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La ricerca find articoli where soggetti phrase all words 'O-6-METHYLGUANINE-DNA METHYLTRANSFERASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 235 riferimenti
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    1. Ishikawa, T; Ide, F; Qin, XS; Zhang, SM; Takahashi, T; Sekiguchi, M; Tanaka, K; Nakatsuru, Y
      Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    2. Fukushima, S
      Possible involvement of O-6-methylguanine formation and p53 dysfunction inmouse urinary bladder carcinogenesis

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    3. Liu, L; Spiro, TP; Qin, XS; Majka, S; Haaga, J; Schupp, J; Willson, JKV; Gerson, SL
      Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O-6-benzylguanine

      CLINICAL CANCER RESEARCH
    4. Virmani, AK; Muller, C; Rathi, A; Zoechbauer-Mueller, S; Mathis, M; Gazdar, AF
      Aberrant methylation during cervical carcinogenesis

      CLINICAL CANCER RESEARCH
    5. Kokkinakis, DM; Bocangel, DB; Schold, SC; Moschel, RC; Pegg, AE
      Thresholds of O-6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide

      CLINICAL CANCER RESEARCH
    6. Bobola, MS; Blank, A; Berger, MS; Stevens, BA; Silber, JR
      Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas

      CLINICAL CANCER RESEARCH
    7. Vasquez, H; Strobel, H
      Role of cytochrome P450 in DNA damage produced by treatment of colon cellswith 1,2-dimethylhydrazine

      INTERNATIONAL JOURNAL OF ONCOLOGY
    8. Kanugula, S; Pegg, AE
      Novel DNA repair alkyltransferase from Caenorhabditis elegans

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    9. Navasumrit, P; Margison, GP; O'Connor, PJ
      Ethanol modulates rat hepatic DNA repair functions

      ALCOHOL AND ALCOHOLISM
    10. Janssen, K; Eichhorn-Grombacher, U; Schlink, K; Nitzsche, S; Oesch, F; Kaina, B
      Long-time expression of DNA repair enzymes MGMT and APE in human peripheral blood mononuclear cells

      ARCHIVES OF TOXICOLOGY
    11. Noll, DM; Clarke, ND
      Covalent capture of a human O-6-alkylguanine alkyltransferase-DNA complex using N-1,O-6-ethanoxanthosine, a mechanism-based crosslinker

      NUCLEIC ACIDS RESEARCH
    12. Lackinger, D; Eichhorn, U; Kaina, B
      Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both

      MUTAGENESIS
    13. Bredel, M
      Anticancer drug resistance in primary human brain tumors

      BRAIN RESEARCH REVIEWS
    14. Nakamura, M; Watanabe, T; Yonekawa, Y; Kleihues, P; Ohgaki, H
      Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G : C -> A : T mutations of the TP53 tumor suppressor gene

      CARCINOGENESIS
    15. Takagi, M; Kai, Y; Imanaka, T
      Methylguanine methyltransferase from Thermococcus kodakaraensis KOD1

      HYPERTHERMOPHILIC ENZYMES, PT C
    16. Davis, BM; Encell, LP; Zielske, SP; Christians, FC; Liu, LL; Friebert, SE; Loeb, LA; Gerson, SL
      Applied molecular evolution of O-6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    17. Zhou, ZQ; Manguino, D; Kewitt, K; Intano, GW; McMahan, CA; Herbert, DC; Hanes, M; Reddick, R; Ikeno, Y; Walter, CA
      Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O-6-methylguanine-DNA methyltransferase

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    18. Dong, SM; Pang, JCS; Poon, WS; Hu, J; To, KF; Chang, AR; Ng, HK
      Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors

      JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    19. Wolter, M; Reifenberger, J; Blaschke, B; Ichimura, K; Schmidt, EE; Collins, VP; Reifenberger, G
      Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16(INK4a)), p14(ARF), and CDKN2B (MTS2, p15(INK4b)) tumor suppressor genes

      JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    20. Parra, M; Jardi, M; Koziczak, M; Nagamine, Y; Munoz-Canoves, P
      p53 phosphorylation at serine 15 is required for transcriptional inductionof the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N '-nitro-N-nitrosoguanidine

      JOURNAL OF BIOLOGICAL CHEMISTRY
    21. Oue, N; Shigeishi, H; Kuniyasu, H; Yokozaki, H; Kuraoka, K; Ito, R; Yasui, W
      Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma

      INTERNATIONAL JOURNAL OF CANCER
    22. Helmbach, H; Rossmann, E; Kern, MA; Schadendorf, D
      Drug-resistance in human melanoma

      INTERNATIONAL JOURNAL OF CANCER
    23. Reinard, J; Eichhorn, U; Wiessler, M; Kaina, B
      Inactivation of O-6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors

      INTERNATIONAL JOURNAL OF CANCER
    24. Christmann, M; Pick, M; Lage, H; Schadendorf, D; Kaina, B
      Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT

      INTERNATIONAL JOURNAL OF CANCER
    25. Marchenay, C; Cellarier, E; Levi, F; Rolhion, C; Kwiatkowski, F; Claustrat, B; Madelmont, JC; Chollet, P
      Circadian variation in O-6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects

      INTERNATIONAL JOURNAL OF CANCER
    26. Shiraki, K; Nishikori, S; Fujiwara, S; Hashimoto, H; Kai, Y; Takagi, M; Imanaka, T
      Comparative analyses of the conformational stability of a hyperthermophilic protein and its mesophilic counterpart

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    27. Esteller, M; Corn, PG; Baylin, SB; Herman, JG
      A gene hypermethylation profile of human cancer

      CANCER RESEARCH
    28. Kokkinakis, DM; Hoffman, RM; Frenkel, EP; Wick, JB; Han, QH; Xu, MX; Tan, YY; Schold, SC
      Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice

      CANCER RESEARCH
    29. Park, TJ; Han, SU; Cho, YK; Paik, WK; Kim, YB; Lim, IK
      Methylation of O-6-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma

      CANCER
    30. Rashid, A; Shen, LL; Morris, JS; Issa, JPJ; Hamilton, SR
      CpG island methylation in colorectal adenomas

      AMERICAN JOURNAL OF PATHOLOGY
    31. Lackinger, D; Kaina, B
      Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    32. Liu, H; Xu-Welliver, M; Pegg, AE
      The role of human O-6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    33. Pegg, AE
      Repair of O-6-alkylguanine by alkyltransferases

      MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
    34. Roth, RB; Samson, LD
      Gene transfer to suppress bone marrow alkylation sensitivity

      MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
    35. Salmelin, C; Hovinen, J; Vilpo, J
      Polymyxin permeabilization as a tool to investigate cytotoxicity of therapeutic aromatic alkylators in DNA repair-deficient Escherichia coli strains

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    36. Friedman, HS; Kerby, T; Calvert, H
      Temozolomide and treatment of malignant glioma

      CLINICAL CANCER RESEARCH
    37. Aquilina, G; Ceccotti, S; Martinelli, S; Soddu, S; Crescenzi, M; Branch, P; Karran, P; Bignami, M
      Mismatch repair and p53 independently affect sensitivity to N-(2-chloroethyl)-N '-cyclohexyl-N-nitrosourea

      CLINICAL CANCER RESEARCH
    38. Yang, J; Wu, Y; Ma, P; Zhao, YH; You, Y; Kane, SE; Mao, N; Zhang, YP
      Construction and expression of retroviruses encoding dual drug resistance genes in human umbilical cord blood CD34(+) cells

      CHINESE SCIENCE BULLETIN
    39. Inoue, R; Abe, M; Nakabeppu, Y; Sekiguchi, M; Mori, T; Suzuki, T
      Characterization of human polymorphic DNA repair methyltransferase

