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The chemical biology of Ras lipidation
BIOLOGICAL CHEMISTRY
Role of inducible heat shock protein 70 in radiation-induced cell death
CELL STRESS & CHAPERONES
Dimerization of small GTPase Rab5
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Ras inhibitors and radiation therapy
SEMINARS IN RADIATION ONCOLOGY
Genetic dissection of melanoma pathways in the mouse
SEMINARS IN CANCER BIOLOGY
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer
ONCOLOGY REPORTS
Radiosensitization in sarcoma cell lines with a p53 missense mutation correlates with prevention of irradiation G2/M arrest but not with induction ofapoptosis
ONCOLOGY REPORTS
Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice
ONCOLOGY REPORTS
The Ras-Byr2RBD complex: Structural basis for Ras effector recognition in yeast
STRUCTURE
Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene
ONCOGENE
Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: Cleavage of the common alpha subunit during apoptosis
ONCOGENE
Modulation in vitro of H-ras oncogene expression by trans-splicing
ONCOGENE
Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation, migration and resistance to TNF-alpha
ONCOGENE
Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis
ONCOGENE
Radiation sclerosing proliferative atypical nephropathy of peritumoral tissue of renal-cell carcinomas after the Chernobyl accident in Ukraine
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
Non-peptidic prenyltransferase inhibitors: Diverse structural classes and surprising anti-cancer mechanisms
CURRENT MEDICINAL CHEMISTRY
Comparative analysis of ras proto-oncogene mutations in selected mammaliantumors
MOLECULAR CARCINOGENESIS
H-ras oncogene mutation in dedifferentiated chondrosarcoma: Polymerase chain reaction-restriction fragment length polymorphism analysis
MODERN PATHOLOGY
Mutagenesis by O-6-methyl-, O-6-ethyl-, and O-6-benzylguanine and O-4-methylthymine in human cells: Effects of O-6-alkylguanine-DNA alkyltransferase and mismatch repair
CHEMICAL RESEARCH IN TOXICOLOGY
Revisiting the structural flexibility of the complex p21(ras)-GTP: The catalytic conformation of the molecular switch II
PROTEINS-STRUCTURE FUNCTION AND GENETICS
Nuclear ras: Unexpected subcellular distribution of oncogenic forms
JOURNAL OF CELLULAR BIOCHEMISTRY
S-adenosytmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression
JOURNAL OF CELLULAR BIOCHEMISTRY
n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
CANCER LETTERS
Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells
MOLECULAR AND CELLULAR BIOCHEMISTRY
Activation of the Ral and phosphatidylinositol 3 ' kinase signaling pathways by the ras-related protein TC21
MOLECULAR AND CELLULAR BIOLOGY
Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons
JOURNAL OF NEUROSCIENCE
Cloning and characterization of a fourth human lysyl oxidase isoenzyme
BIOCHEMICAL JOURNAL
Farnesyltransferase inhibitors define a role for RhoB in controlling neoplastic pathophysiology
HISTOLOGY AND HISTOPATHOLOGY
Cloning, sequence analysis, and characterization of the 'lysyl oxidase' from Pichia pastoris
JOURNAL OF INORGANIC BIOCHEMISTRY
Modulatory effects of neonatal exposure to TCDD, or a mixture of PCBs, p,p'-DDT, and p-p '-DDE, on methylnitrosourea-induced mammary tumor development in the rat
ENVIRONMENTAL HEALTH PERSPECTIVES
Caveolin and Ras function
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT G
Ras regulation of radioresistance in cell culture
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT G
Ras and Rap1 interaction with AF-6 effector target
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT F, RAS FAMILY I
H-, K-, and N-ras gene mutation in atypical fibroxanthoma and malignant fibrous histiocytoma
HUMAN PATHOLOGY
Dynamic properties of the Ras switch I region and its importance for binding to effectors
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
The role of chemokines and adhesion molecules in the pathogenesis of rheumatoid arthritis
DRUGS OF TODAY
Impact of garlic organosulfides on p21(H-ras) processing
JOURNAL OF NUTRITION
Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor
JOURNAL OF CELLULAR PHYSIOLOGY
Compartmentalization of Ras proteins
JOURNAL OF CELL SCIENCE
Analysis of R-Ras signalling pathways
JOURNAL OF CELL SCIENCE
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation
JOURNAL OF CELL BIOLOGY
Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism
JOURNAL OF CELL BIOLOGY
Oncogenic Ras-induced proliferation requires autocrine fibroblast growth factor 2 signaling in skeletal muscle cells
JOURNAL OF CELL BIOLOGY
Down-regulation of lysyl oxidase-induced tumorigenic transformation in NRK-49F cells characterized by constitutive activation of Ras proto-oncogene
JOURNAL OF BIOLOGICAL CHEMISTRY
The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
gamma-phosphate protonation and pH-dependent unfolding of the Ras center dot GTP center dot Mg2+ complex - A vibrational spectroscopy study
JOURNAL OF BIOLOGICAL CHEMISTRY
Adenovirus-mediated gene therapy for bladder cancer in an orthotopic modelusing a dominant negative H-ras mutant
INTERNATIONAL JOURNAL OF CANCER
Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of human farnesyltransferase, BIM-46228
INTERNATIONAL JOURNAL OF CANCER
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis
GASTROENTEROLOGY
A role for chromosomal instability in the development of and selection forradioresistant cell variants
