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Synergistic effects of clinically achievable concentrations of 12-O-tetradecanoylphorbol-13-acetate in combination with all-trans retinoic acid, 1 alpha,25-dihydroxyvitamin D-3, and sodium butyrate on differentiation in HL-60 cells
ONCOLOGY RESEARCH
Arsenic trioxide, a therapeutic agent for APL
ONCOGENE
Pathways of retinoic acid- or arsenic trioxide-induced PML/RAR alpha catabolism, role of oncogene degradation in disease remission
ONCOGENE
Arsenite induces oxidative DNA adducts and DNA-protein cross-links in mammalian cells
FREE RADICAL BIOLOGY AND MEDICINE
(23S)- and (23R)-25-dehydro-1 alpha-hydroxyvitamin D-3-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1 alpha,25-dihydroxyvitamin D-3
STEROIDS
Apoptosis induction by arsenic: mechanisms of action and possible clinicalapplications for treating therapy-resistant cancers
DRUG RESISTANCE UPDATES
Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases
CELL DEATH AND DIFFERENTIATION
The role of RAR and RXR activation in retinoid-induced tissue factor suppression
LEUKEMIA
Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia
LEUKEMIA
Dissecting the pathways to death
LEUKEMIA
Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis
LEUKEMIA
Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RAR alpha and PLZF-RAR alpha oncoproteins
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-transretinoic acid
BRITISH JOURNAL OF HAEMATOLOGY
Retinoic acid and interferon signaling cross talk in normal and RA-resistant APL cells
LEUKEMIA
Bryostatin-1 and 1 alpha,25-dihydroxyvitamin D-3 synergistically stimulatethe differentiation of NB4 acute promyelocytic leukemia cells
LEUKEMIA
Effects of epoxycarotenoids, beta-carotene, and retinoic acid on the differentiation and viability of the leukemia cell line NB4 in vitro
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation
EMBO JOURNAL
Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RAR alpha) and oncogenic RAR alpha fusion proteins
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Increased adhesion of the promyelocytic leukaemia cell line, NB4, to fibronectin and thrombospondin upon all-trans-retinoic acid treatment
BRITISH JOURNAL OF HAEMATOLOGY
Relationship between degradation of PML-RAR alpha and differentiation
BLOOD
The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases
BLOOD
A SUSTAINED INCREASE IN THE ENDOGENOUS LEVEL OF CAMP REDUCES THE RETINOID CONCENTRATION REQUIRED FOR APL CELL MATURATION TO NEAR PHYSIOLOGICAL LEVELS
Leukemia
1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND PHORBOL ESTER MEDIATE THE EXPRESSION OF ALKALINE-PHOSPHATASE IN NB4 ACUTE PROMYELOCYTIC LEUKEMIA-CELLS
Leukemia research
LYN AND FGR ARE ACTIVATED IN DISTINCT MEMBRANE-FRACTIONS OF HUMAN GRANULOCYTIC CELLS
Oncogene
EXPRESSION OF NADPH OXIDASE IS INDUCED BY ALL-TRANS-RETINOIC ACID BUTNOT BY PHORBOL-MYRISTATE ACETATE AND 1,25-DIHYDROXYVITAMIN-D3 IN THE HUMAN PROMYELOCYTIC CELL-LINE NB4
Leukemia
RETINOIC ACID AND ARSENIC - TOWARDS ONCOGENE-TARGETED TREATMENTS OF ACUTE PROMYELOCYTIC LEUKEMIA
Biochimica et biophysica acta, CR. Reviews on cancer
NEPLANOCIN-A, A POTENT INHIBITOR OF S-ADENOSYLHOMOCYSTEINE HYDROLASE,POTENTIATES GRANULOCYTIC DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA-CELLS INDUCED BY ALL-TRANS-RETINOIC ACID
Experimental hematology
COMMON DEFECTS OF DIFFERENT RETINOIC ACID-RESISTANT PROMYELOCYTIC LEUKEMIA-CELLS ARE PERSISTENT TELOMERASE ACTIVITY AND NUCLEAR-BODY DISORGANIZATION
Differentiation
MODULATION OF P53, WAF1 P21 AND BCL-2 EXPRESSION DURING RETINOIC ACID-INDUCED DIFFERENTIATION OF NB4 PROMYELOCYTIC CELLS/
Leukemia research
MODULATION OF MESSENGER-RNA EXPRESSION OF A NOVEL HUMAN MYELOID-SELECTIVE CCAAT ENHANCER BINDING-PROTEIN GENE (C/EBP-EPSILON)/
Blood