Catalogo Articoli (Spogli Riviste)

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La ricerca find articoli where soggetti phrase all words 'INHIBITOR DESIGN' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 51 riferimenti
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    1. Walker, B; Lynas, JF
      Strategies for the inhibition of serine proteases

      CELLULAR AND MOLECULAR LIFE SCIENCES
    2. Schramm, VL
      Transition state variation in enzymatic reactions

      CURRENT OPINION IN CHEMICAL BIOLOGY
    3. Caselli, E; Powers, RA; Blasczcak, LC; Wu, CYE; Prati, F; Shoichet, BK
      Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases

      CHEMISTRY & BIOLOGY
    4. Leonidas, DD; Chavali, GB; Jardine, AM; Li, SL; Shapiro, R; Acharya, KR
      Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography

      PROTEIN SCIENCE
    5. Su, AI; Lorber, DM; Weston, GS; Baase, WA; Matthews, BW; Shoichet, BK
      Docking molecules by families to increase the diversity of hits in database screens: Computational strategy and experimental evaluation

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    6. Zeng, J; Nheu, T; Zorzet, A; Catimel, B; Nice, E; Maruta, H; Burgess, AW; Treutlein, HR
      Design of inhibitors of Ras-Raf interaction using a computational combinatorial algorithm

      PROTEIN ENGINEERING
    7. Lee, M; Kim, DH
      Inhibition of carboxypeptidase A with beta-lactone-bearing phenylalanine. Design, synthesis, and stereochemistry-dependent inhibition mode

      BULLETIN OF THE KOREAN CHEMICAL SOCIETY
    8. Versees, W; Decanniere, K; Pelle, R; Depoorter, J; Brosens, E; Parkin, DW; Steyaert, J
      Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax

      JOURNAL OF MOLECULAR BIOLOGY
    9. Roberts, NA
      Anti-influenza drugs and neuraminidase inhibitors

      PROGRESS IN DRUG RESEARCH, VOL 56
    10. Shrimpton, CN; Smith, AI
      Soluble neutral metallopeptidases: Physiological regulators of peptide action

      JOURNAL OF PEPTIDE SCIENCE
    11. Wei, YY; Fox, T; Chambers, SP; Sintchak, J; Coll, JT; Golec, JMC; Swenson, L; Wilson, KP; Charifson, PS
      The structures of caspases-1,-3,-7 and-8 reveal the basis for substrate and inhibitor selectivity

      CHEMISTRY & BIOLOGY
    12. Szeltner, Z; Renner, V; Polgar, L
      Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family

      PROTEIN SCIENCE
    13. Gilberger, TW; Schirmer, RH; Walter, RD; Muller, S
      Deletion of the parasite-specific insertions and mutation of the catalytictriad in glutathione reductase from chloroquine-sensitive Plasmodium falciparum 3D7

      MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    14. Li, HY; Raman, CS; Martasek, P; Kral, V; Masters, BSS; Poulos, TL
      Mapping the active site polarity in structures of endothelial nitric oxidesynthase heme domain complexed with isothioureas

      JOURNAL OF INORGANIC BIOCHEMISTRY
    15. Zhang, YL; Yao, ZJ; Sarmiento, M; Wu, L; Burke, TR; Zhang, ZY
      Thermodynamic study of ligand binding to protein-tyrosine phosphatase 1B and its substrate-trapping mutants

      JOURNAL OF BIOLOGICAL CHEMISTRY
    16. Peters, GH; Iversen, LF; Branner, S; Andersen, HS; Mortensen, SB; Olsen, OH; Moller, KB; Moller, NPH
      Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha

      JOURNAL OF BIOLOGICAL CHEMISTRY
    17. Savle, PS; Shelton, TE; Meadows, CA; Potts, M; Gandour, RD; Kennelly, PJ
      N-(cyclohexanecarboxyl)-O-phospho-L-serine, a minimal substrate for the dual-specificity protein phosphatase IphP

      ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

    18. Hepatitis CNS3 protease inhibitors

      EXPERT OPINION ON THERAPEUTIC PATENTS
    19. Tondi, D; Slomczynska, U; Costi, MR; Watterson, DM; Ghelli, S; Shoichet, BK
      Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase

      CHEMISTRY & BIOLOGY
    20. Lee, M; Jin, Y; Kim, DH
      2-benzyl-2-methylsuccinic acid as inhibitor for carboxypeptidase A. Synthesis and evaluation

      BIOORGANIC & MEDICINAL CHEMISTRY
    21. Balendiran, GK; Molina, JA; Xu, YM; Torres-Martinez, J; Stevens, R; Focia, PJ; Eakin, AE; Sacchettini, JC; Craig, SP
      Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitorHPP reveals the involvement of the flexible loop in substrate binding

      PROTEIN SCIENCE
    22. Ham, SW; Park, JG; Lee, SJ; Yoo, JS
      Selective inactivation of protein tyrosine phosphatase PTP1B by sulfone analogue of naphthoquinone

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    23. Zeng, J; Treutlein, HR
      A method for computational combinatorial peptide design of inhibitors of Ras protein

      PROTEIN ENGINEERING
    24. Gomis-Ruth, FX; Companys, V; Qian, Y; Fricker, LD; Vendrell, J; Aviles, FX; Coll, M
      Crystal structure of avian carboxypeptidase D domain II: a prototype for the regulatory metallocarboxypeptidase subfamily

      EMBO JOURNAL
    25. Ringe, D; Mattos, C
      Analysis of the binding surfaces of proteins

      MEDICINAL RESEARCH REVIEWS
    26. Taylor, SS; Radzio-Andzelm, E; Madhusudan; Cheng, XD; Eyck, LT; Narayana, N
      Catalytic subunit of cyclic AMP-dependent protein kinase: Structure and dynamics of the active site cleft

      PHARMACOLOGY & THERAPEUTICS
    27. Schramm, VL
      Enzymatic transition-state analysis and transition-state analogs

      ENZYME KINETICS AND MECHANISM, PT E
    28. Kim, DH
      Design of protease inhibitors on the basis of substrate stereospecificity

      BIOPOLYMERS
    29. Glover, NR; Tracey, AS
      Nuclear magnetic resonance and restrained molecular dynamics studies of the interaction of an epidermal growth factor-derived peptide with protein tyrosine phosphatase 1B

      BIOCHEMISTRY
    30. Chen, H; Cong, LN; Li, YH; Yao, ZJ; Wu, L; Zhang, ZY; Burke, TR; Quon, MJ
      Phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells

      BIOCHEMISTRY
    31. YAN XJ; DAY P; HOLLIS T; MONZINGO AF; SCHELP E; ROBERTUS JD; MILNE GWA; WANG SM
      RECOGNITION AND INTERACTION OF SMALL RINGS WITH THE RICIN A-CHAIN BINDING-SITE

      Proteins
    32. Wallqvist, A; Smythers, GW; Covell, DG
      A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations

      PROTEIN ENGINEERING
    33. CANYUK B; CRAIG SP; EAKIN AE
      BACTERIAL COMPLEMENTATION AS A MEANS TO TEST ENZYME-LIGAND INTERACTIONS

      Applied microbiology and biotechnology
    34. NIEVESALICEA R; FOCIA PJ; CRAIG SP; EAKIN AE
      LIMITED PROTEOLYSIS OF A TRYPANOSOMAL HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE YIELDS CRYSTALS THAT DIFFRACT X-RAYS TO NEAR ATOMIC-RESOLUTION

      Biochimica et biophysica acta. Protein structure and molecular enzymology
    35. SCHRAMM VL
      ENZYMATIC TRANSITION-STATES AND TRANSITION-STATE ANALOG DESIGN

      Annual review of biochemistry
    36. Alexeev, D; Baxter, RL; Campopiano, DJ; McAlpine, RS; McIver, L; Sawyer, L
      Rational design of an inhibitor of dethiobiotin synthetase; Interaction of6-hydroxypyrimidin-4(3H)-one with the adenine base binding site.

