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La ricerca find articoli where soggetti phrase all words 'NOD MICE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 883 riferimenti
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    1. Gross, DJ; Weiss, L; Reibstein, I; Hedlund, G; Dahlen, E; Rapoport, MJ; Slavin, S
      The immunomodulator Linomide: role in treatment and prevention of autoimmune diabetes mellitus

      INTERNATIONAL IMMUNOPHARMACOLOGY
    2. Cooke, A; Phillips, JM; Parish, NM
      Tolerogenic strategies to halt or prevent type I diabetes

      NATURE IMMUNOLOGY
    3. Liesveld, JL; Rosell, K; Panoskaltsis, N; Belanger, T; Harbol, A; Abboud, CN
      Response of human CD34(+) cells to CXC, CC, and CX3C chemokines: Implications for cell migration and activation

      JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
    4. Ko, KS; Lee, M; Koh, JJ; Kim, SW
      Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice

      MOLECULAR THERAPY
    5. Lee, M; Han, SO; Ko, KS; Koh, JJ; Park, JS; Yoon, JW; Kim, SW
      Repression of GAD autoantigen expression in pancreas beta-cells by delivery of antisense plasmid/PEG-g-PLL complex

      MOLECULAR THERAPY
    6. Lee, K; Majumdar, MK; Buyaner, D; Hendricks, JK; Pittenger, MF; Mosca, JD
      Human mesenchymal stem cells maintain transgene expression during expansion and differentiation

      MOLECULAR THERAPY
    7. Gorus, FK; Pipeleers, DG
      Prospects for predicting and stopping the development of type 1 of diabetes

      BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
    8. Balasa, B; Boehm, BO; Fortnagel, A; Karges, W; Van Gunst, K; Jung, N; Camacho, SA; Webb, SR; Sarvetnick, N
      Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection

      CLINICAL IMMUNOLOGY
    9. Falcone, M; Yeung, B; Tucker, L; Rodriguez, E; Krahl, T; Sarvetnick, N
      IL-4 triggers autoimmune diabetes by increasing self-antigen presentation within the pancreatic islets

      CLINICAL IMMUNOLOGY
    10. Beshay, E; Croze, F; Prud'homme, GJ
      The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo

      CLINICAL IMMUNOLOGY
    11. Pakala, SV; Ilic, A; Chen, LP; Sarvetnick, N
      TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells

      CLINICAL IMMUNOLOGY
    12. Ludvigsson, J; Samuelsson, U; Johansson, C; Stenhammar, L
      Treatment with antioxidants at onset of type 1 diabetes in children: a randomized, double-blind placebo-controlled study

      DIABETES-METABOLISM RESEARCH AND REVIEWS
    13. Hackstein, H; Morelli, AE; Thomson, AW
      Designer dendritic cells for tolerance induction: guided not misguided missiles

      TRENDS IN IMMUNOLOGY
    14. Black, P
      Why is the prevalence of allergy and autoimmunity increasing?

      TRENDS IN IMMUNOLOGY
    15. Morel, PA; Feili-Hariri, M
      How do dendritic cells prevent autoimmunity?

      TRENDS IN IMMUNOLOGY
    16. Surbek, DV; Schatt, S; Holzgreve, W
      Stem cell transplantation and gene therapy in utero

      INFUSION THERAPY AND TRANSFUSION MEDICINE-INFUSIONSTHERAPIE UND TRANSFUSIONSMEDIZIN
    17. Hayashi, T; Faustman, DL
      Implications of altered apoptosis in diabetes mellitus and autoimmune disease

      APOPTOSIS
    18. Abel, M; Krokowski, M
      Pathophysiology of immune-mediated (type 1) diabetes mellitus - Potential for immunotherapy

      BIODRUGS
    19. Mustafa, W; Mustafa, A; Elbakri, N; Link, H; Adem, A
      Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS)

      JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
    20. Sharif, S; Arreaza, GA; Zucker, P; Mi, QS; Sharif, S; Arreaza, GA; Zucker, P; Mi, QS; Sondhi, J; Naidenko, OV; Kronenberg, M; Koezuka, Y; Delovitch, TL; Gombert, JM; Leite-De-Moraes, M; Gouarin, C; Zhu, R; Hameg, A; Nakayama, T; Taniguchi, M; Lepault, F; Lehuen, A; Bach, JF; Herbelin, A
      Activation of natural killer T cells by alpha-galactosylceramide treatmentprevents the onset and recurrence of autoimmune Type 1 diabetes

