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La ricerca find articoli where soggetti phrase all words 'MAMMALIAN TELOMERASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 130 riferimenti
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    1. Fujimoto, R; Kamata, N; Yokoyama, K; Ueda, N; Satomura, K; Hayashi, E; Nagayama, M
      Expression of telomerase components in oral keratinocytes and squamous cell carcinomas

      ORAL ONCOLOGY
    2. Fukui, T; Nonomura, N; Tokizane, T; Sato, E; Ono, Y; Harada, Y; Nishimura, K; Takahara, S; Okuyama, A
      Clinical evaluation of human telomerase catalytic subunit in bladder washings from patients with bladder cancer

      MOLECULAR UROLOGY
    3. Siddiqui, MT; Greene, KL; Clark, DP; Xydas, S; Udelsman, R; Smallridge, RC; Zeiger, MA; Saji, M
      Human telomerase reverse transcriptase expression in Diff-Quik-srained FNAsamples from thyroid nodules

      DIAGNOSTIC MOLECULAR PATHOLOGY
    4. Koga, S; Kondo, Y; Komata, T; Kondo, S
      Treatment of bladder cancer cells in vitro and in vivo with 2-5A antisensetelomerase RNA

      GENE THERAPY
    5. Smith, S
      The world according to PARP

      TRENDS IN BIOCHEMICAL SCIENCES
    6. Nishimoto, A; Miura, N; Horikawa, I; Kugoh, H; Murakami, Y; Hirohashi, S; Kawasaki, H; Gazdar, AF; Shay, JW; Barrett, JC; Oshimura, M
      Functional evidence for a telomerase repressor gene on human chromosome 10p15.1

      ONCOGENE
    7. Yudoh, K; Matsuno, H; Nakazawa, F; Katayama, R; Kimura, T
      Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts

      JOURNAL OF BONE AND MINERAL RESEARCH
    8. Kameshima, H; Yagihashi, A; Yajima, T; Kobayashi, D; Hirata, K; Watanabe, N
      Expression of telomerase-associated genes: Reflection of telomerase activity in gastric cancer?

      WORLD JOURNAL OF SURGERY
    9. Stoppler, H; Stoppler, MC; Kisiela, M; Holzbach, A; Moll, I; Houdek, P; Moll, R
      Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell cultures

      ARCHIVES OF DERMATOLOGICAL RESEARCH
    10. Tollefsbol, TO; Andrews, LG
      Mechanisms for telomerase gene control in aging cells and tumorigenesis

      MEDICAL HYPOTHESES
    11. Bachand, F; Triki, F; Autexier, C
      Human telomerase RNA-protein interactions

      NUCLEIC ACIDS RESEARCH
    12. Fiset, S; Chabot, B
      HnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro

      NUCLEIC ACIDS RESEARCH
    13. Rama, S; Suresh, Y; Rao, AJ
      Regulation of telomerase during human placental differentiation: a role for TGF beta 1

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    14. Beattie, TL; Zhou, W; Robinson, MO; Harrington, L
      Functional multimerization of the human telomerase reverse transcriptase

      MOLECULAR AND CELLULAR BIOLOGY
    15. Yu, CC; Lo, SC; Wang, TCV
      Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells

      BIOCHEMICAL JOURNAL
    16. Gonzalez-Suarez, E; Samper, E; Ramirez, A; Flores, JM; Martin-Caballero, J; Jorcano, JL; Blasco, MA
      Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

      EMBO JOURNAL
    17. Koga, S; Hirohata, S; Kondo, Y; Komata, T; Takakura, M; Inoue, M; Kyo, S; Kondo, S
      FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo

      ANTICANCER RESEARCH
    18. Ohno, J; Horio, Y; Sekido, Y; Hasegawa, Y; Takahashi, M; Nishizawa, J; Saito, H; Ishikawa, F; Shimokata, K
      Telomerase activation and p53 mutations in urethane-induced A/J mouse lungtumor development

      CARCINOGENESIS
    19. Mason, DX; Autexier, C; Greider, CW
      Tetrahymena proteins p80 and p95 are not core telomerase components

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    20. Kickhoefer, VA; Liu, Y; Kong, LB; Snow, BE; Stewart, PL; Harrington, L; Rome, LH
      The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle

      JOURNAL OF CELL BIOLOGY
    21. Martin-Rivera, L; Blasco, MA
      Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system

      JOURNAL OF BIOLOGICAL CHEMISTRY
    22. Bosoy, D; Lue, NF
      Functional analysis of conserved residues in the putative "finger" domain of telomerase reverse transcriptase

      JOURNAL OF BIOLOGICAL CHEMISTRY
    23. Nozawa, K; Maehara, K; Isobe, K
      Mechanism for the reduction of telomerase expression during muscle cell differentiation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    24. Knight, JS; Cotter, MA; Robertson, ES
      The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter

      JOURNAL OF BIOLOGICAL CHEMISTRY
    25. Sachsinger, J; Gonzalez-Suarez, E; Samper, E; Heicappell, R; Muller, M; Blasco, MA
      Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells

      CANCER RESEARCH
    26. Yajima, T; Yagihashi, A; Kameshima, H; Kobayashi, D; Hirata, K; Watanabe, N
      Telomerase reverse transcriptase and telomeric-repeat binding factor protein 1 as regulators of telomerase activity in pancreatic cancer cells

      BRITISH JOURNAL OF CANCER
    27. Arai, J; Yasukawa, M; Ohminami, H; Kakimoto, M; Hasegawa, A; Fujita, S
      Identification of human telomerase reverse transcriptase-derived peptides that induce HLA-A24-restricted antileukemia cytotoxic T lymphocytes

      BLOOD
    28. Krams, M; Claviez, A; Heidorn, K; Krupp, G; Parwaresch, R; Harms, D; Rudolph, P
      Regulation of telomerase activity by alternate splicing of human telomerase reverse transcriptase mRNA in a subset of neuroblastomas

      AMERICAN JOURNAL OF PATHOLOGY
    29. Niiyama, H; Mizumoto, K; Sato, N; Nagai, E; Mibu, R; Fukui, T; Kinoshita, M; Tanaka, M
      Quantitative analysis of hTERT mRNA expression in colorectal cancer

      AMERICAN JOURNAL OF GASTROENTEROLOGY
    30. Cech, TR
      Life at the end of the chromosome: Telomeres and telomerase

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    31. Ishikawa, F
      Aging clock: the watchmaker's masterpiece

      CELLULAR AND MOLECULAR LIFE SCIENCES
    32. Cerni, C
      Telomeres, telomerase, and myc. An update

      MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
    33. Kong, LB; Siva, AC; Kickhoefer, VA; Rome, LH; Stewart, PL
      RNA location and modeling of a WD40 repeat domain within the vault

      RNA-A PUBLICATION OF THE RNA SOCIETY
    34. Miller, MC; Collins, K
      The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability

      MOLECULAR CELL
    35. Kitagawa, Y; Kyo, S; Takakura, M; Kanaya, T; Koshida, K; Namiki, M; Inoue, M
      Demethylating reagent 5-azacytidine inhibits telomerase activity in human prostate cancer cells through transcriptional repression of hTERT

      CLINICAL CANCER RESEARCH
    36. Kanaya, T; Kyo, S; Hamada, K; Takakura, M; Kitagawa, Y; Harada, H; Inoue, M
      Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription

      CLINICAL CANCER RESEARCH
    37. Le, SY; Sternglanz, R; Greider, CW
      Identification of two RNA-binding proteins associated with human telomerase RNA

      MOLECULAR BIOLOGY OF THE CELL
    38. Beattie, TL; Zhou, W; Robinson, MO; Harrington, L
      Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding

      MOLECULAR BIOLOGY OF THE CELL
    39. Koga, S; Hirohata, S; Kondo, Y; Komata, T; Takakura, M; Inoue, M; Kyo, S; Kondo, S
      A novel telomerase-specific gene therapy: Gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

      HUMAN GENE THERAPY
    40. Lavelle, F; Riou, JF; Laoui, A; Mailliet, P
      Telomerase: a therapeutic target for the third millennium?

      CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
    41. Oshita, T; Nagai, N; Ohama, K
      Expression of telomerase reverse transcriptase mRNA and its quantitative analysis in human endometrial cancer

      INTERNATIONAL JOURNAL OF ONCOLOGY
    42. Choi, SH; Kang, HK; Im, EO; Kim, YJ; Bae, YT; Choi, YH; Lee, KH; Chung, HY; Chang, HK; Kim, ND
      Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids

      INTERNATIONAL JOURNAL OF ONCOLOGY
    43. Komiya, T; Kawase, I; Nitta, T; Yasumitsu, T; Kikui, M; Fukuoka, M; Nakagawa, K; Hirashima, T
      Prognostic significance of hTERT expression in non-small cell lung cancer

      INTERNATIONAL JOURNAL OF ONCOLOGY
    44. Komata, T; Kondo, Y; Koga, S; Ko, SC; Chung, LWK; Kondo, S
      Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53

      GENE THERAPY
    45. Dhaene, K; Van Marck, E; Parwaresch, R
      Telomeres, telomerase and cancer: an up-date

      VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
    46. Yamada, K; Yajima, T; Yagihashi, A; Kobayashi, D; Koyanagi, Y; Asanuma, K; Yamada, M; Moriai, R; Kameshima, H; Watanabe, N
      Role of human telomerase reverse transcriptase and telomeric-repeat binding factor proteins 1 and 2 in human hematopoietic cells

      JAPANESE JOURNAL OF CANCER RESEARCH
    47. Akiyama, M; Yamada, O; Akita, S; Urashima, M; Horiguchi-Yamada, J; Ohno, T; Mizoguchi, H; Eto, Y; Yamada, H
      Ectopic expression of c-myc fails to overcome downregulation of telomeraseactivity induced by herbimycin A, but ectopic hTERT expression overcomes it

      LEUKEMIA
    48. Suzuki, K; Kashimura, H; Ohkawa, J; Itabashi, M; Watanabe, T; Sawahata, T; Nakahara, A; Muto, H; Tanaka, N
      Expression of human telomerase catalytic subunit gene in cancerous and precancerous gastric conditions

      JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
    49. Davis, AJ; Siu, LL
      Telomerase: Therapeutic potential in cancer

      CANCER INVESTIGATION
    50. Kyo, S; Takakura, M; Taira, T; Kanaya, T; Itoh, H; Yutsudo, M; Ariga, H; Inoue, M
      Spl cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)

      NUCLEIC ACIDS RESEARCH
    51. Fujimoto, K; Kyo, S; Takakura, M; Kanaya, T; Kitagawa, Y; Itoh, H; Takahashi, M; Inoue, M
      Identification and characterization of negative regulatory elements of thehuman telomerase catalytic subunit (hTERT) gene promoter: possible role ofMZF-2 in transcriptional repression of hTERT

      NUCLEIC ACIDS RESEARCH
    52. Zhou, JL; Hidaka, K; Futcher, B
      The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA

      MOLECULAR AND CELLULAR BIOLOGY
    53. Liu, Y; Snow, BE; Hande, MP; Baerlocher, G; Kickhoefer, VA; Yeung, D; Wakeham, A; Itie, A; Siderovski, DP; Lansdorp, PM; Robinson, MO; Harrington, L
      Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo

      MOLECULAR AND CELLULAR BIOLOGY
    54. Niu, HW; Xia, JQ; Lue, NF
      Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex

      MOLECULAR AND CELLULAR BIOLOGY
    55. Xia, JQ; Peng, Y; Mian, IS; Lue, NF
      Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase

      MOLECULAR AND CELLULAR BIOLOGY
    56. Mano, Y; Shimizu, T; Tanuma, S; Takeda, K
      Synergistic down-regulation of telomerase activity and hTERT mRNA expression by combination of retinoic acid and GM-CSF in human myeloblastic leukemia ML-1 cells

      ANTICANCER RESEARCH
    57. Kiyozuka, Y; Yamamoto, D; Yang, JH; Uemura, Y; Senzaki, H; Adachi, S; Tsubura, A
      Correlation of chemosensitivity to anticancer drugs and telomere length, telomerase activity and telomerase RNA expression in human ovarian cancer cells

      ANTICANCER RESEARCH
    58. Kyo, S; Takakura, M; Inoue, M
      Telomerase activity in cancer as a diagnostic and therapeutic target

