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Glucocorticoid-mediated repression of inflammatory cytokine production in fibroblast-like rheumatoid synoviocytes is independent of nuclear factor-kappa B activation induced by tumour necrosis factor alpha
RHEUMATOLOGY
Effect of a mutant form of I kappa B-alpha on 5-fluorouracil-induced apoptosis in transformed human salivary gland cells
ORAL ONCOLOGY
Mechanism of measles virus failure to activate NF-kappa B in neuronal cells
JOURNAL OF NEUROVIROLOGY
Signal transduction events in Chinese hamster ovary cells expressing humanCD14; Effect of endotoxin desensitization
SHOCK
Constitutive activation of nuclear factor-kappa B prevents TRAIL-induced apoptosis in renal cancer cells
ONCOGENE
Her-2/neu overexpression induces NF-kappa B via a PI3-kinase/Akt pathway involving calpain-mediated degradation of I kappa-B-alpha that can be inhibited by the tumor suppressor PTEN
ONCOGENE
Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights into the I kappa B alpha/NF-kappa B survival pathway in skeletal muscle
JOURNAL OF MOLECULAR MEDICINE-JMM
Anti-inflammatory effect of adenovirus-mediated I kappa B alpha overexpression in respiratory epithelial cells
EUROPEAN RESPIRATORY JOURNAL
The heat shock paradox: does NF-kappa B determine cell fate?
FASEB JOURNAL
Oxidative damages are critical in pathogenesis of reflux esophagitis: Implication of antioxidants in its treatment
FREE RADICAL BIOLOGY AND MEDICINE
Monophosphoryl lipid A stimulated up-regulation of reactive oxygen intermediates in human monocytes in vitro
JOURNAL OF LEUKOCYTE BIOLOGY
Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants inNF-kappa B activation and cytokine production
JOURNAL OF LEUKOCYTE BIOLOGY
Differential effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation
JOURNAL OF LEUKOCYTE BIOLOGY
Regulation of Fas-mediated apoptosis by NF-kappa B activity in human hepatocyte derived cell lines
MICROBIOLOGY AND IMMUNOLOGY
LMP1 activates NF-kappa B via degradation of I kappa B alpha in nasopharyngeal carcinoma cells
CHINESE MEDICAL JOURNAL
Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappa B in THP-1 macrophages
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Early activation of IKK beta during in vivo myocardial ischemia
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Enhanced I kappa B kinase activity is responsible for the augmented activity of NF-kappa B in human head and neck carcinoma cells
CANCER LETTERS
Mechanisms of ubiquitin-mediated, limited processing of the NF-kappa B1 precursor protein p105
BIOCHIMIE
Control of I kappa B alpha proteolysis by the ubiquitin-proteasome pathway
BIOCHIMIE
The role of constitutive NF-kappa B activity in PC-3 human prostate cancercell invasive behavior
CLINICAL & EXPERIMENTAL METASTASIS
NEDD8 recruits E2-ubiquitin to SCF E3 ligase
EMBO JOURNAL
Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Cytokine-activated degradation of inhibitory kappa B protein alpha is inhibited by the short-chain fatty acid butyrate
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Developmental patterns of NF-kappa B activation during acute hypoxia in the caudal brainstem of the rat
DEVELOPMENTAL BRAIN RESEARCH
Butyrate inhibits interleukin-1-mediated nuclear factor-kappa B activationin human epithelial cells
DIGESTIVE DISEASES AND SCIENCES
Effects of idoxifene and estradiol on NF-kappa B activation in cultured rat hepatocytes undergoing oxidative stress
LIVER
Relationship between I kappa B alpha deficiency, NF kappa B activity and interleukin-8 production in CF human airway epithelial cells
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
NF-kappa B activation and I kappa B alpha dynamism involved in iNOS and chemokine induction in astroglial cells
LIFE SCIENCES
Cardiac-specific abrogation of NF-kappa B activation in mice by transdominant expression of a mutant I kappa B alpha
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
I kappa B kinase alpha is essential for mature B cell development and function
JOURNAL OF EXPERIMENTAL MEDICINE
A pyrrolidinone derivative inhibits cytokine-induced iNOS expression and NF-kappa B activation by preventing phosphorylation and degradation of I kappa B-alpha
JOURNAL OF BIOCHEMISTRY
Inhibition of NF-kappa B in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice
EUROPEAN JOURNAL OF IMMUNOLOGY
