Catalogo Articoli (Spogli Riviste)

HELP
ATTENZIONE: attualmente gli articoli Current Contents (fonte ISI) a partire dall'anno 2002 sono consultabili sulla Risorsa On-Line

Le informazioni sugli articoli di fonte ISI sono coperte da copyright

La ricerca find articoli where soggetti phrase all words 'MOLECULAR MECHANISMS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 1077 riferimenti
Si mostrano 100 riferimenti a partire da 1
Selezionare un intervallo

Per ulteriori informazioni selezionare i riferimenti di interesse.

    1. Ammit, AJ; Panettieri, RA
      Signal transduction in smooth muscle - Invited review: The circle of life:cell cycle regulation in airway smooth muscle

      JOURNAL OF APPLIED PHYSIOLOGY
    2. Ritter, M; Menon, S; Zhao, LP; Xu, SX; Shelby, J; Barry, WH
      Functional importance and caffeine sensitivity of ryanodine receptors in primary lymphocytes

      INTERNATIONAL IMMUNOPHARMACOLOGY
    3. Chung, SM; Lee, JY; Lee, MY; Bae, ON; Chung, JH
      Adverse consequences of erythrocyte exposure to menadione: Involvement of reactive oxygen species generation in plasma

      JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
    4. Tisaoussis, J; Newsome, PN; Nelson, LJ; Hayes, PC; Plevris, JN
      Which hepatocyte will it be? Hepatocyte choice for bioartificial liver support systems

      LIVER TRANSPLANTATION
    5. Monson, NL; Foster, SJ; Brezinschek, HP; Brezinschek, RI; Dorner, T; Lipsky, PE
      The role of CD40-CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutation

      CLINICAL IMMUNOLOGY
    6. True, JR; Haag, ES
      Developmental system drift and flexibility in evolutionary trajectories

      EVOLUTION & DEVELOPMENT
    7. Schiavo, G; van der Goot, FG
      The bacterial toxin toolkit

      NATURE REVIEWS MOLECULAR CELL BIOLOGY
    8. Hyman, SE; Malenka, RC
      Addiction and the brain: The neurobiology of compulsion and its persistence

      NATURE REVIEWS NEUROSCIENCE
    9. Hacker, J; Carniel, E
      Ecological fitness, genomic islands and bacterial pathogenicity - A Darwinian view of the evolution of microbes

      EMBO REPORTS
    10. Nairn, RS; Kazianis, S; Della Coletta, L; Trono, D; Butler, AP; Walter, RB; Morizot, DC
      Genetic analysis of susceptibility to spontaneous and UV-induced carcinogenesis in Xiphophorus hybrid fish

      MARINE BIOTECHNOLOGY
    11. Gutsmann, T; Haberer, N; Carroll, SF; Seydel, U; Wiese, A
      Interaction between lipopolysaccharide (LPS), LPS-binding protein (LBP), and planar membranes

      BIOLOGICAL CHEMISTRY
    12. Hanke, J
      Apoptosis in cultured rat islets of Langerhans and occurrence of Bcl-2, Bak, Bax, Fas and Fas ligand

      CELLS TISSUES ORGANS
    13. Dahl, R; Nielsen, LP
      Steroids: An overview

      NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
    14. Van Laethem, F; Baus, E; Andris, F; Urbain, J; Leo, O
      A novel aspect of the anti-inflammatory actions of glucocorticoids: inhibition of proximal steps of signaling cascades in lymphocytes

      CELLULAR AND MOLECULAR LIFE SCIENCES
    15. Lu, Z; Gu, YQ; Rooney, SA
      Transcriptional regulation of the lung fatty acid synthase gene by glucocorticoid, thyroid hormone and transforming growth factor-beta 1

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    16. Tilton, RG; Brock, TA; Dixon, RAF
      Therapeutic potential of endothelin receptor antagonists and nitric oxide donors in pulmonary hypertension

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    17. Burt, ET
      Current approaches to the treatment of Candida albicans infections

      EXPERT OPINION ON THERAPEUTIC PATENTS
    18. Granath, B; Taylor, RR; van Bockxmeer, FM; Mamotte, CDS
      Lack of evidence for association between endothelial nitric oxide synthasegene polymorphisms and coronary artery disease in the Australian Caucasianpopulation

