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A functionally active RAR alpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines
CELL DEATH AND DIFFERENTIATION
Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells
CELL GROWTH & DIFFERENTIATION
Clinical significance of low protein phosphatase-1 activity of blasts in acute myelogenous leukemia with high white cell counts
INTERNATIONAL JOURNAL OF ONCOLOGY
Biological features of primary APL blasts: their relevance to the understanding of granulopoiesis, leukemogenesis and patient management
ONCOGENE
C/EBP alpha and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes
LEUKEMIA
Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells
JOURNAL OF LEUKOCYTE BIOLOGY
Molecular analysis of the mouse S100A9 gene and evidence that the myeloid specific transcription factor C/EBPepsilon is not required for the regulation of the S100A9/A8 gene expression in neutrophils
JOURNAL OF CELLULAR BIOCHEMISTRY
ATRA(ouble) in the treatment of acute promyelocytic leukemia
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain
MOLECULAR AND CELLULAR BIOLOGY
Regulation of id gene expression by type I insulin-like growth factor: Roles of STAT3 and the tyrosine 950 residue of the receptor
MOLECULAR AND CELLULAR BIOLOGY
Dichotomy of AML1-ETO functions: Growth arrest versus block of differentiation
MOLECULAR AND CELLULAR BIOLOGY
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
BIOCHEMICAL JOURNAL
The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologicdisease in vivo
CANCER GENETICS AND CYTOGENETICS
Analysis of the molecular genetics of acute promyelocytic leukemia in mouse models
SEMINARS IN HEMATOLOGY
Polyomavirus small t antigen prevents retinoic acid-induced retinoblastomaprotein hypophosphorylation and redirects retinoic acid-induced G(0) arrest and differentiation to apoptosis
JOURNAL OF VIROLOGY
BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRAR alpha) to block neutrophil differentiation and initiate acute leukemia
JOURNAL OF EXPERIMENTAL MEDICINE
PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells
JOURNAL OF BIOLOGICAL CHEMISTRY
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element
JOURNAL OF BIOLOGICAL CHEMISTRY
Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by phosphatidylinositol 3-kinase
JOURNAL OF BIOLOGICAL CHEMISTRY
Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation
EUROPEAN JOURNAL OF IMMUNOLOGY
Regulation of Id2 gene expression by the type 1 IGF receptor and the insulin receptor substrate-1
ENDOCRINOLOGY
Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins
BLOOD
Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
BLOOD
Positive and negative regulation of granulopoiesis by endogenous RAR alpha
BLOOD
A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Overview of the toxicology of benzene
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
Utility of a mouse model for studying the effects of benzene on the myeloid lineage: Effects of hydroquinone on a model myeloid system
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
Tyrosine phosphorylation of cytoplasmic proteins in proliferating, differentiating, apoptotic HL-60 cells and blood neutrophils
CELLULAR AND MOLECULAR LIFE SCIENCES
Retrovirus-mediated gene transfer of granulocyte colony-stimulating factorreceptor (G-CSFR) cDNA into MDS cells and induction of their differentiation by G-CSF
CYTOKINES CELLULAR & MOLECULAR THERAPY
Alterations of the AML1 transcription factor in human leukemia
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)
ONCOGENE
Development of a murine orthotopic model of leukemia: Evaluation of TP53 gene therapy efficacy
CANCER GENE THERAPY
Phosphatidylinositol-3-kinase activation and atypical protein kinase C zeta phosphorylation characterize the DMSO signalling in erythroleukemia cells
CELLULAR SIGNALLING
Phosphatidylinositol 3-kinase translocates to the nucleus of osteoblast-like MC3T3-E1 cells in response to insulin-like growth factor I and platelet-derived growth factor but not to the proapoptotic cytokine tumor necrosis factor alpha
