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Escape from premature senescence is not sufficient for oncogenic transformation by Ras
NATURE CELL BIOLOGY
E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis colon cancer cells
CLINICAL CANCER RESEARCH
Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas
ONCOGENE
Analysis of genetic and epigenetic processes that influence p14ARF expression in breast cancer
ONCOGENE
Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53, and p21(Waf1/Cip1)
MOLECULAR CARCINOGENESIS
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
GENES & DEVELOPMENT
Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas
GENES & DEVELOPMENT
Dual inactivation of RB and p53 pathways in RAS-induced melanomas
MOLECULAR AND CELLULAR BIOLOGY
Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility
MOLECULAR AND CELLULAR BIOLOGY
Animal models of cell cycle dysregulation and the pathogenesis of gliomas
JOURNAL OF NEURO-ONCOLOGY
Regional mapping of suppressor loci for anchorage independence and tumorigenicity on human chromosome 9
CANCER GENETICS AND CYTOGENETICS
Ras regulation of cyclin-dependent immunoprecipitation kinase assays
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT G
Induction of senescence by oncogenic Ras
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT G
Loss of p16(Ink4a) confers susceptibility to metastatic melanoma in mice
NATURE
Loss of p16(Ink4a) with retention of p19(Arf) predisposes mice to tumorigenesis
NATURE
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Invasive melanoma in Cdk4-targeted mice
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Methylation silencing and mutations of the p14(ARF) and p16(INK4a) genes in colon cancer
LABORATORY INVESTIGATION
TRADD domain of Epstein-Barr virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts
JOURNAL OF VIROLOGY
Selection for loss of p53 function in T-cell lymphomagenesis is alleviatedby Moloney murine leukemia virus infection in myc transgenic mice
JOURNAL OF VIROLOGY
Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majorityof head and neck cancers
JOURNAL OF PATHOLOGY
Defining the molecular basis of Arf and Hdm2 interactions
JOURNAL OF MOLECULAR BIOLOGY
Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
Tumor suppressor genes in the 9p21 gene cluster are selective targets of inactivation in neuroendocrine gastroenteropancreatic tumors
CANCER RESEARCH
Alterations of p14(ARF), p53, and p73 genes involved in the E2F-1-mediatedapoptotic pathways in non-small cell lung carcinoma
CANCER RESEARCH
Solution structure of the p53 regulatory domain of the p19(Arf) tumor suppressor protein
BIOCHEMISTRY
p16(INK4A) and p19(ARF) act in overlapping pathways in cellular immortalization
NATURE CELL BIOLOGY
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
MOLECULAR CELL
Mice without telomerase: what can they teach us about human cancer?
NATURE MEDICINE
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers
NATURE GENETICS
A dual-color FISH framework map for the characterization of the Sail tumorsuppression region on rat chromosome 5
GENES CHROMOSOMES & CANCER
A critical role for telomeres in suppressing and facilitating carcinogenesis
CURRENT OPINION IN GENETICS & DEVELOPMENT
The ARF/p53 pathway
CURRENT OPINION IN GENETICS & DEVELOPMENT
Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
ONCOGENE
Ablation of the Retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
GENES & DEVELOPMENT
Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis
GENES & DEVELOPMENT
Tumor suppressors and oncogenes in cellular senescence
EXPERIMENTAL GERONTOLOGY
Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance
CANCER LETTERS
Replicative senescence as a barrier to human cancer
BIOCHEMICAL SOCIETY TRANSACTIONS
Cooperative signals governing ARF-Mdm2 interaction and nucleolar localization of the complex
MOLECULAR AND CELLULAR BIOLOGY
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
MOLECULAR AND CELLULAR BIOLOGY
Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity
MOLECULAR AND CELLULAR BIOLOGY
INK4d-deficient mice are fertile despite testicular atrophy
MOLECULAR AND CELLULAR BIOLOGY
An inducible melanoma model implicates a role for RAS in tumor maintenanceand angiogenesis
CANCER AND METASTASIS REVIEWS
Alterations of P19ARF in rodent hepatoma cell lines but not in human primary liver cancer
CANCER GENETICS AND CYTOGENETICS
The INK4 alpha/ARF locus in murine tumorigenesis
CARCINOGENESIS
Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors
CARCINOGENESIS
Incidence of p14(ARF) gene deletion in high-grade adult and pediatric astrocytomas
HUMAN PATHOLOGY
