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La ricerca find articoli where soggetti phrase all words 'LEXITROPSINS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 71 riferimenti
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    1. Bugreev, DV; Vasyutina, EL; Ryabinin, VA; Sinyakov, AN; Buneva, VN; Nevinsky, GA
      Inhibition of human DNA topoisomerase I by new DNA minor groove ligands: Derivatives of oligo-1,3-thiazolecarboxamides

      ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
    2. Sharma, SK; Morrissey, AT; Miller, GG; Gmeiner, WH; Lown, JW
      Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    3. Reddy, BSP; Sharma, SK; Lown, JW
      Recent developments in sequence selective minor groove DNA effectors

      CURRENT MEDICINAL CHEMISTRY
    4. Goodsell, DS
      Sequence recognition of DNA by lexitropsins

      CURRENT MEDICINAL CHEMISTRY
    5. Thomas, M; Rao, AR; Varshney, U; Bhattacharya, S
      Unusual DNA binding exhibited by synthetic distamycin analogues lacking the N-terminal amide unit under high salt conditions

      JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
    6. Sharma, SK; Reddy, BSN; Lown, JW
      Approaches to develop DNA sequence-specific agents

      DRUGS OF THE FUTURE
    7. Sinyakov, AN; Ryabinin, VA; Grimm, GN; Boutorine, AS
      Stabilization of DNA triple helices using conjugates of oligonucleotides and synthetic ligands

      MOLECULAR BIOLOGY
    8. Sharma, SK; Tandon, M; Lown, JW
      A general solution- and solid-phase synthetic procedure for incorporating three contiguous imidazole moieties into DNA sequence reading polyamides

      JOURNAL OF ORGANIC CHEMISTRY
    9. Satz, AL; Bruice, TC
      Recognition of nine base pairs in the minor groove of DNA by a tripyrrole peptide-Hoechst conjugate

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    10. Sharma, SK; Tandon, M; Lown, JW
      Synthesis of geometrically constrained unsymmetrical bis(polyamides) related to the antiviral distamycin

      EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
    11. Baraldi, PG; Spalluto, G; Cacciari, B; Romagnoli, R
      DNA minor groove alkylating agents structurally related to distamycin A

      EXPERT OPINION ON THERAPEUTIC PATENTS
    12. Sapse, AM; Rothchild, R; Lown, JW
      Semi-empirical, ab initio and molecular modeling studies on the DNA binding of a calicheamicinone-polyamide conjugate

      JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
    13. Reddy, BSP; Damayanthi, Y; Reddy, BSN; Lown, JW
      Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-polyamide conjugates and 2,2 '-PBD dimers

      ANTI-CANCER DRUG DESIGN
    14. Ryabinin, VA; Sinyakov, AN; de Soultrait, VR; Caumont, A; Parissi, V; Zakharova, OD; Vasyutina, EL; Yurchenko, E; Bayandin, R; Litvak, S; Tarrago-Litvak, L; Nevinsky, GA
      Inhibition of HIV-1 integrase-catalysed reaction by new DNA minor groove ligands: the oligo-1,3-thiazolecarboxamide derivatives

      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    15. Khalaf, AI; Pitt, AR; Scobie, M; Suckling, CJ; Urwin, J; Waigh, RD; Fishleigh, RV; Young, SC; Wylie, WA
      The synthesis of some head to head linked DNA minor groove binders

      TETRAHEDRON
    16. Vasyutina, EL; Bugreev, DV; Ryabinin, VA; Sinyakov, AN; Buneva, VN; Nevinskii, GA
      Interaction of the human topoisomerase I-DNA complex with oligo-1,3-thiazolecarboxamides and their oligonucleotide conjugates

      MOLECULAR BIOLOGY
    17. Sharma, SK; Tandon, M; Lown, JW
      Design and synthesis of novel thiazole-containing cross-linked polyamides related to the antiviral antibiotic distamycin

      JOURNAL OF ORGANIC CHEMISTRY
    18. Bartulewicz, D; Markowska, A; Wolczynski, S; Dabrowska, M; Rozanski, A
      Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin - new carriers of alkylating elements

      ACTA BIOCHIMICA POLONICA
    19. Dai, WM; Chow, CW; Zhou, L; Ishii, A; Lau, CW; Li, Q; Hamaguchi, W; Nishimoto, S
      Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    20. Herman, DM; Baird, EE; Dervan, PB
      Tandem hairpin motif for recognition in the minor groove of DNA by pyrrole- Imidazole polyamides

