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Anencephaly: Structural characterization of gangliosides in defined brain regions
BIOLOGICAL CHEMISTRY
Retrovirus-mediated transfer and expression of beta-hexosaminidase alpha-chain cDNA in human fibroblasts from G(M2)-gangliosidosis B1 variant
HUMAN GENE THERAPY
Sphingolipid activator proteins: proteins with complex functions in lipid degradation and skin biogenesis
GLYCOBIOLOGY
The DXD motif is required for GM2 synthase activity but is not critical for nucleotide binding
GLYCOBIOLOGY
High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of Intergroup trial E1694/S9512/C509801
JOURNAL OF CLINICAL ONCOLOGY
Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain
BRAIN & DEVELOPMENT
GM2 ganglioside regulates the function of ciliary neurotrophic factor receptor in murine immortalized motor neuron-like cells (NSC-34)
NEUROCHEMICAL RESEARCH
A ganglioside-specific sialyltransferase localizes to axons and non-Golgi structures in neurons
JOURNAL OF NEUROSCIENCE
Genetic, physiological and molecular interactions of rice and its major dipteran pest, gall midge
PLANT CELL TISSUE AND ORGAN CULTURE
Guillain-Barre syndrome with IgM antibody to the ganglioside GalNAc-GDla
JOURNAL OF NEUROIMMUNOLOGY
Comparison of ganglioside profiles in nuclei and whole cells of NG108-15 and NG-CR72 lines: changes in response to different neuritogenic stimuli
DEVELOPMENTAL BRAIN RESEARCH
Promoter characterization and expression of the gene coding for the human GM2 activator protein
BIOSCIENCE REPORTS
Peripheral and autonomic nervous system involvement in chronic GM2-gangliosidosis
JOURNAL OF INHERITED METABOLIC DISEASE
Tay-Sachs disease: The search for the enzymatic defect
TAY-SACHS DISEASE
The G(M2)-gangliosidoses and the elucidation of the beta-hexosaminidase system
TAY-SACHS DISEASE
Molecular genetics of the beta-hexosaminidase isoenzymes: An introduction
TAY-SACHS DISEASE
The beta-hexosaminidase story in Toronto: From enzyme structure to gene mutation
TAY-SACHS DISEASE
Biosynthesis of normal and mutant beta-hexosaminidases
TAY-SACHS DISEASE
Recognition and delineation of beta-hexosaminidase alpha-chain variants: Ahistorical and personal perspective
TAY-SACHS DISEASE
Late-onset G(M2) gangliosidosis and other hexosaminidase mutations among Jews
TAY-SACHS DISEASE
Naturally occurring mutations in G(M2) gangliosidosis: A compendium
TAY-SACHS DISEASE
Molecular mapping of gene Gm-6(t) which confers resistance against four biotypes of Asian rice gall midge in China
THEORETICAL AND APPLIED GENETICS
Immunization of metastatic breast cancer patients with a fully synthetic globe H conjugate: A phase I trial
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Physical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Ganglioside G(D2) in small cell lung cancer cell lines: Enhancement of cell proliferation and mediation of apoptosis
CANCER RESEARCH
Stable transfection of human beta-1,4N-acetylgalactosaminyltransferase andalpha-2,8-sialyltransferase cDNAs in C6 rat glioma cells induces modifications in ganglioside metabolism
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
Characterization of regulatory elements in the 5 '-flanking region of the GM2 activator gene
BIOLOGICAL CHEMISTRY
Niemann-Pick type C mutations cause lipid traffic jam
TRAFFIC
The anti-idiotypic antibody 4B5 (mimicking ganglioside GD2) for diagnosis and therapy of cancer
EXPERT OPINION ON THERAPEUTIC PATENTS
The G(M2) gangliosidoses databases: Allelic variation at the HEXA, HEKB, and GM2A gene loci
GENETICS IN MEDICINE
Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21
CLINICAL CANCER RESEARCH
Vaccination with a bivalent G(M2) and G(D2) ganglioside conjugate vaccine:A trial comparing doses of G(D2)-keyhole limpet hemocyanin
CLINICAL CANCER RESEARCH
Gangliosides as modulators of dendritogenesis in normal and storage disease-affected pyramidal neurons
CEREBRAL CORTEX
Alteration of tumor phenotypes of B16 melanoma after genetic remodeling ofthe ganglioside profile