Differential requirement for p19ARF in the p53-dependent arrest induced byDNA damage, microtubule disruption, and ribonucleotide depletion
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Isolation of transformation suppressor genes by cDNA subtraction: Lumican suppresses transformation induced by v-src and v-K-ras
JOURNAL OF VIROLOGY
High frequency of loss of heterozygosity on chromosome region 9p21-p22 butlack of p16(INK4a)/p19(ARF) mutations in Greek patients with basal cell carcinoma of the skin
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27(Kip1)
JOURNAL OF BIOLOGICAL CHEMISTRY
Alterations and hypermethylation of the p14(ARF) gene in gastric cancer
INTERNATIONAL JOURNAL OF CANCER
Fine mapping of smallest common regions of deletion on chromosome 12 in liver epithelial and hepatocellular carcinoma cell lines from B6C3F(1) and C3B6F(1) mice
INTERNATIONAL JOURNAL OF CANCER
Nucleolar Arf sequesters Mdm2 and activates p53
NATURE CELL BIOLOGY
Mechanisms of inactivation of p14(ARF), p15(INK4b), and p16(INK4a) genes in human esophageal squamous cell carcinoma
CLINICAL CANCER RESEARCH
Deletion of p16(INK4A)/CDKN2 and p15(INK4B) in human somatic cell hybrids and hybrid-derived tumors
CELL GROWTH & DIFFERENTIATION
P16UV mutations in human skin epithelial tumors
ONCOGENE
Modeling malignant melanoma in mice: pathogenesis and maintenance
ONCOGENE
Suppression of Ras-mediated NIH3T3 transformation by p19(ARF) does not involve alterations of cell growth properties
ONCOGENE
Cdkn2a encodes functional variation of p16(INK4a) but not p19(ARF), which confers selection in mouse lung tumorigenesis
MOLECULAR CARCINOGENESIS
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistanceby disabling p53
GENES & DEVELOPMENT
Analysis of the INK4a/ARF locus in non-Hodgkin's lymphomas using two new internal microsatellite markers
LEUKEMIA
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
MOLECULAR AND CELLULAR BIOLOGY
Short dysfunctional telomeres impair tumorigenesis in the INK4a(Delta 2/3)cancer-prone mouse
CELL
The role of p16(INK4a) (Cdkn2a) in mouse plasma cell tumors
MECHANISMS OF B CELL NEOPLASIA 1998
Tumor spectrum in ARF-deficient mice
CANCER RESEARCH
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
CANCER RESEARCH
Recent news on the molecular mechanisms of oncogenic transformation
BULLETIN DU CANCER
Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines
BRITISH JOURNAL OF CANCER
Target genes and target cells in carcinogenesis
BRITISH JOURNAL OF CANCER
Acquisition of p16(INK4A) and p15(INK4B) gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia
BLOOD
Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas
ACTA NEUROPATHOLOGICA
SELECTIVE DELETION OF EXON 1-BETA OF THE P19(ARF) GENE IN METASTATIC MELANOMA CELL-LINES
Genes chromosomes & cancer (Print)
Cloning and characterization of the CDKN2A and p19ARF genes from Monodelphis domestica
DNA AND CELL BIOLOGY
Negative control elements of the cell cycle in human tumors
CURRENT OPINION IN CELL BIOLOGY
EXPRESSION OF P16INK4A P16-ALPHA AND P19ARF/P16-BETA IS FREQUENTLY ALTERED IN NONSMALL CELL LUNG-CANCER AND CORRELATES WITH P53 OVEREXPRESSION/
Oncogene
TUMOR SURVEILLANCE VIA THE ARF-P53 PATHWAY
Genes & development
SENESCENCE OF HUMAN FIBROBLASTS INDUCED BY ONCOGENIC RAF
Genes & development
PREMATURE SENESCENCE INVOLVING P53 AND P16 IS ACTIVATED IN RESPONSE TO CONSTITUTIVE MEK MAPK MITOGENIC SIGNALING/
Genes & development
A constitutively active epidermal growth factor receptor cooperates with disruption of G(1) cell-cycle arrest pathways to induce glioma-like lesions in mice
GENES & DEVELOPMENT
DIFFERENT PATTERNS OF HOMOZYGOUS P-16(INK4A) AND P15(INK4B) DELETIONSIN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIAS CONTAINING DISTINCT E2A TRANSLOCATIONS
Leukemia
Cyclin-dependent kinase inhibitors in restriction point control, genomic stability, and tumorigenesis
JOURNAL OF CELLULAR BIOCHEMISTRY
THE HUMAN ARF CELL-CYCLE REGULATORY GENE PROMOTER IS A CPG ISLAND WHICH CAN BE SILENCED BY DNA METHYLATION AND DOWN-REGULATED BY WILD-TYPE P53
Molecular and cellular biology (Print)
Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21(Cip-1/WAF1)-null mice, but not in hepatocytes from p16(INK4a)-null mice
BIOCHEMICAL JOURNAL
THE ALTERNATIVE PRODUCT FROM THE HUMAN CDKN2A LOCUS, P14(ARF), PARTICIPATES IN A REGULATORY FEEDBACK LOOP WITH P53 AND MDM2
EMBO journal (Print)
P19(ARF) INDUCES P53-DEPENDENT APOPTOSIS DURING ABELSON VIRUS-MEDIATED PRE-B-CELL TRANSFORMATION
Proceedings of the National Academy of Sciences of the United Statesof America
EXPRESSION OF A P16(INK4A)-SPECIFIC RIBOZYME DOWN-MODULATES P16(INK4A) ABUNDANCE AND ACCELERATES CELL-PROLIFERATION
FEBS letters