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La ricerca find articoli where soggetti phrase all words 'HORMONE BINDING' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 1133 riferimenti
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    1. Davis, DP; Segaloff, DL
      N-linked carbohydrates on G protein-coupled receptors: Mapping sites of attachment and determining functional roles

      G PROTEIN PATHWAYS, PT A, RECEPTORS
    2. Chapurlat, RD; Bauer, DC; Cummings, SR
      Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: Study of osteoporotic fractures

      BONE
    3. Legrand, E; Hedde, C; Gallois, Y; Degasne, I; De Casson, FB; Mathieu, E; Basle, MF; Chappard, D; Audran, M
      Osteoporosis in men: A potential role for the sex hormone binding globulin

      BONE
    4. Tissandier, O; Peres, G; Fiet, J; Piette, F
      Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men

      EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
    5. Saxena, SP; Israels, ED; Israels, LG
      Novel vitamin K-dependent pathways regulating cell survival

      APOPTOSIS
    6. Moghetti, P
      Advances in the treatment of polycystic ovary syndrome

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    7. Eneqvist, T; Sauer-Eriksson, AE
      Structural distribution of mutations associated with familial amyloidotic polyneuropathy in human transthyretin

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    8. Ducluzeau, PH; Laville, M; Vidal, H; Pugeat, M
      Polycystic ovary syndrome and insulin resistance

      DIABETES & METABOLISM
    9. Acerini, L; Williams, M; Dunger, B
      Puberty and type 1 diabetes

      DIABETES & METABOLISM
    10. Alexopoulou, O; Jamart, J; Maiter, D; Hermans, MP; De Hertogh, R; De Nayer, P; Buysschaert, M
      Erectile dysfunction and lower androgenicity in type 1 diabetic patients

      DIABETES & METABOLISM
    11. Lister, AL; Van der Kraak, GJ
      Endocrine disruption: Why is it so complicated?

      WATER QUALITY RESEARCH JOURNAL OF CANADA
    12. Malloy, PJ; Zhu, WJ; Zhao, XY; Pehling, GB; Feldman, D
      A novel inborn error in the ligand-binding domain of the vitamin D receptor causes hereditary vitamin D-resistant rickets

      MOLECULAR GENETICS AND METABOLISM
    13. List, EO; Coschigano, KT; Kopchick, JJ
      Growth hormone receptor/binding protein (GHR/BP) knockout mice: A 3-year update

      MOLECULAR GENETICS AND METABOLISM
    14. Shain, SA
      Neither fibroblast growth factor-1 nor fibroblast growth factor-2 is an androgen receptor coactivator in androgen-resistant prostate cancer

      MOLECULAR UROLOGY
    15. Geisler, J; Detre, S; Berntsen, H; Ottestad, L; Lindtjorn, B; Dowsett, M; Lonning, PE
      Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer

      CLINICAL CANCER RESEARCH
    16. Tirakitsoontorn, P; Nussbaum, E; Moser, C; Hill, M; Cooper, DM
      Fitness, acute exercise, and anabolic and catabolic mediators in cystic fibrosis

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    17. Ozata, M; Oktenli, C; Bingol, N; Ozdemir, IC
      The effects of metformin and diet on plasma testosterone and leptin levelsin obese men

      OBESITY RESEARCH
    18. Rinaldi, S; Dechaud, H; Biessy, C; Morin-Raverot, V; Toniolo, P; Zeleniuch-Jacquotte, A; Akhmedkhanov, A; Shore, RE; Secreto, G; Ciampi, A; Riboli, E; Kaaks, R
      Reliability and validity of commercially available, direct radioimmunoassays for measurement of blood androgens and estrogens in postmenopausal women

      CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
    19. Wu, AH; Whittemore, AS; Kolonel, LN; Stanczyk, FZ; John, EM; Gallagher, RP; West, DW
      Lifestyle determinants of 5 alpha-reductase metabolites in older African-American, white, and Asian-American men

      CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
    20. Allen, NE; Forrest, MS; Key, TJ
      The association between polymorphisms in the CYP17 and 5 alpha-reductase (SRD5A2) genes and serum androgen concentrations in men

      CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
    21. Downer, JD; Jones, LA; Engelbach, JA; Lich, LL; Mao, W; Carlson, KE; Katzenellenbogen, JA; Welch, MJ
      Comparison of animal models for the evaluation of radiolabeled androgens

      NUCLEAR MEDICINE AND BIOLOGY
    22. Rudenko, G; Hohenester, E; Muller, YA
      LG/LNS domains: multiple functions - one business end?