      NATURE MEDICINE
    21. Marrack, P; Kappler, J; Kotzin, BL
      Autoimmune disease: why and where it occurs

      NATURE MEDICINE
    22. Pelegri, C; Rosmalen, JGM; Durant, S; Throsby, M; Alves, V; Coulaud, J; Esling, A; Pleau, JM; Drexhage, HA; Homo-Delarche, F
      Islet endocrine-cell behavior from birth onward in mice with the nonobese diabetic generic background

      MOLECULAR MEDICINE
    23. Rossmanith, T; Schroder, B; Bug, G; Muller, P; Klenner, T; Knaus, R; Hoelzer, D; Ottmann, OG
      Interleukin 3 improves the ex vivo expansion of primitive human cord bloodprogenitor cells and maintains the engraftment potential of SCID repopulating cells

      STEM CELLS
    24. Gao, ZG; Golob, J; Tanavde, VM; Civin, CI; Hawley, RG; Cheng, L
      High levels of transgene expression following transduction of long-term NOD/SCID-repopulating human cells with a modified lentiviral vector

      STEM CELLS
    25. Podesta, M
      Transplantation hematopoiesis

      CURRENT OPINION IN HEMATOLOGY
    26. Adorini, L
      Interleukin 12 and autoimmune diabetes

      NATURE GENETICS
    27. Vaidyanathan, H; Gentry, JD; Weatherman, A; Schwartzbach, SD; Petro, TM
      Differential response of the murine IL-12 p35 gene to lipopolysaccharide compared with interferon-gamma and CD410 ligation

      CYTOKINE
    28. Larson, RS; Menard, V; Jacobs, H; Kim, SW
      Physicochemical characterization of poly(ethylene glycol)-modified anti-GAD antibodies

      BIOCONJUGATE CHEMISTRY
    29. Perez-Losada, J; Gutierrez-Cianca, N; Sanchez-Garcia, I
      Philadelphia-positive B-Cell acute lymphoblastic leukemia is initiated in an uncommitted progenitor cell

      LEUKEMIA & LYMPHOMA
    30. Gu , B; Dao, LP; Wiley, J
      Impaired transendothelial migration of B-CLL lymphocytes: a defect linked to low L-selectin expression

      LEUKEMIA & LYMPHOMA
    31. Pedersen, AA; Videbaek, N; Skak, K; Petersen, HV; Michelsen, BK
      Characterization of the rat Gad67 gene promoter reveals elements importantfor basal transcription and glucose responsiveness

      DNA SEQUENCE
    32. Cucca, F; Lampis, R; Congia, M; Angius, E; Nutland, S; Bain, SC; Barnett, AH; Todd, JA
      A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins

      HUMAN MOLECULAR GENETICS
    33. Zhang, J; Salojin, KV; Delovitch, TL
      CD28 co-stimulation restores T cell responsiveness in NOD mice by overcoming deficiencies in Rac-1/p38 mitogen-activated protein kinase signaling andIL-2 and IL-4 gene transcription

      INTERNATIONAL IMMUNOLOGY
    34. Bach, JF
      Immunotherapy of insulin-dependent diabetes mellitus

      CURRENT OPINION IN IMMUNOLOGY
    35. Rothe, H; Ito, Y; Kolb, H
      Disease resistant, NOD-related strains reveal checkpoints of immunoregulation in the pancreas

      JOURNAL OF MOLECULAR MEDICINE-JMM
    36. Ueda, T; Yoshida, M; Yoshino, H; Kobayashi, K; Kawahata, M; Ebihara, Y; Ito, M; Asano, S; Nakahata, T; Tsuji, K
      Hematopoietic capability of CD34(+) cord blood cells: A comparison with CD34(+) adult bone marrow cells

      INTERNATIONAL JOURNAL OF HEMATOLOGY
    37. Martin, S; van den Engel, NK; Vinke, A; Heidenthal, E; Schulte, B; Kolb, H
      Dominant role of intercellular adhesion molecule-1 in the pathogenesis of autoimmune diabetes in non-obese diabetic mice

      JOURNAL OF AUTOIMMUNITY
    38. Nakazawa, T; Satoh, J; Takahashi, K; Sakata, Y; Ikehata, F; Takizawa, Y; Bando, S; Housai, T; Li, Y; Chen, C; Masuda, T; Kure, S; Kato, I; Takasawa, S; Taniguchi, T; Okamoto, H; Toyota, T
      Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1

