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La ricerca find articoli where soggetti phrase all words 'HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 45 riferimenti
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    1. Kanugula, S; Pegg, AE
      Novel DNA repair alkyltransferase from Caenorhabditis elegans

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    2. Hosfield, DJ; Daniels, DS; Mol, CD; Putnam, CD; Parikh, SS; Tainer, JA
      DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 68
    3. Davis, BM; Encell, LP; Zielske, SP; Christians, FC; Liu, LL; Friebert, SE; Loeb, LA; Gerson, SL
      Applied molecular evolution of O-6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    4. Reinhard, J; Hull, WE; von der Lieth, CW; Eichhorn, U; Kliem, HC; Kaina, B; Wiessler, M
      Monosaccharide-linked inhibitors of O-6-methylguanine-DNA methyltransferase (MGMT): Synthesis, molecular modeling, and structure-activity relationships

      JOURNAL OF MEDICINAL CHEMISTRY
    5. Liu, H; Xu-Welliver, M; Pegg, AE
      The role of human O-6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    6. Roth, RB; Samson, LD
      Gene transfer to suppress bone marrow alkylation sensitivity

      MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
    7. Long, L; Berg, SL; Roy, SK; McCully, CL; Song-Yoo, HW; Moschel, RC; Balis, FM; Dolan, ME
      Plasma and cerebrospinal fluid pharmacokinetics of O-6-benzylguanine and analogues in nonhuman primates

      CLINICAL CANCER RESEARCH
    8. Fairbairn, LJ; Chinnasamy, N; Lashford, LS; Chinnasamy, D; Rafferty, JA
      Enhancing hemopoietic drug resistance: A rationale for reconsidering the clinical use of mitozolomide

      CANCER GENE THERAPY
    9. Brown, LR; Deng, J; Clarke, ND
      Dominant sensitization variants of human O-6-methylguanine-DNA-methyltransferase obtained by a mutational screen of surface residues

      MUTATION RESEARCH-DNA REPAIR
    10. Limp-Foster, M; Kelley, MR
      DNA repair and gene therapy: Implications for translational uses

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    11. Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC
      Potentiation of BCNU antitumor efficacy by 9-substituted O-6-benzylguanines. Effect of metabolism

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    12. Williams, DA; Maze, R; Kurpad, C; Pegg, A; Erickson, LC
      Protection of hematopoietic cells against combined O-6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O-6-methylguanine DNA methyltransferase

      BONE MARROW TRANSPLANTATION
    13. Fairbairn, LJ; Rafferty, JA; Lashford, LS
      Engineering drug resistance in human cells

      BONE MARROW TRANSPLANTATION
    14. Daniels, DS; Mol, CD; Arvai, AS; Kanugula, S; Pegg, AE; Tainer, JA
      Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

      EMBO JOURNAL
    15. Encell, LP; Loeb, LA
      Enhanced in vivo repair of O-4-methylthymine by a mutant human DNA alkyltransferase

      CARCINOGENESIS
    16. Frosina, G
      Overexpression of enzymes that repair endogenous damage to DNA

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    17. Berthet, N; Boturyn, D; Constant, JF
      DNA repair inhibitors

      EXPERT OPINION ON THERAPEUTIC PATENTS
    18. Davis, BM; Roth, JC; Liu, LL; Xu-Welliver, M; Pegg, AE; Gerson, SL
      Characterization of the P140K, PVP(138-140)MLK, and G156A O-6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy

      HUMAN GENE THERAPY
    19. Koc, ON; Reese, JS; Szekely, EM; Gerson, SL
      Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis (2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer

      CANCER GENE THERAPY
    20. Chinnasamy, N; Rafferty, JA; Lashford, LS; Chinnasamy, D; Margison, GP; Thatcher, N; Dexter, TM; Fairbairn, LJ
      Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy

      LEUKEMIA
    21. Phillips, WP; Gerson, SL
      Acquired resistance to O-6-benzylguanine plus chloroethylnitrosoureas in human breast cancer

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    22. Maze, R; Kurpad, C; Pegg, AE; Erickson, LC; Williams, DA
      Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O-6-methylguanine DNA methyltransferase protects hematopoietic cellsagainst O-6-benzylguanine sensitization to chloroethylnitrosourea treatment

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    23. Bibby, MC; Thompson, MJ; Rafferty, JA; Margison, GP; McElhinney, RS
      Influence of O-6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-l-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice

      BRITISH JOURNAL OF CANCER
    24. Loktionova, NA; Xu-Welliver, M; Crone, TM; Kanugula, S; Pegg, AE
      Protection of CHO cells by mutant forms of O(6-)alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O-6-benzylguanine or O-6-benzyl-8-oxoguanine

      BIOCHEMICAL PHARMACOLOGY
    25. CHINNASAMY N; FAIRBAIRN LJ; LAHER J; WILLINGTON MA; RAFFERTY JA
      MODULATION OF O-6-ALKYLATING AGENT INDUCED CLASTOGENICITY BY ENHANCEDDNA-REPAIR CAPACITY OF BONE-MARROW CELLS

      Mutation research. Genetic toxicology and environmental mutagenesis
    26. BUCHDAHL C; ROLHION C; GLASSER AL; DEBITON E; MOUNETOU E; MADELMONT JC; LAVAL F
      MELANOMA-CELL TOXICITY OF CYSTEMUSTINE COMBINED WITH O-6-BENZYL-N-2-ACETYLGUANOSINE

