Catalogo Articoli (Spogli Riviste)

HELP
ATTENZIONE: attualmente gli articoli Current Contents (fonte ISI) a partire dall'anno 2002 sono consultabili sulla Risorsa On-Line

Le informazioni sugli articoli di fonte ISI sono coperte da copyright

La ricerca find articoli where soggetti phrase all words 'MORPHINE-INDUCED ANALGESIA' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 172 riferimenti
Si mostrano 100 riferimenti a partire da 1
Selezionare un intervallo

Per ulteriori informazioni selezionare i riferimenti di interesse.

    1. Zhou, L; Rowley, DL; Mi, QS; Sefcovic, N; Matthes, HWD; Kieffer, BL; Donovan, DM
      Murine inter-strain polymorphisms alter gene targeting frequencies at the mu opioid receptor locus in embryonic stem cells

      MAMMALIAN GENOME
    2. Keskil, IS; Keskil, ZA; Canseven, AG; Seyhan, N
      No effect of 50 Hz magnetic field observed in a pilot study on pentylenetetrazol-induced seizures and mortality in mice

      EPILEPSY RESEARCH
    3. Abdollahi, M; Nikfar, S; Abdoli, N
      Potentiation by nitric oxide synthase inhibitor and calcium channel blocker of aspartame-induced antinociception in the mouse formalin test

      FUNDAMENTAL & CLINICAL PHARMACOLOGY
    4. Slowe, SJ; Clarke, S; Lena, I; Goody, RJ; Lattanzi, R; Negri, L; Simonin, F; Matthes, HWD; Filliol, D; Kieffer, BL; Kitchen, I
      Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice

      NEUROSCIENCE
    5. Gilbert, AK; Franklin, KBJ
      GABAergic modulation of descending inhibitory systems from the rostral ventromedial medulla (RVM). Dose-response analysis of nociception and neurological deficits

      PAIN
    6. Bi, J; Hu, XL; Loh, HH; Wei, LN
      Regulation of mouse kappa opioid receptor gene expression by retinoids

      JOURNAL OF NEUROSCIENCE
    7. Ikeda, K; Kobayashi, T; Ichikawa, T; Kumanishi, T; Niki, H; Yano, R
      The untranslated region of mu-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice

      JOURNAL OF NEUROSCIENCE
    8. Manning, BH; Merin, NM; Meng, ID; Amaral, DG
      Reduction in opioid- and cannabinoid-induced antinociception in rhesus monkeys after bilateral lesions of the amygdaloid complex

      JOURNAL OF NEUROSCIENCE
    9. Diaz-Reval, MI; Ventura-Martinez, R; Hernandez-Delgadillo, GP; Dominguez-Ramirez, AM; Lopez-Munoz, FJ
      Effect of caffeine on antinociceptive action of ketoprofen in rats

      ARCHIVES OF MEDICAL RESEARCH
    10. Sharifi, N; Diehl, N; Yaswen, L; Brennan, MB; Hochgeschwender, U
      Generation of dynorphin knockout mice

      MOLECULAR BRAIN RESEARCH
    11. Wilson, SG; Mogil, JS
      Measuring pain in the (knockout) mouse: big challenges in a small mammal

      BEHAVIOURAL BRAIN RESEARCH
    12. Prado, WA
      Involvement of calcium in pain and antinociception

      BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
    13. Mandillo, S; Kanarek, RB
      Chronic sucrose intake enhances nicotine-induced antinociception in femalebut not male Long-Evans rats

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    14. Zubieta, JK; Smith, YR; Bueller, JA; Xu, YJ; Kilbourn, MR; Jewett, DM; Meyer, CR; Koeppe, RA; Stohler, CS
      Regional mu opioid receptor regulation of sensory and affective dimensionsof pain

      SCIENCE
    15. Mogil, JS; Pasternak, GW
      The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family

      PHARMACOLOGICAL REVIEWS
    16. LaBuda, CJ; Fuchs, PN
      A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis

      LIFE SCIENCES
    17. Guo, GW; Liu, ZH; Jin, WQ; Zhang, HP; Chen, XJ; Zhu, YC; Chi, ZQ
      Quantitative comparison of ohmefentanyl isomers induced conditioning placepreference in mice

      LIFE SCIENCES
    18. Pasternak, GW
      Insights into mu opioid pharmacology - The role of mu opioid receptor subtypes

      LIFE SCIENCES
    19. Heinricher, MM; McGaraughty, S; Tortorici, V
      Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla

      JOURNAL OF NEUROPHYSIOLOGY
    20. Hu, XL; Bi, J; Loh, HH; Wei, LN
      An intronic Ikaros-binding element mediates retinoic acid suppression of the kappa opioid receptor gene, accompanied by histone deacetylation on the promoters

      JOURNAL OF BIOLOGICAL CHEMISTRY
    21. Befort, K; Filliol, D; Decaillot, FM; Gaveriaux-Ruff, C; Hoehe, MR; Kieffer, BL
      A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

      JOURNAL OF BIOLOGICAL CHEMISTRY
    22. Chaturvedi, K; Bandari, P; Chinen, N; Howells, RD
      Proteasome involvement in agonist-induced down-regulation of mu and delta opioid receptors

      JOURNAL OF BIOLOGICAL CHEMISTRY
    23. Ko, JL; Loh, HH
      Single-stranded DNA-binding complex involved in transcriptional regulationof mouse mu-opioid receptor gene

      JOURNAL OF BIOLOGICAL CHEMISTRY
    24. Vrinten, DH; Kalkman, CJ; Adan, RAH; Gispen, WH
      Neuropathic pain: a possible role for the melanocortin system?

      EUROPEAN JOURNAL OF PHARMACOLOGY
    25. Neilan, CL; Nguyen, TMD; Schiller, PW; Pasternak, GW
      Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, ahighly potent and selective mu-opioid peptide

      EUROPEAN JOURNAL OF PHARMACOLOGY
    26. Kamei, J; Zushida, K; Nagase, H
      Role of cholecystokinin in the reduction of endomorphin-2-induced antinociception in diabetic mice

      EUROPEAN JOURNAL OF PHARMACOLOGY
    27. Maldonado, R; Severini, C; Matthes, HWD; Kieffer, BL; Melchiorri, P; Negri, L
      Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene

      BRITISH JOURNAL OF PHARMACOLOGY
    28. Shoda, T; Fukuda, K; Uga, H; Mima, H; Morikawa, H
      Activation of mu-opioid receptor induces expression of c-fos and junB via mitogen-activated protein kinase cascade

      ANESTHESIOLOGY
    29. Pasternak, GW
      Incomplete cross tolerance and multiple mu opioid peptide receptors

      TRENDS IN PHARMACOLOGICAL SCIENCES
    30. Hall, FS; Sora, I; Uhl, GR
      Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice

      PSYCHOPHARMACOLOGY
    31. Kieffer, BL
      Opioid receptors: From genes to mice

      JOURNAL OF PAIN
    32. Mogil, JS; McCarson, KE
      Identifying pain genes: Bottom-up and top-down approaches

      JOURNAL OF PAIN
    33. Calixto, JB; Beirith, A; Ferreira, J; Santos, ARS; Cechinel, V; Yunes, RA
      Naturally occurring antinociceptive substances from plants

      PHYTOTHERAPY RESEARCH
    34. Bolivar, V; Cook, M; Flaherty, L
      List of transgenic and knockout mice: behavioral profiles

      MAMMALIAN GENOME
    35. Suh, HW; Song, DK; Huh, SO; Kim, YH
      Involvement of dynorphin in immobilization stress-induced antinociception in the mouse

      EUROPEAN NEUROPSYCHOPHARMACOLOGY
    36. Jordan, BA; Cvejic, S; Devi, LA
      Opioids and their complicated receptor complexes

      NEUROPSYCHOPHARMACOLOGY
    37. Compton, P; Charuvastra, VC; Kintaudi, K; Ling, W
      Pain responses in methadone-maintained opioid abusers

      JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
    38. Wiedenmayer, CP; Barr, GA
      mu opioid receptors in the ventrolateral periaqueductal gray mediate stress-induced analgesia but not immobility in rat pups

      BEHAVIORAL NEUROSCIENCE
    39. Suh, HW; Song, DK; Huh, SO; Son, KH; Kim, YH
      Antinociceptive mechanisms of Dipsacus saponin C administered intrathecally in mice

      JOURNAL OF ETHNOPHARMACOLOGY
    40. Pomonis, JD; Jewett, DC; Kotz, CM; Briggs, JE; Billington, CJ; Levine, AS
      Sucrose consumption increases naloxone-induced c-Fos immunoreactivity in limbic forebrain

