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Src inhibitors: genomics to therapeutics
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Inhibitors of p56(lck): assessing their potential as tools for manipulating T-lymphocyte activation
EXPERT OPINION ON THERAPEUTIC PATENTS
Differential regulation of T cell receptor-mediated Th1 cell IFN-gamma production and proliferation by divergent cAMP-mediated redox pathways
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
TGF-beta abrogates TCR-mediated signaling by upregulating tyrosine phosphatases in T cells
SHOCK
Herpesvirus saimiri Tip gene causes T-cell lymphomas in transgenic mice
DNA AND CELL BIOLOGY
Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation
SEMINARS IN IMMUNOLOGY
A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells
CURRENT BIOLOGY
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
NEUROREPORT
Notch signaling in lymphocyte development
CURRENT OPINION IN GENETICS & DEVELOPMENT
Altered functional and biochemical response by CD8(+) T cells that remain after tolerance
INTERNATIONAL IMMUNOLOGY
A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness
INTERNATIONAL IMMUNOLOGY
Progression of T cell lineage restriction in the earliest subpopulation ofmurine adult thymus visualized by the expression of lck proximal promoter activity
INTERNATIONAL IMMUNOLOGY
Sequence-specific H-1, C-13 and N-15 resonance assignments of lymphocyte specific kinase unique and SH3 domains
JOURNAL OF BIOMOLECULAR NMR
Dysregulation of p56(lck) kinase in patients with systemic lupus erythematosus
AUTOIMMUNITY
Regulation of ion channels by protein tyrosine phosphorylation
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Anergy and acquired immune deficiency syndrome
MEDICAL HYPOTHESES
ELF magnetic fields initiate protein tyrosine phosphorylation of the T cell receptor complex
BIOELECTROCHEMISTRY
A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor
EMBO JOURNAL
Signal transduction events in human peripheral blood mononuclear cells stimulated by Schistosoma mansoni antigens
HUMAN IMMUNOLOGY
Phosphorylation-induced activation of tilapia nonspecific cytotoxic cells by serum cytokines
DISEASES OF AQUATIC ORGANISMS
Comparison of spectrum-like representation of 3D chemical structure with other representations when used for modelling biological activity
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
Inhibition of phosphatidylserine synthesis in Jurkat T cells by hydrogen peroxide
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation
IMMUNOLOGY LETTERS
Signal transduction in thymus development
CELLULAR AND MOLECULAR BIOLOGY
Allelic exclusion and differentiation by protein kinase C-mediated signalsin immature thymocytes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Monomeric class I molecules mediate TCR/CD3 epsilon/CD8 interaction on thesurface of T cells
JOURNAL OF IMMUNOLOGY
A molecular framework for two-step T cell signaling: Lck Src homology 3 mutations discriminate distinctly regulated lipid raft reorganization events
JOURNAL OF IMMUNOLOGY
Sensory adaptation in naive peripheral CD4 T cells
JOURNAL OF EXPERIMENTAL MEDICINE
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
JOURNAL OF EXPERIMENTAL MEDICINE
Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk)
JOURNAL OF EXPERIMENTAL MEDICINE
Herpesvirus saimiri replaces ZAP-70 for CD3- and CD2-mediated T cell activation
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification of Lck-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with distant metastases
INTERNATIONAL JOURNAL OF CANCER
Glycolipid-enriched membrane domains are assembled into membrane patches by associating with the actin cytoskeleton
EXPERIMENTAL CELL RESEARCH
Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases
EUROPEAN JOURNAL OF IMMUNOLOGY
Recognition of the Lck tyrosine kinase as a tumor antigen by cytotoxic T lymphocytes of cancer patients with distant metastases
EUROPEAN JOURNAL OF IMMUNOLOGY
Organization of plasma membrane functional rafts upon T cell activation
EUROPEAN JOURNAL OF IMMUNOLOGY
Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation
EUROPEAN JOURNAL OF IMMUNOLOGY
Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm
EUROPEAN JOURNAL OF BIOCHEMISTRY
Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes
BLOOD
Association of MUC-1 and PSGL-1 with low-density microdomain in T-lymphocytes: A preliminary note
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Lck is involved in interleukin-2-induced proliferation, but not cell survival, in human T cells through a MAP kinase-independent pathway
EUROPEAN CYTOKINE NETWORK
The tyrosine kinase p56(lck) is essential in coxsackievirus B3-mediated heart disease
NATURE MEDICINE
Lck activity controls CD4/CD8 T cell lineage commitment
IMMUNITY
Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck)
MOLECULAR BIOLOGY OF THE CELL
The CD45 tyrosine phosphatase: a positive and negative regulator of immunecell function
SEMINARS IN IMMUNOLOGY
Tyrosine kinases open lymphocyte chloride channels
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
TCR V-beta usage and clonality of T cells isolated from progressing and rejected tumor sites before and after in vitro culture