JOURNAL OF BONE AND MINERAL RESEARCH
Specific association of increased cyclin-dependent kinase 5 expression with monocytic lineage of differentiation of human leukemia HL60 cells
JOURNAL OF LEUKOCYTE BIOLOGY
Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide
JOURNAL OF CLINICAL ONCOLOGY
Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1
GENE
Role of the transcription factor AML-1 in acute leukemia and hematopoieticdifferentiation
GENE
Garlic and onion oils inhibit proliferation and induce differentiation of HL-60 cells
CANCER LETTERS
IL-6 enhanced the retinoic acid-induced differentiation of human acute promyelocytic leukemia cells
CANCER LETTERS
All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells
EXPERIMENTAL HEMATOLOGY
Retinoic acid-induced apoptotic pathway in T-cell lymphoma: Identificationof four groups of genes with differential biological functions
EXPERIMENTAL HEMATOLOGY
mNotch1 signaling reduces proliferation of myeloid progenitor cells by altering cell-cycle kinetics
EXPERIMENTAL HEMATOLOGY
Differential display as an approach to study differentiation and differentiation therapy in AML
HEMATOLOGICAL ONCOLOGY
Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells
BIOCHEMICAL JOURNAL
Notch signalling via RBP-J promotes myeloid differentiation
EMBO JOURNAL
Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells
JOURNAL OF BIOSCIENCES
Enhanced migration of the acute promyelocytic leukemia cell line NB4 underin vitro conditions during short-term all-trans-retinoic acid treatment
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Partial restoration of all trans retinoic acid (ATRA) sensitivity by compactin in ATRA-resistant leukemic cells (ATRA-R HL-60)
LEUKEMIA RESEARCH
Notch signaling enhances survival and alters differentiation of 32D myeloblasts
JOURNAL OF IMMUNOLOGY
Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production
JOURNAL OF IMMUNOLOGY
Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF alpha/AML/PEBP2 alpha) dependent activation of tissue-specific gene transcription
JOURNAL OF CELL SCIENCE
Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis
JOURNAL OF BIOLOGICAL CHEMISTRY
Retinoic acid-induced blr1 expression promotes ERK2 activation and cell differentiation in HL-60 cells
EXPERIMENTAL CELL RESEARCH
B-myb alters the response of myeloid precursor cells to G-CSF
EXPERIMENTAL CELL RESEARCH
Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia
CANCER RESEARCH
A minimal c-fes cassette directs myeloid-specific expression in transgenicmice
BLOOD
Leukemia initiated by PMLRAR alpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable
BLOOD
All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells
BLOOD
Vitamin A deficiency in mice causes a systemic expansion of myeloid cells
BLOOD
Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situhybridization
JOURNAL OF HUMAN GENETICS
Enhancement of myeloid cell growth by benzene metabolites via the production of active oxygen species
FREE RADICAL RESEARCH
Adenosine analogs as possible differentiation-inducing agents against acute myeloid leukemia
LEUKEMIA & LYMPHOMA
UDP-GlcNAc : Gal beta 1 -> 3GalNAc (GlcNac to GalNAc) beta 1 -> 6N-acetylglucosaminyltransferase holds a key role on the control of CD15s expression in human pre-B lymphoid cell lines
GLYCOBIOLOGY
Granulocytic differentiation of myeloid progenitor cells by p130, the retinoblastoma tumor suppressor homologue
ONCOGENE
Acute promyelocytic leukemia: from treatment to genetics and back
ONCOGENE
Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2
ONCOGENE
Alterations in ganglioside expression during the differentiation of human mast cells
EXPERIMENTAL DERMATOLOGY
Expressions of four major protein Ser/Thr phosphatases in human primary leukemic cells
LEUKEMIA
Leukemogenesis by CBF oncoproteins
LEUKEMIA
Suppression of G-CSF-mediated Stat signalling by IL-3
LEUKEMIA
