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La ricerca find articoli where soggetti phrase all words 'GLUTAMINE-SYNTHETASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 1407 riferimenti
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    1. Castro, C; Britt, BM
      Binding thermodynamics of the transition state analogue coformycin and of the ground state analogue 1-deazaadenosine to bovine adenosine deaminase

      JOURNAL OF ENZYME INHIBITION
    2. Kutlesa, NJ; Caveney, S
      Insecticidal activity of glufosinate through glutamine depletion in a caterpillar

      PEST MANAGEMENT SCIENCE
    3. Butterfield, DA; Drake, J; Pocernich, C; Castegna, A
      Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

      TRENDS IN MOLECULAR MEDICINE
    4. Bogdanovic, N; Zilmer, M; Zilmer, K; Rehema, A; Karelson, E
      The Swedish APP670/671 Alzheimer's disease mutation: The first evidence for strikingly increased oxidative injury in the temporal inferior cortex

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    5. Shringarpure, R; Grune, T; Davies, KJA
      Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells

      CELLULAR AND MOLECULAR LIFE SCIENCES
    6. Okeson, CD; Riley, MR
      Glutamine replenishment and ammonia removal in hybridoma cell cultures viaimmobilized glutamine synthetase

      BIOCHEMICAL ENGINEERING JOURNAL
    7. Coruzzi, GM; Zhou, L
      Carbon and nitrogen sensing and signaling in plants: emerging 'matrix effects'

      CURRENT OPINION IN PLANT BIOLOGY
    8. Voelker, F; Altaba, S
      Nitrogen source governs the patterns of growth and pristinamycin production in 'Streptomyces pristinaespiralis'

      MICROBIOLOGY-SGM
    9. Meier-Wagner, J; Nolden, L; Jakoby, M; Siewe, R; Kramer, R; Burkovski, A
      Multiplicity of ammonium uptake systems in Corynebacterium glutamicum: role of Amt and AmtB

      MICROBIOLOGY-UK
    10. Todgham, AE; Anderson, PM; Wright, PA
      Effects of exercise on nitrogen excretion, carbamoyl phosphate synthetase III activity and related urea cycle enzymes in muscle and liver tissues of juvenile rainbow trout (Oncorhynchus mykiss)

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    11. Saha, N; Das, L; Dutta, S; Goswami, UC
      Role of ureogenesis in the mud-dwelled Singhi catfish (Heteropneustes fossilis) under condition of water shortage

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    12. Arcondeguy, T; Jack, R; Merrick, M
      P-II signal transduction proteins, pivotal players in microbial nitrogen control

      MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
    13. Jablonski, M; Iannaccone, A
      Lactose supports Muller cell protein expression patterns in the absence ofthe retinal pigment epithelium

      MOLECULAR VISION
    14. Kiang, CH
      Single-particle study of protein assembly - art. no. 041911

      PHYSICAL REVIEW E
    15. Falke, S; Fisher, MT; Gogol, EP
      Classification and reconstruction of a heterogeneous set of electron microscopic images: A case study of GroEL-substrate complexes

      JOURNAL OF STRUCTURAL BIOLOGY
    16. Antonyuk, LP; Smirnova, VE; Kamnev, AA; Serebrennikova, OB; Vanoni, MA; Zanetti, G; Kudelina, IA; Sokolov, OI; Ignatov, VV
      Influence of divalent cations on the catalytic properties and secondary structure of unadenylylated glutamine synthetase from Azospirillum brasilense

      BIOMETALS
    17. Enosawa, S; Miyashita, T; Fujita, Y; Suzuki, S; Amemiya, H; Omasa, T; Hiramatsu, S; Suga, K; Matsumura, T
      In vivo estimation of bioartificial liver with recombinant HepG2 cells using pigs with ischemic liver failure

      CELL TRANSPLANTATION
    18. Avila, C; Suarez, MF; Gomez-Maldonado, J; Canovas, FM
      Spatial and temporal expression of two cytosolic glutamine synthetase genes in Scots pine: functional implications on nitrogen metabolism during early stages of conifer development