      TRENDS IN BIOCHEMICAL SCIENCES
    23. Shanmugavelu, M; Porubleva, L; Chitnis, P; Bonning, BC
      Ligand blot analysis of juvenile hormone esterase binding proteins in Manduca sexta L.

      INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
    24. Vermunt, AMW; Kamimura, M; Hirai, M; Kiuchi, M; Shiotsuki, T
      The juvenile hormone binding protein of silkworm haemolymph: gene and functional analysis

      INSECT MOLECULAR BIOLOGY
    25. Petra, PH; Adman, ET; Orr, WR; Woodcock, KT; Groff, C; Sui, LM
      Arginine-140 and isoleucine-141 determine the 17 beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma

      PROTEIN SCIENCE
    26. Tamimi, R; Mucci, LA; Spanos, E; Lagiou, A; Benetou, V; Trichopoulos, D
      Testosterone and oestradiol in relation to tobacco smoking, body mass index, energy consumption and nutrient intake among adult men

      EUROPEAN JOURNAL OF CANCER PREVENTION
    27. Friedenreich, CM
      Review of anthropometric factors and breast cancer risk

      EUROPEAN JOURNAL OF CANCER PREVENTION
    28. Lee, IM; Sesso, HD; Paffenbarger, RS
      A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States)

      CANCER CAUSES & CONTROL
    29. Verkasalo, PK; Thomas, HV; Appleby, PN; Davey, GK; Key, TJ
      Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom)

      CANCER CAUSES & CONTROL
    30. Kemmeren, JM; Algra, A; Grobbee, DE
      Effect of second and third generation oral contraceptives on lipid metabolism in the absence or presence of the factor V Leiden mutation

      JOURNAL OF INTERNAL MEDICINE
    31. Martinez-Guisasola, J; Guerrero, M; Alonso, F; Diaz, F; Cordero, J; Ferrer, J
      Plasma beta-endorphin levels in obese and non-obese patients with polycystic ovary disease

      GYNECOLOGICAL ENDOCRINOLOGY
    32. Kopp, HP; Festa, A; Krugluger, W; Schernthaner, G
      Low levels of Sex-Hormone-Binding Globulin predict insulin requirement in patients with gestational diabetes mellitus

      EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
    33. De Palo, EF; Gatti, R; Cappellin, E; Schiraldi, C; De Palo, CB; Spinella, P
      Plasma lactate, GH and GH-binding protein levels in exercise following BCAA supplementation in athletes

      AMINO ACIDS
    34. Diaz-Guerra, GM; Hawkins, F; Rapado, A; Diaz, MAR; Diaz-Curiel, M
      Hormonal and anthropometric predictors of bone mass in healthy elderly men: Major effect of sex hormone binding globulin, parathyroid hormone and body weight

      OSTEOPOROSIS INTERNATIONAL
    35. Buist, DSM; LaCroix, AZ; Barlow, WE; White, E; Weiss, NS
      Bone mineral density and breast cancer risk in postmenopausal women

      JOURNAL OF CLINICAL EPIDEMIOLOGY
    36. Iuorno, MJ; Nestler, JE
      Insulin-lowering drugs in polycystic ovary syndrome

      OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA
    37. Feng, WJ; Webb, P; Nguyen, P; Liu, XH; Li, JD; Karin, M; Kushner, PJ
      Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway

      MOLECULAR ENDOCRINOLOGY
    38. Pluijm, SMF; Visser, M; Smit, JH; Popp-Snijders, C; Roos, JC; Lips, P
      Determinants of bone mineral density in older men and women: Body composition as mediator

      JOURNAL OF BONE AND MINERAL RESEARCH
    39. Puustinen, R; Sarvilinna, N; Manninen, T; Tuohimaa, P; Ylikomi, T
      Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodies

      EUROPEAN JOURNAL OF ENDOCRINOLOGY
    40. Velasco, B; Cacicedo, L; Melian, E; Fernandez-Vazquez, G; Sanchez-Franco, F
      Sensitivity to exogenous GH and reversibility of the reduced IGF-I gene expression in aging rats

      EUROPEAN JOURNAL OF ENDOCRINOLOGY
    41. Zitzmann, M; Nieschlag, E
      Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs

      EUROPEAN JOURNAL OF ENDOCRINOLOGY
    42. Maccario, M; Tassone, F; Gauna, C; Oleandri, SE; Aimaretti, G; Procopio, M; Grottoli, S; Pflaum, CD; Strasburger, CJ; Ghigo, E
      Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH

      EUROPEAN JOURNAL OF ENDOCRINOLOGY
    43. Shameena, B; Renuka, TR; Varghese, S; Paulose, CS; Oommen, OV
      Hypothyroidism and nutritional status alter 3,5,3 '-triiodothyronine (T-3)receptors in isolated liver nuclei of Anabas testudineus (Bloch)

      ENDOCRINE RESEARCH
    44. Adkins, RM; Gelke, EL; Rowe, D; Honeycutt, RL
      Molecular phylogeny and divergence time estimates for major rodent groups:Evidence from multiple genes

      MOLECULAR BIOLOGY AND EVOLUTION
    45. De Simone, M; Verrotti, A; Iughetti, L; Palumbo, M; Farello, G; Di Cesare, E; Bernabei, R; Rosato, T; Lozzi, S; Criscione, S
      Increased visceral adipose tissue is associated with increased circulatinginsulin and decreased sex hormone binding globulin levels in massively obese adolescent girls

      JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
    46. Benvenga, S; Lapa, D; Trimarchi, F
      Re-evaluation of the thyroxine binding to human plasma lipoproteins using three techniques

      JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
    47. Puder, BA; Papka, RE
      Distribution and origin of corticotropin-releasing factor-immunoreactive axons in the female rat lumbosacral spinal cord

      JOURNAL OF NEUROSCIENCE RESEARCH
    48. Zadik, Z; Wittenberg, I; Segal, N; Altman, Y; Zung, A; Gross, V; Reifen, R
      Interrelationship between insulin, leptin and growth hormone in growth hormone-treated children

      INTERNATIONAL JOURNAL OF OBESITY
    49. Thornwall-Le Greves, M; Zhou, Q; Lagerholm, S; Huang, W; Le Greves, P; Nyberg, F
      Morphine decreases the levels of the gene transcripts of growth hormone receptor and growth hormone binding protein in the male rat hippocampus and spinal cord

      NEUROSCIENCE LETTERS
    50. Lombardo, KA; Herringa, RJ; Balachandran, JS; Hsu, DT; Bakshi, VP; Roseboom, PH; Kalin, NH
      Effects of acute and repeated restraint stress on corticotropin-releasing hormone binding protein mRNA in rat amygdala and dorsal hippocampus

      NEUROSCIENCE LETTERS
    51. Matthews, JB; Clemons, JH; Zacharewski, TR
      Reciprocal mutagenesis between human alpha(L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    52. Takagi, K; Saito, Y; Sawada, J
      Proteasome inhibitor enhances growth hormone-binding protein release

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    53. Savage, MO; Burren, CP; Blair, JC; Woods, KA; Metherell, L; Clark, AJL; Camacho-Hubner, C
      Growth hormone insensitivity: Pathophysiology, diagnosis, clinical variation and future perspectives

      HORMONE RESEARCH
    54. Clemmons, DR
      Commercial assays available for insulin-like growth factor I and their usein diagnosing growth hormone deficiency

      HORMONE RESEARCH
    55. Maliqueo, M; Sir-Petermann, T; Salazar, G; Perez-Bravo, F; Recabarren, SE; Wildt, L
      Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: metabolic aspects

      HUMAN REPRODUCTION
    56. Cibula, D; Hill, M; Fanta, M; Sindelka, G; Zivny, J
      Does obesity diminish the positive effect of oral contraceptive treatment on hyperandrogenism in women with polycystic ovarian syndrome?

      HUMAN REPRODUCTION
    57. Giacomello, E; Morali, O; Vallin, J; Thiery, JP; Broders, F
      A hormone-dependent post-translationally regulated mutant for investigating type I cadherin function

      INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
    58. Bhasin, S; Buckwalter, JG
      Testosterone supplementation in older men: a rational idea whose time has not yet come

      JOURNAL OF ANDROLOGY
    59. Hebiguchi, T; Kato, T; Yoshino, H; Mizuno, M; Takahashi, T; Fukuda, J; Tanaka, T
      Biliary atresia with hyperandrogenic amenorrhea

