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Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues
INTERNATIONAL JOURNAL OF CANCER
A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms inringed and grey seals from the Baltic Sea and reference sites
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Metabolism of aflatoxin B-1 by normal human bronchial epithelial cells
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
Physiologically based pharmacokinetic modeling of benzene metabolism in mice through extrapolation from in vitro to in vivo
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
Steroid 5 alpha-reductases and 3 alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
Contrasting effects of acute and chronic dietary exposure to 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) on xenobiotic metabolising enzymes in the male Fischer 344 Rat: implications for chemoprevention studies
EUROPEAN JOURNAL OF NUTRITION
Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH : ubiquinone oxidoreductase flavoproteins
JOURNAL OF HUMAN GENETICS
Structure of the human acyl-CoA : cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Primary cultures of human hepatocytes but not HepG2 hepatoblastoma cells are suitable for the study of glycosidic conjugation of bile acids
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Direct chiral assay of tramadol and detection of the phase II metabolite O-demethyl tramadol glucuronide in human urine using capillary electrophoresis with laser-induced native fluorescence detection
JOURNAL OF CHROMATOGRAPHY B
Separation and identification methods for metalloproteinase inhibitors
JOURNAL OF CHROMATOGRAPHY B
Cyclophosphamide and related anticancer drugs
JOURNAL OF CHROMATOGRAPHY B
Rapid high-performance liquid chromatographic method for the separation ofhydroxylated testosterone metabolites
JOURNAL OF CHROMATOGRAPHY B
High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy - II. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP2D6 inhibition assessment
JOURNAL OF CHROMATOGRAPHY B
On-line extraction using an alkyl-diol silica precolumn for racemic citalopram and its metabolites in plasma - Results compared with solid-phase extraction methodology
JOURNAL OF CHROMATOGRAPHY B
In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Forging the links between metabolism and carcinogenesis
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Screening of drug candidates for their drug-drug interaction potential
CURRENT OPINION IN CHEMICAL BIOLOGY
Identification of human ccn2*(connective tissue growth factor) promoter polymorphisms
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Eubacterial arylamine N-acetyltransferases - identification and comparisonof 18 members of the protein family with conserved active site cysteine, histidine and aspartate residues
MICROBIOLOGY-SGM
Differences in transcutaneous bilirubin readings in Japanese term infants according to feeding method
PEDIATRICS INTERNATIONAL
Enhanced expression of basement-membrane-type heparan sulfate proteoglycanin tumor fibro-myxoid stroma of intrahepatic cholangiocarcinoma
PATHOLOGY INTERNATIONAL
Venlafaxine extended-release - A review of its use in the management of major depression
CNS DRUGS
Selective serotonin reuptake inhibitors for late-life depression - A comparative review
DRUGS & AGING
Genetic polymorphisms in drug-metabolizing enzymes and drug targets
MOLECULAR GENETICS AND METABOLISM
Hepatic carnitine palmitoyl transferase 1 (CPT1 A) deficiency in North American Hutterites (Canadian and American): Evidence for a founder effect andresults of a pilot study on a DNA-based newborn screening program
MOLECULAR GENETICS AND METABOLISM
Inhibition of human cytochrome P450 2E1 by nicotine, cotinine, and aqueouscigarette tar extract in vitro
TOXICOLOGICAL SCIENCES
A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: Implementing sensitivity and variability analyses
TOXICOLOGICAL SCIENCES
Accumulation of metals in autopsy tissues of subjects living in Tarragona County, Spain
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach
JOURNAL OF BIOMOLECULAR SCREENING
Development of a miniaturized 384-well high throughput screen for the detection of substrates of cytochrome P-450 2D6 and 3A4 metabolism
JOURNAL OF BIOMOLECULAR SCREENING
Hematopoietic stem cell transplantation in Utero produces sheep-goat chimeras
BLOOD CELLS MOLECULES AND DISEASES
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
CLINICAL CANCER RESEARCH
The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6 alpha-hydroxypaclitaxel, a major metabolite of paclitaxel
CLINICAL CANCER RESEARCH
Profiling the specific reactivity of the proteome with non-directed activity-based probes
CHEMISTRY & BIOLOGY
Structure of human biliverdin IX beta reductase, an early fetal bilirubin IX beta producing enzyme
NATURE STRUCTURAL BIOLOGY
Establishment of a human hepatocyte line (OUMS-29) having CYP 1A1 and 1A2 activities from fetal liver tissue by transfection of SV-10 LT
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
Microarray analysis of genes differentially expressed in HEPG2 cells cultured in simulated microgravity: Preliminary report
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
An efficient method for the cryopreservation of fetal human liver hematopoeitic progenitor cells
STEM CELLS
Expression of adhesion molecules on CD34(+) cells in peripheral blood of non-Hodgkin's lymphoma patients mobilized with different growth factors
STEM CELLS
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
NATURE GENETICS
Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications
HUMAN MUTATION