      CHEMISTRY-A EUROPEAN JOURNAL
    21. Reddy, BSP; Damayanthi, Y; Lown, JW
      Design and efficient synthesis of novel DNA interstrand cross-linking agents: C2-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

      SYNLETT
    22. Gmeiner, WH; Cui, W; Konerding, DE; Keifer, PA; Sharma, SK; Soto, AM; Marky, LA; Lown, JW
      Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins

      JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
    23. Soderlind, KJ; Gorodetsky, B; Singh, AK; Bachur, NR; Miller, GG; Lown, JW
      Bis-benzimidazole anticancer agents: targeting human tumour helicases

      ANTI-CANCER DRUG DESIGN
    24. Reddy, BSP; Sondhi, SM; Lown, JW
      Synthetic DNA minor groove-binding drugs

      PHARMACOLOGY & THERAPEUTICS
    25. Damayanthi, Y; Reddy, BSP; Lown, JW
      Design and synthesis of novel pyrrolo[2,1-c][1,4]benzodiazepine-lexitropsin conjugates

      JOURNAL OF ORGANIC CHEMISTRY
    26. Yang, XL; Kaenzig, C; Lee, M; Wang, AHJ
      Binding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    27. de Clairac, RPL; Seel, CJ; Geierstanger, BH; Mrksich, M; Baird, EE; Dervan, PB; Wemmer, DE
      NMR characterization of the aliphatic beta/beta pairing for recognition ofa A center dot T/T center dot A base pairs in the minor groove of DNA

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    28. WALKER WL; GOODSELL DS; LANDAW EM
      AN ANALYSIS OF A CLASS OF DNA-SEQUENCE READING MOLECULES

      Journal of computational biology
    29. BAILLY C; CHAIRES JB
      SEQUENCE-SPECIFIC DNA MINOR-GROOVE BINDERS - DESIGN AND SYNTHESIS OF NETROPSIN AND DISTAMYCIN ANALOGS

      Bioconjugate chemistry
    30. DAI WM; LI Q; FONG KC; CHOW CW; ZHOU L; HAMAGUCHI W; NISHIMOTO S
      REMARKABLE TETHERING EFFECT ON DNA CLEAVAGE OF PROPARGYLIC SULFONE CONJUGATES WITH INTERCALATING MOIETIES

      Bioorganic & medicinal chemistry letters
    31. GREENBERG WA; BAIRD EE; DERVAN BP
      A COMPARISON OF H-PIN AND HAIRPIN POLYAMIDE MOTIFS FOR THE RECOGNITION OF THE MINOR-GROOVE OF DNA

      Chemistry
    32. Kaenzig, C; Hubbard, R; Zhang, MZ; Harris, CM; Harris, TM; Lee, M
      Synthesis of a deoxyguanosine-2-amino adduct of a triimidazole-containing tallimustine analog

      HETEROCYCLIC COMMUNICATIONS
    33. SAPSE AM; LOWN JW
      THEORETICAL-STUDIES EMPLOYING AN AB-INITIO AND MOLECULAR MODELING COMBINATION METHOD ON THE DNA-BINDING OF BIS-BENZIMIDAZOLES DESIGNED FOR BIOREDUCTIVE ACTIVATION

      Journal of biomolecular structure & dynamics
    34. HERFELD P; HELISSEY P; NAFZIGER J; GIORGIRENAULT S
      SYNTHESIS, DNA-BINDING PROPERTIES AND CYTOTOXIC ACTIVITY OF FLAVIN-OLIGOPYRROLECARBOXAMIDE AND FLAVIN-OLIGOIMIDAZOLECARBOXAMIDE CONJUGATES

      Anti-cancer drug design
    35. DAI WM; LEE MYH
      GENERAL STEREOSELECTIVE SYNTHESIS OF (E)-EXO-ALKYLIDENE TETRAHYDROFURANS VIA BASE-MEDIATED CYCLIZATION OF HYDROXYL PROPARGYLIC SULFONES

      Tetrahedron
    36. PINDUR U; LEMSTER T
      ANTITUMOR DRUG DESIGN - DNA-BINDING LIGANDS, WHICH INHIBIT THE TOPOISOMERASE-I