      JOURNAL OF AUTOIMMUNITY
    39. Flynn, JC; Fuller, BE; Giraldo, AA; Panos, JC; David, CS; Kong, YCM
      Flexibility of TCR repertoire and permissiveness of HLA-DR3 molecules in experimental autoimmune thyroiditis in nonobese diabetic mice

      JOURNAL OF AUTOIMMUNITY
    40. Suarez-Pinzon, WL; Mabley, JG; Strynadka, K; Power, RF; Szabo, C; Rabinovitch, A
      An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice

      JOURNAL OF AUTOIMMUNITY
    41. Panoutsakopoulou, V; Cantor, H
      On the relationship between viral infection and autoimmunity

      JOURNAL OF AUTOIMMUNITY
    42. Bach, JF
      Protective role of infections and vaccinations on autoimmune diseases

      JOURNAL OF AUTOIMMUNITY
    43. Suri-Payer, E; Cantor, H
      Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells

      JOURNAL OF AUTOIMMUNITY
    44. Yu, SG; Medling, B; Yagita, H; Braley-Mullen, H
      Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice

      JOURNAL OF AUTOIMMUNITY
    45. Buschard, K; Hanspers, K; Fredman, P; Reich, EP
      Treatment with sulfatide or its precursor, galactosylceramide, prevents diabetes in NOD mice

      AUTOIMMUNITY
    46. Funae, O; Shimada, A; Tokui, M; Takei, I; Saruta, T
      Balance of GAD65-specific IL-10 production and polyclonal Th1-type response in type 1 diabetes

      AUTOIMMUNITY
    47. Silveira, PA; Baxter, AG
      The NOD mouse as a model of SLE

      AUTOIMMUNITY
    48. Hartoft-Nielsen, ML; Rasmussen, AK; Kaas, A; Bock, T; Buschard, K; Feldt-Rasmussen, U
      Linomide does not prevent spontaneous autoimmune thyroiditis in NOD mice

      AUTOIMMUNITY
    49. Rogner, UC; Boitard, C; Morin, J; Melanitou, E; Avner, P
      Three loci on mouse chromosome 6 influence onset and final incidence of type 1 diabetes in NOD.C3H congenic strains

      GENOMICS
    50. de Wynter, EA; Heyworth, CM; Mukaida, N; Matsushima, K; Testa, NG
      NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34(+) cells expressing the CCR1 chemokine receptor

      LEUKEMIA
    51. Shoham, T; Sternberg, D; Brosh, N; Krupsky, M; Barda-Saad, M; Zipori, D
      The promotion of plasmacytoma tumor growth by mesenchymal stroma is antagonized by basic fibroblast growth factor induced activin A

      LEUKEMIA
    52. Mathieu, C; Van Etten, E; Gysemans, C; Decallonne, B; Kato, S; Laureys, J; Depovere, J; Valckx, D; Verstuyf, A; Bouillon, R
      In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice

      JOURNAL OF BONE AND MINERAL RESEARCH
    53. Canning, MO; Grotenhuis, K; de Wit, H; Ruwhof, C; Drexhage, HA
      1-alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) hampers the maturation offully active immature dendritic cells from monocytes

      EUROPEAN JOURNAL OF ENDOCRINOLOGY
    54. Kommajosyula, S; Reddy, S; Nitschke, K; Kanwar, JR; Karanam, M; Krissansen, GW
      Leukocytes infiltrating the pancreatic islets of nonobese diabetic mice are transformed into inactive exiles by combinational anti-cell adhesion therapy

      JOURNAL OF LEUKOCYTE BIOLOGY
    55. Bach, JF; Chatenoud, L
      Tolerance to islet autoantigens in type 1 diabetes

      ANNUAL REVIEW OF IMMUNOLOGY
    56. Papaccio, G; Latronico, MVG; Graziano, A; Lanza, A; Pedulla, M
      Tacrolimus, but not cyclosporine A, significantly ily increases expressionof ICAM-1 and IFN-gamma in the NOD mouse

      JOURNAL OF CELLULAR BIOCHEMISTRY
    57. Bruno, S; Gammaitoni, L; Gunetti, M; Sanavio, F; Fagioli, F; Aglietta, M; Piacibello, W
      Different growth factor requirements for the ex vivo amplification of transplantable human cord blood cells in a NOD/SCID mouse model

      JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
    58. Costi, G; Ten, S; Maclaren, NK
      Medical care from childhood to adulthood in Type 1 and Type 2 diabetes

      JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
    59. Nitsche, A; Becker, M; Junghahn, I; Aumann, J; Landt, O; Fichtner, I; Wittig, B; Siegert, W
      Quantification of human cells in NOD/SCID mice by duplex real-time polymerase-chain reaction

      HAEMATOLOGICA
    60. Wilpshaar, J; Noort, WA; Kanhai, HHH; Willemze, R; Falkenburg, JHF
      Engraftment potential into NOD/SCID mice of CD34(+) cells derived from human fetal liver as compared to fetal bone marrow

      HAEMATOLOGICA
    61. Petlevski, R; Hadzija, M; Slijepcevic, M; Juretic, D
      Effect of 'antidiabetis' herbal preparation on serum glucose and fructosamine in NOD mice

      JOURNAL OF ETHNOPHARMACOLOGY
    62. Hacein-Bey, S; Gross, F; Nusbaum, P; Yvon, E; Fischer, A; Cavazzana-Calvo, M
      Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

      PATHOLOGIE BIOLOGIE
    63. Domenick, MA; Ildstad, ST
      Impact of bone marrow transplantation on type I diabetes

      WORLD JOURNAL OF SURGERY
    64. Niemeyer, GP; Hudson, J; Bridgman, R; Spano, J; Nash, RA; Lothrop, CD
      Isolation and characterization of canine hematopoietic progenitor cells

      EXPERIMENTAL HEMATOLOGY
    65. Rietz, C; Screpanti, V; Brenden, N; Fernandez, C
      Neonatal pattern of V-H gene utilization in nonobese diabetic mice does not correlate with development of insulitis

      SCANDINAVIAN JOURNAL OF IMMUNOLOGY
    66. Bach, JF
      Non-Th2 regulatory T-cell control of Th1 autoimmunity

      SCANDINAVIAN JOURNAL OF IMMUNOLOGY
    67. Thivolet, C
      New therapeutic approaches to type 1 diabetes: from prevention to cellularor gene therapies

      CLINICAL ENDOCRINOLOGY
    68. Noort, WA; Wilpshaar, J; Hertogh, CDP; Rad, M; Lurvink, EGA; van Luxemburg-Heijs, SAP; Zwinderman, K; Verwey, RA; Willemze, R; Falkenburg, JHF
      Similar myeloid recovery despite superior overall engraftment in NOD/SCID mice after transplantation of human CD34(+) cells from umbilical cord bloodas compared to adult sources

      BONE MARROW TRANSPLANTATION
    69. Moore, MAS
      The role of chemoattraction in cancer metastases

      BIOESSAYS
    70. Schloot, NC; Willemen, SJM; Duinkerken, G; Drijfhout, JW; de Vries, RRP; Roep, BO
      Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to coxsackie or proinsulin peptides do not crossreact with homologous counterpart

      HUMAN IMMUNOLOGY
    71. Lee, M; Han, SO; Ko, KS; Kim, SW
      Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer

      JOURNAL OF CONTROLLED RELEASE
    72. Hypponen, E; Laara, E; Reunanene, A; Jarvelin, MR; Virtanen, SM
      Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study

      LANCET
    73. Bradstock, K
      Wanderings of the bone-marrow stem cell

      LANCET
    74. Chatenoud, L; Salomon, B; Bluestone, JA
      Suppressor T cells - they're back and critical for regulation of autoimmunity!

      IMMUNOLOGICAL REVIEWS
    75. Homo-Delarche, F
      Is pancreas development abnormal in the non-obese diabetic mouse, a spontaneous model of type I diabetes?

      BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
    76. Chun, T; Hermel, E; Gaskins, HR; Aldrich, CJ
      Cytotoxic T lymphocyte and cDNA sequence analyses of the MHC class lb molecule Qa1 in nonobese diabetic mice

      IMMUNOGENETICS
    77. McDevitt, H
      The role of MHC class II molecules in the pathogenesis and prevention of type I diabetes

      MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION VIII: AUTOIMMUNITY 2000 AND BEYOND
    78. Bach, JF
      Control of autoreactive T cell activation by immunoregulatory T cells (ART)

      MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION VIII: AUTOIMMUNITY 2000 AND BEYOND
    79. Prange, S; Zucker, P; Jevnikar, AM; Singh, B
      Transplanted MHC class I-deficient nonobese diabetic mouse islets are protected from autoimmune injury in diabetic nonobese recipients

      TRANSPLANTATION
    80. Xu, RL; Reems, JA
      Umbilical cord blood progeny cells that retain a CD34+phenotype after ex vivo expansion have less engraftment potential than unexpended CD34+cells