      PHARMACOGENETICS
    40. Esteller, M
      Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes

      EUROPEAN JOURNAL OF CANCER
    41. Roy, G; Horton, JK; Roy, R; Denning, T; Mitra, S; Boldogh, I
      Acquired alkylating drug resistance of a human ovarian carcinoma cell lineis unaffected by altered levels of pro- and anti-apoptotic proteins

      ONCOGENE
    42. Mariani, L; Citti, L; Nevischi, S; Eckstein, F; Rainaldi, G
      Ribozyme and free alkylated base: a dual approach for sensitizing Mex(+) cells to the alkylating antineoplastic drug

      CANCER GENE THERAPY
    43. Daniels, DS; Tainer, JA
      Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O-6-alkylguanine-DNA alkyltransferase

      MUTATION RESEARCH-DNA REPAIR
    44. Brown, LR; Deng, J; Clarke, ND
      Dominant sensitization variants of human O-6-methylguanine-DNA-methyltransferase obtained by a mutational screen of surface residues

      MUTATION RESEARCH-DNA REPAIR
    45. Qin, XS; Zhang, SM; Matsukuma, S; Zarkovic, M; Shimizu, S; Ishikawa, T; Nakatsuru, Y
      Protection against malignant progression of spontaneously developing livertumors in transgenic mice expressing O-6-methylguanine-DNA methyltransferase

      JAPANESE JOURNAL OF CANCER RESEARCH
    46. Chen, J; Yu, Z; Ford, BN; Brackley, ME; Haesevoets, RJC; Khaidakov, M; Glickman, BW
      Screening a human population sample for DNA repair gene deficiencies utilizing the protein truncation test

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    47. Antoun, G; Baylin, SB; Ali-Osman, F
      DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA

      JOURNAL OF CELLULAR BIOCHEMISTRY
    48. Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC
      Potentiation of BCNU antitumor efficacy by 9-substituted O-6-benzylguanines. Effect of metabolism

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    49. Wibley, JEA; Pegg, AE; Moody, PCE
      Crystal structure of the human O-6-alkylguanine-DNA alkyltransferase

      NUCLEIC ACIDS RESEARCH
    50. Verdemato, PE; Brannigan, JA; Damblon, C; Zuccotto, F; Moody, PCE; Lian, LY
      DNA-binding mechanism of the Escherichia coli Ada O-6-alkylguanine-DNA alkyltransferase

      NUCLEIC ACIDS RESEARCH
    51. Wenzel, A; Grimm, C; Marti, A; Kueng-Hitz, N; Hafezi, F; Niemeyer, G; Reme, CE
      c-fos controls the "private pathway" of light-induced apoptosis of retinalphotoreceptors

      JOURNAL OF NEUROSCIENCE
    52. Lim, IK; Park, TJ; Paik, WK
      Phosphorylation of methylated-DNA-protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion

      BIOCHEMICAL JOURNAL
    53. Mullapudi, SRS; Ali-Osman, F; Shou, J; Srivenugopal, KS
      DNA repair protein O-6-alkylguanine-DNA alkyltransferase is phosphorylatedby two distinct and novel protein kinases in human brain tumour cells

      BIOCHEMICAL JOURNAL
    54. Xu-Welliver, M; Pegg, AE
      Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O-6-alkylguanine-DNA alkyltransferase insensitive to O-6-benzylguanine

      BIOCHEMICAL JOURNAL
    55. Xu-Welliver, M; Kanugula, S; Loktionova, NA; Crone, TM; Pegg, AE
      Conserved residue lysine(165) is essential for the ability of O-6-alkylguanine-DNA alkyltransferase to react with O-6-benzylguanine

      BIOCHEMICAL JOURNAL
    56. Daniels, DS; Mol, CD; Arvai, AS; Kanugula, S; Pegg, AE; Tainer, JA
      Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