INTERNATIONAL IMMUNOLOGY
Defective p56(Lck) activity in T cells from an adult patient with idiopathic CD4(+) lymphocytopenia
INTERNATIONAL IMMUNOLOGY
The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity
ONCOGENE
Active-oxygen involvement in canine NK-mediated cytotoxicity
JOURNAL OF VETERINARY MEDICAL SCIENCE
Activation of the interleukin 2 receptor: a possible role for tyrosine phosphatases
CELLULAR SIGNALLING
Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein
GENOMICS
Lactoferrin upregulates the expression of CD4 antigen through the stimulation of the mitogen-activated protein kinase in the human lymphoblastic T Jurkat cell line
JOURNAL OF CELLULAR BIOCHEMISTRY
Extracellular Nef of HIV-1 can target CD4 memory T population
AIDS
Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice
EMBO JOURNAL
Molecular and immunological approaches to mammalian fertilization
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
The extracellular domain of CD4 regulates the initiation of T cell activation
MOLECULAR IMMUNOLOGY
Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase
MOLECULAR IMMUNOLOGY
Restoration of thymic development in an Lck(-/-) thymoma overexpressing ZAP-70
MOLECULAR IMMUNOLOGY
Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions
VIROLOGY
Long-term survival but impaired homeostatic proliferation of naive T cellsin the absence of p56(lck)
SCIENCE
Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri
JOURNAL OF VIROLOGY
Primary structure of the Herpesvirus ateles genome
JOURNAL OF VIROLOGY
Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri
JOURNAL OF VIROLOGY
SH2-directed ligands of the Lck tyrosine kinase
JOURNAL OF MEDICINAL CHEMISTRY
Structure-based design of novel bicyclic nonpeptide inhibitors for the SrcSH2 domain
JOURNAL OF MEDICINAL CHEMISTRY
Serine 6 of Lck tyrosine kinase: A critical site for Lck myristoylation, membrane localization, and function in T lymphocytes
JOURNAL OF IMMUNOLOGY
Early onset of CD8 transgene expression inhibits the transition from DN3 to DP thymocytes
JOURNAL OF IMMUNOLOGY
Specific deficiency of p56(lck) expression in T lymphocytes from type 1 diabetic patients
JOURNAL OF IMMUNOLOGY
TCR/CD3-induced activation and binding of Emt/Itk to linker of activated Tcell complexes: Requirement for the Src homology 2 domain
JOURNAL OF IMMUNOLOGY
The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase
JOURNAL OF IMMUNOLOGY
Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions
JOURNAL OF EXPERIMENTAL MEDICINE
Src-like adaptor protein (SLAP) is a negative regulator of T cell receptorsignaling
JOURNAL OF EXPERIMENTAL MEDICINE
Phosphorylation of a Src kinase at the autophosphorylation site in the absence of Src kinase activity
JOURNAL OF BIOLOGICAL CHEMISTRY
Direct interaction of the CD38 cytoplasmic tail and the Lck SH2 domain - CD38 transduces T cell activation signals through associated Lck
JOURNAL OF BIOLOGICAL CHEMISTRY
Ultraviolet light-induced stimulation of the JNK mitogen-activated proteinkinase in the absence of Src family tyrosine kinase activation
JOURNAL OF BIOLOGICAL CHEMISTRY
Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip
JOURNAL OF BIOLOGICAL CHEMISTRY
Protein tyrosine kinase p56(lck) is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY
Chemometrical treatment of electronic structures of 28 flavonoid derivatives
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY
Assembly of the CD8 alpha/p56(lck) protein complex in stably expressing rat epithelial cells
FEBS LETTERS
Intra- and intermolecular interactions of the catalytic domains of human CD45 protein tyrosine phosphatase
FEBS LETTERS
Developmental regulation of TCR efficiency
EUROPEAN JOURNAL OF IMMUNOLOGY
Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects
EUROPEAN JOURNAL OF IMMUNOLOGY
Conversion of p56(lck) to p60(lck) in human peripheral blood T lymphocytesis dependent on co-stimulation through accessory receptors: involvement ofphospholipase C, protein kinase C and MAP-kinases in vivo
EUROPEAN JOURNAL OF IMMUNOLOGY
Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development
EUROPEAN JOURNAL OF IMMUNOLOGY
Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products
EUROPEAN JOURNAL OF BIOCHEMISTRY
Dietary zinc deficiency and expression of T lymphocyte signal transductionproteins
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo
BIOCHEMISTRY
Clinical significance of decreased zeta chain expression in peripheral blood lymphocytes of patients with head and neck cancer
CLINICAL CANCER RESEARCH
Biochemical association of CD45 with the T cell receptor complex: Regulation by CD45 isoform and during T cell activation
IMMUNITY
Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms
SEMINARS IN IMMUNOLOGY
Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s)
SEMINARS IN IMMUNOLOGY
Inhibitors of Src-family tyrosine kinases favour Th2 differentiation
CYTOKINE
Signal transduction via CD44: Role of plasma membrane microdomains
LEUKEMIA & LYMPHOMA
CD148, a new membrane tyrosine phosphatase involved in leukocyte function
LEUKEMIA & LYMPHOMA
Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias
LEUKEMIA & LYMPHOMA