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    1. Peeper, DS; Dannenberg, JH; Douma, S; Riele, HT; Bernards, R
      Escape from premature senescence is not sufficient for oncogenic transformation by Ras

      NATURE CELL BIOLOGY
    2. Elliott, MJ; Dong, YB; Yang, HL; McMasters, KM
      E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis colon cancer cells

      CLINICAL CANCER RESEARCH
    3. Labuhn, M; Jones, G; Speel, EJM; Maier, D; Zweifel, C; Gratzl, O; Van Meir, EG; Hegi, ME; Merlo, A
      Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas

      ONCOGENE
    4. Silva, J; Dominguez, G; Silva, JM; Garcia, JM; Gallego, I; Corbacho, C; Provencio, M; Espana, P; Bonilla, F
      Analysis of genetic and epigenetic processes that influence p14ARF expression in breast cancer

      ONCOGENE
    5. Obata, M; Imamura, E; Yoshida, Y; Goto, J; Kishibe, K; Yasuda, A; Ogawa, K
      Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53, and p21(Waf1/Cip1)

      MOLECULAR CARCINOGENESIS
    6. Wagner, M; Greten, FR; Weber, CK; Koschnick, S; Mattfeldt, T; Deppert, W; Kern, H; Adler, G; Schmid, RM
      A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

      GENES & DEVELOPMENT
    7. Inoue, K; Zindy, F; Randle, DH; Rehg, JE; Sherr, CJ
      Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas

      GENES & DEVELOPMENT
    8. Bardeesy, N; Bastian, BC; Hezel, A; Pinkel, D; DePinho, RA; Chin, L
      Dual inactivation of RB and p53 pathways in RAS-induced melanomas

      MOLECULAR AND CELLULAR BIOLOGY
    9. Zhang, SL; DuBois, W; Ramsay, ES; Bliskovski, V; Morse, HC; Taddesse-Heath, L; Vass, WC; DePinho, RA; Mock, BA
      Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility

      MOLECULAR AND CELLULAR BIOLOGY
    10. Holland, EC
      Animal models of cell cycle dysregulation and the pathogenesis of gliomas

      JOURNAL OF NEURO-ONCOLOGY
    11. Eklund, LK; Islam, K; Soderkvist, P; Islam, MQ
      Regional mapping of suppressor loci for anchorage independence and tumorigenicity on human chromosome 9

      CANCER GENETICS AND CYTOGENETICS
    12. Zafonte, BT; Amanatullah, DF; Sage, D; Augenlicht, LH; Pestell, RG
      Ras regulation of cyclin-dependent immunoprecipitation kinase assays

      REGULATORS AND EFFECTORS OF SMALL GTPASES, PT G
    13. Palmero, I; Serrano, M
      Induction of senescence by oncogenic Ras

      REGULATORS AND EFFECTORS OF SMALL GTPASES, PT G
    14. Krimpenfort, P; Quon, KC; Mooi, WJ; Loonstra, A; Berns, A
      Loss of p16(Ink4a) confers susceptibility to metastatic melanoma in mice

      NATURE
    15. Sharpless, NE; Bardeesy, N; Lee, KH; Carrasco, D; Castrillon, DH; Aguirre, AJ; Wu, EA; Horner, JW; DePinho, RA
      Loss of p16(Ink4a) with retention of p19(Arf) predisposes mice to tumorigenesis

      NATURE
    16. Lin, AW; Lowe, SW
      Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    17. Sotillo, R; Garcia, JF; Ortega, S; Martin, J; Dubus, P; Barbacid, M; Malumbres, M
      Invasive melanoma in Cdk4-targeted mice

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    18. Randle, DH; Zindy, F; Sherr, CJ; Roussel, MF
      Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    19. Alani, RM; Young, AZ; Shifflett, CB
      Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    20. Burri, N; Shaw, P; Bouzourene, H; Sordat, I; Sordat, B; Gillet, M; Schorderet, D; Bosman, FT; Chaubert, P
      Methylation silencing and mutations of the p14(ARF) and p16(INK4a) genes in colon cancer

      LABORATORY INVESTIGATION
    21. Xin, BZ; He, ZM; Yang, XH; Chan, CP; Ng, MH; Cao, L
      TRADD domain of Epstein-Barr virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts

      JOURNAL OF VIROLOGY
    22. Baxter, EW; Blyth, K; Cameron, ER; Neil, JC
      Selection for loss of p53 function in T-cell lymphomagenesis is alleviatedby Moloney murine leukemia virus infection in myc transgenic mice

      JOURNAL OF VIROLOGY
    23. Gruttgen, A; Reichenzeller, M; Junger, M; Schlien, S; Affolter, A; Bosch, FX
      Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majorityof head and neck cancers

      JOURNAL OF PATHOLOGY
    24. Bothner, B; Lewis, WS; DiGiammarino, EL; Weber, JD; Bothner, SJ; Kriwacki, RW
      Defining the molecular basis of Arf and Hdm2 interactions

      JOURNAL OF MOLECULAR BIOLOGY
    25. Sugihara, T; Kaul, SC; Kato, J; Reddel, RR; Nomura, H; Wadhwa, R
      Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway

      JOURNAL OF BIOLOGICAL CHEMISTRY
    26. Lubomierski, N; Kersting, M; Bert, T; Muench, K; Wulbrand, U; Schuermann, M; Bartsch, D; Simon, B
      Tumor suppressor genes in the 9p21 gene cluster are selective targets of inactivation in neuroendocrine gastroenteropancreatic tumors

      CANCER RESEARCH
    27. Nicholson, SA; Okby, NT; Khan, MA; Welsh, JA; McMenamin, MG; Travis, WD; Jett, JR; Tazelaar, HD; Trastek, V; Pairolero, PC; Corn, PG; Herman, JG; Liotta, LA; Caporaso, NE; Harris, CC
      Alterations of p14(ARF), p53, and p73 genes involved in the E2F-1-mediatedapoptotic pathways in non-small cell lung carcinoma

      CANCER RESEARCH
    28. DiGiammarino, EL; Filippov, I; Weber, JD; Bothner, B; Kriwacki, RW
      Solution structure of the p53 regulatory domain of the p19(Arf) tumor suppressor protein

      BIOCHEMISTRY
    29. Carnero, A; Hudson, JD; Price, CM; Beach, DH
      p16(INK4A) and p19(ARF) act in overlapping pathways in cellular immortalization

      NATURE CELL BIOLOGY
    30. Frank, KM; Sharpless, NE; Gao, YJ; Sekiguchi, JM; Ferguson, DO; Zhu, CM; Manis, JP; Horner, J; DePinho, RA; Alt, FW
      DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

      MOLECULAR CELL
    31. Artandi, SE; DePinho, RA
      Mice without telomerase: what can they teach us about human cancer?

      NATURE MEDICINE
    32. Jacobs, JJL; Keblusek, P; Robanus-Maandag, E; Kristel, P; Lingbeek, M; Nederlof, PM; van Welsem, T; van de Vijver, MJ; Koh, EY; Daley, GQ; van Lohuizen, M
      Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers

      NATURE GENETICS
    33. Helou, K; Lu, XC; Montelius-Alatalo, K; Stahl, F; Klinga-Levan, K; Levan, G; Rohme, D
      A dual-color FISH framework map for the characterization of the Sail tumorsuppression region on rat chromosome 5

      GENES CHROMOSOMES & CANCER
    34. Artandi, SE; DePinho, RA
      A critical role for telomeres in suppressing and facilitating carcinogenesis

      CURRENT OPINION IN GENETICS & DEVELOPMENT
    35. Sherr, CJ; Weber, JD
      The ARF/p53 pathway

      CURRENT OPINION IN GENETICS & DEVELOPMENT
    36. Rizos, H; Darmanian, AP; Mann, GJ; Kefford, RF
      Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization

      ONCOGENE
    37. Dannenberg, JH; van Rossum, A; Schuijff, L; Riele, HT
      Ablation of the Retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

      GENES & DEVELOPMENT
    38. Inoue, K; Wen, RR; Rehg, JE; Adachi, M; Cleveland, JL; Roussel, MF; Sherr, CJ
      Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis

      GENES & DEVELOPMENT
    39. Bringold, F; Serrano, M
      Tumor suppressors and oncogenes in cellular senescence