      TRANSFUSION
    81. Toivonen, A; Kulmala, P; Savola, K; Akerblom, HK; Knip, M
      Soluble adhesion molecules in preclinical type 1 diabetes

      PEDIATRIC RESEARCH
    82. Mathis, D; Vence, L; Benoist, C
      beta-cell death during progression to diabetes

      NATURE
    83. Amat, L; Querol, S; Lailla, JM
      In utero hematopoietic stem cell transplantation: current status and future potential

      MEDICINA CLINICA
    84. Beshay, E; Prud'homme, GJ
      Inhibitors of phosphodiesterase isoforms III or IV suppress islet-cell nitric oxide production

      LABORATORY INVESTIGATION
    85. Hasel, C; Rau, B; Perner, S; Strater, J; Moller, P
      Differential and mutually exclusive expression of CD95 and CD95 ligand in epithelia of normal pancreas and chronic pancreatitis

      LABORATORY INVESTIGATION
    86. Han, SB; Park, SH; Jeon, YJ; Kim, YK; Kim, HM; Yang, KH
      Prodigiosin blocks T cell activation by inhibiting interleukin-2R alpha expression and delays progression of autoimmune diabetes and collagen-inducedarthritis

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    87. Prasad, K
      Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat

      JOURNAL OF LABORATORY AND CLINICAL MEDICINE
    88. Chen, W; Bergerot, I; Elliott, JF; Harrison, LC; Abiru, N; Eisenbarth, GS; Delovitch, TL
      Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes

      JOURNAL OF IMMUNOLOGY
    89. Geminder, H; Sagi-Assif, O; Goldberg, L; Meshel, T; Rechavi, G; Witz, IP; Ben-Baruch, A
      A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma

      JOURNAL OF IMMUNOLOGY
    90. Trembleau, S; Gregori, S; Penna, G; Gorny, I; Adorini, L
      IL-12 administration reveals diabetogenic T cells in genetically resistantI-E alpha-transgenic nonobese diabetic mice: Resistance to autoimmune diabetes is associated with binding of E alpha-derived peptides to the I-A(g7) molecule

      JOURNAL OF IMMUNOLOGY
    91. Bot, A; Smith, D; Bot, S; Hughes, A; Wolfe, T; Wang, LL; Woods, C; von Herrath, M
      Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice

      JOURNAL OF IMMUNOLOGY
    92. Costa, GL; Sandora, MR; Nakajima, A; Nguyen, EV; Taylor-Edwards, C; Slavin, AJ; Contag, CH; Fathman, CG; Benson, JM
      Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit

      JOURNAL OF IMMUNOLOGY
    93. Weaver, DJ; Poligone, B; Bui, T; Abdel-Motal, UM; Baldwin, AS; Tisch, R
      Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa Bregulation due to a hyperactive I kappa B kinase

      JOURNAL OF IMMUNOLOGY
    94. Koarada, S; Wu, YH; Ridgway, WM
      Increased entry into the IFN-gamma effector pathway by CD4(+) T cells selected by I-A(g7) on a nonobese diabetic versus C57BL/6 genetic background

      JOURNAL OF IMMUNOLOGY
    95. Quinn, A; McInerney, MF; Sercarz, EE
      MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity

      JOURNAL OF IMMUNOLOGY
    96. Kreuwel, HTC; Biggs, JA; Pilip, IM; Pamer, EG; Lo, D; Sherman, LA
      Defective CD8(+) T cell peripheral tolerance in nonobese diabetic mice

      JOURNAL OF IMMUNOLOGY
    97. Braley-Mullen, H; Chen, KM; Wei, YZ; Yu, SG
      Role of TGF beta in development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice

      JOURNAL OF IMMUNOLOGY
    98. Chiu, PPL; Jevnikar, AM; Danska, JS
      Genetic control of T and B lymphocyte activation in nonobese diabetic mice

      JOURNAL OF IMMUNOLOGY
    99. Phillips, JM; Parish, NM; Drage, M; Cooke, A
      Cutting edge: Interactions through the IL-10 receptor regulate autoimmune diabetes

      JOURNAL OF IMMUNOLOGY
    100. Zhan, YF; Brady, JL; Sutherland, RM; Lew, AM
      Without CD4 help, CD8 rejection of pig xenografts requires CD28 costimulation but not perforin killing

      JOURNAL OF IMMUNOLOGY


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Documento generato il 23/01/21 alle ore 13:29:31