      EMBO JOURNAL
    57. Mehl, A; Rolseth, V; Gordon, S; Bjoraas, M; Seeberg, E; Fonnum, F
      Brain hypoplasia caused by exposure to trichlorfon and dichlorvos during development can be ascribed to DNA alkylation damage and inhibition of DNA alkyltransferase repair

      NEUROTOXICOLOGY
    58. Encell, LP; Loeb, LA
      Enhanced in vivo repair of O-4-methylthymine by a mutant human DNA alkyltransferase

      CARCINOGENESIS
    59. Shiraishi, A; Sakumi, K; Sekiguchi, M
      Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase

      CARCINOGENESIS
    60. Brandes, AA; Pasetto, LM; Vastola, F; Monfardini, S
      Temozolomide in patients with high grade gliomas

      ONCOLOGY
    61. Esteller, M; Garcia-Foncillas, J; Andion, E; Goodman, SN; Hidalgo, OF; Vanaclocha, V; Baylin, SB; Herman, JG
      Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

      NEW ENGLAND JOURNAL OF MEDICINE
    62. Petrenko, AA; Eshilev, EM; Kisseljova, NP
      Identification of CpG islands hypermethylated in tumor and transformed cells by the methylation-sensitive arbitrarily primed polymerase chain reaction

      MOLECULAR BIOLOGY
    63. Nakatani, M; Ezaki, S; Atomi, H; Imanaka, T
      A DNA ligase from a hyperthermophilic archaeon with unique cofactor specificity

      JOURNAL OF BACTERIOLOGY
    64. Povey, AC; Hall, CN; Cooper, DP; O'Connor, PJ; Margison, GP
      Determinants of O-6-alkylguanine-DNA alkyltransferase activity in normal and tumour tissue from human colon and rectum

      INTERNATIONAL JOURNAL OF CANCER
    65. Srivenugopal, KS; Mullapudi, SRS; Shou, JA; Hazra, TK; Ali-Osman, F
      Protein phosphorylation is a regulatory mechanism for O-6-alkylguanine-DNAalkyltransferase in human brain tumor cells

      CANCER RESEARCH
    66. Ragg, S; Xu-Welliver, M; Bailey, J; D'Souza, M; Cooper, R; Chandra, S; Seshadri, R; Pegg, AE; Williams, DA
      Direct reversal of DNA damage by mutant methyltransferase protein protectsmice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells

      CANCER RESEARCH
    67. Nutt, CL; Noble, M; Chambers, AF; Cairncross, JG
      Differential expression of drug resistance genes and chemosensitivity in glial cell lineages correlate with differential response of oligodendrogliomas and astrocytomas to chemotherapy

      CANCER RESEARCH
    68. Boley, SE; McManus, TP; Maher, VM; McCormick, JJ
      Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: Evidence of elimination of p53 by homologous recombination

      CANCER RESEARCH
    69. Bearzatto, A; Szadkowski, M; Macpherson, P; Jiricny, J; Karran, P
      Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents

      CANCER RESEARCH
    70. Xiao, W; Fontanie, T; Bawa, S; Kohalmi, L
      REV3 is required for spontaneous but not methylation damage-induced mutagenesis of Saccharomyces cerevisiae cells lacking O-6-methylguanine DNA methyltransferase

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    71. Dolan, ME; McRae, BL; Ferries-Rowe, E; Belanich, M; van Seventer, GA; Guitart, J; Pezen, D; Kuzel, TM; Yarosh, DB
      O-6-alkylguanine-DNA alkyltransferase in cutaneous T-cell lymphoma: Implications for treatment with alkylating agents

      CLINICAL CANCER RESEARCH
    72. Gerson, SL; Schupp, J; Liu, LL; Pegg, AE; Srinivasen, S
      Leukocyte O-6-akylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O-6-benzylguanine

