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Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors
G PROTEIN PATHWAYS, PT A, RECEPTORS
Three-dimensional representations of G protein-coupled receptor structuresand mechanisms
G PROTEIN PATHWAYS, PT A, RECEPTORS
The surface accessibility of the glycine receptor M2-M3 loop is increased in the channel open state
JOURNAL OF NEUROSCIENCE
A beta-strand in the gamma(2) subunit lines the benzodiazepine binding site of the GABA(A) receptor: Structural rearrangements detected during channel gating
JOURNAL OF NEUROSCIENCE
Evidence for distinct conformations of the two alpha(1) subunits in diazepam-bound GABA(A) receptors
NEUROPHARMACOLOGY
Structural mimicry in G protein-coupled receptors: Implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
MOLECULAR PHARMACOLOGY
Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter
JOURNAL OF NEUROCHEMISTRY
3-aryl[1,2,4]triazino[4,3-alpha]benzimidazol-4(10H)-ones: A new class of selective A(1) adenosine receptor antagonists
JOURNAL OF MEDICINAL CHEMISTRY
Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity andselectivity in quinoline tachykinin receptor antagonists
JOURNAL OF MEDICINAL CHEMISTRY
CFTR: Covalent and noncovalent modification suggests a role for fixed charges in anion conduction
JOURNAL OF GENERAL PHYSIOLOGY
Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis
JOURNAL OF BIOLOGICAL CHEMISTRY
Cysteine substitutions reveal dual functions of the amino-terminal tail incystic fibrosis transmembrane conductance regulator channel gating
JOURNAL OF BIOLOGICAL CHEMISTRY
Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors
JOURNAL OF BIOLOGICAL CHEMISTRY
The TXP motif in the second transmembrane helix of CCR5 - A structural determinant of chemokine-induced activation
JOURNAL OF BIOLOGICAL CHEMISTRY
Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta(2) adrenergic receptor mapped by site-selectivefluorescent labeling
JOURNAL OF BIOLOGICAL CHEMISTRY
The first transmembrane segment of the dopamine D2 receptor: Accessibilityin the binding-site crevice and position in the transmembrane bundle
BIOCHEMISTRY
Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors
BIOCHEMISTRY
Asymmetric structure of the cystic fibrosis transmembrane conductance regulator chloride channel pore suggested by mutagenesis of the twelfth transmembrane region
BIOCHEMISTRY
Dopamine receptors and locomotor responses: Molecular aspects
ANNALS OF NEUROLOGY
On the spatial disposition of the fifth transmembrane helix and the structural integrity of the transmembrane binding site in the opioid and ORL1 G protein-coupled receptor family
PROTEIN ENGINEERING
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
ENDOCRINE REVIEWS
CCK-B/gastrin receptor transmembrane domain mutations selectively alter synthetic agonist efficacy without affecting the activity of endogenous peptides
MOLECULAR PHARMACOLOGY
Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M-1 muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine
MOLECULAR PHARMACOLOGY
Theoretical study on mutation-induced activation of the luteinizing hormone receptor
JOURNAL OF MOLECULAR BIOLOGY
CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors
JOURNAL OF MEDICINAL CHEMISTRY
Permeation through the CFTR chloride channel
JOURNAL OF EXPERIMENTAL BIOLOGY
Cystic fibrosis transmembrane conductance regulator - Structure and function of an epithelial chloride channel
JOURNAL OF BIOLOGICAL CHEMISTRY
The forgotten serine - A critical role for Ser-203(5.42) in ligand bindingto and activation of the beta(2)-adrenergic receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Architecture of Ca2+ channel pore-lining segments revealed by covalent modification of substituted cysteines
JOURNAL OF BIOLOGICAL CHEMISTRY
Interaction between transmembrane domains five and six of the alpha-factorreceptor
JOURNAL OF BIOLOGICAL CHEMISTRY
The yeast mitochondrial citrate transport protein - Probing the secondary structure of transmembrane domain IV and identification of residues that likely comprise a portion of the citrate translocation pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
The dopamine D-4 receptor: one decade of research
EUROPEAN JOURNAL OF PHARMACOLOGY
Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol
BRITISH JOURNAL OF PHARMACOLOGY
Interaction between permeation and gating in a putative pore domain mutantin the cystic fibrosis transmembrane conductance regulator
BIOPHYSICAL JOURNAL
Molecular determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel pore
BIOPHYSICAL JOURNAL
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
BIOCHEMISTRY
The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors
BIOCHEMISTRY
The fourth transmembrane segment of the dopamine D2 receptor: Accessibility in the binding-site crevice and position in the transmembrane bundle
BIOCHEMISTRY
Inhibition of the human sodium/bile acid cotransporters by side-specific methanethiosulfonate sulfhydryl reagents: Substrate-controlled accessibilityof site of inactivation
BIOCHEMISTRY
Ligand-ligand and ligand-receptor approaches to modeling the cannabinoid CB1 and CB2 receptors: Achievements and challenges
CURRENT MEDICINAL CHEMISTRY
Structural organization of G-protein-coupled receptors
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
Mapping the agonist binding site of the GABA(A) receptor: Evidence for a beta-strand
JOURNAL OF NEUROSCIENCE
3D modeling, ligand binding and activation studies of the cloned mouse delta, mu and kappa opioid receptors
PROTEIN ENGINEERING
The difference between the CB1 and CB2 cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB2
MOLECULAR PHARMACOLOGY
Mutation of a highly conserved aspartic acid in the beta(2) adrenergic receptor: Constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6
MOLECULAR PHARMACOLOGY
Mapping the substrate binding site of the prostaglandin transporter PGT bycysteine scanning mutagenesis
JOURNAL OF BIOLOGICAL CHEMISTRY
Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Phe(310) in transmembrane VI of the alpha(1B)-adrenergic receptor is a keyswitch residue involved in activation and catecholamine ring aromatic bonding
JOURNAL OF BIOLOGICAL CHEMISTRY
C5a receptor activation - Genetic identification of critical residues in four transmembrane helices
JOURNAL OF BIOLOGICAL CHEMISTRY
Arg352 is a major determinant of charge selectivity in the cystic fibrosistransmembrane conductance regulator chloride channel
BIOCHEMISTRY
MOLECULAR-BASIS OF RECEPTOR G-PROTEIN-COUPLING SELECTIVITY/
Pharmacology & therapeutics (Oxford)
A PROPOSED STRUCTURE FOR TRANSMEMBRANE SEGMENT-7 OF G-PROTEIN-COUPLEDRECEPTORS INCORPORATING AN ASN-PRO ASP-PRO MOTIF/
Biophysical journal
OPIOID RECEPTOR 3-DIMENSIONAL STRUCTURES FROM DISTANCE GEOMETRY CALCULATIONS WITH HYDROGEN-BONDING CONSTRAINTS
Biophysical journal
AN ALPHA-CARBON TEMPLATE FOR THE TRANSMEMBRANE HELICES IN THE RHODOPSIN FAMILY OF G-PROTEIN-COUPLED RECEPTORS
Journal of Molecular Biology
A NEW APPROACH TO DOCKING IN THE BETA(2)-ADRENERGIC RECEPTOR THAT EXPLOITS THE DOMAIN-STRUCTURE OF G-PROTEIN-COUPLED RECEPTORS
Journal of medicinal chemistry