      HISTOLOGY AND HISTOPATHOLOGY
    59. Kiyozuka, Y; Asai, A; Yamamoto, D; Senzaki, H; Yoshioka, S; Takahashi, H; Hioki, K; Tsubura, A
      Establishment of novel human esophageal cancer cell line in relation to telomere dynamics and telomerase activity

      DIGESTIVE DISEASES AND SCIENCES
    60. Autexier, C
      Tetrahymena telomerase activity, purification, and reconstitution

      METHODS IN CELL BIOLOGY, VOL 62
    61. Urquidi, V; Tarin, D; Goodison, S
      Role of telomerase in cell senescence and oncogenesis

      ANNUAL REVIEW OF MEDICINE
    62. Evans, SK; Lundblad, V
      Positive and negative regulation of telomerase access to the telomere

      JOURNAL OF CELL SCIENCE
    63. Ulaner, GA; Hu, JF; Vu, TH; Oruganti, H; Giudice, LC; Hoffman, AR
      Regulation of telomerase by alternate splicing of human telomerase reversetranscriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium

      INTERNATIONAL JOURNAL OF CANCER
    64. Schrader, M; Muller, M; Heicappell, R; Krause, H; Schulze, W; Miller, K
      Telomerase activity and expression of telomerase subunits in the testicular tissue of infertile patients

      FERTILITY AND STERILITY
    65. Yajima, T; Yagihashi, A; Kameshima, H; Furuya, D; Kobayashi, D; Hirata, K; Watanabe, N
      Establishment of quantitative reverse transcription-polymerase chain reaction assays for human telomerase-associated genes

      CLINICA CHIMICA ACTA
    66. Gunes, C; Lichtsteiner, S; Vasserot, AP; Englert, C
      Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1

      CANCER RESEARCH
    67. Wang, Z; Kyo, S; Takakura, M; Tanaka, M; Yatabe, N; Maida, Y; Fujiwara, M; Hayakawa, J; Ohmichi, M; Koike, K; Inoue, M
      Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway

      CANCER RESEARCH
    68. Mukai, S; Kondo, Y; Koga, S; Komata, T; Barna, BP; Kondo, S
      2-5A antisense telomerase RNA therapy for intracranial malignant gliomas'

      CANCER RESEARCH
    69. Toshikuni, N; Nouso, K; Higashi, T; Nakatsukasa, H; Onishi, T; Kaneyoshi, T; Kobayashi, Y; Kariyama, K; Yamamoto, K; Tsuji, T
      Expression of telomerase-associated protein 1 and telomerase reverse transcriptase in hepatocellular carcinoma

      BRITISH JOURNAL OF CANCER
    70. Sato, N; Mizumoto, K; Kusumoto, M; Nishio, S; Maehara, N; Urashima, T; Ogawa, T; Tanaka, M
      Up-regulation of telomerase activity in human pancreatic cancer cells after exposure to etoposide

      BRITISH JOURNAL OF CANCER
    71. Yoo, J; Robinson, RA
      Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas

      ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
    72. Helder, MN; de Jong, S; de Vries, EGE; van der Zee, AGJ
      Telomerase targeting in cancer treatment: new developments

      DRUG RESISTANCE UPDATES
    73. Saji, M; Xydas, S; Westra, WH; Liang, CK; Clark, DP; Udelsman, R; Umbricht, CB; Sukumar, S; Zeiger, MA
      Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms

      CLINICAL CANCER RESEARCH
    74. Sugihara, M; Ohshima, K; Nakamura, H; Suzumiya, J; Nakayama, Y; Kanda, M; Haraoka, S; Kikuchi, M
      Decreased expression of telomerase-associated RNAs in the proliferation ofstem cells in comparison with continuous expression in malignant tumors

      INTERNATIONAL JOURNAL OF ONCOLOGY
    75. Cong, YS; Wen, JP; Bacchetti, S
      The human telomerase catalytic subunit hTERT: organization of the gene andcharacterization of the promoter

      HUMAN MOLECULAR GENETICS
    76. Akiyama, M; Horiguchi-Yamada, J; Saito, S; Hoshi, Y; Yamada, O; Mizoguchi, H; Yamada, H
      Cytostatic concentrations of anticancer agents do not affect telomerase activity of leukaemic cells in vitro