      JOURNAL OF CARDIOVASCULAR RISK
    19. Perry, RLS; Parker, MH; Rudnicki, MA
      Activated MEK1 binds the nuclear MyoD transcriptional complex to repress transactivation

      MOLECULAR CELL
    20. Scheuner, D; Song, BB; McEwen, E; Liu, C; Laybutt, R; Gillespie, P; Saunders, T; Bonner-Weir, S; Kaufman, RJ
      Translational control is required for the unfolded protein response and invivo glucose homeostasis

      MOLECULAR CELL
    21. Shultz, VD; Phillips, S; Sar, M; Foster, PMD; Gaido, KW
      Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate

      TOXICOLOGICAL SCIENCES
    22. Jacob, T; Hingorani, A; Ascher, E
      Examination of the apoptotic pathway and proteolysis in the pathogenesis of popliteal artery aneurysms

      EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
    23. Brudler, R; Rammelsberg, R; Woo, TT; Getzoff, ED; Gerwert, K
      Structure of the I-1 early intermediate of photoactive yellow protein by FTIR spectroscopy

      NATURE STRUCTURAL BIOLOGY
    24. Vuolteenaho, K; Moilanen, T; Al-Saffar, N; Knowles, RG; Moilanen, E
      Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage

      OSTEOARTHRITIS AND CARTILAGE
    25. Vidali, L; McKenna, ST; Hepler, PK
      Actin polymerization is essential for pollen tube growth

      MOLECULAR BIOLOGY OF THE CELL
    26. Miller, NS; Goldsmith, RJ
      Craving for alcohol and drugs in animals and humans: Biology and behavior

      JOURNAL OF ADDICTIVE DISEASES
    27. Lopes, EC; Garcia, MG; Vellon, L; Alvarez, E; Hajos, SE
      Correlation between decreased apoptosis and multidrug resistance (MDR) in murine leukemic T cell lines

      LEUKEMIA & LYMPHOMA
    28. Perotti, ME; Cattaneo, F; Pasini, ME; Verni, F; Hackstein, JHP
      Male sterile mutant casanova gives clues to mechanisms of sperm-egg interactions in Drosophila melanogaster

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    29. Kotani, T; Yoshida, N; Mita, K; Yamashita, M
      Requirement of cyclin B2, but not cyclin B1, for bipolar spindle formationin frog (Rana japonica) oocytes

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    30. Bonnet, S; Belus, A; Hyvelin, JM; Roux, E; Marthan, R; Savineau, JP
      Effect of chronic hypoxia on agonist-induced tone and calcium signaling inrat pulmonary artery

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    31. Walter, H; Ramskogler, K; Semler, B; Lesch, OM; Platz, W
      Dopamine and alcohol relapse: D-1 and D-2 antagonists increase relapse rates in animal studies and in clinical trials

      JOURNAL OF BIOMEDICAL SCIENCE
    32. Seol, JG; Park, WH; Kim, ES; Jung, CW; Hyun, JM; Lee, YY; Kim, BK
      Potential role of caspase-3 and-9 in arsenic trioxide-mediated apoptosis in PCI-1 head and neck cancer cells

      INTERNATIONAL JOURNAL OF ONCOLOGY
    33. Kokura, S; Rhoads, CA; Wolf, RE; Yoshikawa, T; Granger, DN; Aw, TY
      NF kappa B signaling in posthypoxic endothelial cells: Relevance to E-selectin expression and neutrophil adhesion

      JOURNAL OF VASCULAR RESEARCH
    34. Shifrin, AL; Auricchio, A; Yu, QC; Wilson, J; Raper, SE
      Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia

      GENE THERAPY
    35. Cochran, JR; Aivazian, D; Cameron, TO; Stern, LJ
      Receptor clustering and transmembrane signaling in T cells

      TRENDS IN BIOCHEMICAL SCIENCES
    36. Thorarensen, A; Douglas, MR; Rohrer, DC; Vosters, AF; Yem, AW; Marshall, VD; Lynn, JC; Bohanon, MJ; Tomich, PK; Zurenko, GE; Sweeney, MT; Jensen, RM; Nielsen, JW; Seest, EP; Dolak, LA
      Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    37. Price, MS; Classen, JJ; Payne, GA
      Aspergillus niger absorbs copper and zinc from swine wastewater