Retinoic acid induces apoptosis of human CD34(+) hematopoietic progenitor cells: Involvement of retinoic acid receptors and retinoid X receptors depends on lineage commitment of the hematopoietic progenitor cells
EXPERIMENTAL HEMATOLOGY
Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation
EXPERIMENTAL HEMATOLOGY
Induction of a functional vitamin D receptor in all-trans-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells
CANCER RESEARCH
The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: Biology and clinical significance
BRITISH JOURNAL OF HAEMATOLOGY
Deconstructing a disease: RAR alpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
BLOOD
C/EBP epsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters
BLOOD
ANTISENSE INHIBITION OF BAX MESSENGER-RNA INCREASES SURVIVAL OF TERMINALLY DIFFERENTIATED HL60 CELLS
Antisense & nucleic acid drug development
THE HUMAN HOMOLOG OF RAT JAGGED1 EXPRESSED BY MARROW STROMA INHIBITS DIFFERENTIATION OF 32D CELLS THROUGH INTERACTION WITH NOTCH1
Immunity
DISTINCT INTERACTIONS OF PML-RAR-ALPHA AND PLZF-RAR-ALPHA WITH CO-REPRESSORS DETERMINE DIFFERENTIAL RESPONSES TO RA IN APL
Nature genetics
ACUTE PROMYELOCYTIC LEUKEMIA AS A MODEL FOR CROSS-TALK BETWEEN INTERFERON AND RETINOIC ACID PATHWAYS - FROM MOLECULAR-BIOLOGY TO CLINICAL-APPLICATIONS
Leukemia & lymphoma
POSSIBLE INVOLVEMENT OF CALCINEURIN IN RETINOIC ACID-INDUCED INHIBITION OF LEUKEMIC HL-60 CELL-PROLIFERATION
International journal of oncology
DEFICIENT POSTTRANSLATIONAL PROCESSING OF RAP 1A IN VARIANT HL-60 CELLS
Oncogene
TARGETING THE PML RAR-ALPHA TRANSLOCATION PRODUCT TRIGGERS APOPTOSIS IN PROMYELOCYTIC LEUKEMIA-CELLS/
Oncogene
FUNCTIONAL SPECIFICITY OF THE 2 RETINOIC ACID RECEPTOR RAR AND RXR FAMILIES IN MYOGENESIS
Oncogene
SRC KINASES AND NOT JAKS ACTIVATE STATS DURING IL-3 INDUCED MYELOID CELL-PROLIFERATION
Oncogene
NOTCH1 AND NOTCH2 INHIBIT MYELOID DIFFERENTIATION IN RESPONSE TO DIFFERENT CYTOKINES
Molecular and cellular biology
TLS FUS, A PRO-ONCOGENE INVOLVED IN MULTIPLE CHROMOSOMAL TRANSLOCATIONS, IS A NOVEL REGULATOR OF BCR/ABL-MEDIATED LEUKEMOGENESIS/
EMBO journal (Print)
UP-REGULATION OF INDUCIBLE NITRIC-OXIDE (NO) SYNTHASE AND NO PRODUCTION IN HL-60 CELLS STIMULATED TO DIFFERENTIATE BY PHORBOL 12-MYRISTATE 13-ACETATE PLUS 1,25-DIHYDROXYVITAMIN D-3 IS NOT OBTAINED WITH DIMETHYLSULFOXIDE PLUS 1,25-DIHYDROXYVITAMIN D-3
Calcified tissue international
REGULATION OF THE EXPRESSION OF ENZYMES INVOLVED IN THE REPLICATION OF DNA IN CHEMICALLY-INDUCED GRANULOCYTIC DIFFERENTIATION OF HL-60 LEUKEMIA-CELLS
Leukemia research
A NOVEL RETINOIC ACID RECEPTOR (RAR)-SELECTIVE ANTAGONIST INHIBITS DIFFERENTIATION AND APOPTOSIS OF HL-60 CELLS - IMPLICATIONS OF RAR-ALPHA-MEDIATED SIGNALS IN MYELOID LEUKEMIC-CELLS
Leukemia research
APPEARANCE OF GLUTAMATE RECEPTORS ON THE SURFACE OF HL-60 CELLS UPON DIFFERENTIATION
Bioorganiceskaa himia
SINGLE GLYCOSYLTRANSFERASE, CORE 2 BETA-1-]6-N-ACETYLGLUCOSAMINYLTRANSFERASE, REGULATES CELL-SURFACE SIALYL-LE(X) EXPRESSION LEVEL IN HUMANPRE-B LYMPHOCYTIC-LEUKEMIA CELL-LINE KM3 TREATED WITH PHORBOLESTER
The Journal of biological chemistry
TARGETING OF PML RAR-ALPHA IS LETHAL TO RETINOIC ACID-RESISTANT PROMYELOCYTIC LEUKEMIA-CELLS/
Blood
WILMS-TUMOR GENE (WT1) COMPETES WITH DIFFERENTIATION-INDUCING SIGNAL IN HEMATOPOIETIC PROGENITOR CELLS
Blood
Phosphatidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
INCREASED MESSENGER-RNA EXPRESSION OF PHOSPHOLIPASE-D (PLD) ISOZYMES DURING GRANULOCYTIC DIFFERENTIATION OF HL60 CELLS
Biochimica et biophysica acta, L. Lipids and lipid metabolism
PRESENCE OF A FUNCTIONAL VITAMIN-D-RECEPTOR DOES NOT CORRELATE WITH VITAMIN-D3 PHENOTYPIC EFFECTS IN MYELOID DIFFERENTIATION
Cell death and differentiation
INVOLVEMENT OF BCL-2 AND BAX GENE-EXPRESSION IN APOPTOSIS AND DIFFERENTIATION OF THE NONTUMORIGENIC MURINE HEMATOPOIETIC-CELL LINE, 32DC13(G)
International journal of oncology
EXPRESSION OF EXOGENOUS WT-P53 DOES NOT AFFECT NORMAL HEMATOPOIESIS -IMPLICATIONS FOR BONE-MARROW PURGING
Gene therapy