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    41. Park, Y; Ma, T; Tanaka, S; Jang, CG; Loh, HH; Ko, KH; Ho, IK
      Comparison of G-protein activation in the brain by mu-, delta-, and kappa-opioid receptor agonists in mu-opioid receptor knockout mice

      BRAIN RESEARCH BULLETIN
    42. Honore, P; Rogers, SD; Schwei, MJ; Salak-Johnson, JL; Luger, NM; Sabino, MC; Clohisy, DR; Mantyh, PW
      Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons

      NEUROSCIENCE
    43. Ugarte, SD; Homanics, GE; Firestone, LL; Hammond, DL
      Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta(3) subunit of the GABA(A) receptor

      NEUROSCIENCE
    44. Mogil, JS; Grisel, JE; Hayward, MD; Bales, JR; Rubinstein, M; Belknap, JD; Low, MJ
      Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice

      NEUROSCIENCE
    45. Han, NL; Luo, F; Bian, ZP; Han, JS
      Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats

      PAIN
    46. Prato, FS; Kavaliers, M; Thomas, AW
      Extremely low frequency magnetic fields can either increase or decrease analgaesia in the land snail depending on field and light conditions

      BIOELECTROMAGNETICS
    47. Chaturvedi, K; Jiang, XJ; Christoffers, KH; Chinen, N; Bandari, P; Raveglia, LF; Ronzoni, S; Dondio, G; Howells, RD
      Pharmacological profiles of selective non-peptidic delta opioid receptor ligands

      MOLECULAR BRAIN RESEARCH
    48. Chaturvedi, K; Shahrestanifar, M; Howells, RD
      mu opioid receptor: role for the amino terminus as a determinant of ligandbinding affinity

      MOLECULAR BRAIN RESEARCH
    49. Chen, HC; Seybold, VS; Loh, HH
      An autoradiographic study in mu-opioid receptor knockout mice

      MOLECULAR BRAIN RESEARCH
    50. MacPherson, RD
      The pharmacological basis of contemporary pain management

      PHARMACOLOGY & THERAPEUTICS
    51. Mogil, JS; Yu, L; Basbaum, AI
      Pain genes?: Natural variation and transgenic mutants

      ANNUAL REVIEW OF NEUROSCIENCE
    52. Jeong, JH; Choi, KB; Yi, BC; Chun, CH; Sung, KY; Sung, JY; Gimm, YM; Huh, IH; Sohn, UD
      Effects of extremely low frequency magnetic fields on pain thresholds in mice: roles of melatonin and opioids

      JOURNAL OF AUTONOMIC PHARMACOLOGY
    53. D'Anci, KE; Gerstein, AV; Kanarek, RB
      Long-term voluntary access to running wheels decreases kappa-opioid antinociception

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    54. Kanarek, RB; Homoleski, BA; Wiatr, C
      Intake of a palatable sucrose solution modifies the actions of spiradoline, a kappa opioid receptor agonist, on analgesia and feeding behavior in male and female rats

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    55. Wei, LN; Hu, XL; Bi, J; Loh, H
      Post-transcriptional regulation of mouse kappa-opioid receptor expression

      MOLECULAR PHARMACOLOGY
    56. Mizoguchi, H; Narita, M; Nagase, H; Tseng, LF
      Activation of G-proteins in the mouse pons/medulla by beta-endorphin is mediated by the stimulation of mu- and putative epsilon-receptors

      LIFE SCIENCES
    57. Del Seppia, C; Luschi, P; Ghione, S; Crosio, E; Choleris, E; Papi, F
      Exposure to a hypogeomagnetic field or to oscillating magnetic fields similarly reduce stress-induced analgesia in C57 male mice

      LIFE SCIENCES
    58. Zaki, PA; Keith, DE; Brine, GA; Carroll, FI; Evans, CJ
      Ligand-induced changes in surface mu-opioid receptor number: Relationship to G protein activation?

