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La ricerca find articoli where soggetti phrase all words 'HEREGULIN' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 242 riferimenti
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    1. Gullick, WJ
      The Type 1 growth factor receptors and their ligands considered as a complex system

      ENDOCRINE-RELATED CANCER
    2. Guerra-Vladusic, FK; Vladusic, EA; Tsai, MS; Lupu, R
      Signaling molecules implicated in heregulin induction of growth arrest andapoptosis

      ONCOLOGY REPORTS
    3. Raj, EH; Skinner, A; Mahji, U; Nirmala, KN; Ravichandran, K; Shanta, V; Hurst, HC; Gullick, WJ; Rajkumar, T
      Neuregulin 1-alpha expression in locally advanced breast cancer

      BREAST
    4. Le, XF; Marcelli, M; McWatters, A; Nan, BC; Mills, GB; O'Brian, CA; Bast, RC
      Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity

      ONCOGENE
    5. Yao, J; Xiong, SB; Klos, K; Nguyen, N; Grijalva, R; Li, P; Yu, D
      Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta 1 in human breast cancer cells

      ONCOGENE
    6. Azios, NG; Romero, FJ; Denton, MC; Doherty, JK; Clinton, GM
      Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor

      ONCOGENE
    7. Berquin, IM; Dziubinski, ML; Nolan, GP; Ethier, SP
      A functional screen for genes inducing epidermal growth factor autonomy ofhuman mammary epithelial cells confirms the role of amphiregulin

      ONCOGENE
    8. Zhou, WL; Carpenter, G
      Heregulin-dependent translocation and hyperphosphorylation of ErbB-2

      ONCOGENE
    9. Bacus, SS; Gudkov, AV; Lowe, M; Lyass, L; Yung, Y; Komarov, AP; Keyomarsi, K; Yarden, Y; Seger, R
      Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53

      ONCOGENE
    10. Belsches-Jablonski, AP; Biscardi, JS; Peavy, DR; Tice, DA; Romney, DA; Parsons, SJ
      Src family kinases and HER2 interactions in human breast cancer cell growth and survival

      ONCOGENE
    11. Srinivasan, R; Leverton, KE; Sheldon, H; Hurst, HC; Sarraf, C; Gullick, WJ
      Intracellular expression of the truncated extracellular domain of c-erbB-3/HER3

      CELLULAR SIGNALLING
    12. Meintanis, S; Thomaidou, D; Jessen, KR; Mirsky, R; Matsas, R
      The neuron-glia signal beta-neuregulin promotes Schwann cell motility via the MAPK pathway

      GLIA
    13. Goodearl, A; Viehover, A; Vartanian, T
      Neuregulin-induced association of SOS Ras exchange protein with HER2(erhB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erb62) interaction

      DEVELOPMENTAL NEUROSCIENCE
    14. Lessor, TJ; Hamburger, AW
      Regulation of the ErbB3 binding protein Ebp1 by protein kinase C

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    15. Carter, WB
      HER2 signaling-induced microvessel dismantling

      SURGERY
    16. Sapru, MK
      Neuregulin-1 regulates expression of the Ets-2 transcription factor

      LIFE SCIENCES
    17. Ma, L; de Roquancourt, A; Bertheau, P; Chevret, S; Millot, G; Sastre-Garau, X; Espie, M; Marty, M; Janin, A; Calvo, F
      Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions

      JOURNAL OF PATHOLOGY
    18. Krainock, R; Murphy, S
      Regulation of functional nitric oxide synthase-1 expression in cerebellar granule neurons by heregulin is post-transcriptional, and involves mitogen-activated protein kinase

      JOURNAL OF NEUROCHEMISTRY
    19. Krainock, R; Murphy, S
      Heregulin upregulates the expression of nitric oxide synthase (NOS)-1 in rat cerebellar granule neurons via the ErbB4 receptor

      JOURNAL OF NEUROCHEMISTRY
    20. Gerecke, KM; Wyss, JM; Karavanova, I; Buonanno, A; Carroll, SL
      ErbB transmembrane tyrosine kinase receptors are differentially expressed throughout the adult rat central nervous system