      BIORESOURCE TECHNOLOGY
    38. Eggert, M; Schulz, M; Neeck, G
      Molecular mechanisms of glucocorticoid action in rheumatic autoimmune diseases

      JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
    39. Moore, F; Bernal, AL
      Myosin light chain kinase and the onset of labour in humans

      EXPERIMENTAL PHYSIOLOGY
    40. Aziz, Q
      Acid sensors in the gut: a taste of things to come

      EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
    41. Koseki, S; Miura, S; Fujimori, H; Hokari, R; Komoto, S; Hara, Y; Ogino, T; Nagata, H; Goto, M; Hachimura, S; Kaminogawa, S; Ishii, H
      In situ demonstration of intraepithelial lymphocyte adhesion to villus microvessels of the small intestine

      INTERNATIONAL IMMUNOLOGY
    42. Rendu, F; Brohard-Bohn, B
      The platelet release reaction: granules' constituents, secretion and functions

      PLATELETS
    43. Ng, PWP; Iha, H; Iwanaga, Y; Bittner, M; Chen, YD; Jiang, Y; Gooden, G; Trent, JM; Meltzer, P; Jeang, KT; Zeichner, SL
      Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappa B activation

      ONCOGENE
    44. Offermanns, S
      In vivo functions of heterotrimeric G-proteins: studies in G alpha-deficient mice

      ONCOGENE
    45. Naruta, E; Buko, V
      Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose

      EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
    46. Freidig, AP; Hermens, JLM
      Narcosis and chemical reactivity QSARs for acute fish toxicity

      QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS
    47. Cao, CC; Lu, SG; Dong, C; Zhao, RM
      Abnormal DNA-binding of transcription factors in minimal change nephrotic syndrome

      PEDIATRIC NEPHROLOGY
    48. McLachlan, JA; Newbold, RR; Burow, ME; Li, SF
      From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters

      APMIS
    49. McLachlan, JA; Newbold, RR; Burow, ME; Li, SF
      From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters

      APMIS
    50. Renden, R; Berwin, B; Davis, W; Ann, K; Chin, CT; Kreber, R; Ganetzky, B; Martin, TFJ; Broadie, K
      Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion

      NEURON
    51. Torres, GE; Yao, WD; Mohn, AR; Quan, H; Kim, KM; Levey, AI; Staudinger, J; Caron, MG
      Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

      NEURON
    52. Brandon, CL; Marinelli, M; Baker, LK; White, FJ
      Enhanced reactivity and vulnerability to cocaine following methylphenidatetreatment in adolescent rats

      NEUROPSYCHOPHARMACOLOGY
    53. Brunetti, A; Manfioletti, G; Chiefari, E; Goldfine, ID; Foti, D
      Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y)

      FASEB JOURNAL
    54. Frantseva, MV; Carlen, PL; Velazquez, JLP
      Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons

      FREE RADICAL BIOLOGY AND MEDICINE
    55. Belessi, C; Stamatopoulos, K; Stavroyianni, N; Zoi, K; Papadaki, T; Kosmas, C
      Somatic hypermutation targeting to intrinsic hotspots of immunoglobulin genes in follicular lymphoma and multiple myeloma

      LEUKEMIA
    56. Dagher, A; Bleicher, C; Aston, JAD; Gunn, RN; Clarke, PBS; Cumming, P
      Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers

      SYNAPSE
    57. Kubes, P; Kerfoot, SM
      Leukocyte recruitment in the microcirculation: the rolling paradigm revisited

      NEWS IN PHYSIOLOGICAL SCIENCES
    58. Adcock, IM; Caramori, G
      Cross-talk between pro-inflammatory transcription factors and glucocorticoids

      IMMUNOLOGY AND CELL BIOLOGY
    59. Seitz, M; Park, CK; Wong, JY; Israelachvili, JN
      Long-range interaction forces between polymer-supported lipid bilayer membranes