      Die Pharmazie
    37. WALKER WL; LANDAW EM; DICKERSON RE; GOODSELL DS
      THE THEORETICAL LIMITS OF DNA-SEQUENCE DISCRIMINATION BY LINKED POLYAMIDES

      Proceedings of the National Academy of Sciences of the United Statesof America
    38. BARTULEWICZ D; BIELAWSKI K; MARKOWSKA A; ZWIERZ K; PUCKOWSKA A; ROZANSKI A
      SYNTHETIC ANALOGS OF NETROPSIN AND DISTAMYCIN - SYNTHESIS OF A NEW PYRIDINE AND CARBOCYCLIC ANALOGS OF THE PYRROLECARBOXAMIDE ANTITUMOR ANTIBIOTICS

      Acta Biochimica Polonica
    39. KITTLER L; MATESOI D; BELL A; BAGULEY BC; UNGER E; LOBER G
      SEQUENCE-SPECIFIC INTERACTIONS OF MINOR-GROOVE BINDERS WITH THE 154 BASE-PAIR HINDIII-RSAI RESTRICTION FRAGMENT OF CDNA OF THE HUMAN TAU-40PROTEIN INVOLVED IN PATHOLOGY OF ALZHEIMERS-DISEASE

      Biochemistry and molecular biology international
    40. KOPKA ML; GOODSELL DS; HAN GW; CHIU TK; LOWN JW; DICKERSON RE
      DEFINING GC-SPECIFICITY IN THE MINOR-GROOVE - SIDE-BY-SIDE BINDING OFTHE DI-IMIDAZOLE LEXITROPSIN TO C-A-T-G-G-C-C-A-T-G

      Structure
    41. WALKER WL; KOPKA ML; DICKERSON RE; GOODSELL DS
      DESIGN OF STAPLED DNA-MINOR-GROOVE-BINDING MOLECULES WITH A MUTABLE ATOM SIMULATED ANNEALING METHOD

      Journal of computer-aided molecular design
    42. SAPSE AM; JAIN DC; LOWN JW
      THEORETICAL-STUDIES USING AN AB-INITIO AND MOLECULAR MODELING COMBINATION METHOD ON THE BINDING OF SEQUENCE RECOGNITION ALTERED BIS-BENZIMIDAZOLES TO THE MINOR-GROOVE OF DNA

      Journal of biomolecular structure & dynamics
    43. SINYAKOV AN; RYABININ VA; SEREGIN SV; LOKHOV SG; KUTYAVIN IV; GAMPER HB; MAYER RB
      SELECTIVE STABILIZATION OF AT-RICH DNA-DNA DUPLEXES BY OLIGODEOXYRIBONUCLEOTIDE CONJUGATES WITH DISTAMYCIN ANALOGS

      Bioorganiceskaa himia
    44. TIMOFEEVA OA; RYABININ VA; SINYAKOV AN; ZAKHAROVA OD; YAMKOVOI VI; TARRAGOLITVAK L; LITVAK S; NEVINSKII GA
      INHIBITION OF HIV REVERSE TRANSCRIPTASE-CATALYZED POLYMERIZATION OF MODEL SUBSTRATES BY OLIGO-1,3-THIAZOLECARBOXAMIDE DERIVATIVES

      Molecular biology
    45. WALKER WL; KOPKA ML; GOODSELL DS
      PROGRESS IN THE DESIGN OF DNA SEQUENCE-SPECIFIC LEXITROPSINS

      Biopolymers
    46. GUAN LL; ZHAO RL; LOWN JW
      ENHANCED DNA ALKYLATION ACTIVITIES OF HOECHST-33258 ANALOGS DESIGNED FOR BIOREDUCTIVE ACTIVATION

      Biochemical and biophysical research communications
    47. DECLAIRAC RPL; GEIERSTANGER BH; MRKSICH M; DERVAN PB; WEMMER DE
      NMR CHARACTERIZATION OF HAIRPIN POLYAMIDE COMPLEXES WITH THE MINOR-GROOVE OF DNA

      Journal of the American Chemical Society
    48. SINGH MP; WYLIE WA; LOWN JW
      STRUCTURAL CHARACTERIZATION OF SIDE-BY-SIDE BINDING FOR A CROSS-LINKED LEXITROPSIN DIMER DESIGNED TO TARGET G-CENTER-DOT-C BASE-PAIRS IN THE DNA MINOR-GROOVE