      EXPERIMENTAL GERONTOLOGY
    40. Fan, GC; Wu, CT
      Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance

      CANCER LETTERS
    41. Parkinson, EK; Munro, J; Steeghs, K; Morrison, V; Ireland, H; Forsyth, N; Fitzsimmons, S; Bryce, S
      Replicative senescence as a barrier to human cancer

      BIOCHEMICAL SOCIETY TRANSACTIONS
    42. Weber, JD; Kuo, ML; Bothner, B; DiGiammarino, EL; Kriwacki, RW; Roussel, MF; Sherr, CJ
      Cooperative signals governing ARF-Mdm2 interaction and nucleolar localization of the complex

      MOLECULAR AND CELLULAR BIOLOGY
    43. Dulic, V; Beney, GE; Frebourg, G; Drullinger, LF; Stein, GH
      Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts

      MOLECULAR AND CELLULAR BIOLOGY
    44. Franklin, DS; Godfrey, VI; O'Brien, DA; Deng, CX; Xiong, Y
      Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity

      MOLECULAR AND CELLULAR BIOLOGY
    45. Zindy, F; Van Deursen, J; Grosveld, G; Sherr, CJ; Roussel, MF
      INK4d-deficient mice are fertile despite testicular atrophy

      MOLECULAR AND CELLULAR BIOLOGY
    46. Wong, AK; Chin, L
      An inducible melanoma model implicates a role for RAS in tumor maintenanceand angiogenesis

      CANCER AND METASTASIS REVIEWS
    47. Laes, JF; Parada, LA; Johansson, B; Levan, G; Szpirer, C; Szpirer, T
      Alterations of P19ARF in rodent hepatoma cell lines but not in human primary liver cancer

      CANCER GENETICS AND CYTOGENETICS
    48. Serrano, M
      The INK4 alpha/ARF locus in murine tumorigenesis

      CARCINOGENESIS
    49. Zheng, SC; Chen, PC; McMillan, A; Lafuente, A; Lafuente, MJ; Ballesta, A; Trias, M; Wiencke, JK
      Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors

      CARCINOGENESIS
    50. Newcomb, EW; Alonso, M; Sung, T; Miller, DC
      Incidence of p14(ARF) gene deletion in high-grade adult and pediatric astrocytomas

      HUMAN PATHOLOGY
    51. Khan, SH; Moritsugu, J; Wahl, GM
      Differential requirement for p19ARF in the p53-dependent arrest induced byDNA damage, microtubule disruption, and ribonucleotide depletion

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    52. Classon, M; Salama, S; Gorka, C; Mulloy, R; Braun, P; Harlow, E
      Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    53. Yoshioka, N; Inoue, H; Nakanishi, K; Oka, K; Yutsudo, M; Yamashita, A; Hakura, A; Nojima, H
      Isolation of transformation suppressor genes by cDNA subtraction: Lumican suppresses transformation induced by v-src and v-K-ras

      JOURNAL OF VIROLOGY
    54. Saridaki, Z; Koumantaki, E; Liloglou, T; Sourvinos, G; Papadopoulos, O; Zoras, O; Spandidos, DA
      High frequency of loss of heterozygosity on chromosome region 9p21-p22 butlack of p16(INK4a)/p19(ARF) mutations in Greek patients with basal cell carcinoma of the skin

      JOURNAL OF INVESTIGATIVE DERMATOLOGY
    55. Collado, M; Medema, RH; Garcia-Cao, I; Dubuisson, MLN; Barradas, M; Glassford, J; Rivas, C; Burgering, BMT; Serrano, M; Lam, EWF
      Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27(Kip1)

      JOURNAL OF BIOLOGICAL CHEMISTRY
    56. Iida, S; Akiyama, Y; Nakajima, T; Ichikawa, W; Nihei, Z; Sugihara, KK; Yuasa, Y
      Alterations and hypermethylation of the p14(ARF) gene in gastric cancer

      INTERNATIONAL JOURNAL OF CANCER
    57. Ishizaki, K; Ogawa, K
      Fine mapping of smallest common regions of deletion on chromosome 12 in liver epithelial and hepatocellular carcinoma cell lines from B6C3F(1) and C3B6F(1) mice