      JOURNAL OF COMPARATIVE NEUROLOGY
    21. Xia, XM; Cheng, AW; Lessor, T; Zhang, YX; Hamburger, AW
      Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation

      JOURNAL OF CELLULAR PHYSIOLOGY
    22. Aguilar, Z; Slamon, DJ
      The transmembrane heregulin precursor is functionally active

      JOURNAL OF BIOLOGICAL CHEMISTRY
    23. Carter, WB; Hoying, JB; Boswell, C; Williams, SK
      HER2/neu over-expression induces endothelial cell retraction

      INTERNATIONAL JOURNAL OF CANCER
    24. Mann, M; Sheng, HM; Shao, JY; Williams, CS; Pisacane, PI; Sliwkowski, MX; DuBois, RN
      Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth

      GASTROENTEROLOGY
    25. Altiok, N; Changeux, JP
      Electrical activity regulates AChR gene expression via JNK, PKC zeta and Sp1 in skeletal chick muscle

      FEBS LETTERS
    26. Olayioye, MA; Badache, A; Daly, JM; Hynes, NE
      An essential role for Src kinase in ErbB receptor signaling through the MAPK pathway

      EXPERIMENTAL CELL RESEARCH
    27. Gilmour, LMR; Macleod, KG; McCaig, A; Gullick, WJ; Smyth, JF; Langdon, SP
      Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer

      CANCER RESEARCH
    28. Xiong, SB; Grijalva, R; Zhang, LL; Nguyen, NT; Pisters, PW; Pollock, RE; Yu, DH
      Up regulation of vascular endothelial growth factor in breast cancer cellsby the heregulin-beta 1-activated p38 signaling pathway enhances endothelial cell migration

      CANCER RESEARCH
    29. Xia, XM; Lessor, TJ; Zhang, YX; Woodford, N; Hamburger, AW
      Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    30. Egeblad, M; Mortensen, OH; van Kempen, LCLT; Jaattela, M
      BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    31. Zvibel, I; Mintz, Y; Brill, S; Halpern, Z; Papa, M
      The role of the liver environment in the regulation of colon cancer metastasis

      ISRAEL MEDICAL ASSOCIATION JOURNAL
    32. Zamborelli, TJ; Dodson, WS; Harding, BJ; Zhang, J; Bennett, BD; Lenz, DM; Young, Y; Haniu, M; Liu, CF; Jones, T; Jarosinski, MA
      A comparison of folding techniques in the chemical synthesis of the epidermal growth factor-like domain in neu differentiation factor alpha/beta

      JOURNAL OF PEPTIDE RESEARCH
    33. Dunbar, AJ; Goddard, C
      Structure-function and biological role of betacellulin

      INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
    34. Keir, M; Fiddes, R; Biggs, JC; Kearney, PP
      Sensitivity of c-erbB positive cells to a ligand toxin and its utility in purging breast cancer cells from peripheral blood stem cell (PBSC) collections

      STEM CELLS
    35. Patel, NV; Acarregui, MJ; Snyder, JM; Klein, JM; Sliwkowski, MX; Kern, JA
      Neuregulin-1 and human epidermal growth factor receptors 2 and 3 play a role in human lung development in vitro

      AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
    36. Chun, MH
      Serum signaling factors and spheroids

      CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
    37. Hijazi, MM; Thompson, EW; Tang, C; Coopman, P; Torri, JA; Yang, DJ; Mueller, SC; Lupu, R
      Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines

      INTERNATIONAL JOURNAL OF ONCOLOGY
    38. Baeckstrom, D; Alford, D; Taylor-Papadimitriou, J
      Morphogenetic and proliferative responses to heregulin of mammary epithelial cells in vitro are dependent on HER2 and HER3 and differ from the responses to HER2 homodimerisation or hepatocyte growth factor

      INTERNATIONAL JOURNAL OF ONCOLOGY
    39. Adelaide, J; Chaffanet, M; Mozziconacci, MJ; Popovici, C; Conte, N; Fernandez, F; Sobol, H; Jacquemier, J; Pebusque, MJ; Ron, D; Lafage-Pochitaloff, M; Birnbaum, D
      Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line