      LANGMUIR
    60. Baldi, A; Santini, D; Battista, T; Dragonetti, E; Ferranti, G; Petitti, T; Groeger, AM; Angelini, A; Rossiello, R; Baldi, F; Natali, PG; Paggi, MG
      Expression of AP-2 transcription factor and of its downstream target genesc-kit, E-cadherin and p21 in human cutaneous melanoma

      JOURNAL OF CELLULAR BIOCHEMISTRY
    61. Warner, HR
      Support for basic gerontological research in the USA

      EXPERIMENTAL GERONTOLOGY
    62. Formisano, P; Beguinot, F
      The role of protein kinase C isoforms in insulin action

      JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
    63. Sharpe, RM
      Hormones and testis development and the possible adverse effects of environmental chemicals

      TOXICOLOGY LETTERS
    64. Xu, YH; Carr, LG
      Binding of Sp1/Sp3 to the proximal promoter of the hMOR gene is enhanced by DAMGO

      GENE
    65. Apostolova, MD; Chen, SL; Chakrabarti, S; Cherian, MG
      High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    66. Dechert, MA; Holder, JM; Gerthoffer, WT
      p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 MAPK

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    67. Kollum, M; Cottin, Y; Chan, RC; Kim, HS; Bhargava, B; Vodovotz, Y; Waksman, R
      Delayed re-endothelialization and T-cell infiltration following intracoronary radiation therapy in the porcine model

      INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
    68. Du, YH; Ho, PC
      Arsenic compounds induce cytotoxicity and apoptosis in cisplatin-sensitiveand -resistant gynecological cancer cell lines

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    69. Shen, MC; Lin, JS; Tsay, W
      Factor V Arg(306)-> Gly mutation is not associated with activated protein C resistance and is rare in Taiwanese Chinese

      THROMBOSIS AND HAEMOSTASIS
    70. Donnelly, R; Seale, JP
      Clinical pharmacokinetics of inhaled budesonide

      CLINICAL PHARMACOKINETICS
    71. Aller, MA; Arias, JL; Lorente, L; Nava, MP; Duran, HJ; Arias, J
      Neuro-immune-endocrine functional system and vascular pathology

      MEDICAL HYPOTHESES
    72. Narita, M; Aoki, T; Ozaki, S; Yajima, Y; Suzuki, T
      Involvement of protein kinase C gamma isoform in morphine-induced reinforcing effects

      NEUROSCIENCE
    73. Maebashi, K; Niimi, M; Kudoh, M; Fischer, FJ; Makimura, K; Niimi, K; Piper, RJ; Uchida, K; Arisawa, M; Cannon, RD; Yamaguchi, H
      Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients

      Journal of antimicrobial chemotherapy
    74. Borgland, S
      Acute opioid receptor desensitization and tolerance: Is there a link?

      CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
    75. Dabrowski, K; Lee, KJ; Rinchard, J; Ciereszko, A; Blom, JH; Ottobre, JS
      Gossypol isomers bind specifically to blood plasma proteins and spermatozoa of rainbow trout fed diets containing cottonseed meal

      BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
    76. Roza, C; Reeh, PW
      Substance P, calcitonin gene related peptide and PGE(2) co-released from the mouse colon: a new model to study nociceptive and inflammatory responsesin viscera, in vitro

      PAIN
    77. Macedo, DS; Sousa, FCF; Vasconcelos, SMM; Lima, VTM; Viana, GSB
      Different times of withdrawal from cocaine administration cause changes inmuscarinic and dopaminergic receptors in rat premotor cortex

      NEUROSCIENCE LETTERS
    78. Jaquet, PE; Ferrer-Alcon, M; Ventayol, P; Guimon, J; Garcia-Sevilla, JA
      Acute and chronic effects of morphine and naloxone on the phosphorylation of neurofilament-H proteins in the rat brain

      NEUROSCIENCE LETTERS
    79. Wang, F; Samudio, I; Safe, S
      Transcriptional activation of cathepsin D gene expression by 17 beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    80. Shichinohe, S; Ozawa, H; Hashimoto, E; Tatschner, T; Riederer, P; Saito, T
      Changes in the cAMP-related signal transduction mechanism in postmortem human brains of heroin addicts

      JOURNAL OF NEURAL TRANSMISSION
    81. Diez, J; Lopez, B; Gonzalez, A; Ardanaz, N; Fortuno, MA
      Myocardial response to biomechanical stress