Kinetics of acetyl coenzyme A: Arylamine N-acetyltransferase from human cumulus cells
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Problems associated with in vitro assessment of drug inhibition of CYP3A4 and other P-450 enzymes and its impact on drug discovery
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Epidemiological study of urinary 6 beta-hydroxycortisol to cortisol ratiosand breast cancer risk
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Therapeutic drug monitoring in methadone maintenance: Choosing a matrix
JOURNAL OF ADDICTIVE DISEASES
A role for CYP2D6 in nicotine metabolism? Target article on nicotine-addiction
PSYCOLOQUY
Nicotine metabolism by the polymorphic cytochrome P450 2A6 (CYP2A6) enzyme: Implications for interindividual differences in smoking behaviour target article on nicotine-addiction
PSYCOLOQUY
Pharmacokinetics of cyclosporine in heart transplant recipients receiving metabolic inhibitors
JOURNAL OF HEART AND LUNG TRANSPLANTATION
Palpebral twitching in a depressed adolescent on citalopram
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
Ion trap tandem mass spectrometry study of dexamethasone transformation products on light activated TiO2 surface
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug
BIOCONJUGATE CHEMISTRY
Differences in the human and mouse amino-terminal leader peptides of ornithine transcarbamylase affect mitochondrial import and efficacy of adenoviral vectors
HUMAN GENE THERAPY
A review of quantitative studies of benzene metabolism
CRITICAL REVIEWS IN TOXICOLOGY
Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches
CRITICAL REVIEWS IN TOXICOLOGY
Identification, characterization, and ontogeny of a second cytochrome P4503A gene from the fresh water teleost medaka (Oryzias latipes)
MOLECULAR REPRODUCTION AND DEVELOPMENT
Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung
INTERNATIONAL JOURNAL OF ONCOLOGY
Parenchymal and nonparenchymal cellular responses in human hepatic regeneration
JOURNAL OF KOREAN MEDICAL SCIENCE
Effects of hypoxia, hyperoxia on the regulation of expression and activityof matrix metalloproteinase-2 in hepatic stellate cells
WORLD JOURNAL OF GASTROENTEROLOGY
Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copperATPase
HUMAN MOLECULAR GENETICS
A "real time" PCR assay to detect transplanted human liver cells in RAG-1(-/-) mice
CELL TRANSPLANTATION
Role of the single cysteine residue, Cys 3, of human and bovine cystatin B(stefin B) in the inhibition of cysteine proteinases
PROTEIN SCIENCE
The N-terminal portion of mature aldehyde dehydrogenase affects protein folding and assembly
PROTEIN SCIENCE
Application of photoaffinity labeling with [H-3] all trans- and 9-cis-retinoic acids for characterization of cellular retinoic acid-binding proteins I and II
PROTEIN SCIENCE
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Determination of coumarin metabolism in Turkish population
HUMAN & EXPERIMENTAL TOXICOLOGY
Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19
PHARMACOGENETICS
Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
PHARMACOGENETICS
Polymorphism of human Alpha class glutathione transferases
PHARMACOGENETICS
Characterization of the CYP2D6*29 allele commonly present in a blade Tanzanian population causing reduced catalytic activity
PHARMACOGENETICS
Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2
PHARMACOGENETICS
Identification and functional characterization of eight CYP3A4 protein variants
PHARMACOGENETICS
Use of midazolam urinary metabolic ratios for cytochrome P450 3A (CYP3A) phenotyping
PHARMACOGENETICS
Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms
PHARMACOGENETICS
In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelicvariant forms of human liver microsomal cytochrome P4502C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics
PHARMACOGENETICS
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene
PHARMACOGENETICS
Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects
PHARMACOGENETICS
Inhibition of cytochrome P4502C9 activity in vitro by 5-hydroxytryptamine and adrenaline
PHARMACOGENETICS
Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects
PHARMACOGENETICS
Human dehydroepiandrosterone sulfotransferase: purification and characterization of a recombinant protein
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Pharmacokinetics of oral cyclosporin A when co-administered to enhance theoral absorption of paclitaxel
ANTI-CANCER DRUGS
Toxicity of irinotecan (CPT-11) and hepato-renal dysfunction
ANTI-CANCER DRUGS
Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2
CURRENT OPINION IN LIPIDOLOGY
Cytosolic enzymes from rat tissues that activate the cooked meat mutagen metabolite N-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP)
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Elevation of serum cystatin C concentrations in patients with chronic liver disease
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Distinctive gene expression profiles associated with Hepatitis B virus x protein
ONCOGENE
Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1rat hepatoma cells and HepG2 human hepatoblastoma cells
HISTOCHEMISTRY AND CELL BIOLOGY
Drug interactions of them statins and consequences for drug selection
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Midazolam and cortisol metabolism before and after CYP3A induction in humans
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Nitrosative stress by cyclosporin A in the endothelium: studies with the NO-sensitive probe diaminofluorescein-2/diacetate using flow cytometry
NEPHROLOGY DIALYSIS TRANSPLANTATION
Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer
CURRENT MEDICINAL CHEMISTRY