      INTERNATIONAL JOURNAL OF ONCOLOGY
    40. Oka, N; Kawasaki, T; Matsui, M; Tachibana, H; Sugita, M; Akiguchi, I
      Neuregulin is associated with nerve regeneration in axonal neuropathies

      NEUROREPORT
    41. Keilhoff, G; Fansa, H; Smalla, KH; Schneider, W; Wolf, G
      Neuroma: a donor-age independent source of human Schwann cells for tissue engineered nerve grafts

      NEUROREPORT
    42. Lim, SJ; Lopez-Berestein, G; Hung, MC; Lupu, R; Tari, AM
      Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells

      ONCOGENE
    43. Harari, D; Yarden, Y
      Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

      ONCOGENE
    44. Castagnino, P; Lorenzi, MV; Yeh, J; Breckenridge, D; Sakata, H; Munz, B; Werner, S; Bottaro, DP
      Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors

      ONCOGENE
    45. Baeckstrom, D; Lu, PJ; Taylor-Papadimitriou, J
      Activation of the alpha(2)beta(1) integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen

      ONCOGENE
    46. Yen, L; You, XL; Al Moustafa, AE; Batist, G; Hynes, NE; Mader, S; Meloche, S; Alaoui-Jamali, MA
      Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis

      ONCOGENE
    47. Deadwyler, GD; Pouly, S; Antel, JP; Devries, GH
      Neuregulins and ErbB receptor expression in adult human oligodendrocytes

      GLIA
    48. Medina-Kauwe, LK; Leung, V; Wu, L; Kedes, L
      Assessing the binding and endocytosis activity of cellular receptors usingGFP-ligand fusions

      BIOTECHNIQUES
    49. Kirschbaum, MH; Yarden, Y
      The ErbB/HER family of receptor tyrosine kinases: A potential target for chemoprevention of epithelial neoplasms

      JOURNAL OF CELLULAR BIOCHEMISTRY
    50. Kornblum, HI; Yanni, DS; Easterday, MC; Seroogy, KB
      Expression of the EGF receptor family members ErbB2, ErbB3, and ErbB4 in germinal zones of the developing brain and in neurosphere cultures containing CNS stem cells

      DEVELOPMENTAL NEUROSCIENCE
    51. Thompson, RJ; Roberts, B; Alexander, CL; Williams, SK; Barnett, SC
      Comparison of neuregulin-1 expression in olfactory ensheathing cells, schwann cells and astrocytes

      JOURNAL OF NEUROSCIENCE RESEARCH
    52. Luo, J; Miller, MW
      Ethanol enhances erbB-mediated migration of human breast cancer cells in culture

      BREAST CANCER RESEARCH AND TREATMENT
    53. Gerlai, R; Pisacane, P; Erickson, S
      Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks

      BEHAVIOURAL BRAIN RESEARCH
    54. Kumar, R; Mandal, M; Vadlamudi, R
      New insights into anti-HER-2 receptor monoclonal antibody research

      SEMINARS IN ONCOLOGY
    55. Pegram, M; Slamon, D
      Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapy

      SEMINARS IN ONCOLOGY
    56. Carter, WB; Ward, MD
      HER2 regulatory control of angiopoietin-2 in breast cancer

      SURGERY
    57. Lin, WC; Sanchez, HB; Deerinck, T; Morris, JK; Ellisman, M; Lee, KF
      Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    58. Vaskovsky, A; Lupowitz, Z; Erlich, S; Pinkas-Kramarski, R
      ErbB-4 activation promotes neurite outgrowth in PC12 cells

      JOURNAL OF NEUROCHEMISTRY
    59. Wang, LS; Marchionni, MA; Tassava, RA
      Cloning and neuronal expression of a type III newt neuregulin and rescue of denervated, nerve-dependent newt limb blastemas by rhGGF2

      JOURNAL OF NEUROBIOLOGY
    60. Rio, C; Buxbaum, JD; Peschon, JJ; Corfas, G
      Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

