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The Src-like adaptor protein downregulates the T cell receptor on CD4(+)CD8(+) thymocytes and regulates positive selection
IMMUNITY
Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes
IMMUNITY
Expression and selection of productively rearranged TCR beta VDJ genes aresequentially regulated by CD3 signaling in the development of NK1.1(+) alpha beta T cells
INTERNATIONAL IMMUNOLOGY
MAP-kinase signaling pathways in T cells
CURRENT OPINION IN IMMUNOLOGY
Molecular determinants of TCR expression and selection
CURRENT OPINION IN IMMUNOLOGY
Signal transduction by MAP kinases in T lymphocytes
ONCOGENE
Developmentally regulated expression of the transmembrane adaptor protein TRIM in fetal and adult T cells
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Thymic epithelial cells induce Fas-independent activation apoptosis of thymocytes
IMMUNOLOGY LETTERS
UEA-I-binding to thymic medullary epithelial cells selectively reduces numbers of cortical TCR alpha beta(+) thymocytes in FTOCs
IMMUNOLOGY LETTERS
Establishment of a mouse thymic epithelial cell line, IT-76MHC and a briefreview on cultured thymic epithelial cells
CELLULAR AND MOLECULAR BIOLOGY
Signal transduction in thymus development
CELLULAR AND MOLECULAR BIOLOGY
The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest
LIFE SCIENCES
A reliable and safe T cell repertoire based on low-affinity T cell receptors
JOURNAL OF THEORETICAL BIOLOGY
Duration and strength of extracellular signal-regulated kinase signals arealtered during positive versus negative thymocyte selection
JOURNAL OF IMMUNOLOGY
Integrin functions play a key role in the differentiation of thymocytes invivo
JOURNAL OF IMMUNOLOGY
Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45
JOURNAL OF IMMUNOLOGY
Opposite ability of pre-TCR and alpha beta TCR to induce apoptosis
JOURNAL OF IMMUNOLOGY
Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development
JOURNAL OF IMMUNOLOGY
Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors
JOURNAL OF IMMUNOLOGY
Early TCR alpha beta expression promotes maturation of T cells expressing Fc epsilon RI gamma containing TCR/CD3 complexes
JOURNAL OF IMMUNOLOGY
Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development
JOURNAL OF EXPERIMENTAL MEDICINE
An endoplasmic reticulum retention function for the cytoplasmic tail of the human pre-T cell receptor (TCR) alpha chain: Potential role in the regulation of cell surface pre-TCR expression levels
JOURNAL OF EXPERIMENTAL MEDICINE
p38 MAP kinase activity modulates alpha beta T cell development
EUROPEAN JOURNAL OF IMMUNOLOGY
Low rate of proliferation in immature thymocytes of the non-obese diabeticmouse maps to the ldd6 diabetes susceptibility region
DIABETOLOGIA
p53 and thymic 'death by neglect': thymic epithelial cell-induced apoptosis of CD4(+)8(+) thymocytes is p53-independent
CELL DEATH AND DIFFERENTIATION
Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8(+) bone marrow subpopulation that promotes allogeneic stem cell engraftment
NATURE MEDICINE
On the dynamics of TCR : CD3 complex cell surface expression and downmodulation
IMMUNITY
Cell migration and the anatomic control of thymocyte precursor differentiation
SEMINARS IN IMMUNOLOGY
The role of endoplasmic reticular Ca2+ stores in cell viability and tumor necrosis factor-alpha production of the murine macrophage RAW 264.7 cell line
JOURNAL OF BIOMEDICAL SCIENCE
Identification of a novel pre-TCR isoform in which the accessibility of the TCR beta subunit is determined by occupancy of the 'missing' V domain of pre-T alpha
INTERNATIONAL IMMUNOLOGY
Isolated ricin B-chain-mediated apoptosis in U937 cells
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Alteration of protein composition in mouse thymocytes by signals through T-cell receptor
ELECTROPHORESIS
A comprehensive characterization of the T-cell antigen receptor complex composition by microcapillary liquid chromatography-tandem mass spectrometry
ELECTROPHORESIS
Pre-B and pre-T-cell receptors: conservation of strategies in regulating early lymphocyte development
IMMUNOLOGICAL REVIEWS
Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture
TOXICOLOGY AND APPLIED PHARMACOLOGY
Possible involvement of cyclophilin B and caspase-activated deoxyribonuclease in the induction of chromosomal DNA degradation in TCR-stimulated thymocytes
JOURNAL OF IMMUNOLOGY
Group B Streptococcus induces apoptosis in macrophages
JOURNAL OF IMMUNOLOGY
Opening a window on thymic positive selection: Developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced by TCR engagement
JOURNAL OF IMMUNOLOGY
Aberrant trafficking of the B cell receptor Ig-alpha beta subunit in a B lymphoma cell line
JOURNAL OF IMMUNOLOGY
Hoxa3 and Pax1 transcription factors regulate the ability of fetal thymic epithelial cells to promote thymocyte development
JOURNAL OF IMMUNOLOGY
Premature expression of T cell receptor (TCR)alpha beta suppresses TCR gamma delta gene rearrangement but permits development of gamma delta lineage T cells
JOURNAL OF EXPERIMENTAL MEDICINE
Cell surface expression of calnexin, a molecular chaperone in the endoplasmic reticulum
JOURNAL OF BIOLOGICAL CHEMISTRY
Developmental regulation of TCR efficiency
EUROPEAN JOURNAL OF IMMUNOLOGY
T cell receptor assembly and expression in the absence of calnexin
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Allelic exclusion of the T cell receptor alpha-chain: developmental regulation of a post-translational event
SEMINARS IN IMMUNOLOGY
Signals involved in gamma/delta T cell versus alpha/beta T cell lineage commitment
SEMINARS IN IMMUNOLOGY
Signals involved in thymocyte positive and negative selection
SEMINARS IN IMMUNOLOGY
Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms
SEMINARS IN IMMUNOLOGY
Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints
INTERNATIONAL IMMUNOLOGY
Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia
MAMMALIAN GENOME
The role of Fas-mediated apoptosis in thyroid autoimmune disease
AUTOIMMUNITY
The regulation of CD4 and CD8 coreceptor gene expression during T cell development
ANNUAL REVIEW OF IMMUNOLOGY
Apoptosis of human T-cells: induction by glucocorticoids or surface receptor ligation in vitro and ex vivo
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
Adhesion molecules involved in the interactions between early T cells and mesenchymal bone marrow stromal cells
EXPERIMENTAL HEMATOLOGY
Apoptosis of thymic lymphoma clones by thymic epithelial cells: a putativemodel for 'death by neglect'
IMMUNOLOGY LETTERS
The impact of pre-T-cell receptor signals on gene expression in developingT cells
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
Regulation of antigen receptor function by protein tyrosine kinases
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death
SCIENCE
Role of IL-12 in intrathymic negative selection
JOURNAL OF IMMUNOLOGY
Signals transduced by CD3 epsilon, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro
JOURNAL OF IMMUNOLOGY
The extracellular domain of the zeta-chain is essential for TCR function
JOURNAL OF IMMUNOLOGY
T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta
JOURNAL OF IMMUNOLOGY
Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes
JOURNAL OF EXPERIMENTAL MEDICINE
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
JOURNAL OF EXPERIMENTAL MEDICINE
Laminin 5 in the human thymus: Control of T cell proliferation via alpha(6)beta(4) integrins
JOURNAL OF CELL BIOLOGY
Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules
JOURNAL OF BIOLOGICAL CHEMISTRY
Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus
CELLULAR IMMUNOLOGY
beta-selection is associated with the onset of CD8 beta chain expression on CD4(+)CD8 alpha alpha(+) pre-T cells during human intrathymic development
BLOOD
THE MECHANISM OF THIOACETAMIDE-INDUCED APOPTOSIS IN THE L37 ALBUMIN-SV40 T-ANTIGEN TRANSGENIC RAT HEPATOCYTE-DERIVED CELL-LINE OCCURS WITHOUT DNA FRAGMENTATION
In vitro cellular & developmental biology. Animal
REQUIREMENT FOR P56(LCK) TYROSINE KINASE ACTIVATION IN T-H SUBSET DIFFERENTIATION
International immunology
GLYCOSYLTRANSFERASE REGULATION MEDIATED BY PRE-TCR SIGNALING IN EARLYTHYMOCYTE DEVELOPMENT
International immunology
ALTERED FUNCTIONAL RESPONSIVENESS OF THYMOCYTE SUBSETS FROM CD3-DELTA-DEFICIENT MICE TO TCR-CD3 ENGAGEMENT
