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La ricerca find articoli where soggetti phrase all words 'INBRED STRAINS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 916 riferimenti
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    1. van der Meulen, MCH; Jepsen, KJ; Mikic, B
      Understanding bone strength: Size isn't everything

      BONE
    2. Akhter, MP; Cullen, DM; Gong, G; Recker, RR
      Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice

      BONE
    3. Gorman, AL; Yu, CG; Ruenes, GR; Daniels, L; Yezierski, RP
      Conditions affecting the onset, severity, and progression of a spontaneouspain-like behavior after excitotoxic spinal cord injury

      JOURNAL OF PAIN
    4. Jimenez, AM; Stagner, BB; Martin, GK; Lonsbury-Martin, BL
      Susceptibility of DPOAEs to sound overexposure in inbred mice with AHL

      JARO
    5. Cheatham, MA; Pearce, M; Richter, CP; Onodera, K; Shavit, JA
      Use of the pinna reflex as a test of hearing in mutant mice

      AUDIOLOGY AND NEURO-OTOLOGY
    6. Vollmayr, B; Faust, H; Lewicka, S; Henn, FA
      Brain-derived-neurotrophic-factor (BDNF) stress response in rats bred for learned helplessness

      MOLECULAR PSYCHIATRY
    7. Srivastava, RAK; Averna, M; Srivastava, N; Pape, ME
      Dietary cholate increases plasma levels of apolipoprotein B in mice by posttranscriptional mechanisms

      INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
    8. Anunciado, RVP; Nishimura, M; Mori, M; Ishikawa, A; Tanaka, S; Hori, F; Ohno, T; Namikawa, T
      Quantitative trait loci for body weight in the intercross between SM/J andA/J mice

      EXPERIMENTAL ANIMALS
    9. Montmayeur, JP; Liberles, SD; Matsunami, H; Buck, LB
      A candidate taste receptor gene near a sweet taste locus

      NATURE NEUROSCIENCE
    10. Saito, M; Kitamura, H; Sugiyama, K
      Liver gangliosides of various animals ranging from fish to mammalian species

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    11. Ivandic, BT; Utz, HF; Kaczmarek, PM; Aherrahrou, Z; Axtner, SB; Klepsch, C; Lusis, AJ; Katus, HA
      New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice

      PHYSIOLOGICAL GENOMICS
    12. Drake, TA; Schadt, E; Hannani, K; Kabo, JM; Krass, K; Colinayo, V; Greaser, LE; Goldin, J; Lusis, AJ
      Genetic loci determining bone density in mice with diet-induced atherosclerosis

      PHYSIOLOGICAL GENOMICS
    13. Peirce, J
      Looking at old tools in new ways: Using knockouts as congenics to study QTLs

      GENOME RESEARCH
    14. Bolivar, VJ; Cook, MN; Flaherty, L
      Mapping of quantitative trait loci with knockout/congenic strains

      GENOME RESEARCH
    15. Frisbee, JC; Roman, RJ; Falck, JR; Krishna, M; Lombard, JH
      20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats

      MICROCIRCULATION
    16. Jones, MW; Peckham, HM; Errington, ML; Bliss, TVP; Routtenberg, A
      Synaptic plasticity in the hippocampus of awake C57BL/6 and DBA/2 mice: Interstrain differences and parallels with behavior

      HIPPOCAMPUS
    17. Lu, KM; Lee, MH; Patel, SB
      Dietary cholesterol absorption; more than just bile

      TRENDS IN ENDOCRINOLOGY AND METABOLISM
    18. Genevois-Charmeau, C; Binet, S; Bonnet, P; Lafontaine, M; Brandt, H; Kriech, A; De Groot, PC; Wissel, H; Garren, L; Morele, Y; Nunge, H; Castegnaro, M
      Inhalation study on exposure to bitumen fumes: Formation of DNA adducts invarious rat tissues following nose-only inhalation

      POLYCYCLIC AROMATIC COMPOUNDS
    19. Busygina, TV; Osadchuk, AV
      The effects of the genotype and social stress on cAMP- and substrate-dependent mechanism regulating the hormone-producing function of mouse testes

      RUSSIAN JOURNAL OF GENETICS
    20. Busygina, TV; Osadchuk, AV
      Role of genotype, social stress, and season in the regulation of hormonal function of testes incubated in vitro in mice