      JOURNAL OF BIOLOGICAL CHEMISTRY
    61. Srinivasan, R; Gillett, CE; Barnes, DM; Gullick, WJ
      Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers

      CANCER RESEARCH
    62. Tsai, MS; Hornby, AE; Lakins, J; Lupu, R
      Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies

      CANCER RESEARCH
    63. Weinstein, EJ; Leder, P
      The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis

      CANCER RESEARCH
    64. Kew, TY; Bell, JA; Pinder, SE; Denley, H; Srinivasan, R; Gullick, WJ; Nicholson, RI; Blamey, RW; Ellis, IO
      c-erbB-4 protein expression in human breast cancer

      BRITISH JOURNAL OF CANCER
    65. Yoo, JY; Wang, XW; Rishi, AK; Lessor, T; Xia, XM; Gustafson, TA; Hamburger, AW
      Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of thisbinding by heregulin

      BRITISH JOURNAL OF CANCER
    66. Srinivasan, R; Benton, E; McCormick, F; Thomas, H; Gullick, WJ
      Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer

      CLINICAL CANCER RESEARCH
    67. Krymskaya, VP; Hoffman, R; Eszterhas, A; Kane, S; Ciocca, V; Panettieri, RA
      EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in humanairway smooth muscle cells

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    68. Guerra-Vladusic, FK; Scott, G; Weaver, V; Vladusic, EA; Tsai, MS; Benz, CC; Lupu, R
      Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3

      INTERNATIONAL JOURNAL OF ONCOLOGY
    69. Pegues, JC; Kannan, B; Stromberg, K
      ErbB receptor expression and growth response to heregulin beta 1 in five ovarian carcinoma lines

      INTERNATIONAL JOURNAL OF ONCOLOGY
    70. Lichtner, RB; Parczyk, K; Birchmeier, W; Schneider, MR
      Differential cross-talk of estrogen and growth factor receptors in two human mammary tumor cell lines

      JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
    71. Vadlamudi, R; Adam, L; Talukder, A; Mendelsohn, J; Kumar, R
      Serine phosphorylation of paxillin by heregulin-beta 1: role of p38 mitogen activated protein kinase

      ONCOGENE
    72. Liu, XF; Baker, E; Eyre, HJ; Sutherland, GR; Zhou, MD
      gamma-Heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation

      ONCOGENE
    73. Balana, ME; Lupu, R; Labriola, L; Charreau, EH; Elizalde, PV
      Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas

      ONCOGENE
    74. Aguilar, Z; Akita, RW; Finn, RS; Ramos, BL; Pegram, MD; Kabbinavar, FF; Pietras, RJ; Pisacane, P; Sliwkowski, MX; Slamon, DJ
      Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells

      ONCOGENE
    75. Harari, D; Tzahar, E; Romano, J; Shelly, M; Pierce, JH; Andrews, GC; Yarden, Y
      Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase

      ONCOGENE
    76. Ugolini, F; Adelaide, J; Charafe-Jauffret, E; Nguyen, C; Jacquemier, J; Jordan, B; Birnbaum, D; Pebusque, MJ
      Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes

      ONCOGENE
    77. Kern, JA; Wakita, R; Sliwkowski, MX
      Neuregulin receptor-mediated gene transfer by human epidermal growth factor receptor 2-targeted antibodies and neuregulin-1

      CANCER GENE THERAPY
    78. Castellino, AM; Chao, MV
      Differential association of phosphatidylinositol-5-phosphate 4-kinase withthe EGF/ErbB family of receptors

      CELLULAR SIGNALLING
    79. Daly, RJ
      Take your partners, please - Signal diversification by the erbB family of receptor tyrosine kinases

      GROWTH FACTORS
    80. Osheroff, PL; Tsai, SP; Chiang, NY; King, KL; Li, RH; Lewis, GD; Wong, K; Henzel, W; Mather, J
      Receptor binding and biological activity of mammalian expressed sensory and motor neuron-derived factor (SMDF)

      GROWTH FACTORS
    81. Campiglio, M; Ali, S; Knyazev, PG; Ullrich, A
      Characteristics of EGFR family-mediated HRG signals in human ovarian cancer