      CLINICAL CANCER RESEARCH
    73. Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC
      Eradication of human medulloblastoma tumor xenografts with a combination of O-6-benzyl-2 '-deoxyguanosine and 1,3-bis(2-chloroethyl)-1-nitrosoureal

      CLINICAL CANCER RESEARCH
    74. Wu, MH; Lohrbach, KE; Olopade, OI; Kokkinakis, DM; Friedman, HS; Dolan, ME
      Lack of evidence for a polymorphism at codon 160 of human O-6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer

      CLINICAL CANCER RESEARCH
    75. Deng, CJ; Xie, DW; Capasso, H; Zhao, YJ; Wang, LD; Hong, JY
      Genetic polymorphism of human O-6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region

      PHARMACOGENETICS
    76. Allay, E; Veigl, M; Gerson, SL
      Mice over-expressing human O(6)alkylguanine-DNA alkyltransferase selectively reduce O(6)methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea

      ONCOGENE
    77. Gander, M; Leyvraz, S; Decosterd, L; Bonfanti, M; Marzolini, C; Shen, F; Lienard, D; Perey, L; Colella, G; Biollaz, J; Lejeune, F; Yarosh, D; Belanich, M; D'Incalci, M
      Sequential administration of temozolomide and fotemustine: Depletion of O-6-alkyl guanine-DNA transferase in blood lymphocytes and in tumours

      ANNALS OF ONCOLOGY
    78. Herfarth, KKF; Brent, TP; Danam, RP; Remack, JS; Kodner, IJ; Wells, SA; Goodfellow, PJ
      A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

      MOLECULAR CARCINOGENESIS
    79. Yu, Z; Chen, J; Ford, BN; Brackley, ME; Glickman, BW
      Human DNA repair systems: An overview

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    80. Kirches, E; Scherlach, C; von Bossanyi, P; Schneider, T; Szibor, R; Kutz, E; Warich-Kirches, M; Dietzmann, K
      MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas

      CLINICAL NEUROPATHOLOGY
    81. Ji, SP; Zhang, YP
      Modulation of O-6-methylguanine-DNA methyltransferase-mediated 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea resistance by antisense RNA

      CANCER DETECTION AND PREVENTION
    82. Dong, Q; Johnson, SP; Colvin, OM; Bullock, N; Kilborn, C; Runyon, G; Sullivan, DM; Easton, J; Bigner, DD; Nahta, R; Marks, J; Modrich, P; Friedman, HS
      Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR)

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    83. Friedman, HS; Pegg, AE; Johnson, SP; Loktionova, NA; Dolan, ME; Modrich, P; Moschel, RC; Struck, R; Brent, TP; Ludeman, S; Bullock, N; Kilborn, C; Keir, S; Dong, Q; Bigner, DD; Colvin, OM
      Modulation of cyclophosphamide activity by O-6-alkylguanine-DNA alkyltransferase

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    84. Schlink, K; Janssen, K; Nitzsche, S; Gebhard, S; Hengstler, JG; Klein, S; Oesch, F
      Activity of O-6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students

      ARCHIVES OF TOXICOLOGY
    85. Kooistra, R; Zonneveld, JBM; Watson, AJ; Margison, GP; Lohman, PHM; Pastink, A
      Identification and characterisation of the Drosophila melanogaster O-6-alkylguanine-DNA alkyltransferase cDNA

      NUCLEIC ACIDS RESEARCH
    86. Glassner, BJ; Weeda, G; Allan, JM; Broekhof, JLM; Carls, NHE; Donker, I; Engelward, BP; Hampson, RJ; Hersmus, R; Hickman, MJ; Broth, RB; Warren, HB; Wu, MM; Hoeijmakers, JHJ; Samson, LD
      DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

