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Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I
INTERNATIONAL IMMUNOPHARMACOLOGY
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis
RHEUMATOLOGY
Substrate phage as a tool to identify novel substrate sequences of proteases
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction
MOLECULAR HUMAN REPRODUCTION
Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes
APOPTOSIS
Control of murine cytomegalovirus replication in salivary glands during acute infection is independent of the Fas ligand/Fas system
MICROBIOLOGICA
C/EBP beta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival
MOLECULAR CELL
The T cell death knell: Immune-mediated tumor death in renal cell carcinoma
CLINICAL CANCER RESEARCH
Caspase activity is involved in, but is dispensable for, early motoneuron death in the chick embryo cervical spinal cord
MOLECULAR AND CELLULAR NEUROSCIENCE
Tissue eosinophilia in relation to immunopathological and clinical characteristics in Hodgkin's disease
LEUKEMIA & LYMPHOMA
Familial hemophagocytic lymphohistiocytosis: Too little cell death can seriously damage your health
LEUKEMIA & LYMPHOMA
Natural killer cells and the syndrome of chronic natural killer cell lymphocytosis
LEUKEMIA & LYMPHOMA
Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Granzyme-B-containing lymphocyte involvement in epidermal injury in graft-versus-host disease
DERMATOLOGY
Pathogenesis of drug-induced exanthema
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Apoptosis in the absence of caspase 3
ONCOGENE
Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms
ONCOGENE
Comparative ultrastructural study of cytotoxic granules in nasal natural killer cell lymphoma, intestinal T-cell lymphoma, and anaplastic large cell lymphoma
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
Pregnancy-associated cytotoxic lymphoma: A report of 4 cases
INTERNATIONAL JOURNAL OF HEMATOLOGY
In vitro prevention of cell-mediated xenograft rejection via the Fas/FasL-pathway in CrmA-transducted porcine kidney cells
XENOTRANSPLANTATION
Monoclonal antibodies derived from BALB/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens
JOURNAL OF AUTOIMMUNITY
A unique downstream estrogen responsive unit mediates estrogen induction of proteinase inhibitor-9, a cellular inhibitor of IL-1 beta-converting enzyme (caspase 1)
MOLECULAR ENDOCRINOLOGY
Percentage of activated cytotoxic T-lymphocytes in anaplastic large cell lymphoma and Hodgkin's disease: an independent biological prognostic marker
LEUKEMIA
Remodeling of the actin cytoskeleton of target hepatocytes and NK cells during induction of apoptosis
CELL MOTILITY AND THE CYTOSKELETON
Virulence of mousepox virus is independent of serpin-mediated control of cellular cytotoxicity
VIRAL IMMUNOLOGY
Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34(cdc2) kinase: Fas dependentkilling of cells arrested in the cell cycle
IMMUNOLOGY AND CELL BIOLOGY
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
Phosphatidylinositol 3-kinase inhibitors prevent mouse cytotoxic T-cell development in vitro
JOURNAL OF LEUKOCYTE BIOLOGY
Interleukin-12 can replace CD28-dependent T-cell costimulation during nonspecific cytotoxic T lymphocyte induction by anti-CD3 antibody
JOURNAL OF LEUKOCYTE BIOLOGY
CD8+T cells in cutaneous T-cell lymphoma: Expression of cytotoxic proteins, Fas ligand, and killing inhibitory receptors and their relationship with clinical behavior
JOURNAL OF CLINICAL ONCOLOGY
Expression of CD40 and apoptosis, related molecules in autoimmune thyroid diseases
YONSEI MEDICAL JOURNAL
Granzyme B and TIA-1 expression in chronic and acute on chronic renal allograft rejection
YONSEI MEDICAL JOURNAL
Perforin- and granzyme-B-mediated apoptosis
ALLERGOLOGIE
Murine hypodense eosinophils induce tumour cell apoptosis by a granzyme B-dependent mechanism
CANCER IMMUNOLOGY IMMUNOTHERAPY
Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinomacells
CANCER IMMUNOLOGY IMMUNOTHERAPY
Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction
NEUROSCIENCE
Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies
DRUG DEVELOPMENT RESEARCH
Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1
MOLECULAR AND CELLULAR BIOLOGY
Enzymatic control of apoptosis
NATURAL PRODUCT REPORTS
Granzyme B: a marker of risk for influenza in institutionalized older adults
VACCINE
Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases
EMBO JOURNAL
Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation
EMBO JOURNAL
Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation
HUMAN IMMUNOLOGY
Caspase-3 activation and DNA fragmentation in primary hippocampal neurons following glutamate excitotoxicity
MOLECULAR BRAIN RESEARCH
Caspase-3-like proteases are activated by infection but are not required for replication of vesicular stomatitis virus
VIRUS RESEARCH
Apoptotic pathways in primary biliary cirrhosis and autoimmune hepatitis
LIVER
Isolation and assay of caspases
METHODS IN CELL BIOLOGY, VOL 66
The (holey) study of mitochondria in apoptosis
METHODS IN CELL BIOLOGY, VOL 66
Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantation
TRANSPLANTATION
Apoptosis and allograft rejection in the absence of CD8(+) T cells
TRANSPLANTATION
Involvement of granule-mediated apoptosis in the cyclic changes of the normal human endometrium