      PEDIATRIC SURGERY INTERNATIONAL
    60. Le Roith, D; Bondy, C; Yakar, S; Liu, JL; Butler, A
      The somatomedin hypothesis: 2001

      ENDOCRINE REVIEWS
    61. McCann, SE; Moysich, KB; Mettlin, C
      Intakes of selected nutrients and food groups and risk of ovarian cancer

      NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
    62. Roldan, B; Escobar-Morreale, HF; Barrio, R; de la Calle, H; Alonso, M; Garcia-Robles, R; Sancho, J
      Identification of the source of androgen excess in hyperandrogenic type 1 diabetic patients

      DIABETES CARE
    63. English, KM; Pugh, PJ; Parry, H; Scutt, NE; Channer, KS; Jones, TH
      Effect of cigarette smoking on levels of bioavailable testosterone in healthy men

      CLINICAL SCIENCE
    64. Wong, AST; Lui, WY; Hui, ITC; Lee, WM
      Rabbit sex hormone-binding globulin: expression in the liver and testis during postnatal development and structural characterization by truncated proteins

      INTERNATIONAL JOURNAL OF ANDROLOGY
    65. Kousteni, S; Bellido, T; Plotkin, LI; O'Brien, CA; Bodenner, DL; Han, L; Han, K; DiGregorio, GB; Katzenellenbogen, JA; Katzenellenbogen, BS; Roberson, PK; Weinstein, RS; Jilka, RL; Manolagas, SC
      Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity

      CELL
    66. Whitten, PL; Patisaul, HB
      Cross-species and interassay comparisons of phytoestrogen action

      ENVIRONMENTAL HEALTH PERSPECTIVES
    67. Becker, AJ; Uckert, S; Stief, CG; Scheller, F; Knapp, WH; Hartmann, U; Jonas, U
      Cavernous and systemic testosterone plasma levels during different penile conditions in healthy males and patients with erectile dysfunction

      UROLOGY
    68. Mohr, SC; Swamy, N; Xu, WR; Ray, R
      Why do we need a three-dimensional architecture of the ligand-binding domain of the nuclear 1 alpha,25-dihydroxyvitamin D-3 receptor?

      STEROIDS
    69. Vasudevan, N; Kow, LM; Pfaff, DW
      Early membrane estrogenic effects required for full expression of slower genomic actions in a nerve cell line

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    70. Davis, S
      Testosterone deficiency in women

      JOURNAL OF REPRODUCTIVE MEDICINE
    71. Bachmann, G
      Physiologic aspects of natural and surgical menopause

      JOURNAL OF REPRODUCTIVE MEDICINE
    72. Notelovitz, M
      Effects of estrogen/androgen therapy on bone mineral density parameters

      JOURNAL OF REPRODUCTIVE MEDICINE
    73. Goodman-Gruen, D; Kritz-Silverstein, D
      Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women

      JOURNAL OF NUTRITION
    74. van den Akker, F
      Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors

      JOURNAL OF MOLECULAR BIOLOGY
    75. McCann, JP; Mayes, JS; Hendricks, GR; Harjo, JB; Watson, GH
      Subcellular distribution and glycosylation pattern of androgen receptor from sheep omental adipose tissue

      JOURNAL OF ENDOCRINOLOGY
    76. Vermeulen, A
      Androgen replacement therapy in the aging male - A critical evaluation

      JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
    77. Miller, KK
      Androgen deficiency in women

      JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
    78. Boehmer, ALM; Brinkmann, AO; Nijman, RM; Verleun-Mooijman, MCT; de Ruiter, P; Niermeijer, MF; Drop, SLS
      Phenotypic variation in a family with partial androgen insensitivity syndrome explained by differences in 5 alpha dihydrotestosterone availability

      JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
    79. Potter, LR; Hunter, T
      Guanylyl cyclase-linked natriuretic peptide receptors: Structure and regulation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    80. Eubanks, S; Nguyen, TL; Deeb, R; Villafania, A; Alfadhli, A; Breslow, E
      Effects of diabetes insipidus mutations on neurophysin folding and function

      JOURNAL OF BIOLOGICAL CHEMISTRY
    81. Murphy, PJM; Kanelakis, KC; Galigniana, MD; Morishima, Y; Pratt, WB
      Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate

      JOURNAL OF BIOLOGICAL CHEMISTRY
    82. Gardezi, SA; Nguyen, C; Malloy, PJ; Posner, GH; Feldman, D; Peleg, S
      A rationale for treatment of hereditary vitamin D-resistant rickets with analogs of 1 alpha,25-dihydroxyvitamin D-3

