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Inhibition of repolarizing ionic currents by drugs
EUROPEAN HEART JOURNAL SUPPLEMENTS
Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs
EUROPEAN HEART JOURNAL SUPPLEMENTS
Genetic aspects in acquired long QT syndrome - a piece in the puzzle
EUROPEAN HEART JOURNAL SUPPLEMENTS
Native and cloned ion channels from human heart: laboratory models for evaluating the cardiac safety of new drugs
EUROPEAN HEART JOURNAL SUPPLEMENTS
Genetic variations in five genes involved in the excitement of cardiomyocytes
JOURNAL OF HUMAN GENETICS
Multiple single-nucleotide polymorphisms (SNPs) in the Japanese populationin six candidate genes for long QT syndrome
JOURNAL OF HUMAN GENETICS
Correlation of genetic etiology with response to beta-adrenergic blockade among symptomatic patients with familial long-QT syndrome
JOURNAL OF HUMAN GENETICS
Screening lead compounds for QT interval prolongation
DRUG DISCOVERY TODAY
Response of the QT interval to mental and physical stress in types LQT1 and LQT2 of the long QT syndrome
HEART
The long QT syndrome
EUROPACE
ERG proteins and functional cardiac I-Kr channels in rat, mouse, and humanheart
TRENDS IN CARDIOVASCULAR MEDICINE
Evidence for a single nucleotide polymorphism in the KCNQ1 potassium channel that underlies susceptibility to life-threatening arrhythmias
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
A novel long-QT 5 gene mutation in the C-terminus (V1091) is associated with a mild phenotype
JOURNAL OF MOLECULAR MEDICINE-JMM
Long QT syndrome.
ARCHIVES DE PEDIATRIE
Sympathetic stimulation produces a greater increase in both transmural andspatial dispersion of repolarization in LQT1 than LQT2 forms of congenitallong QT syndrome
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
A founder mutation of the potassium channel KCNQ1 in long QT syndrome - Implications for estimation of disease prevalence and molecular diagnostics
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
I-Ks channel blockers: potential antiarrhythmic agents
DRUGS OF THE FUTURE
On the mechanism of selective action of probucol on the inwardly rectifying potassium current in GH(3) lactotrophs
DRUG DEVELOPMENT RESEARCH
Clozapine and sudden death
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
A novel extracellular calcium sensing mechanism in voltage-gated potassiumion channels
JOURNAL OF NEUROSCIENCE
Molecular autopsy of sudden unexplained death in the young
AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY
"Janus face" of nitric oxide action on plasma membrane and intracellular ionic channels
ARCHIVES OF GERONTOLOGY AND GERIATRICS
Bradycardia-induced long QT syndrome caused by a de novo missense mutationin the S2-S3 inner loop of HERG
AMERICAN JOURNAL OF MEDICAL GENETICS
Evaluation of drug-induced QT interval prolongation - Implications for drug approval and labelling
DRUG SAFETY
Genotype and severity of long QT syndrome
DRUG METABOLISM AND DISPOSITION
Inhibition of cardiac delayed rectifier K+ currents by an antisense oligodeoxynucleotide against IsK (minK) and over-expression of IsK mutant D77N inneonatal mouse hearts
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Molecular cloning and expression of cERG, the ether a go-go-related gene from canine myocardium
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Slowing of ERG current deactivation in NG108-15 cells by the histidine-specific reagent diethylpyrocarbonate
NEUROPHARMACOLOGY
The S4-S5 linker couples voltage sensing and activation of pacemaker channels
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K+ channels
MOLECULAR PHARMACOLOGY
Inhibition of human ether-a-go-go potassium channels by cocaine
MOLECULAR PHARMACOLOGY
Re-entrant cardiac arrhythmias in computational models of long QT myocardium
JOURNAL OF THEORETICAL BIOLOGY
Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-a-gogo K+ channel
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Defective ion channel function in the long QT syndrome: Multiple unexpected mechanisms
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Characterization and subcellular localization of KCNQ1 with a heterozygousmutation in the C terminus
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
3-(4-fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonist
JOURNAL OF MEDICINAL CHEMISTRY
An amino acid residue whose change by mutation affects drug binding to theHERG channel
FEBS LETTERS
[H-3]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen
EUROPEAN JOURNAL OF PHARMACOLOGY
"Use-dependent" effects of cisapride on postrest action potentials in rabbit ventricular myocardium
EUROPEAN JOURNAL OF PHARMACOLOGY
[H-3]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?