Tyrosine phosphorylation-dependent activation of NF-kappa B - Requirement for p56 LCK and ZAP-70 protein tyrosine kinases
EUROPEAN JOURNAL OF BIOCHEMISTRY
The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-kappa B targeting in the alveolar epithelium
BRITISH JOURNAL OF PHARMACOLOGY
Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages
BIOCHEMICAL PHARMACOLOGY
Degradation of I kappa B alpha is limited by a postphosphorylation/ubiquitination event
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Cytokine-induced stabilization of newly synthesized I kappa B-alpha
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
A MEK inhibitor, PD98059 enhances IL-1-induced NF-kappa B activation by the enhanced and sustained degradation of I kappa B alpha
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Acetaminophen inhibits NF-kappa B activation by interfering with the oxidant signal in murine Hepa 1-6 cells
TOXICOLOGICAL SCIENCES
Activation of NF-kappa B varies in different regions of the gastrointestinal tract during endotoxemia
SHOCK
Inhibition of LPS-induced NF kappa B activation by a glucan ligand involves down-regulation of IKK beta kinase activity and altered phosphorylation and degradation of I kappa B alpha
SHOCK
NF-kappa B regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome
SHOCK
Effect of steroid on hyperoxia-induced ICAM-1 expression in pulmonary endothelial cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Inhibition with antisense oligonucleotide suggests that I kappa B-a does not form a negative autoregulatory loop for NF-kappa B in mesangial cells
EXPERIMENTAL NEPHROLOGY
Selective up-regulation of I kappa B-alpha in ischemic penumbra following focal cerebral ischemia
NEUROREPORT
N-terminal determinants of I kappa B alpha necessary for the cytoplasmic regulation of c-Rel
ONCOGENE
SCF beta-TRCP and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4
ONCOGENE
Dynamic expression and activity of NF-kappa B during post-natal mammary gland morphogenesis
MECHANISMS OF DEVELOPMENT
Role and regulation of Rel/NF-kappa B activity in anti-immunoglobulin-induced apoptosis in WEHI-231 B lymphoma cells
CELLULAR SIGNALLING
Protein kinase C-alpha is an upstream activator of the I kappa B kinase complex in the TPA signal transduction pathway to NF-kappa B in U2OS cells
CELLULAR SIGNALLING
The effect of age on cyclooxygenase-2 gene expression: NF-kappa b activation and I kappa B alpha degradation
FREE RADICAL BIOLOGY AND MEDICINE
Induction of I kappa B alpha mRNA expression in the brain by glucocorticoids: A negative feedback mechanism for immune-to-brain signaling
JOURNAL OF NEUROSCIENCE
Homocysteine stimulates nuclear factor kappa B activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possiblerole for protein kinase C
BIOCHEMICAL JOURNAL
Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes
ACTA PHARMACOLOGICA SINICA
NF-kappa B activation is inhibited in human pulmonary epithelial cells transfected with alpha-melanocyte-stimulating hormone vector
PEPTIDES
A caspase-3-like protease is involved in NF-kappa B activation induced by stimulation of N-methyl-D-aspartate receptors in rat striatum
MOLECULAR BRAIN RESEARCH
Silica induces nuclear factor-kappa B activation through tyrosine phosphorylation of I kappa B-alpha in RAW264.7 macrophages
TOXICOLOGY AND APPLIED PHARMACOLOGY
The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Kainic acid-induced apoptosis in rat striatum is associated with nuclear factor-kappa B activation
JOURNAL OF NEUROCHEMISTRY
RAG2-/-, I kappa B-alpha-/- chimeras display a psoriasiform skin disease
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Clonal deleterious mutations in the I kappa B alpha gene in the malignant cells in Hodgkin's lymphoma
JOURNAL OF EXPERIMENTAL MEDICINE
Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated I kappa B alpha/nuclear factor kappa B pathway perturbation in mice
JOURNAL OF CELL BIOLOGY
Inhibition of the production of rat cytokine-induced neutrophil chemoattractant (CINC)-1, a member of the interleukin-8 family, by adenovirus-mediated overexpression of I kappa B alpha
JOURNAL OF BIOCHEMISTRY
Identification of I kappa B alpha as a substrate of Fas-associated phosphatase-1
EUROPEAN JOURNAL OF BIOCHEMISTRY
Inhibition of I kappa B-alpha phosphorylation at serine and tyrosine acts independently on sensitization to DNA damaging agents in human glioma cells
BRITISH JOURNAL OF CANCER