      Magnetic resonance in chemistry
    49. CHANG DK; CHENG SF
      ON THE IMPORTANCE OF VAN-DER-WAALS INTERACTION IN THE GROOVE BINDING OF DNA WITH LIGANDS - RESTRAINED MOLECULAR-DYNAMICS STUDY

      International journal of biological macromolecules
    50. YAMAMOTO Y; KIMACHI T; KANAOKA Y; KATO S; BESSHO K; MATSUMOTO T; KUSAKABE T; SUGIURA Y
      SYNTHESIS AND DNA-BINDING PROPERTIES OF AMIDE BOND-MODIFIED ANALOGS RELATED TO DISTAMYCIN

      Tetrahedron letters
    51. SINGH MP; FREGEAU NL; PON RT; LOWN JW
      HIGH-RESOLUTION 2D-NMR STUDIES INCLUDING COMPLETE ASSIGNMENTS AND CONFORMATIONAL CHARACTERISTICS OF THE NF-KAPPA-B BINDING ENHANCER ELEMENTOF HIV-LTR

      Journal of biomolecular structure & dynamics
    52. SAPSE AM; SAPSE D; JAIN DC; LOWN JW
      QUANTUM-CHEMICAL STUDIES EMPLOYING AN AB-INITIO COMBINATION APPROACH ON THE BINDING OF THE BIS-BENZIMIDAZOLE HOECHST-33258 TO THE MINOR-GROOVE OF DNA

      Journal of biomolecular structure & dynamics
    53. SPIELMANN HP; FAGAN PA; BREGANT TM; LITTLE RD; WEMMER DE
      THE BINDING MODES OF A RATIONALLY DESIGNED PHOTOACTIVATED DNA NUCLEASE DETERMINED BY NMR

      Nucleic acids research
    54. XIE GJ; GUPTA R; LOWN JW
      DESIGN, SYNTHESIS, DNA-SEQUENCE PREFERENTIAL ALKYLATION AND BIOLOGICAL EVALUATION OF N-MUSTARD DERIVATIVES OF DISTAMYCIN AND NETROPSIN ANALOGS

      Anti-cancer drug design
    55. GUPTA R; WANG HY; HUANG LR; LOWN JW
      DESIGN, SYNTHESIS, DNA-SEQUENCE PREFERENTIAL ALKYLATION AND BIOLOGICAL EVALUATION OF N-MUSTARD DERIVATIVES OF HOECHST-33258 ANALOGS

      Anti-cancer drug design
    56. SALMANOVA DV; NIKITIN AM; ZHUZE AL; GURSKII GV; ZASEDATELEV AS
      INTERACTION OF DNA WITH SYNTHETIC LIGANDS CONTAINING N,4-DISUBSTITUTED MONOPHTHALIMIDES AND DIPHTHALIMIDES

      Molecular biology
    57. FORROW SM; LEE M; SOUHAMI RL; HARTLEY JA
      THE EFFECT OF AT AND GC SEQUENCE-SPECIFIC MINOR GROOVE-BINDING AGENTSON RESTRICTION-ENDONUCLEASE ACTIVITY

      Chemico-biological interactions
    58. CHANG DK; CHENG SF; CHIEN TL
      MOLECULAR MECHANICS CALCULATIONS ON THE COMPLEXES BETWEEN ANALOGS OF HOECHST-33258 AND D(CGCGAATTCGCG)(2) - INFLUENCE OF BULKY GROUP SUBSTITUTION ON BASE-PAIR PREFERENCE OF DNA MINOR-GROOVE BINDERS

      Canadian journal of chemistry
    59. WYATT MD; LEE M; GARBIRAS BJ; SOUHAMI RL; HARTLEY JA
      SEQUENCE SPECIFICITY OF ALKYLATION FOR A SERIES OF NITROGEN MUSTARD-CONTAINING ANALOGS OF DISTAMYCIN OF INCREASING BINDING-SITE SIZE - EVIDENCE FOR INCREASED CYTOTOXICITY WITH ENHANCED SEQUENCE SPECIFICITY

      Biochemistry
    60. WYATT MD; GARBIRAS BJ; LEE M; FORROW SM; HARTLEY JA
      SYNTHESIS AND DNA-BINDING PROPERTIES OF A SERIES OF N TO C LINKED ANDIMIDAZOLE-CONTAINING ANALOGS OF DISTAMYCIN