      Melanoma research
    27. MOON KY; MOSCHEL RC
      EFFECT OF IONIC STATE OF 2'-DEOXYGUANOSINE AND SOLVENT ON ITS ARALKYLATION BY BENZYL BROMIDE

      Chemical research in toxicology
    28. VORA RA; PEGG AE; EALICK SE
      A NEW MODEL FOR HOW O-6-METHYLGUANINE-DNA METHYLTRANSFERASE BINDS DNA

      Proteins
    29. KLEIBL K; MARGISON GP
      INCREASING DNA-REPAIR CAPACITY IN BONE-MARROW BY GENE-TRANSFER AS A PROSPECTIVE TOOL IN CANCER-THERAPY

      Neoplasma
    30. ENCELL LP; COATES MM; LOEB LA
      ENGINEERING HUMAN DNA ALKYLTRANSFERASES FOR GENE-THERAPY USING RANDOMSEQUENCE MUTAGENESIS

      Cancer research
    31. DOLAN ME; PEGG AE
      O-6-BENZYLGUANINE AND ITS ROLE IN CHEMOTHERAPY

      Clinical cancer research
    32. SINGER B; HANG B
      WHAT STRUCTURAL FEATURES DETERMINE REPAIR ENZYME SPECIFICITY AND MECHANISM IN CHEMICALLY-MODIFIED DNA

      Chemical research in toxicology
    33. TERASHIMA I; KAWATE H; SAKUMI K; SEKIGUCHI M; KOHDA K
      SUBSTRATE-SPECIFICITY OF HUMAN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE FOR O-6-BENZYLGUANINE DERIVATIVES IN OLIGODEOXYNUCLEOTIDES

      Chemical research in toxicology
    34. LUDLUM DB
      THE CHLOROETHYLNITROSOUREAS SENSITIVITY AND RESISTANCE TO CANCER-CHEMOTHERAPY AT THE MOLECULAR-LEVEL

      Cancer investigation
    35. EDWARDS C; BOCHE G; STEINBRECHER T; SCHEER S
      SYNTHESIS OF 2-SUBSTITUTED 2'-DEOXYGUANOSINES AND 6-O-ALLYLGUANINES VIA THE ACTIVATION OF C-2 BY A TRIFLUOROMETHANESULFONATE GROUP

      Journal of the Chemical Society. Perkin transactions. I
    36. DOLAN ME
      INHIBITION OF DNA-REPAIR AS A MEANS OF INCREASING THE ANTITUMOR-ACTIVITY OF DNA REACTIVE AGENTS

      Advanced drug delivery reviews
    37. PIEPER RO
      UNDERSTANDING AND MANIPULATING O-6-METHYLGUANINE-DNA METHYLTRANSFERASE EXPRESSION

      Pharmacology & therapeutics
    38. GOODTZOVA K; KANUGULA S; EDARA S; PAULY GT; MOSCHEL RC; PEGG AE
      REPAIR OF O-6-BENZYLGUANINE BY THE ESCHERICHIA-COLI ADA AND OGT AND THE HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASES

      The Journal of biological chemistry
    39. CHRISTIANS FC; DAWSON BJ; COATES MM; LOEB LA
      CREATION OF HUMAN ALKYLTRANSFERASES RESISTANT TO O-6-BENZYLGUANINE

      Cancer research
    40. HAZRA TK; ROY R; BISWAS T; GRABOWSKI DT; PEGG AE; MITRA S
      SPECIFIC RECOGNITION OF O-6-METHYLGUANINE IN DNA BY ACTIVE-SITE MUTANTS OF HUMAN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE

      Biochemistry
    41. TERASHIMA I; KOHDA K
      CYTOTOXICITY OF FLUOROETHYLATING AGENTS IS POTENTIATED BY O-6-BENZYLGUANINE

      Biological & pharmaceutical bulletin
    42. LIM A; LI BFL
      THE NUCLEAR TARGETING AND NUCLEAR RETENTION PROPERTIES OF A HUMAN DNA-REPAIR PROTEIN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE ARE BOTH REQUIRED FOR ITS NUCLEAR-LOCALIZATION - THE POSSIBLE IMPLICATIONS

      EMBO journal
    43. KOYAMA K; HITOMI K; TERASHIMA I; KOHDA K
      MECHANISM OF FORMATION OF N-2-BENZYLGUANINE IN THE REACTION OF 2-AMINO-6-CHLOROPURINE WITH SODIUM BENZYL OXIDE, AND BENZYLATION OF NUCLEIC-ACID BASES

      Chemical and Pharmaceutical Bulletin
    44. SRIVENUGOPAL KS; YUAN XH; FRIEDMAN HS; ALIOSMAN F
      UBIQUITINATION-DEPENDENT PROTEOLYSIS OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE IN HUMAN AND MURINE TUMOR-CELLS FOLLOWING INACTIVATION WITHO-6-BENZYLGUANINE OR 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA

      Biochemistry
    45. MORITZ T; MACKAY W; GLASSNER BJ; WILLIAMS DA; SAMSON L
      RETROVIRUS-MEDIATED EXPRESSION OF A DNA-REPAIR PROTEIN IN BONE-MARROWPROTECTS HEMATOPOIETIC-CELLS FROM NITROSOUREA-INDUCED TOXICITY IN-VITRO AND IN-VIVO

      Cancer research


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/01/21 alle ore 08:21:32