Prevention of etoposide-induced apoptosis by proteasome inhibitors in a human leukemic cell line but not in fresh acute leukemia blasts - A differential role of NF-kappa B activation
BIOCHEMICAL PHARMACOLOGY
Inhibition of nuclear factor-kappa B activation in mouse macrophages and the RAW 264.7 cell line by a synthetic adenyl carbocyclic nucleoside
BIOCHEMICAL PHARMACOLOGY
17 beta-Estradiol inhibits tumor necrosis factor-alpha-induced nuclear factor-kappa B activation by increasing nuclear factor-kappa B p105 level in MCF-7 breast cancer cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappa B by increasing intracellular copper level in human aortic smooth muscle cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Involvement of nuclear factor-kappa B (NF-kappa B) signaling in the expression of inducible nitric oxide synthase (iNOS) gene in rat C6 glioma cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
5-fluorouracil induces apoptosis through the suppression of NF-kappa B activity in human salivary gland cancer cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
NF-kappa B activation is related to the resistance of lung cancer cells toTNF-alpha-induced apoptosis
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome
CHEMISTRY & BIOLOGY
Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for I kappa B alpha
ONCOGENE
Studies into the effect of tyrosine phosphatase inhibitor phenylarsine oxide on NF kappa B activation in T lymphocytes during aging: Evidence for altered I kappa B-alpha phosphorylation and degradation
EXPERIMENTAL GERONTOLOGY
Early activation of transcription factor NF-kappa B during ischemia in perfused rat heart
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Autocrine alpha-melanocyte-stimulating hormone inhibits NF-kappa B activation in human glioma
JOURNAL OF NEUROSCIENCE RESEARCH
Molecular role of ascorbate in enhancement of NO production in activated macrophage-like cell line, J774.1
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of I kappa B alpha
EMBO JOURNAL
Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappa B activation and apoptosis in rat striatum
MOLECULAR BRAIN RESEARCH
Interleukin-17 stimulates the expression of I kappa B alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines
JOURNAL OF NEUROIMMUNOLOGY
Structural analysis, expression, and chromosomal localization of the mouseikba gene
IMMUNOGENETICS
Posttransplant recurrent FSGS: Molecular insights and future directions
NEPHRON
Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Cell specific effects of glucocorticoid treatment on the NF-kappa Bp65/I kappa B alpha system in patients with Crohn's disease
GUT
A complex containing beta TrCP recruits Ccd34 to catalyse ubiquitination of I kappa B alpha
FEBS LETTERS
alpha-melanocyte-stimulating hormone inhibits NF-kappa B activation and I kappa B alpha degradation in human glioma cells and in experimental brain inflammation
EXPERIMENTAL NEUROLOGY
TGF-beta 1 inhibits NF-kappa B activity through induction of I kappa B-alpha expression in human salivary gland cells: A possible mechanism of growthsuppression by TGF-1 beta
EXPERIMENTAL CELL RESEARCH
Glucocorticoids prevent NF-kappa B activation by inhibiting the early release of platelet-activating factor in response to lipopolysaccharide
EUROPEAN JOURNAL OF IMMUNOLOGY
Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects I kappa B alpha turnover
EUROPEAN JOURNAL OF BIOCHEMISTRY
NF kappa B activation is required for interferon regulatory factor-1-mediated interferon beta induction
EUROPEAN JOURNAL OF BIOCHEMISTRY
Systemically administered alpha-melanocyte-stimulating peptides inhibit NF-kappa B activation in experimental brain inflammation
BRAIN RESEARCH
Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Differential serine phosphorylation regulates I kappa B-alpha inactivation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
NO INHIBITS CYTOKINE-INDUCED INOS EXPRESSION AND NF-KAPPA-B ACTIVATION BY INTERFERING WITH PHOSPHORYLATION AND DEGRADATION OF I-KAPPA-B-ALPHA
Arteriosclerosis, thrombosis, and vascular biology
THE NF-KAPPA-B AND I-KAPPA-B SYSTEM IN INJURED ARTERIES
Pathobiology
EMODIN (3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE) INHIBITS TNF-INDUCED NF-KAPPA-B ACTIVATION, I-KAPPA-B DEGRADATION, AND EXPRESSION OF CELL-SURFACE ADHESION PROTEINS IN HUMAN VASCULAR ENDOTHELIAL-CELLS
Oncogene