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    59. Abbadie, C; Pan, YX; Pasternak, GW
      Differential distribution in rat brain of mu opioid receptor carboxy terminal splice variants MOR-1C-like and MOR-1-like immunoreactivity: Evidence for region-specific processing

      JOURNAL OF COMPARATIVE NEUROLOGY
    60. Adan, RAH; Gispen, WH
      Melanocortins and the brain: from effects via receptors to drug targets

      EUROPEAN JOURNAL OF PHARMACOLOGY
    61. Hosohata, Y; Vanderah, TW; Burkey, TH; Ossipov, MH; Kovelowski, CJ; Sora, I; Uhl, GR; Zhang, XY; Rice, KC; Roeske, WR; Hruby, VJ; Yamamura, HI; Lai, J; Porreca, F
      delta-opioid receptor agonists produce antinociception and [S-35]GTP gammaS binding in mu receptor knockout mice

      EUROPEAN JOURNAL OF PHARMACOLOGY
    62. Qiu, CY; Sora, I; Ren, K; Uhl, G; Dubner, R
      Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice

      EUROPEAN JOURNAL OF PHARMACOLOGY
    63. Newman, LC; Wallace, DR; Stevens, CW
      Selective opioid agonist and antagonist competition for [H-3]-naloxone binding in amphibian spinal cord

      BRAIN RESEARCH
    64. Zarauza, R; Saez-Fernandez, AN; Iribarren, MJ; Carrascosa, F; Adame, M; Fidalgo, I; Monedero, P
      A comparative study with oral nifedipine, intravenous nimodipine, and magnesium sulfate in postoperative analgesia

      ANESTHESIA AND ANALGESIA
    65. Roques, BP
      Novel approaches to targeting neuropeptide systems

      TRENDS IN PHARMACOLOGICAL SCIENCES
    66. Cook, CD; Barrett, AC; Roach, EL; Bowman, JR; Picker, MJ
      Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity, and efficacy at the muopioid receptor

      PSYCHOPHARMACOLOGY
    67. Spreekmeester, E; Rochford, J
      Selective mu and delta, but not kappa, opiate receptor antagonists inhibitthe habituation of novelty-induced hypoalgesia in the rat

      PSYCHOPHARMACOLOGY
    68. Gelernter, J; Kranzler, H; Cubells, J
      Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects

      MOLECULAR PSYCHIATRY
    69. Schuller, AGP; King, MA; Zhang, JW; Bolan, E; Pan, YX; Morgan, DJ; Chang, A; Czick, ME; Unterwald, EM; Pasternak, GW; Pintar, JE
      Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1

      NATURE NEUROSCIENCE
    70. Mizoguchi, H; Narita, M; Oji, DE; Suganuma, C; Nagase, H; Sora, I; Uhl, GR; Cheng, EY; Tseng, LF
      The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice

      NEUROSCIENCE
    71. Peckys, D; Landwehrmeyer, GB
      Expression of mu, kappa, and delta opioid receptor messenger RNA in the human CNS: A P-33 in situ hybridization study

      NEUROSCIENCE
    72. Foo, H; Helmstetter, FJ
      Hypoalgesia elicited by a conditioned stimulus is blocked by a mu, but nota delta or a kappa, opioid antagonist injected into the rostral ventromedial medulla

      PAIN
    73. Mogil, JS; Wilson, SG; Bon, K; Lee, SE; Chung, K; Raber, P; Pieper, JO; Hain, HS; Belknap, JK; Hubert, L; Elmer, GI; Chung, JM; Devor, M
      Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

      PAIN
    74. Seaman, RL; Belt, ML; Doyle, JM; Mathur, SP
      Hyperactivity caused by a nitric oxide synthase inhibitor is countered by ultra-wideband pulses

      BIOELECTROMAGNETICS
    75. Burchard, JF; Nguyen, DH; Block, E
      Macro- and trace element concentrations in blood plasma and cerebrospinal fluid of dairy cows exposed to electric and magnetic fields

      BIOELECTROMAGNETICS
    76. Goodman, CB; Heyliger, S; Emilien, B; Partilla, JS; Yang, HYT; Lee, CH; Cadet, JL; Rothman, RB
      Chronic exposure to antibodies directed against anti-opiate peptides alterdelta-opioid receptor levels

      PEPTIDES
    77. Andria, ML; Simon, EJ
      Localization of promoter elements in the human mu-opioid receptor gene andregulation by DNA methylation

      MOLECULAR BRAIN RESEARCH
    78. Hu, XL; Cao, S; Loh, HH; Wei, LN
      Promoter activity of mouse kappa opioid receptor gene in transgenic mouse

      MOLECULAR BRAIN RESEARCH
    79. Ikeda, K; Ichikawa, T; Kobayashi, T; Kumanishi, T; Oike, S; Yano, R
      Unique behavioural phenotypes of recombinant-inbred CXBK mice: partial deficiency of sensitivity to mu- and kappa-agonists

      NEUROSCIENCE RESEARCH
    80. Moreau, JL; Huber, G
      Central adenosine A(2A) receptors: an overview