      REVISTA ESPANOLA DE CARDIOLOGIA
    82. Srivastava, K; Dash, D
      Altered membrane fluidity and signal transduction in the platelets from patients of thrombotic stroke

      MOLECULAR AND CELLULAR BIOCHEMISTRY
    83. Huang, CS; Li, JX; Ding, M; Costa, M; Castranova, V; Vallyathan, V; Ju, G; Shi, XL
      Transactivation of RARE and GRE in the cellular response to arsenic

      MOLECULAR AND CELLULAR BIOCHEMISTRY
    84. Costa, M; Sutherland, JE; Peng, W; Salnikow, K; Broday, L; Kluz, T
      Molecular biology of nickel carcinogenesis

      MOLECULAR AND CELLULAR BIOCHEMISTRY
    85. Luna, JAC
      Origin, present and future of resistance in tuberculosis

      ARCHIVOS DE BRONCONEUMOLOGIA
    86. Nakahata, S; Mita, K; Katsu, Y; Nagahama, Y; Yamashita, M
      Immunological detection and characterization of poly(A) polymerase, poly(A)-binding protein and cytoplasmic polyadenylation element-binding protein in goldfish and Xenopus oocytes

      ZOOLOGICAL SCIENCE
    87. Lasa, M; Brook, M; Saklatvala, J; Clark, AR
      Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38

      MOLECULAR AND CELLULAR BIOLOGY
    88. Reimers, K; Antoine, M; Zapatka, M; Blecken, V; Dickson, C; Kiefer, P
      NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth

      MOLECULAR AND CELLULAR BIOLOGY
    89. Ueda, H; Inoue, M; Matsumoto, T
      Protein kinase C-mediated inhibition of mu-opioid receptor internalizationand its involvement in the development of acute tolerance to peripheral mu-agonist analgesia

      JOURNAL OF NEUROSCIENCE
    90. Schmidt, EF; Sutton, MA; Schad, CA; Karanian, DA; Brodkin, ES; Self, DW
      Extinction training regulates tyrosine hydroxylase during withdrawal from cocaine self-administration

      JOURNAL OF NEUROSCIENCE
    91. Yakovlev, AG; Ota, K; Wang, GP; Movsesyan, V; Bao, WL; Yoshihara, K; Faden, AI
      Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury

      JOURNAL OF NEUROSCIENCE
    92. Vekovischeva, OY; Zamanillo, D; Echenko, O; Seppala, T; Uusi-Oukari, M; Honkanen, A; Seeburg, PH; Sprengel, R; Korpi, ER
      Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits

      JOURNAL OF NEUROSCIENCE
    93. Hendriks, EF; Robinson, DR; Hinkins, M; Matthews, KR
      A novel CCCH protein which modulates differentiation of Trypanosoma bruceito its procyclic form

      EMBO JOURNAL
    94. Ung, TL; Cao, C; Lu, JM; Ozato, K; Dever, TE
      Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR

      EMBO JOURNAL
    95. Zalba, G; Gonzalez, A; Beaumont, J; San Jose, G; Moreno, U; Lopez, B; Ravassa, S; Muniz, P; Fortuno, A; Fortuno, MA; Diez, J
      Vascular oxidative stress and endothelial dysfunction

      NEFROLOGIA
    96. Kirkup, AJ; Brunsden, AM; Grundy, D
      Receptors and transmission in the brain-gut axis: Potential for novel therapies - I. Receptors on visceral afferents

      AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
    97. Youngren, JF; Keen, S; Kulp, JL; Tanner, CJ; Houmard, JA; Goldfine, ID
      Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training

      AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
    98. Schliess, F; Haussinger, D
      Hepatic encephalopathy and nitric oxide

      JOURNAL OF HEPATOLOGY
    99. Lopez-Figueroa, MO; Caamano, C; Marin, R; Guerra, B; Alonso, R; Morano, MI; Akil, H; Watson, SJ
      Characterization of basal nitric oxide production in living cells

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
    100. Jyonouchi, H; Sun, SN; Le, H
      Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression

      JOURNAL OF NEUROIMMUNOLOGY


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:41:34