      RUSSIAN JOURNAL OF GENETICS
    21. Yagil, Y; Yagil, C
      Genetic models of hypertension in experimental animals

      EXPERIMENTAL NEPHROLOGY
    22. Estill, SJ; Fay, K; Garcia, JA
      Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J : 129S6/SvEvTac mixed strain mice

      TRANSGENIC RESEARCH
    23. Venault, P; Rudrauf, D; Lepicard, EM; Berthoz, A; Jouvent, R; Chapouthier, G
      Balance control and posture in anxious mice improved by SSRI treatment

      NEUROREPORT
    24. Encinas, JA; Lees, MB; Sobel, RA; Symonowicz, C; Weiner, HL; Seidman, CE; Seidman, JG; Kuchroo, VK
      Identification of genetic loci associated with paralysis, inflammation andweight loss in mouse experimental autoimmune encephalomyelitis

      INTERNATIONAL IMMUNOLOGY
    25. Takeuchi, T; Kiyama, Y; Nakamura, K; Tsujita, M; Matsuda, I; Mori, H; Munemoto, Y; Kuriyama, H; Natsume, R; Sakimura, K; Mishina, M
      Roles of the glutamate receptor epsilon 2 and delta 2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex

      EUROPEAN JOURNAL OF NEUROSCIENCE
    26. Dockstader, CL; Rubinstein, M; Grandy, DK; Low, MJ; van der Kooy, D
      The D-2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice

      EUROPEAN JOURNAL OF NEUROSCIENCE
    27. Bergeson, SE; Helms, ML; O'Toole, LA; Jarvis, MW; Hain, HS; Mogil, JS; Belknap, JK
      Quantitative trait loci influencing morphine antinociception in four mapping populations

      MAMMALIAN GENOME
    28. Suzuki, T; Ishikawa, A; Yoshimura, T; Namikawa, T; Abe, H; Honma, S; Honma, K; Ebihara, S
      Quantitative trait locus analysis of abnormal circadian period in CS mice

      MAMMALIAN GENOME
    29. Pravenec, M; Jansa, P; Kostka, V; Zidek, V; Kren, V; Forejt, J; Kurtz, TW
      Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat

      MAMMALIAN GENOME
    30. Belknap, JK; Atkins, AL
      The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies

      MAMMALIAN GENOME
    31. Zhou, L; Rowley, DL; Mi, QS; Sefcovic, N; Matthes, HWD; Kieffer, BL; Donovan, DM
      Murine inter-strain polymorphisms alter gene targeting frequencies at the mu opioid receptor locus in embryonic stem cells

      MAMMALIAN GENOME
    32. Rosen, CJ; Beamer, WG; Donahue, LR
      Defining the genetics of osteoporosis: Using the mouse to understand man

      OSTEOPOROSIS INTERNATIONAL
    33. Redei, EE; Solberg, LC; Kluczynski, JM; Pare, WP
      Paradoxical hormonal and behavioral responses to hypo-thyroid and hyperthyroid states in the Wistar-Kyoto rat

      NEUROPSYCHOPHARMACOLOGY
    34. Dimitrijevic, M; Laban, O; Djuric, VJ; Stanojevic, S; Miletic, T; Kovacevic-Jovanovic, V; Todorovic, C; Radulovic, J
      Behavior and severity of adjuvant arthritis in four rat strains

      BRAIN BEHAVIOR AND IMMUNITY
    35. Fortin, A; Diez, E; Rochefort, D; Laroche, L; Malo, D; Rouleau, GA; Gros, P; Skamene, E
      Recombinant congenic strains derived from A/J and C57BL/6J: A tool for genetic dissection of complex traits

      GENOMICS
    36. Iakoubova, OA; Olsson, CL; Dains, KM; Ross, DA; Andalibi, A; Lau, K; Choi, J; Kalcheva, I; Cunanan, M; Louie, L; Nimon, V; Machrus, M; Bentley, LG; Beauheim, C; Silvey, S; Cavalcoli, J; Lusis, AJ; West, DB
      Genome-tagged mice (GTM): Two sets of genome-wide congenic strains

      GENOMICS
    37. Haile, CN; Hiroi, N; Nestler, EJ; Kosten, TA
      Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats

      SYNAPSE
    38. Alexander, JM; Bab, I; Fish, S; Muller, R; Uchiyama, T; Gronowicz, G; Nahounou, M; Zhao, Q; White, DW; Chorev, M; Gazit, D; Rosenblatt, M
      Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice

      JOURNAL OF BONE AND MINERAL RESEARCH
    39. Richman, C; Kutilek, S; Miyakoshi, N; Srivastava, AK; Beamer, WG; Donahue, LR; Rosen, CJ; Wergedal, JE; Baylink, DJ; Mohan, S
      Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice

      JOURNAL OF BONE AND MINERAL RESEARCH
    40. Klein, RF; Carlos, AS; Vartanian, KA; Chambers, VK; Turner, RJ; Phillips, TJ; Belknap, JK; Orwoll, ES
      Confirmation and fine mapping of chromosomal regions influencing peak bonemass in mice

      JOURNAL OF BONE AND MINERAL RESEARCH
    41. Orwoll, ES; Belknap, JK; Klein, RF
      Gender specificity in the genetic determinants of peak bone mass

      JOURNAL OF BONE AND MINERAL RESEARCH
    42. Ohl, F; Holsboer, F; Landgraf, R
      The modified hole board as a differential screen for behavior in rodents

      BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS
    43. Tritto, T; Marley, RJ; Bastidas, D; Stitzel, JA; Collins, AC
      Potential regulation of nicotine and ethanol actions by alpha 4-containingnicotinic receptors

      ALCOHOL
    44. Ishimori, N; Iwabuchi, K; Fujii, S; Watano, K; Iwabuchi, C; Ato, M; Chiba, H; Tanaka, S; Kitabatake, A; Onoe, K
      Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice

      JOURNAL OF LEUKOCYTE BIOLOGY
    45. Holmes, A; Hollon, TR; Gleason, TC; Liu, Z; Dreiling, J; Sibley, DR; Crawley, JN
      Behavioral characterization of dopamine D-5 receptor null mutant mice

      BEHAVIORAL NEUROSCIENCE
    46. Anisman, H; Hayley, S; Kelly, O; Borowski, T; Merali, Z
      Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes

      BEHAVIORAL NEUROSCIENCE
    47. Cook, MN; Williams, RW; Flaherty, L
      Anxiety-related behaviors in the elevated zero-maze are affected by genetic factors and retinal degeneration

      BEHAVIORAL NEUROSCIENCE
    48. Zou, W; Hakim, I; Tschoep, K; Endres, S; Bar-Shavit, Z
      Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclastdifferentiation by an autocrine mechanism

      JOURNAL OF CELLULAR BIOCHEMISTRY
    49. Bachmanov, AA; Tordoff, MG; Beauchamp, GK
      Sweetener preference of C57BL/6ByJ and 129P3/J mice

      CHEMICAL SENSES
    50. Inoue, M; McCaughey, SA; Bachmanov, AA; Beauchamp, GK
      Whole nerve chorda tympani responses to sweeteners in C57BL/6ByJ and 129P3/J mice

      CHEMICAL SENSES
    51. Bachmanov, AA; Li, X; Reed, DR; Ohmen, JD; Li, SR; Chen, ZY; Tordoff, MG; de Jong, PJ; Wu, CY; West, DB; Chatterjee, A; Ross, DA; Beauchamp, GK
      Positional cloning of the mouse saccharin preference (Sac) locus

      CHEMICAL SENSES
    52. Schellinck, HM; Forestell, CA; LoLordo, VM
      A simple and reliable test of olfactory learning and memory in mice

      CHEMICAL SENSES
    53. Davis, RR; Newlander, JK; Ling, XB; Cortopassi, GA; Krieg, EF; Erway, LC
      Genetic basis for susceptibility to noise-induced hearing loss in mice

      HEARING RESEARCH
    54. Festing, MFW
      Experimental approaches to the determination of genetic variability

      TOXICOLOGY LETTERS
    55. Lorincz, AM; Shoemaker, MB; Heideman, PD
      Genetic variation in photoperiodism among naturally photoperiodic rat strains

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    56. Smith, BK; Volaufova, J; West, DB
      Increased flavor preference and lick activity for sucrose and corn oil in SWR/J vs. AKR/J mice

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    57. Basavarajappa, BS; Hungund, BL
      Cannabinoid receptor agonist-stimulated [S-35]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice

      JOURNAL OF NEUROSCIENCE RESEARCH
    58. Teunissen, CE; Steinbusch, HWM; Angevaren, M; Appels, M; De Bruijn, C; Prickaerts, J; De Vente, J
      Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: Disturbed walking pattern and spatial orientation

      NEUROSCIENCE
    59. Liu, CN; Raber, P; Ziv-Sefer, S; Devor, M
      Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype

      NEUROSCIENCE
    60. Wan, Y; Wilson, SG; Han, JS; Mogil, JS
      The effect of genotype on sensitivity to electroacupuncture analgesia

      PAIN
    61. Brayton, C; Justice, M; Montgomery, CA
      Evaluating mutant mice: Anatomic pathology

      VETERINARY PATHOLOGY
    62. Festing, MFW; Diamanti, P; Turton, JA
      Strain differences in haematological response to chloroamphenicol succinate in mice: implications for toxicological research

      FOOD AND CHEMICAL TOXICOLOGY
    63. Franken, P; Chollet, D; Tafti, M
      The homeostatic regulation of sleep need is under genetic control

      JOURNAL OF NEUROSCIENCE
    64. Ikeda, K; Kobayashi, T; Ichikawa, T; Kumanishi, T; Niki, H; Yano, R
      The untranslated region of mu-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice

      JOURNAL OF NEUROSCIENCE
    65. Bowers, BJ; Wehner, JM
      Ethanol consumption and behavioral impulsivity are increased in protein kinase C gamma null mutant mice

      JOURNAL OF NEUROSCIENCE
    66. Andreasson, KI; Savonenko, A; Vidensky, S; Goellner, JJ; Zhang, Y; Shaffer, A; Kaufmann, WE; Worley, PF; Isakson, P; Markowska, AL
      Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice

      JOURNAL OF NEUROSCIENCE
    67. Lu, L; Airey, DC; Williams, RW
      Complex trait analysis of the hippocampus: Mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice

      JOURNAL OF NEUROSCIENCE
    68. Pravenec, M; Zidek, V; Musilova, A; Vorlicek, J; Kren, V; St Lezin, E; Kurtz, TW
      Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat

      JOURNAL OF HYPERTENSION
    69. Galipeau, D; Arikawa, E; Sekirov, I; McNeill, JH
      Chronic thromboxane synthase inhibition prevents fructose-induced hypertension

      HYPERTENSION
    70. Cantini, C; Kieffer, P; Corman, B; Liminana, P; Atkinson, J; Lartaud-Idjouadiene, I
      Aminoguanidine and aortic wall mechanics, structure, and composition in aged rats

      HYPERTENSION
    71. DiBona, GF; Jones, SY
      Effect of dietary sodium intake on the responses to bicuculline in the paraventricular nucleus of rats

      HYPERTENSION
    72. Kren, V; Qi, NN; Krenova, D; Zidek, V; Sladka, M; Jachymova, M; Mikova, B; Horky, K; Bonne, A; Van Lith, HA; Van Zutphen, BFM; Lau, YFC; Pravenec, M; St Lezin, E
      Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR

      HYPERTENSION
    73. Hamet, P; Thorin-Trescases, N; Moreau, P; Dumas, P; Tea, BS; deBlois, D; Kren, V; Pravenec, L; Kunes, J; Sun, YL; Tremblay, J
      Excess growth and apoptosis - Is hypertension a case of accelerated aging of cardiovascular cells?

      HYPERTENSION
    74. Gerlai, R
      Gene targeting: technical confounds and potential solutions in behavioral brain research

      BEHAVIOURAL BRAIN RESEARCH
    75. Douglas, WA; Crabbe, JC; Dudek, BC
      Behavioural testing of standard inbred and 5HT(IB) knockout mice: implications of absent corpus callosum

      BEHAVIOURAL BRAIN RESEARCH
    76. Hatcher, JP; Jones, DNC; Rogers, DC; Hatcher, PD; Reavill, C; Hagan, JJ; Hunter, AJ
      Development of SHIRPA to characterise the phenotype of gene-targeted mice

      BEHAVIOURAL BRAIN RESEARCH
    77. Le Isabelle, R; Carlier, M; Roubertoux, PL
      Sensory and motor development in mice: genes, environment and their interactions

      BEHAVIOURAL BRAIN RESEARCH
    78. Rinaldi, D; Larrigaldie, V; Chapouthier, G; Martin, B
      Unexpected absence of correlation between the genetic mechanisms regulating beta-carboline-induced seizures and anxiety manifested in an elevated plus-maze test