BRITISH JOURNAL OF CANCER
Metastatic MHC class I-negative mouse cells derived by transformation withhuman papillomavirus type 16
BRITISH JOURNAL OF CANCER
Molecular dynamics simulations of Gly-12 -> Val mutant of p21(ras): Dynamic inhibition mechanism
BIOPHYSICAL JOURNAL
Effect of sequence context on O-6-methylguanine repair and replication in vivo
BIOCHEMISTRY
A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release
BIOCHEMISTRY
DnaA protein Lys-415 is close to the ATP-binding site: ATP-pyridoxal affinity labeling
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
H-ras oncogene mutation in dedifferentiated liposarcoma - Polymerase chainreaction-restriction fragment length polymorphism analysis
AJCP. American journal of clinical pathology
Expression of extracellular matrix genes: Transforming growth factor (TGF)-beta 1 and ras in tibial fracture healing of lathyritic rats
BONE
Linking the fields - The interplay of organic synthesis, biophysical chemistry, and cell biology in the chemical biology of protein lipidation
CHEMBIOCHEM
Evidence that error-prone DNA repair converts dibenzo[a, l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
DNA repair: counteragent in mutagenesis and carcinogenesis - accomplice incancer therapy resistance
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Molecular pathogenesis of oral squamous carcinoma
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Radiosensitivity of tumor cells - Oncogenes and apoptosis
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
H-ras-1 point mutation in malignant peripheral nerve sheath tumors: Polymerase chain reaction restriction fragment length polymorphism analysis and direct sequencing from paraffin-embedded tissues
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Correlation between Bcl-2 overexpression and H-ras mutation in naturally occurring hepatocellular proliferative lesions of the B6C3F1 mouse
TOXICOLOGICAL SCIENCES
Cyclooxygenase-2 expression is up-regulated in transitional cell carcinomaand its preneoplastic lesions in the human urinary bladder
CLINICAL CANCER RESEARCH
Lovastatin potentiates antitumor activity and attenuates cardiotoxicity ofdoxorubicin in three tumor models in mice
CLINICAL CANCER RESEARCH
BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer - An immunohistochemical study
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms
MOLECULAR BIOLOGY OF THE CELL
Promoter demethylation accompanies reactivation of the HOXII proto-oncogene in leukemia
GENES CHROMOSOMES & CANCER
Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
The influence of the oncogene N-ras on cell cycle delay in a human melanoma cell line with reduced radioresistance
ONCOLOGY REPORTS
Mutation profile of the p53, fhit, p16(INK4a)/p19(ARF) and H-ras genes in Indian breast carcinomas
INTERNATIONAL JOURNAL OF ONCOLOGY
Structural changes induced in p21(Ras) upon GAP-334 complexation as probedby ESEEM spectroscopy and molecular-dynamics simulation
STRUCTURE
Ras-induced cellular events (review)
MOLECULAR MEMBRANE BIOLOGY
Role of the switch II region in the conformational transition of activation of Ha-ras-p21
PROTEIN SCIENCE
A step toward the prediction of the fluorescence lifetimes of tryptophan residues in proteins based on structural and spectral data
PROTEIN SCIENCE
Cisplatin resistance and oncogene - a review
ANTI-CANCER DRUGS
DNA as an important target in radiation-induced apoptosis of MYC and MTC plus RAS transfected rat embryo fibroblasts
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects
CURRENT OPINION IN CELL BIOLOGY
Positive regulation of skeletal myogenesis by R-Ras
ONCOGENE
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
ONCOGENE
Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta
ONCOGENE
Oncogenic insertional mutations in the P-loop of Ras are overactive in MAPkinase signaling
ONCOGENE
Human breast carcinoma desmoplasia is PDGF initiated
ONCOGENE
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis
ONCOGENE
Analysis of the local conformation of proteins with two-dimensional fluorescence techniques
APPLIED PHYSICS B-LASERS AND OPTICS
Structure of the nucleotide-binding domain of Plasmodium falciparum Rab6 in the GDP-bound form
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Molecular abnormalities of p53, MDM2, and H-ras in synovial sarcoma
MODERN PATHOLOGY
Cell death beyond apoptosis
LEUKEMIA
Overexpression of c-H-ras p21 is correlated with vascular endothelial growth factor expression and neovascularization in advanced gastric carcinoma
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Oral premalignancies and squamous cell carcinoma
CLINICS IN DERMATOLOGY
Protein kinases as therapeutic targets
PHARMACEUTICAL RESEARCH
Metabolic activation capacity of neonatal mice in relation to the neonatalmouse tumorigenicity bioassay
DRUG METABOLISM REVIEWS
The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication
NUCLEIC ACIDS RESEARCH
Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype
CANCER LETTERS
Suppressive effects of dominant negative ras mutant N116Y on transformed phenotypes of human bladder cancer cells
CANCER LETTERS
Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation
JOURNAL OF NEUROSCIENCE
Enhancement of proliferation and differentiation of erythroid progenitors by co-transduction of erythropoietin receptor and H-ras cDNAs into single CD34(3+) cord blood cells
BONE MARROW TRANSPLANTATION