      BRAIN RESEARCH REVIEWS
    81. Suh, HW; Song, DK; Huh, SO; Kim, YH
      Effects of ginsenosides injected intrathecally or intracerebroventricularly on antinociception induced by beta-endorphin administered intracerebroventricularly in the mouse

      NEUROPEPTIDES
    82. Suh, HW; Chung, KM; Kim, YH; Huh, SO; Song, DK
      Effects of histamine receptor antagonists injected intrathecally on antinociception induced by opioids administered intracerebroventricularly in the mouse

      NEUROPEPTIDES
    83. Kim, JA; Siegel, S; Patenall, VRA
      Drug-onset cues as signals: Intraadministration associations and tolerance

      JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
    84. Mogil, JS
      The genetic mediation of individual differences in sensitivity to pain andits inhibition

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    85. Uhl, GR; Sora, I; Wang, ZJ
      The mu opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    86. Pan, YX; Xu, J; Bolan, E; Abbadie, C; Chang, A; Zuckerman, A; Rossi, G; Pasternak, GW
      Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms

      MOLECULAR PHARMACOLOGY
    87. Sanchez-Blazquez, P; Rodriguez-Diaz, M; DeAntonio, I; Garzon, J
      Endomorphin-1 and endomorphin-2 show differences in their activation of muopioid receptor-regulated G proteins in supraspinal antinociception in mice

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    88. Law, PY; Loh, HH
      Regulation of opioid receptor activities

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    89. Williams, M; Kowaluk, EA; Arneric, SP
      Emerging molecular approaches to pain therapy

      JOURNAL OF MEDICINAL CHEMISTRY
    90. Wang, H; Wessendorf, MW
      mu- and delta-opioid receptor mRNAs are expressed in spinally projecting serotonergic and nonserotonergic neurons of the rostral ventromedial medulla

      JOURNAL OF COMPARATIVE NEUROLOGY
    91. Narita, M; Mizoguchi, H; Narita, M; Sora, I; Uhl, GR; Tseng, LF
      Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice

      BRITISH JOURNAL OF PHARMACOLOGY
    92. Wiesenfeld-Hallin, Z; Lucas, GA; Alster, P; Xu, XJ; Hokfelt, T
      Cholecystokinin/opioid interactions

      BRAIN RESEARCH
    93. Fuchs, PN; Roza, C; Sora, I; Uhl, G; Raja, SN
      Characterization of mechanical withdrawal responses and effects of mu-, delta- and kappa-opioid agonists in normal and mu-opioid receptor knockout mice

      BRAIN RESEARCH
    94. Slowe, SJ; Simonin, F; Kieffer, B; Kitchen, I
      Quantitative autoradiography of mu-, delta- and kappa(1) opioid receptors in kappa-opioid receptor knockout mice

      BRAIN RESEARCH
    95. Kieffer, BL
      Opioids: first lessons from knockout mice

      TRENDS IN PHARMACOLOGICAL SCIENCES
    96. Smith, MA; Barrett, AC; Picker, MJ
      Antinociceptive effects of opioids following acute and chronic administration of butorphanol: influence of stimulus intensity and relative efficacy at the mu receptor

      PSYCHOPHARMACOLOGY
    97. WATKINS LR; WIERTELAK EP; MCGORRY M; MARTINEZ J; SCHWARTZ B; SISK D; MAIER SF
      NEUROCIRCUITRY OF CONDITIONED INHIBITION OF ANALGESIA - EFFECTS OF AMYGDALA, DORSAL RAPHE, VENTRAL MEDULLARY, AND SPINAL-CORD LESIONS ON ANTIANALGESIA IN THE RAT

      Behavioral neuroscience
    98. CESSELIN F
      UPDATE ON PHARMACOLOGICAL APPROACH TO CHRONIC PAIN

      Gastroenterologie clinique et biologique
    99. BURCHARD JF; NGUYEN DH; RICHARD L; YOUNG SN; HEYES MP; BLOCK E
      EFFECTS OF ELECTROMAGNETIC-FIELDS ON THE LEVELS OF BIOGENIC-AMINE METABOLITES, QUINOLINIC ACID, AND BETA-ENDORPHIN IN THE CEREBROSPINAL-FLUID OF DAIRY-COWS

      Neurochemical research
    100. MOGIL JS; GRISEL JE
      TRANSGENIC STUDIES OF PAIN

      Pain


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 02:37:14