      EUROPEAN JOURNAL OF CANCER
    77. Tahara, H; Yasui, W; Tahara, E; Fujimoto, J; Ito, K; Tamai, K; Nakayama, J; Ishikawa, F; Tahara, E; Ide, T
      Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections

      ONCOGENE
    78. Li, H; Cao, Y; Berndt, MC; Funder, JW; Liu, JP
      Molecular interactions between telomerase and the tumor suppressor proteinp53 in vitro

      ONCOGENE
    79. Tanaka, H; Horikawa, I; Kugoh, H; Shimizu, M; Barrett, JC; Oshimura, M
      Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer

      MOLECULAR CARCINOGENESIS
    80. Licht, JD; Collins, K
      Telomerase RNA function in recombinant Tetrahymena telomerase

      GENES & DEVELOPMENT
    81. Zhang, XL; Mar, V; Zhou, W; Harrington, L; Robinson, MO
      Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

      GENES & DEVELOPMENT
    82. Fujita, M; Tomita, S; Fukui, H; Ueda, Y; Fujimori, T
      Semi-quantitative procedure for telomeric repeat amplification protocol (TRAP) assay in colorectal carcinomas

      JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
    83. Wick, M; Zubov, D; Hagen, G
      Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)

      GENE
    84. Lue, NF
      Sequence-specific and conformation-dependent binding of yeast telomerase RNA to single-stranded telomeric DNA

      NUCLEIC ACIDS RESEARCH
    85. Autexier, C; Triki, I
      Tetrahymena telomerase ribonucleoprotein RNA-protein interactions

      NUCLEIC ACIDS RESEARCH
    86. Akiyama, M; Iwase, S; Horiguchi-Yamada, J; Saito, S; Furukawa, Y; Yamada, O; Mizoguchi, H; Ohno, T; Yamada, H
      Interferon-alpha repressed telomerase along with G1-accumulation of Daudi cells

      CANCER LETTERS
    87. Ye, AJ; Haynes, WJ; Romero, DP
      Expression of mutated Paramecium telomerase RNAs in vivo leads to templating errors that resemble those made by retroviral reverse transcriptase

      MOLECULAR AND CELLULAR BIOLOGY
    88. Mitchell, JR; Cheng, J; Collins, K
      A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3 ' end

      MOLECULAR AND CELLULAR BIOLOGY
    89. Herrera, E; Samper, E; Blasco, MA
      Telomere shortening in mTR(-/-) embryos is associated with failure to close the neural tube

      EMBO JOURNAL
    90. Herrera, E; Samper, E; Martin-Caballero, J; Flores, JM; Lee, HW; Blasco, MA
      Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

      EMBO JOURNAL
    91. Nguyen, DC; Crowe, DL
      Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity

      BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
    92. Cowell, JK
      Telomeres and telomerase in ageing and cancer

      AGE
    93. Collins, K
      Ciliate telomerase biochemistry

      ANNUAL REVIEW OF BIOCHEMISTRY
    94. Gilley, D; Blackburn, EH
      The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    95. Kiaris, H; Schally, AV
      Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    96. Suzuki, T; Suzuki, Y; Fujioka, T
      Expression of the catalytic subunit associated with telomerase gene in human urinary bladder cancer

      JOURNAL OF UROLOGY
    97. Kickhoefer, VA; Siva, AC; Kedersha, NL; Inman, EM; Ruland, C; Streuli, M; Rome, LH
      The 193-kD vault protein, VPARP, is a novel Poly(ADP-ribose) polymerase

      JOURNAL OF CELL BIOLOGY
    98. Hande, MP; Samper, E; Lansdorp, P; Blasco, MA
      Telomere length dynamics and chromosomal instability in cells derived fromtelomerase null mice

      JOURNAL OF CELL BIOLOGY
    99. Kickhoefer, VA; Stephen, AG; Harrington, L; Robinson, MO; Rome, LH
      Vaults and telomerase share a common subunit, TEP1

      JOURNAL OF BIOLOGICAL CHEMISTRY
    100. SUMIDA T; HAMAKAWA H; SOGAWA K; SUGITA A; TANIOKA H; UEDA N
      TELOMERASE COMPONENTS AS A DIAGNOSTIC-TOOL IN HUMAN ORAL LESIONS

      International journal of cancer


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Documento generato il 28/02/20 alle ore 22:56:29