-NITROSOGUANIDINE TOLERANCE IN O-6 METHYLGUANINE DNA METHYLTRANSFERASE-DEFICIENT YEAST-CELLS

      Carcinogenesis


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 01:52:40