      INTERNATIONAL JOURNAL OF CANCER
    58. Weber, JD; Taylor, LJ; Roussel, MF; Sherr, CJ; Bar-Sagi, D
      Nucleolar Arf sequesters Mdm2 and activates p53

      NATURE CELL BIOLOGY
    59. Xing, EP; Nie, Y; Song, YL; Yang, GY; Cai, YC; Wang, LD; Yang, CS
      Mechanisms of inactivation of p14(ARF), p15(INK4b), and p16(INK4a) genes in human esophageal squamous cell carcinoma

      CLINICAL CANCER RESEARCH
    60. Kuerbitz, SJ; Malandro, J; Compitello, N; Baylin, SB; Graff, JR
      Deletion of p16(INK4A)/CDKN2 and p15(INK4B) in human somatic cell hybrids and hybrid-derived tumors

      CELL GROWTH & DIFFERENTIATION
    61. Soufir, N; Moles, JP; Vilmer, C; Moch, C; Verola, O; Rivet, J; Tesniere, A; Dubertret, L; Basset-Seguin, N
      P16UV mutations in human skin epithelial tumors

      ONCOGENE
    62. Chin, L
      Modeling malignant melanoma in mice: pathogenesis and maintenance

      ONCOGENE
    63. Calabro, V; Parisi, T; Di Cristofano, A; La Mantia, G
      Suppression of Ras-mediated NIH3T3 transformation by p19(ARF) does not involve alterations of cell growth properties

      ONCOGENE
    64. Herzog, CR; Noh, S; Lantry, LE; Guan, KL; You, M
      Cdkn2a encodes functional variation of p16(INK4a) but not p19(ARF), which confers selection in mouse lung tumorigenesis

      MOLECULAR CARCINOGENESIS
    65. Schmitt, CA; McCurrach, ME; de Stanchina, E; Wallace-Brodeur, RR; Lowe, SW
      INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistanceby disabling p53

      GENES & DEVELOPMENT
    66. Herranz, M; Urioste, M; Santos, J; Rivas, C; Martinez, B; Benitez, J; Fernandez-Piqueras, J
      Analysis of the INK4a/ARF locus in non-Hodgkin's lymphomas using two new internal microsatellite markers

      LEUKEMIA
    67. Stein, GH; Drullinger, LF; Soulard, A; Dulic, V
      Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

      MOLECULAR AND CELLULAR BIOLOGY
    68. Greenberg, RA; Chin, L; Femino, A; Lee, KH; Gottlieb, GJ; Singer, RH; Greider, CW; DePinho, RA
      Short dysfunctional telomeres impair tumorigenesis in the INK4a(Delta 2/3)cancer-prone mouse

      CELL
    69. Zhang, SL; Mock, BA
      The role of p16(INK4a) (Cdkn2a) in mouse plasma cell tumors

      MECHANISMS OF B CELL NEOPLASIA 1998
    70. Kamijo, T; Bodner, S; van de Kamp, E; Randle, DH; Sherr, CJ
      Tumor spectrum in ARF-deficient mice

      CANCER RESEARCH
    71. Wei, S; Wei, WY; Sedivy, JM
      Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts

      CANCER RESEARCH
    72. Blanchard, JM
      Recent news on the molecular mechanisms of oncogenic transformation

      BULLETIN DU CANCER
    73. Sartor, M; Steingrimsdottir, H; Elamin, F; Gaken, J; Warnakulasuriya, S; Partridge, M; Thakker, N; Johnson, NW; Tavassoli, M
      Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines

      BRITISH JOURNAL OF CANCER
    74. Frame, S; Balmain, A
      Target genes and target cells in carcinogenesis

      BRITISH JOURNAL OF CANCER
    75. Maloney, KW; McGavran, L; Odom, LF; Hunger, SP
      Acquisition of p16(INK4A) and p15(INK4B) gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia

      BLOOD
    76. Simon, M; Koster, G; Menon, AG; Schramm, J
      Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas

      ACTA NEUROPATHOLOGICA
    77. KUMAR R; SAUROJA I; PUNNONEN K; JANSEN C; HEMMINKI K
      SELECTIVE DELETION OF EXON 1-BETA OF THE P19(ARF) GENE IN METASTATIC MELANOMA CELL-LINES