      JOURNAL OF CELLULAR BIOCHEMISTRY
    82. Fernandes, AM; Hamburger, AW; Gerwin, BI
      Production of epidermal growth factor related ligands in tumorigenic and benign human lung epithelial cells

      CANCER LETTERS
    83. Landgraf, R; Fischer, D; Eisenberg, D
      Analysis of heregulin symmetry by weighted evolutionary tracing

      PROTEIN ENGINEERING
    84. O-charoenrat, P; Rhys-Evans, P; Court, WJ; Box, GM; Eccles, SA
      Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands

      CLINICAL & EXPERIMENTAL METASTASIS
    85. Waterman, H; Alroy, I; Strano, S; Seger, R; Yarden, Y
      The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing

      EMBO JOURNAL
    86. Al Moustafa, AE; Alaoui-Jamali, M; Paterson, J; O'Connor-McCourt, M
      Expression of P185erbB-2, P160erbB-3, P180erbB-4, and heregulin alpha in human normal bronchial epithelial and lung cancer cell lines

      ANTICANCER RESEARCH
    87. Hines, SJ; Litz, JS; Krystal, GW
      Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors

      BREAST CANCER RESEARCH AND TREATMENT
    88. Cannella, B; Pitt, D; Marchionni, M; Raine, CS
      Neuregulin and erbB receptor expression in normal and diseased human whitematter

      JOURNAL OF NEUROIMMUNOLOGY
    89. Chang, JL; Tsao, YP; Liu, DW; Han, CP; Lee, WH; Chen, SL
      The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix

      GYNECOLOGIC ONCOLOGY
    90. Nagy, P; Jenei, A; Kirsch, AK; Szollosi, J; Damjanovich, S; Jovin, TM
      Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy

      JOURNAL OF CELL SCIENCE
    91. Carraway, KL; Rossi, EA; Komatsu, M; Price-Schiavi, SA; Huang, DM; Guy, PM; Carvajal, ME; Fregien, N; Carraway, CAC; Carraway, KL
      An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling

      JOURNAL OF BIOLOGICAL CHEMISTRY
    92. Keely, SJ; Barrett, KE
      ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloridesecretion in colonic epithelial cells

      JOURNAL OF BIOLOGICAL CHEMISTRY
    93. Kim, DG; Chi, SS; Lee, KH; Rhee, SY; Kwon, YH; Chung, CH; Kwon, HM; Kang, MS
      Neuregulin stimulates myogenic differentiation in an autocrine manner

      JOURNAL OF BIOLOGICAL CHEMISTRY
    94. Schaefer, G; Akita, RW; Sliwkowski, MX
      A discrete three-amino acid segment (LVI) at the C-terminal end of kinase-impaired ErbB3 is required for transactivation of ErbB2

      JOURNAL OF BIOLOGICAL CHEMISTRY
    95. Harris, RA; Eichholtz, TJ; Hiles, ID; Page, MJ; O'Hare, MJ
      New model of ErbB-2 over-expression in human mammary luminal epithelial cells

      INTERNATIONAL JOURNAL OF CANCER
    96. Jones, JT; Akita, RW; Sliwkowski, MX
      Binding specificities and affinities of egf domains for ErbB receptors

      FEBS LETTERS
    97. Lopez, TJ; De Vries, GH
      Isolation and serum-free culture of primary Schwann cells from human fetalperipheral nerve

      EXPERIMENTAL NEUROLOGY
    98. Ignatoski, KMW; Lapointe, AJ; Radany, EH; Ethier, SP
      erbB-2 overexpression in human mammary epithelial cells confers growth factor independence

      ENDOCRINOLOGY
    99. Toyoda-Ohno, H; Obinata, M; Matsui, Y
      Members of the ErbB receptor tyrosine kinases are involved in germ cell development in fetal mouse gonads

      DEVELOPMENTAL BIOLOGY
    100. Tang, CK; Concepcion, XZW; Milan, M; Gong, XQ; Montgomery, E; Lippman, ME
      Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo

      CANCER RESEARCH


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Documento generato il 25/10/20 alle ore 02:28:43