International immunology (Print)
EXPRESSION OF TCF-1 MESSENGER-RNA AND SURFACE TCR-CD3 COMPLEXES ARE REDUCED DURING APOPTOSIS OF T-CELLS
International immunology (Print)
SIGNALING CHECKPOINTS DURING THE DEVELOPMENT OF T-LYMPHOCYTES
Current opinion in immunology
INVOLVEMENT OF MACROMOLECULE SYNTHESIS, ENDONUCLEASE ACTIVATION AND C-FOS EXPRESSION IN CISPLATIN-INDUCED APOPTOSIS OF MOUSE PROXIMAL TUBULE CELLS
Toxicology letters
DELETERIOUS NETWORK HYPOTHESIS OF APOPTOSIS
Medical hypotheses
INDUCTION OF APOPTOSIS WITH FUSARENON-X IN MOUSE THYMOCYTES
Toxicology
A CASPASE INHIBITOR PROTECTS THYMOCYTES FROM DIVERSE SIGNAL-MEDIATED APOPTOSIS BUT NOT FROM CLONAL DELETION IN FETAL THYMUS ORGAN-CULTURE
Immunology letters
MOLECULAR REQUIREMENTS FOR LINEAGE COMMITMENT IN THE THYMUS - ANTIBODY-MEDIATED RECEPTOR ENGAGEMENTS REVEAL A CENTRAL ROLE FOR LCK IN LINEAGE DECISIONS
Immunological reviews
CD4 CD8 LINEAGE COMMITMENT - MATCHING FATE WITH COMPETENCE/
Immunological reviews
THYMOCYTE SELECTION - NOT BY TCR ALONE
Immunological reviews
THE LY45.1 ALLOANTIGEN - PREFERENTIAL EXPRESSION ON CD4(-)CD8(-) CD4(+)CD8(+) THYMOCYTES/
Immunogenetics (New York)
OVEREXPRESSION OF THE ANTI-APOPTOTIC ONCOGENE, BCL-2, IN THE THYMUS DOES NOT PREVENT THYMIC ATROPHY INDUCED BY ESTRADIOL OR 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN
Toxicology and applied pharmacology
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AND DIETHYLSTILBESTROL AFFECT THYMOCYTES AT DIFFERENT STAGES OF DEVELOPMENT IN FETAL THYMUS ORGAN-CULTURE
Toxicology and applied pharmacology
EFFECTS OF IN-VIVO EXPOSURE TO BIS(TRI-N-BUTYLTIN)OXIDE, HEXACHLOROBENZENE, AND BENZO(A)PYRENE ON CYTOKINE (RECEPTOR) MESSENGER-RNA LEVELS IN CULTURED RAT SPLENOCYTES AND ON IL-2 RECEPTOR PROTEIN-LEVELS
Toxicology and applied pharmacology
ABNORMAL THYMOCYTE DEVELOPMENT AND GENERATION OF AUTOREACTIVE T-CELLSIN MIXED AND CORTICAL THYMOMAS
Laboratory investigation
TCR-ALPHA-BETA CHAINS ASSOCIATE WITH THE PLASMA-MEMBRANE INDEPENDENTLY OF CD3 AND TCR-ZETA CHAINS IN MURINE PRIMARY T-CELLS
The Journal of immunology (1950)
SEQUESTRATION OF CD4-ASSOCIATED LCK FROM THE TCR COMPLEX MAY ELICIT T-CELL HYPORESPONSIVENESS IN NONOBESE DIABETIC MICE
The Journal of immunology
OPPOSITE CD4 CD8 LINEAGE DECISIONS OF CD4(+)8(+) MOUSE AND RAT THYMOCYTES TO EQUIVALENT TRIGGERING SIGNALS - CORRELATION WITH THYMIC EXPRESSION OF A TRUNCATED CD8-ALPHA CHAIN IN MICE BUT NOT RATS/
The Journal of immunology
TNF RECEPTOR-DEFICIENT MICE REVEAL STRIKING DIFFERENCES BETWEEN SEVERAL MODELS OF THYMOCYTE NEGATIVE SELECTION
The Journal of immunology
REGULATION OF TCR SIGNAL-TRANSDUCTION IN MURINE THYMOCYTES BY MULTIPLE TCR ZETA-CHAIN SIGNALING MOTIFS
The Journal of immunology
REQUIREMENT OF CD3 COMPLEX-ASSOCIATED SIGNALING FUNCTIONS FOR EXPRESSION OF REARRANGED T-CELL RECEPTOR-BETA VDJ GENES IN EARLY THYMIC DEVELOPMENT
The Journal of experimental medicine
IDENTIFICATION OF A LATE-STAGE OF SMALL NONCYCLING PT-ALPHA(-) PRE-T CELLS AS IMMEDIATE PRECURSORS OF T-CELL RECEPTOR ALPHA BETA(+) THYMOCYTES/
The Journal of experimental medicine
ESSENTIAL AND PARTIALLY OVERLAPPING ROLE OF CD3-GAMMA AND CD3-DELTA FOR DEVELOPMENT OF ALPHA-BETA AND GAMMA-DELTA T-LYMPHOCYTES
The Journal of experimental medicine
THE CD3-GAMMA-DELTA-EPSILON AND CD3-ZETA ETA MODULES ARE EACH ESSENTIAL FOR ALLELIC EXCLUSION AT THE T-CELL RECEPTOR-BETA LOCUS BUT ARE BOTH DISPENSABLE FOR THE INITIATION OF V TO (D)J RECOMBINATION AT THE T-CELL RECEPTOR-BETA, RECEPTOR-GAMMA, AND RECEPTOR-DELTA LOCI/
The Journal of experimental medicine
MOLECULAR-CLONING OF PTAC12 AN ALTERNATIVE SPLICING PRODUCT OF THE CD3-GAMMA CHAIN AS A COMPONENT OF THE PRE-T CELL ANTIGEN-RECEPTOR COMPLEX
The Journal of biological chemistry
CALNEXIN ASSOCIATES WITH MONOMERIC AND OLIGOMERIC (DISULFIDE-LINKED) CD3-DELTA PROTEINS IN MURINE T-LYMPHOCYTES
The Journal of biological chemistry
CHARACTERIZATION OF THE REGION INVOLVED IN CD3 PAIRWISE INTERACTIONS WITHIN THE T-CELL RECEPTOR COMPLEX
The Journal of biological chemistry
Enhancement of activation-induced cell death by fibronectin in murine CD4(+) CD8(+) thymocytes
IMMUNOLOGY