      BEHAVIOURAL BRAIN RESEARCH
    79. Miczek, KA; Maxson, SC; Fish, EW; Faccidomo, S
      Aggressive behavioral phenotypes in mice

      BEHAVIOURAL BRAIN RESEARCH
    80. Plappert, CF; Pilz, PKD
      The acoustic startle response as an effective model for elucidating the effect of genes on the neural mechanism of behavior in mice

      BEHAVIOURAL BRAIN RESEARCH
    81. Ammassari-Teule, M; Restivo, L; Pietteur, V; Passino, E
      Learning about the context in genetically-defined mice

      BEHAVIOURAL BRAIN RESEARCH
    82. Steckler, T
      Using signal detection methods for analysis of operant performance in mice

      BEHAVIOURAL BRAIN RESEARCH
    83. Contet, C; Rawlins, JNP; Deacon, RMJ
      A comparison of 129S2/SvHsd and C57BL/6JO1aHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice

      BEHAVIOURAL BRAIN RESEARCH
    84. Dirks, A; de Jongh, R; Groenink, L; van der Gugten, J; Hijzen, TH; Olivier, B
      Footshock-induced sensitization of the acoustic startle response in two strains of mice

      BEHAVIOURAL BRAIN RESEARCH
    85. Zimmermann, A; Stauffacher, M; Langhans, W; Wurbel, H
      Enrichment-dependent differences in novelty exploration in rats can be explained by habituation

      BEHAVIOURAL BRAIN RESEARCH
    86. DeVries, AC; Nelson, RJ; Traystman, RJ; Hurn, PD
      Cognitive and behavioral assessment in experimental stroke research: will it prove useful?

      NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
    87. Holmes, A
      Targeted gene mutation approaches to the study of anxiety-like behavior inmice

      NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
    88. Smoller, JW; Acierno, JS; Rosenbaum, JF; Biederman, J; Pollack, MH; Meminger, S; Pava, JA; Chadwick, LH; White, C; Bulzacchelli, M; Slaugenhaupt, SA
      Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions

      AMERICAN JOURNAL OF MEDICAL GENETICS
    89. Wehner, JM; Radcliffe, RA; Bowers, BJ
      Quantitative genetics and mouse behavior

      ANNUAL REVIEW OF NEUROSCIENCE
    90. Zimatkin, SM; Liopo, AV; Satanovskaya, VI; Bardina, LR; Deitrich, RA
      Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    91. Cailhol, S; Mormede, P
      Sex and strain differences in ethanol drinking: Effects of gonadectomy

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    92. Rikke, BA; Simpson, VJ; Montoliu, L; Johnson, TE
      No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    93. Owens, JC; Bennett, B; Johnson, TE
      Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/hypnotic sensitivity to ethanol

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    94. Knapp, DJ; Braun, CJ; Duncan, GE; Qian, Y; Fernandes, A; Crews, FT; Breese, GR
      Regional specificity of ethanol and NMDA action in brain revealed with FOS-like immunohistochemistry and differential routes of drug administration

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    95. Iraqi, F; Sekikawa, K; Rowlands, J; Teale, A
      Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection

      PARASITE IMMUNOLOGY
    96. Boles, KS; Stepp, SE; Bennett, M; Kumar, V; Mathew, PA
      2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulinsuperfamily molecules expressed on natural killer cells and other leukocytes

      IMMUNOLOGICAL REVIEWS
    97. Lee, SH; Gitas, J; Zafer, A; Lepage, P; Hudson, TJ; Belouchi, A; Vidal, SM
      Haplotype mapping indicates two independent origins for the Cmv1(s) susceptibility allele to cytomegalovirus infection and refines its localization within the Ly49 cluster

      IMMUNOGENETICS
    98. Stevens, KE; Bullock, AE; Collins, AC
      Chronic corticosterone treatment alters sensory gating in C3H mice

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    99. Reed, CL; Hood, KE; Cortes, DA; Jones, BC
      Genetic-environment analysis of sensitivity and acute tolerance to ethanolin mice

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    100. Grainger, DJ; McWilliam, NA; Baglin, TP; Byrne, CD
      Suppressing thrombin generation is compatible with the development of atherosclerosis in mice

      THROMBOSIS RESEARCH


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Documento generato il 27/05/20 alle ore 08:53:15