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Blocking CTL-based cytotoxic pathways reduces apoptosis of transplanted hepatocytes
JOURNAL OF SURGICAL RESEARCH
CD8(+) T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: a clinicopathological analysis
JOURNAL OF PATHOLOGY
Potential environmental and host participants in the early white matter lesion of adreno-leukodystrophy: Morphologic evidence for CD8 cytotoxic T cells, cytolysis of oligodendrocytes, and CD1-mediated lipid antigen presentation
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Autoantibodies to the amino-terminal fragment of beta-fodrin expressed in glandular epithelial cells in patients with Sjogren's syndrome
JOURNAL OF IMMUNOLOGY
A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells
JOURNAL OF IMMUNOLOGY
A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis
JOURNAL OF IMMUNOLOGY
Virally infected hepatocytes are resistant to perforin-dependent CTL effector mechanisms
JOURNAL OF IMMUNOLOGY
Accelerated Fas-mediated apoptosis of monocytes and maturing macrophages from patients with systemic lupus erythematosus: Relevance to in vitro impairment of interaction with iC3b-opsonized apoptotic cells
JOURNAL OF IMMUNOLOGY
A distinct pathway of cell-mediated apoptosis initiated by granulysin
JOURNAL OF IMMUNOLOGY
CD99 signals caspase-independent T cell death
JOURNAL OF IMMUNOLOGY
Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells
JOURNAL OF EXPERIMENTAL MEDICINE
Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: Differential modulation by T helper type 1 and type 2 cells
JOURNAL OF EXPERIMENTAL MEDICINE
Expression of killer cell inhibitory receptors is restricted to true NK cell lymphomas and a subset of intestinal enteropathy-type T cell lymphomas with a cytotoxic phenotype
JOURNAL OF CLINICAL PATHOLOGY
Executioner caspase-3,-6, and-7 perform distinct, non-redundant roles during the demolition phase of apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY
Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells
JOURNAL OF BIOCHEMISTRY
Role of Fas and granule exocytosis pathways in tumor-infiltrating T lymphocyte-induced apoptosis of autologous human lung-carcinoma cells
INTERNATIONAL JOURNAL OF CANCER
The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses
CELLULAR IMMUNOLOGY
Functional CD4(+) and CD8(+) T-cell responses induced by autologous mitomycin C treated Epstein-Barr virus transformed lymphoblastoid cell lines
CELLULAR IMMUNOLOGY
Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis
CANCER RESEARCH
The significance of granzyme B expression in patients with angiocentric lymphoma of the head and neck
CANCER
Pathogenesis of haemophagocytic lymphohistiocytosis
BRITISH JOURNAL OF HAEMATOLOGY
Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis
BRITISH JOURNAL OF DERMATOLOGY
Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4-anaplastic lymphoma kinase gene fusion
BLOOD
Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice
BLOOD
Novel properties of the nucleolar targeting signal of human angiogenin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen
ARTHRITIS AND RHEUMATISM
Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens - Implications for systemic autoimmunity
ARTHRITIS AND RHEUMATISM
Novel fragments of the Sjogren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death
ARTHRITIS AND RHEUMATISM
Differential expression of cytotoxic molecules and killer cell inhibitory receptors in CD8+and CD56+cutaneous lymphomas
AMERICAN JOURNAL OF PATHOLOGY
Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants
AMERICAN JOURNAL OF PATHOLOGY
Expression of granzyme B and perforin in multiple myeloma
ACTA HAEMATOLOGICA
Hsp27 negatively regulates cell death by interacting with cytochrome c
NATURE CELL BIOLOGY
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue
BIOLOGICAL CHEMISTRY
Caspase-dependent cleavage of nucleic acids
CELL DEATH AND DIFFERENTIATION
Properties of DNA fragmentation activity generated by ATP depletion
CELL DEATH AND DIFFERENTIATION
Nuclear translocation of granzyme B in target cell apoptosis
CELL DEATH AND DIFFERENTIATION
Granzyme B-positive primary gastric T-cell lymphoma: Gastric T-cell lymphoma with the possibility of extrathymic T cell origin
PATHOLOGY INTERNATIONAL
Up-regulated perforin expression of CD8(+) blood lymphocytes in generalized non-anaphylactic drug eruptions and exacerbated psoriasis
EUROPEAN JOURNAL OF DERMATOLOGY
Proteolytic regulation of apoptosis
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
The structures of caspases-1,-3,-7 and-8 reveal the basis for substrate and inhibitor selectivity
CHEMISTRY & BIOLOGY
Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Nuclear events in apoptosis
JOURNAL OF STRUCTURAL BIOLOGY
Molecular mechanism of staurosporine-induced apoptosis in osteoblasts
PHARMACOLOGICAL RESEARCH
TNF-alpha induces apoptosis mediated by AEBSF-sensitive serine protease(s)that may involve upstream caspase-3/CPP32 protease activation in a human gastric cancer cell line
INTERNATIONAL JOURNAL OF ONCOLOGY
Crystal structure of the apoptotic suppressor CrmA in its cleaved form
STRUCTURE WITH FOLDING & DESIGN
Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs
EUROPEAN JOURNAL OF CANCER
Caspases: key players in programmed cell death
CURRENT OPINION IN STRUCTURAL BIOLOGY
Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions
CLINICAL AND EXPERIMENTAL ALLERGY