INTERNATIONAL JOURNAL OF ONCOLOGY
Human interferon-gamma enhances expression of ganglioside GM2 on human lung cancer cells and their susceptibility for antiganglioside GM2 monoclonal antibody-dependent cellular cytotoxicity
ONCOLOGY RESEARCH
Alleviation of neuronal ganglioside storage does not improve the clinical course of the Niemann-Pick C disease mouse
HUMAN MOLECULAR GENETICS
Stemming the tide: glycosphingolipid synthesis inhibitors as therapy for storage diseases
GLYCOBIOLOGY
Evidence supporting a late Golgi location for lactosylceramide to ganglioside GM3 conversion
GLYCOBIOLOGY
Peripheral neuropathy associated with anti-GM2 ganglioside antibodies: Clinical and immunopathological studies
AUTOIMMUNITY
Natural and induced human antibody response to cancer
CANCER INVESTIGATION
Therapeutic advances in melanoma
DERMATOLOGIC CLINICS
Clinical and immune responses in advanced melanoma patients immunized withan anti-idiotype antibody mimicking disialoganglioside GD2
JOURNAL OF CLINICAL ONCOLOGY
The IgM antibody level against ganglioside GM2 correlates to the disease status of HIV-1-infected patients
MICROBIOLOGY AND IMMUNOLOGY
Recombinant antibodies against ganglioside expressed on tumor cells
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Development of a new vaccine formulation that enhances the immunogenicity of tumor-associated antigen CaMBr1
CANCER IMMUNOLOGY IMMUNOTHERAPY
Clinical manifestations of psychiatric patients who are carriers of Tay-Sachs disease - Possible role of psychotropic drugs
NEUROPSYCHOBIOLOGY
Autoimmune and antitumor consequences of antibodies against antigens shared by normal and malignant tissues
JOURNAL OF CLINICAL IMMUNOLOGY
Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues
LUNG CANCER
Dissection and optimization of immune effector functions of humanized anti-ganglioside GM2 monoclonal antibody
MOLECULAR IMMUNOLOGY
Sphingolipid hydrolases and activator proteins
SPHINGOLIPID METABOLISM AND CELL SIGNALING, PT A
Enzymatic N-deacylation of sphingolipids
SPHINGOLIPID METABOLISM AND CELL SIGNALING, PT A
Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barre syndrome
NEUROLOGY
Polyclonal antibodies from patients immunized with a globe H-keyhole limpet hemocyanin vaccine: Isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
An AFLP marker that differentiates biotypes of the Asian rice gall midge (Orseolia oryzae, Wood-Mason) is sex-linked and also linked to avirulence
MOLECULAR AND GENERAL GENETICS
High-affinity anti-ganglioside IgG antibodies raised in complex ganglioside knockout mice: Reexamination of GD1a immunolocalization
JOURNAL OF NEUROCHEMISTRY
Crystal structure of human GM2-activator protein with a novel beta-cup topology
JOURNAL OF MOLECULAR BIOLOGY
Development of salt-responsive neurons in the nucleus of the solitary tract
JOURNAL OF COMPARATIVE NEUROLOGY
Role of beta Arg(211) in the active site of human beta-hexosaminidase B
BIOCHEMISTRY
Gangliosides as modulators of dendritogenesis in storage disease-affected and normal pyramidal neurons
DEVELOPMENTAL NEUROPSYCHOLOGY
Sphingolipids - Their metabolic pathways and the pathobiochemistry of neurodegenerative diseases
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Prospects for the development of new vaccine adjuvants
BIODRUGS
Immunogenicity of a fucosyl-GM1-keyhole limpet hemocyanin conjugate vaccine in patients with small cell lung cancer
CLINICAL CANCER RESEARCH
Metabolic disorders presenting with behavioral symptoms in the school-agedchild
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Differentiation of Asian rice gall midge, Orseolia oryzae (Wood-Mason), biotypes by sequence characterized amplified regions (SCARs)
INSECT MOLECULAR BIOLOGY
Reevaluating the effect of Brefeldin A (BFA) on ganglioside synthesis: thelocation of GM2 synthase cannot be deduced from the inhibition of GM2 synthesis by BFA
GLYCOBIOLOGY
Enhancement of TNF-alpha production by ganglioside GM2 in human mononuclear cell culture
NEUROREPORT