      JOURNAL OF BIOLOGICAL CHEMISTRY
    83. Hainer, V; Kunesova, M; Stunkard, AJ; Parikova, J; Stich, V; Mikulova, R; Starka, L
      The within-pair resemblance in serum levels of androgens, sex-hormone binding globulin and cortisol in female obese identical twins - Effect of negative energy balance induced by very low-calorie diet

      HORMONE AND METABOLIC RESEARCH
    84. Caldwell, JD
      Evidence of sex hormone binding globulin binding sites in the medial preoptic area and hypothalamus

      HORMONE AND METABOLIC RESEARCH
    85. Thiboutot, D; Archer, DF; Lemay, A; Washenik, K; Roberts, J; Harrison, DD
      A randomized, controlled trial of a low-dose contraceptive containing 20 mu g of ethinyl estradiol and 100 mu g of levonorgestrel for acne treatment

      FERTILITY AND STERILITY
    86. Gruschke, A; Kuhl, H
      Validity of radioimmunological methods for determining free testosterone in serum

      FERTILITY AND STERILITY
    87. Slayden, SM; Moran, C; Sams, WM; Boots, LR; Azziz, R
      Hyperandrogenemia in patients presenting with acne

      FERTILITY AND STERILITY
    88. Zhu, XL; Sexton, PS; Cenedella, RJ
      Characterization of membrane steroid binding protein mRNA and protein in lens epithelial cells

      EXPERIMENTAL EYE RESEARCH
    89. Pietschmann, P; Kudlacek, S; Grisar, J; Spitzauer, S; Woloszczuk, W; Willvonseder, R; Peterlik, M
      Bone turnover markers and sex hormones in men with idiopathic osteoporosis

      EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
    90. Davey, HW; Xie, T; McLachlan, MJ; Wilkins, RJ; Waxman, DJ; Grattan, DR
      STAT5b is required for GH-induced liver Igf-I gene expression

      ENDOCRINOLOGY
    91. Issa, LL; Leong, GM; Barry, JB; Sutherland, RL; Eisman, JA
      Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin D receptor (VDR) and regulate VDR-retinoid X receptor transcriptional cross-talk

      ENDOCRINOLOGY
    92. Maamra, M; Bidlingmaier, M; Postel-Vinay, MC; Wu, Z; Strasburger, CJ; Ross, RJM
      Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors

      ENDOCRINOLOGY
    93. Boyd, RA; Zegarac, EA; Posvar, EL; Flack, MR
      Minimal androgenic activity of a new oral contraceptive containing norethindrone acetate and graduated doses of ethinyl estradiol

      CONTRACEPTION
    94. Midgley, JEM
      Direct and indirect free thyroxine assay methods: Theory and practice

      CLINICAL CHEMISTRY
    95. Jiang, T; Liu, SX; Tan, M; Huang, FX; Sun, TL; Dong, XQ; Guan, WM; Huang, LH; Zhou, FY
      The phase-shift mutation in the glucocorticoid receptor gene: potential etiologic significance of neuroendocrine mechanisms in lupus nephritis

      CLINICA CHIMICA ACTA
    96. De Palo, EF; Bassanello, M; Lancerin, F; Spinella, P; Gatti, R; D'Amico, D; Cillo, U
      GH/IGF system, cirrhosis and liver transplantation

      CLINICA CHIMICA ACTA
    97. De Palo, EF; Gatti, R; Lancerin, F; Cappellin, E; Spinella, P
      Correlations of growth hormone (GH) and insulin-like growth factor I (IGF-I): effects of exercise and abuse by athletes

      CLINICA CHIMICA ACTA
    98. Paradisi, G; Steinberg, HO; Hempfling, A; Cronin, J; Hook, G; Shepard, MK; Baron, AD
      Polycystic ovary syndrome is associated with endothelial dysfunction

      CIRCULATION
    99. Yamauchi, K; Tata, JR
      Characterization of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity

      CHEMICO-BIOLOGICAL INTERACTIONS
    100. Sharma, RK; Yadav, P; Duda, T
      Allosteric regulatory step and configuration of the ATP-binding pocket in atrial natriuretic factor receptor guanylate cyclase transduction mechanism

      CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY


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Documento generato il 28/10/20 alle ore 12:27:15