      TETRAHEDRON
    37. FOCIA PJ; CRAIG SP; NIEVESALICEA R; FLETTERICK RJ; EAKIN AE
      A 1.4 ANGSTROM CRYSTAL-STRUCTURE FOR THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE OF TRYPANOSOMA-CRUZI

      Biochemistry (Easton)
    38. Focia, PJ; Craig, SP; Eakin, AE
      Approaching the transition state in the crystal structure of a phosphoribosyltransferase

      BIOCHEMISTRY
    39. OBST U; BANNER DW; WEBER L; DIEDERICH F
      MOLECULAR RECOGNITION AT THE THROMBIN ACTIVE-SITE - STRUCTURE-BASED DESIGN AND SYNTHESIS OF POTENT AND SELECTIVE THROMBIN INHIBITORS AND THE X-RAY CRYSTAL-STRUCTURES OF 2 THROMBIN-INHIBITOR COMPLEXES

      Chemistry & biology
    40. HORSCH M; MAYER C; SENNHAUSER U; RAST DM
      BETA-N-ACETYLHEXOSAMINIDASE - A TARGET FOR THE DESIGN OF ANTIFUNGAL AGENTS

      Pharmacology & therapeutics
    41. HSIEH KH
      THROMBIN INTERACTION WITH FIBRIN POLYMERIZATION SITES

      Thrombosis research
    42. SHOKHEN M; ARAD D
      ANIONIC TETRAHEDRAL COMPLEXES AS SERINE-PROTEASE INHIBITORS

      JOURNAL OF MOLECULAR MODELING
    43. PARKIN DW
      PURINE-SPECIFIC NUCLEOSIDE N-RIBOHYDROLASE FROM TRYPANOSOMA-BRUCEI-BRUCEI PURIFICATION, SPECIFICITY, AND KINETIC MECHANISM

      The Journal of biological chemistry
    44. ROSENFELD R; VAJDA S; DELISI C
      FLEXIBLE DOCKING AND DESIGN

      Annual review of biophysics and biomolecular structure
    45. KUHN LA; SWANSON CA; PIQUE ME; TAINER JA; GETZOFF ED
      ATOMIC AND RESIDUE HYDROPHILICITY IN THE CONTEXT OF FOLDED PROTEIN STRUCTURES

      Proteins
    46. MAURY G; DIVITA G
      DOES RECENT RESEARCH ON THE STRUCTURE OF HUMAN-IMMUNODEFICIENCY-VIRUSTRANSCRIPTASE SUGGEST ANY INTERESTING DESIGN OR SYNTHESIS OF NEW ENZYME-INHIBITORS AND NEW ANTI-AIDS DRUGS

      Bulletin de la Societe chimique de France
    47. GOMEZ J; FREIRE E
      THERMODYNAMIC MAPPING OF THE INHIBITOR SITE OF THE ASPARTIC PROTEASE ENDOTHIAPEPSIN

      Journal of Molecular Biology
    48. EGNER U; HOYER GA; SCHLEUNING WD
      RATIONAL DESIGN OF HIRULOG-TYPE INHIBITORS OF THROMBIN

      Journal of computer-aided molecular design
    49. RING CS; COHEN FE
      MODELING PROTEIN STRUCTURES - CONSTRUCTION AND THEIR APPLICATIONS

      The FASEB journal
    50. SHOICHET BK; KUNTZ ID
      MATCHING CHEMISTRY AND SHAPE IN MOLECULAR DOCKING

      Protein engineering
    51. HENDRIKS D; VINGRON M; VRIEND G; WANG W; NALIS D; SCHARPE S
      ON THE SPECIFICITY OF CARBOXYPEPTIDASE-N, A COMPARATIVE-STUDY

      Biological chemistry Hoppe-Seyler


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 16:21:28