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Selective deletion of p14(ARF) exon 1 beta of the INK4a locus in oral squamous cell carcinomas of Indians
ORAL ONCOLOGY
The parkin gene S/N167 polymorphism in Australian Parkinson's disease patients and controls
PARKINSONISM & RELATED DISORDERS
A long distance-PCR derived FISH probe detects a deletion between p15 and p16 in CML and T-ALL patients
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Comprehensive allelotyping of human intrahepatic cholangiocarcinoma
CLINICAL CANCER RESEARCH
Chromosomal alterations in squamous cell carcinomas of the head and neck: Window to the biology of disease
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism
HUMAN MOLECULAR GENETICS
The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas
ONCOGENE
Evidence for further genetic heterogeneity in nephronophthisis
NEPHROLOGY DIALYSIS TRANSPLANTATION
New insights: nephronophthisis-medullary cystic kidney disease
PEDIATRIC NEPHROLOGY
Somatic INK4a-ARF locus mutations: A significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck
MOLECULAR CARCINOGENESIS
Transcript map of the 8p23 putative tumor suppressor region
GENOMICS
Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus
GENOMICS
Prognostic significance of p16(INK4a) immunocytochemistry in adult ALL with standard risk karyotype
LEUKEMIA
Deletion of chromosomal region 13q14.3 in childhood acute lymphoblastic leukemia
LEUKEMIA
Clinical and genetic studies on familial parkinsonism: The first report ona parkin gene mutation in a Taiwanese family
MOVEMENT DISORDERS
Parkin and Parkinson's: More than homonymy?
ANNALS OF NEUROLOGY
Fragile and unstable chromosomes in cancer: causes and consequences
TRENDS IN GENETICS
Identification of a 1.2 Kb cDNA fragment from a region on 9p21 commonly deleted in multiple tumor types
CANCER GENETICS AND CYTOGENETICS
Establishing an algorithm for molecular genetic diagnostics in 127 families with juvenile nephronophthisis
KIDNEY INTERNATIONAL
Pseudo-dominant inheritance and exon 2 triplication in a family with parkin gene mutations
NEUROLOGY
New mutation (RA2P) of the parkin gene in the ubiquitinlike domain associated with parkinsonism
NEUROLOGY
Frequently deleted loci on chromosome 9 may harbor several tumor suppressor genes in human renal cell carcinoma
JOURNAL OF UROLOGY
Detailed gene expression analysis but not microsatellite marker analysis of 9p21 reveals differential defects in the INK4a gene locus in the majorityof head and neck cancers
JOURNAL OF PATHOLOGY
Three parkin gene mutations in a sibship with autosomal recessive early onset parkinsonism
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Parkin is associated with cellular vesicles
JOURNAL OF NEUROCHEMISTRY
The cell cycle inhibitor p16(INK4A) sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels (vol 276, pg 10984, 2001)
JOURNAL OF BIOLOGICAL CHEMISTRY
The cell cycle inhibitor p16(INK4A) sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels
JOURNAL OF BIOLOGICAL CHEMISTRY
Overexpression of p16(ink4a) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
INTERNATIONAL JOURNAL OF CANCER
Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development
CANCER RESEARCH
p16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium
CANCER RESEARCH
Methylation of p15 and p16 genes in adult acute leukemia - Lack of prognostic significance
CANCER
In vitro drug resistance and prognostic impact of p16(INK4A)/p15(INK4B) deletions in childhood T-cell acute lymphoblastic leukaemia
BRITISH JOURNAL OF HAEMATOLOGY
Inn-eased expression of the INK4a/ARF locus in polycythemia vera
BLOOD
Altered expression of the fragile histidine triad gene in primary gastric adenocarcinomas
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas
AMERICAN JOURNAL OF PATHOLOGY
Molecular clonality of in-transit melanoma metastasis
AMERICAN JOURNAL OF PATHOLOGY
CDKN2A mutation analysis, protein expression, and deletion mapping of chromosome 9p in conventional clear-cell renal carcinomas - Evidence for a second tumor suppressor gene proximal to CDKN2A
AMERICAN JOURNAL OF PATHOLOGY
Origin of the mutations in the parkin gene in europe: Exon rearrangements are independent recurrent events, whereas point mutations may result from founder effects
AMERICAN JOURNAL OF HUMAN GENETICS
The FHIT gene in oral squamous cell carcinoma: allelic imbalance is frequent but cDNA aberrations are uncommon
ORAL ONCOLOGY
Preferentially deleted chromosome region 9p21 in large hepatocellular carcinomas
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
CDKN2A mutation and deletion status in thin and thick primary melanoma
CLINICAL CANCER RESEARCH
INK4a gene expression and methylation in primary breast cancer: Overexpression of p16(INK4a) messenger RNA is a marker of poor prognosis
CLINICAL CANCER RESEARCH
Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia
CLINICAL CANCER RESEARCH
Definition and refinement of chromosome 8p regions of loss of heterozygosity in gastric cancer
CLINICAL CANCER RESEARCH
Human acid ceramidase is overexpressed but not mutated in prostate cancer
GENES CHROMOSOMES & CANCER
Decreased expression of the INK4 family of cyclin-dependent kinase inhibitors in Wilms tumor
GENES CHROMOSOMES & CANCER
Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas
GENES CHROMOSOMES & CANCER
Alteration of the CDKN2/p16 gene is not required for HPV-positive uterine cervical cancer cell lines
INTERNATIONAL JOURNAL OF ONCOLOGY
Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
TRENDS IN BIOCHEMICAL SCIENCES
Large deletions of chromosome 9p in cutaneous malignant melanoma identify patients with a high risk of developing metastases
MELANOMA RESEARCH
Initiation-development modelling of allelic losses on chromosome 9 in multifocal bladder cancer
EUROPEAN JOURNAL OF CANCER
Regional and cellular expression of the parkin gene in the rat cerebral cortex
EUROPEAN JOURNAL OF NEUROSCIENCE
A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer
ONCOGENE
p16/MTS1/INK4A suppresses prostate cancer by both pRb dependent and independent pathways
ONCOGENE
Adenoviral vector containing wild-type p16 suppresses prostate cancer growth and prolongs survival by inducing cell senescence
CANCER GENE THERAPY
Delineation of the frequently deleted region on chromosome arm 13q in B-cell non-Hodgkin's lymphoma
INTERNATIONAL JOURNAL OF HEMATOLOGY
Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay
LEUKEMIA
De novo methylation of tumor suppressor gene p16/INK4a is a frequent finding in multiple myeloma patients at diagnosis
LEUKEMIA
Parkin gene mutations and Parkinson's disease
M S-MEDECINE SCIENCES
Autosomal recessive early-onset parkinsonism with diurnal fluctuation: clinicopathologic characteristics and molecular genetic identification
BRAIN & DEVELOPMENT
Autosomal recessive juvenile parkinsonism
BRAIN & DEVELOPMENT
Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism
ANNALS OF NEUROLOGY
Genetic influence on the development of Parkinson's disease
JOURNAL OF NEUROLOGY
The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives
CANCER LETTERS
p16(INK4) gene mutation and allelic loss of chromosome 9p21-22 in Taiwanese hepatocellular carcinoma
ANTICANCER RESEARCH
Epidemiology and biology of human urinary bladder cancer
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Cloning and distribution of the rat parkin mRNA
MOLECULAR BRAIN RESEARCH
Frequent loss of 1p32 region but no mutation if the p18 tumor suppressor gene in meningiomas
JOURNAL OF NEURO-ONCOLOGY
Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia
LEUKEMIA RESEARCH
Comparison of genetic changes in schistosome-related transitional and squamous bladder cancers using comparative genomic hybridization
CARCINOGENESIS
Diagnostic criteria for idiopathic Parkinson's disease.
REVUE NEUROLOGIQUE
Association between early-onset Parkinson's disease and mutations in the parkin gene
NEW ENGLAND JOURNAL OF MEDICINE
P18 tumor suppressor gene and progression of oligodendrogliomas to anaplasia
NEUROLOGY
Allelic loss at the D9S171 focus on chromosome 9p13 is associated with progression of papillary renal cell carcinoma
JOURNAL OF PATHOLOGY
Cloning of rat parkin cDNA and distribution of parkin in rat brain
JOURNAL OF NEUROCHEMISTRY
CDKN2A/p16 inactivation in the prognosis of oligodendrogliomas
INTERNATIONAL JOURNAL OF CANCER
Polymorphisms of the parkin gene in sporadic Parkinson's disease among Chinese in Taiwan
EUROPEAN NEUROLOGY
Deletion of p16 and p15 genes In schistosomiasis-associated bladder cancer(SABC)
CLINICA CHIMICA ACTA
Inactivation of the human fragile histidine triad gene at 3p14.2 in monochromosomal human/mouse microcell hybrid-derived severe combined immunodeficient mouse tumors
CANCER RESEARCH
Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth
CANCER RESEARCH
Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers
CANCER RESEARCH
p16 is a major inactivation target in hepatocellular carcinoma
CANCER
Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases
BRITISH JOURNAL OF CANCER
Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications
BLOOD
Expression of p16(INK4A) induces dominant suppression of glioblastoma growth in situ through necrosis and cell cycle arrest
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma
AMERICAN JOURNAL OF GASTROENTEROLOGY
Genome and neurology - The example of Parkinson's disease
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
Familial melanoma; CDKN2A and beyond
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS
Loss of FHIT expression in acute lymphoblastic leukemia
CLINICAL CANCER RESEARCH
The prognostic significance of p16(INK4a)/p14(ARF) and p15(INK4b) deletions in adult acute lymphoblastic leukemia
CLINICAL CANCER RESEARCH
Aberrant fragile histidine triad gene transcripts in primary hepatocellular carcinoma and liver cirrhosis
CLINICAL CANCER RESEARCH
Molecular genetic basis of pancreatic adenocarcinoma
GENES CHROMOSOMES & CANCER
Alternative splicing, but not allelic loss, of the FHIT gene increases with development of lung cancer
INTERNATIONAL JOURNAL OF ONCOLOGY
Interphase cytogenetic diagnosis of bladder cancer on cells from urine andbladder washing
INTERNATIONAL JOURNAL OF ONCOLOGY
Somatic genetic alterations in human malignant mesothelioma (Review)
INTERNATIONAL JOURNAL OF ONCOLOGY
Loss of heterozygosity at chromosome 9p21 (INK4-p14(ARF) locus): homozygous deletions and mutations in the p16 and p14(ARF) genes in sporadic primarymelanomas
MELANOMA RESEARCH
Multiple abnormalities of the p16(INK4a)-pRb regulatory pathway in cultured melanoma cells
MELANOMA RESEARCH
Association of codon 167 Ser/Asn heterozygosity in the parkin gene with sporadic Parkinson's disease
NEUROREPORT
High frequency of p16(INK4A) gene alterations in hepatocellular carcinoma
ONCOGENE
p16(INK4a) inactivation is not frequent in uncultured sporadic primary cutaneous melanoma
ONCOGENE