      Genes chromosomes & cancer (Print)
    78. Sherburn, TE; Gale, JM; Ley, RD
      Cloning and characterization of the CDKN2A and p19ARF genes from Monodelphis domestica

      DNA AND CELL BIOLOGY
    79. Adams, PD; Kaelin, WG
      Negative control elements of the cell cycle in human tumors

      CURRENT OPINION IN CELL BIOLOGY
    80. VONLANTHEN S; HEIGHWAY J; TSCHAN MP; BORNER MM; ALTERMATT HJ; KAPPELER A; TOBLER A; FEY MF; THATCHER N; YARBROUGH WG; BETTICHER D
      EXPRESSION OF P16INK4A P16-ALPHA AND P19ARF/P16-BETA IS FREQUENTLY ALTERED IN NONSMALL CELL LUNG-CANCER AND CORRELATES WITH P53 OVEREXPRESSION/

      Oncogene
    81. SHERR CJ
      TUMOR SURVEILLANCE VIA THE ARF-P53 PATHWAY

      Genes & development
    82. ZHU JY; WOODS D; MCMAHON M; BISHOP JM
      SENESCENCE OF HUMAN FIBROBLASTS INDUCED BY ONCOGENIC RAF

      Genes & development
    83. LIN AW; BARRADAS M; STONE JC; VANAELST L; SERRANO M; LOWE SW
      PREMATURE SENESCENCE INVOLVING P53 AND P16 IS ACTIVATED IN RESPONSE TO CONSTITUTIVE MEK MAPK MITOGENIC SIGNALING/

      Genes & development
    84. Holland, EC; Hively, WP; DePinho, RA; Varmus, HE
      A constitutively active epidermal growth factor receptor cooperates with disruption of G(1) cell-cycle arrest pathways to induce glioma-like lesions in mice

      GENES & DEVELOPMENT
    85. MALONEY KW; MCGAVRAN L; ODOM LF; HUNGER SP
      DIFFERENT PATTERNS OF HOMOZYGOUS P-16(INK4A) AND P15(INK4B) DELETIONSIN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIAS CONTAINING DISTINCT E2A TRANSLOCATIONS

      Leukemia
    86. Millard, SS; Koff, A
      Cyclin-dependent kinase inhibitors in restriction point control, genomic stability, and tumorigenesis

      JOURNAL OF CELLULAR BIOCHEMISTRY
    87. ROBERTSON KD; JONES PA
      THE HUMAN ARF CELL-CYCLE REGULATORY GENE PROMOTER IS A CPG ISLAND WHICH CAN BE SILENCED BY DNA METHYLATION AND DOWN-REGULATED BY WILD-TYPE P53

      Molecular and cellular biology (Print)
    88. Auer, KL; Park, JS; Seth, P; Coffey, RJ; Darlington, G; Abo, A; McMahon, M; DePinho, RA; Fisher, PB; Dent, P
      Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21(Cip-1/WAF1)-null mice, but not in hepatocytes from p16(INK4a)-null mice

      BIOCHEMICAL JOURNAL
    89. STOTT FJ; BATES S; JAMES MC; MCCONNELL BB; STARBORG M; BROOKES S; PALMERO I; RYAN K; HARA E; VOUSDEN KH; PETERS G
      THE ALTERNATIVE PRODUCT FROM THE HUMAN CDKN2A LOCUS, P14(ARF), PARTICIPATES IN A REGULATORY FEEDBACK LOOP WITH P53 AND MDM2

      EMBO journal (Print)
    90. RADFAR A; UNNIKRISHNAN I; LEE HW; DEPINHO RA; ROSENBERG N
      P19(ARF) INDUCES P53-DEPENDENT APOPTOSIS DURING ABELSON VIRUS-MEDIATED PRE-B-CELL TRANSFORMATION

      Proceedings of the National Academy of Sciences of the United Statesof America
    91. NYLANDSTED J; ROHDE M; BARTEK J; STRAUSS M
      EXPRESSION OF A P16(INK4A)-SPECIFIC RIBOZYME DOWN-MODULATES P16(INK4A) ABUNDANCE AND ACCELERATES CELL-PROLIFERATION

      FEBS letters


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Documento generato il 16/01/21 alle ore 10:57:16