EUROPEAN JOURNAL OF PHARMACOLOGY
Screening for mutations and polymorphisms in the genes KCNH2 and KCNE2 encoding the cardiac HERG/MiRPI ion channel: Implications for acquired and congenital long Q-T syndrome
CLINICAL CHEMISTRY
Clinical implications for affected parents and siblings of probands with long-QT syndrome
CIRCULATION
Divergent expression of delayed rectifier K+ channel subunits during mouseheart development
CARDIOVASCULAR RESEARCH
A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome
CARDIOVASCULAR RESEARCH
Transgenic mice overexpressing human KvLQT1 dominant-negative isoform PartII: Pharmacological profile
CARDIOVASCULAR RESEARCH
Inhibition of depolarization-induced [H-3]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H-1 receptor antagonists through blockade of store-operated Ca2+ channels (SOCs)
BIOCHEMICAL PHARMACOLOGY
Testosterone-mediated modulation of HERG blockade by proarrhythmic agents
BIOCHEMICAL PHARMACOLOGY
Long-term modulation of HERG channel gating in hypoxia
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The antipsychotic drugs sertindole and pimozide block erg3, a human brain K+ channel
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Inhibition of HERG potassium channel current by the Class 1a antiarrhythmic agent disopyramide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Effect of the antimalarial drug Halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A
AMERICAN JOURNAL OF CARDIOLOGY
Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population
JOURNAL OF HUMAN GENETICS
Neonatal long QT syndrome and sudden cardiac death
PROGRESS IN PEDIATRIC CARDIOLOGY
The assessment of potential for QT interval prolongation with new pharmaceuticals Impact on drug development
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Hypokalemia-induced long QT syndrome with an underlying novel missense mutation in S4-S5 linker of KCNQ1
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Long QT syndrome: Cellular basis and arrhythmia mechanism in LQT2
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Cloning and functional expression of rat eag2, a new member of the ether-a-go-go family of potassium channels and comparison of its distribution withthat of eag1
MOLECULAR AND CELLULAR NEUROSCIENCE
Cytoplasmic residues influence the voltage-dependence of the gating of human K+ channels
NEUROREPORT
erg gene(s) expression during development of the nervous and muscular system of quail embryos
MECHANISMS OF DEVELOPMENT
Molecular diagnosis and treatment of cardiovascular diseases
CANADIAN JOURNAL OF CARDIOLOGY
Mechanisms of I-Ks suppression in LQT1 mutants
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Ultrafast inactivation causes inward rectification in a voltage-gated K+ channel from Caenorhabditis elegans
JOURNAL OF NEUROSCIENCE
Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes
JOURNAL OF NEUROSCIENCE
The heart of psychotropic drug therapy
LANCET
Evaluation of the cardiac safety of second-generation antihistamines
ALLERGY
Effect of magnesium sulfate on the haloperidol-induced QT prolongation assessed in the canine in vivo model under the monitoring of monophasic actionpotential
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
Cardiac K+ channels and drug-acquired long QT syndrome
THERAPIE
QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Altered gating of HERG potassium channels by cobalt and lanthanum
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
The effect of external pH on the delayed rectifying K+ current in cardiac ventricular myocytes
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
A molecular link between the sudden infant death syndrome and the long-QT syndrome.
NEW ENGLAND JOURNAL OF MEDICINE
Channel structure and drug-induced cardiac arrhythmias
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
A structural basis for drug-induced long QT syndrome
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
A common polymorphism associated with antibiotic-induced cardiac arrhythmia
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Pharmacological blockade of ERG K+ channels and Ca2+ influx through store-operated channels exerts opposite effects on intracellular Ca2+ oscillations in pituitary GH(3) cells
MOLECULAR PHARMACOLOGY
Protein kinase C enhances the rapidly activating delayed rectifier potassium current, I-Kr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes
JOURNAL OF PHYSIOLOGY-LONDON
Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K+ channels expressed in a mammalian cell line
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Loratadine blockade of K+ channels in human heart: Comparison with terfenadine under physiological conditions
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Retention in the endoplasmic reticulum as a mechanism of dominant-negativecurrent suppression in human long QT syndrome
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Expression of distinct ERG proteins in rat, mouse, and human heart - Relation to functional I-Kr channels
JOURNAL OF BIOLOGICAL CHEMISTRY
Functional coupling of human beta(3)-adrenoreceptors to the KvLQT1/MinK potassium channel
JOURNAL OF BIOLOGICAL CHEMISTRY
Drug-induced torsade de pointes: From molecular biology to bedside
JAPANESE JOURNAL OF PHARMACOLOGY
Identical twins with long QT syndrome associated with a missense mutation in the S4 region of the HERG
JAPANESE HEART JOURNAL
Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation
FEBS LETTERS
Pharmacogenetics of cardiac K+ channels
EUROPEAN JOURNAL OF PHARMACOLOGY
Effects of fluoroquinolones on HERG currents
EUROPEAN JOURNAL OF PHARMACOLOGY
High affinity blockade of the HERG cardiac K+ channel by the neuroleptic pimozide
EUROPEAN JOURNAL OF PHARMACOLOGY
Long QT syndrome with a high mortality rate caused by a novel G572R missense mutation in KCNH2
CLINICAL GENETICS
Probing the interaction between inactivation gating and D-sotalol block ofHERG
CIRCULATION RESEARCH
LQT2 - Amplitude reduction and loss of selectivity in the tail that wags the HERG channel
CIRCULATION RESEARCH
Effects of a K+ channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of thelong-QT syndrome
CIRCULATION
Delayed rectifier K currents have reduced amplitudes and altered kinetics in myocytes from infarcted canine ventricle
CARDIOVASCULAR RESEARCH
Inhibition of HERG potassium channels by the antimalarial agent halofantrine
BRITISH JOURNAL OF PHARMACOLOGY
Mechanism of terfenadine block of ATP-sensitive K+ channels
BRITISH JOURNAL OF PHARMACOLOGY
Blockade of the HERG human cardiac K+ channel by the antidepressant drug amitriptyline
BRITISH JOURNAL OF PHARMACOLOGY