      MUTAGENESIS
    87. Manome, Y; Watanabe, M; Futaki, K; Ishiguro, H; Iwagami, S; Noda, K; Dobashi, H; Ochiai, Y; Ohara, Y; Sanuki, K; Kunieda, T; Ohno, T
      Development of a syngenic brain-tumor model resistant to chloroethyl-nitrosourea using a methylguanine DNA methyltransferase cDNA

      ANTICANCER RESEARCH
    88. O'Driscoll, M; Martinelli, S; Ciotta, C; Karran, P
      Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage

      CARCINOGENESIS
    89. Humbert, O; Fiumicino, S; Aquilina, G; Branch, P; Oda, S; Zijno, A; Karran, P; Bignami, M
      Mismatch repair and differential sensitivity of mouse and human cells to methylating agents

      CARCINOGENESIS
    90. Edara, S; Kanugula, S; Pegg, AE
      Expression of the inactive C145A mutant human O-6-alkylguanine-DNA alkyltransferase in E-coli increases cell killing and mutations by N-methyl-N '-nitro-N-nitrosoguanidine

      CARCINOGENESIS
    91. Hashimoto, H; Inoue, T; Nishioka, M; Fujiwara, S; Takagi, M; Imanaka, T; Kai, Y
      Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O-6-methylguanine-DNA methyltransferase

      JOURNAL OF MOLECULAR BIOLOGY
    92. Case, MC; Burt, AD; Hughes, J; Palmer, JM; Collier, JD; Bassendine, MF; Yeaman, SJ; Hughes, MA; Major, GN
      Enhanced ultrasensitive detection of structurally diverse antigens using asingle immuno-PCR assay protocol

      JOURNAL OF IMMUNOLOGICAL METHODS
    93. Venkataraman, GM; Yatin, M; Marcinek, R; Ain, KB
      Restoration of iodide uptake in dedifferentiated thyroid carcinoma: Relationship to human Na+/I- symporter gene methylation status

      JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
    94. Xu-Welliver, M; Leitao, J; Kanugula, S; Pegg, AE
      Alteration of the conserved residue tyrosine-158 to histidine renders human O-6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O-6-benzylguanine

      CANCER RESEARCH
    95. Cai, YN; Wu, MH; Ludeman, SM; Grdina, DJ; Dolan, ME
      Role of O-6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity

      CANCER RESEARCH
    96. Encell, LP; Loeb, LA
      Redesigning the substrate specificity of human O-6-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O-4-methylthymine

      BIOCHEMISTRY
    97. Xu-Welliver, M; Leitao, J; Kanugula, S; Meehan, WJ; Pegg, AE
      Role of codon 160 in the sensitivity of human O-6-alkylguanine-DNA a alkyltransferase to O-6-benzylguanine

      BIOCHEMICAL PHARMACOLOGY
    98. KAINA B; FRITZ G; OCHS K; HAAS S; GROMBACHER T; DOSCH J; CHRISTMANN M; LUND P; GREGEL CM; BECKER K
      TRANSGENIC SYSTEMS IN STUDIES ON GENOTOXICITY OF ALKYLATING-AGENTS - CRITICAL LESIONS, THRESHOLDS AND DEFENSE-MECHANISMS

      Mutation research. Fundamental and molecular mechanisms of mutagenesis
    99. LIU LL; LEE KY; SCHUPP J; KOC ON; GERSON SL
      HETEROGENEITY OF O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE MEASURED BY FLOW CYTOMETRIC ANALYSIS IN BLOOD AND BONE-MARROW MONONUCLEAR-CELLS

      Clinical cancer research
    100. LIU LL; LEE KY; SCHUPP J; KOC ON; GERSON SL
      HETEROGENEITY OF O-6-ALKYLGUANINE-DNA-ALKYLTRANSFERASE MEASURED BY FLOW CYTOMETRIC ANALYSIS IN BLOOD AND BONE-MARROW MONONUCLEAR-CELLS

      Clinical cancer research


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Documento generato il 22/10/20 alle ore 00:47:34