      Bioorganic & medicinal chemistry letters
    61. FERIOTTO G; CIUCCI A; MISCHIATI C; ANIMATI F; LOMBARDI P; GIACOMINI P; ARCAMONE F; GAMBARI R
      BINDING OF EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-1 TO DNA - INHIBITION BY DISTAMYCIN AND 2 NOVEL DISTAMYCIN ANALOGS

      European journal of pharmacology. Molecular pharmacology section
    62. LU D; GREHN L; DECLERCQ E; ANDREI G; SNOECK R; BALZARINI J; FRANSSON B; RAGNARSSON U
      SYNTHESIS AND ANTIVIRAL ACTIVITY OF 3 PYRAZOLE ANALOGS OF DISTAMYCIN-A

      Acta chemica Scandinavica
    63. LEE M; WALKER C; COOPER M; FORROW SM; HARTLEY JA
      SEQUENCE SELECTIVE MOLECULAR RECOGNITION OF LONG DNA-SEQUENCES BY OLIGOMETHYLENE-LINKED OLIGOIMIDAZOLE ANALOGS OF DISTAMYCIN

      Journal of bioactive and compatible polymers
    64. WYATT MD; GARBIRAS BJ; HASKELL MK; LEE M; SOUHAMI RL; HARTLEY JA
      STRUCTURE-ACTIVITY RELATIONSHIP OF A SERIES OF NITROGEN MUSTARD-CONTAINING AND PYRROLE-CONTAINING MINOR GROOVE-BINDING AGENTS RELATED TO DISTAMYCIN

      Anti-cancer drug design
    65. HARTLEY JA; MCADAM SR; DAS S; ROLDAN MC; HASKELL MK; LEE M
      MOLECULAR AND CELLULAR PHARMACOLOGY OF NOVEL PHOTOACTIVE PSORALEN ANDCOUMARIN CONJUGATES OF PYRROLE-CONTAINING AND IMIDAZOLE-CONTAINING ANALOGS OF NETROPSIN

      Anti-cancer drug design
    66. LEE M; PRETI CS; VINSON E; WYATT MD; HARTLEY JA
      GC SEQUENCE-SPECIFIC RECOGNITION BY AN N-FORMAMIDO, C-TERMINUS-MODIFIED AND IMIDAZOLE-CONTAINING ANALOG OF NETROPSIN

      Journal of medicinal chemistry
    67. GUO DQ; GUPTA R; LOWN JW
      DNA SEQUENCE-SELECTIVE BINDING OF HEAD-TO-TAIL LINKED BIS-LEXITROPSINS - RELATION OF PHASING TO CYTOTOXIC POTENCY

      Anti-cancer drug design
    68. LEE M; RHODES AL; WYATT MD; FORROW S; HARTLEY JA
      DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF DNA-SEQUENCE AND MINOR-GROOVE SELECTIVE ALKYLATING-AGENTS

      Anti-cancer drug design
    69. STORL K; BURCKHARDT G; LOWN JW; ZIMMER C
      STUDIES ON THE ABILITY OF MINOR-GROOVE BINDERS TO INDUCE SUPERCOILINGIN DNA

      FEBS letters
    70. LEE M; RHODES AL; WYATT MD; FORROW S; HARTLEY JA
      GC-BASE SEQUENCE RECOGNITION BY OLIGO(IMIDAZOLECARBOXAMIDE) AND C-TERMINUS-MODIFIED ANALOGS OF DISTAMYCIN DEDUCED FROM CIRCULAR-DICHROISM, PROTON NUCLEAR-MAGNETIC-RESONANCE, AND ETHIDIUMPROPYLETHYLENEDIAMINETETRAACETATE-IRON(II) FOOTPRINTING STUDIES

      Biochemistry
    71. GEIERSTANGER BH; DWYER TJ; BATHINI Y; LOWN JW; WEMMER DE
      NMR CHARACTERIZATION OF A HETEROCOMPLEX FORMED BY DISTAMYCIN AND ITS ANALOG 2-IMD WITH D(CGCAAGTTGGC)-D(GCCAACTTGCG) - PREFERENCE FOR THE 11/1 2-IMD-DST-DNA COMPLEX OVER THE 2/1 2-IMD-DNA AND THE 2/1 DST-DNA COMPLEXES/

      Journal of the American Chemical Society


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Documento generato il 15/08/20 alle ore 02:08:59