Synthesis of a structurally defined antigen - Immunostimulant combination for use in cancer vaccines
CHEMISTRY-A EUROPEAN JOURNAL
Biochemical consequences of mutations causing the GM2 gangliosidoses
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Human IgM antibody therapy for HIV-1 infection
MICROBIOLOGY AND IMMUNOLOGY
G(M2)-ganglioside metabolism in situ in mucolipidosis IV fibroblasts
NEUROCHEMICAL RESEARCH
GM2 promotes ciliary neurotrophic factor-dependent rescue of immortalized motor neuron-like cell (NSC-34)
NEUROCHEMICAL RESEARCH
Recombinant GM2-activator protein stimulates in vivo degradation of GA2 inGM2 gangliosidosis AB variant fibroblasts but exhibits no detectable binding of GA2 in an in vitro assay
NEUROCHEMICAL RESEARCH
Immunization of mice with fucosyl-GM1 conjugated with keyhole limpet hemocyanin results in antibodies against human small-cell lung cancer cells
CANCER IMMUNOLOGY IMMUNOTHERAPY
Recent advances in the biochemistry of glycosphingolipid metabolism
BIOCHEMICAL SOCIETY TRANSACTIONS
Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugatecancer vaccines
VACCINE
Anti-GM2 IgM antibodies: clinical correlates and reactivity with a human neuroblastoma cell line
JOURNAL OF NEUROIMMUNOLOGY
An unusual case of facial diplegia
MUSCLE & NERVE
The structural basis for the susceptibility of gangliosides to enzymatic degradation
BIOSCIENCE REPORTS
alpha-mannosidosis in the guinea pig: A new animal model for lysosomal storage disorders
PEDIATRIC RESEARCH
Hexosaminidase deficiency is a differential diagnosis of spinocerebellar degeneration
NERVENARZT
Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globoH hexasaccharide conjugate in man
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
A specific loss of c-series gangliosides in pancreas streptozotocin-induced diabetic rats
LIFE SCIENCES
Clinical presentation and outcome of Guillain-Barre and related syndromes in relation to anti-ganglioside antibodies
JOURNAL OF THE NEUROLOGICAL SCIENCES
Antiganglioside antibodies in Guillain-Barre syndrome after a recent cytomegalovirus infection
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Ferret pyramidal cell dendritogenesis: Changes in morphology and ganglioside expression during cortical development
JOURNAL OF COMPARATIVE NEUROLOGY
The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo
JOURNAL OF BIOLOGICAL CHEMISTRY
Isolation and characterization of a novel Forssman active acidic glycosphingolipid with branched isoglobo-, ganglio-, and neolacto-series hybrid sugar chains
JOURNAL OF BIOCHEMISTRY
Interaction of the GM2-activator protein with phospholipid-ganglioside bilayer membranes and with monolayers at the air-water interface
EUROPEAN JOURNAL OF BIOCHEMISTRY
Thermodynamic characterisation of the mutated isoenzyme A of beta-N-acetylhexosaminidase in GM2-gangliosidosis B1 variant
CLINICA CHIMICA ACTA
Cytoreductive surgery and adjuvant immunotherapy: A new management paradigm for metastatic melanoma
CA-A CANCER JOURNAL FOR CLINICIANS
Expression of Niemann-Pick type C transcript in rodent cerebellum in vivo and in vitro
BRAIN RESEARCH
Enzymatic hydrolysis of glycosphingolipids
ANALYTICAL BIOCHEMISTRY
Structure of the GM2A gene: Identification of an exon 2 nonsense mutation and a naturally occurring transcript with an in-frame deletion of exon 2
AMERICAN JOURNAL OF HUMAN GENETICS
Naturally occurring G(M2) gangliosidosis in two Muntjak deer with pathological and biochemical features of human classical Tay-Sachs disease (type B G(M2) gangliosidosis)
ACTA NEUROPATHOLOGICA
OVERVIEW OF MELANOMA VACCINES - ACTIVE SPECIFIC IMMUNOTHERAPY FOR MELANOMA PATIENTS
Seminars in surgical oncology
At least six different mutations in HEXA gene cause Tay-Sachs disease among the Turkish population
MOLECULAR GENETICS AND METABOLISM
ANTIBODY-RESPONSES IN MELANOMA PATIENTS IMMUNIZED WITH AN ANTIIDIOTYPE ANTIBODY MIMICKING DISIALOGANGLIOSIDE GD2
Clinical cancer research
ANTIBODY-RESPONSES IN MELANOMA PATIENTS IMMUNIZED WITH AN ANTIIDIOTYPE ANTIBODY MIMICKING DISIALOGANGLIOSIDE GD2
Clinical cancer research