      PLANT JOURNAL
    19. Costa, SL; Paillaud, E; Fages, C; Rochette-Egly, C; Plassat, JL; Jouault, H; Perzelova, A; Tardy, M
      Effects of a novel synthetic retinoid on malignant glioma in vitro: inhibition of cell proliferation, induction of apoptosis and differentiation

      EUROPEAN JOURNAL OF CANCER
    20. Cardile, V; Pavone, A; Renis, M; Maci, T; Perciavalle, V
      Effects of Gabapentin and Topiramate in primary rat astrocyte cultures

      NEUROREPORT
    21. Rothman, DL
      Studies of metabolic compartmentation and glucose transport using in vivo MRS

      NMR IN BIOMEDICINE
    22. Luque, I; Zabulon, G; Contreras, A; Houmard, J
      Convergence of two global transcriptional regulators on nitrogen inductionof the stress-acclimation gene nblA in the cyanobacterium Synechococcus spPCC 7942

      MOLECULAR MICROBIOLOGY
    23. de Marsac, NT; Lee, HM; Hisbergues, M; Castets, AM; Bedu, S
      Control of nitrogen and carbon metabolism in cyanobacteria

      JOURNAL OF APPLIED PHYCOLOGY
    24. Derouiche, A; Frotscher, M
      Peripheral astrocyte processes: Monitoring by selective immunostaining forthe actin-binding ERM proteins

      GLIA
    25. Tate, R; Mandrich, L; Spinosa, MR; Riccio, A; Lamberti, A; Iaccarino, M; Patriarca, EJ
      The rhizobium GstI protein reduces the NH4+ assimilation capacity of Rhizobium leguminosarum

      MOLECULAR PLANT-MICROBE INTERACTIONS
    26. Grune, T; Klotz, LO; Gieche, J; Rudeck, M; Sies, H
      Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite

      FREE RADICAL BIOLOGY AND MEDICINE
    27. Ureta, A; Nordlund, S
      Glutamine synthetase from Acetobacter diazotrophicus: properties and regulation

      FEMS MICROBIOLOGY LETTERS
    28. Vitorino, JC; Steffens, MBR; Machado, HB; Yates, MG; Souza, EM; Pedrosa, FO
      Potential roles for the glnB and ntr YX genes in Azospirillum brasilense

      FEMS MICROBIOLOGY LETTERS
    29. Nolden, L; Farwick, M; Kramer, R; Burkovski, A
      Glutamine synthetases of Corynebacterium glutamicum: transcriptional control and regulation of activity

      FEMS MICROBIOLOGY LETTERS
    30. Kanski, J; Lauderback, C; Butterfield, DA
      5-aminosalicylic acid protection against oxidative damage to synaptosomal membranes by alkoxyl radicals in vitro

      NEUROCHEMICAL RESEARCH
    31. Knecht, K; Wiesmuller, KH; Gnau, V; Jung, G; Meyermann, R; Todd, KG; Hamprecht, B
      AMP deaminase in rat brain: Localization in neurons and ependymal cells

      JOURNAL OF NEUROSCIENCE RESEARCH
    32. Dommelen, A; De Mot, R; Vanderleyden, J
      Ammonium transport: unifying concepts and unique aspects

      AUSTRALIAN JOURNAL OF PLANT PHYSIOLOGY
    33. Kimura, K; Kanda, F; Okuda, S; Chihara, K
      Insulin-like growth factor 1 inhibits glucocorticoid-induced glutamine synthetase activity in cultured L6 rat skeletal muscle cells

      NEUROSCIENCE LETTERS
    34. Rawlings, DE
      The molecular genetics of Thiobacillus ferrooxidans and other mesophilic, acidophilic, chemolithotrophic, iron- or sulfur-oxidizing bacteria

      HYDROMETALLURGY
    35. Mitaka, T; Sato, F; Ikeda, SI; Sugimoto, SI; Higaki, N; Hirata, K; Lamers, WH; Mochizuki, Y
      Expression of carbamoylphosphate synthetase I and glutamine synthetase in hepatic organoids reconstructed by rat small hepatocytes and hepatic nonparenchymal cells

      CELL AND TISSUE RESEARCH
    36. Marcaggi, P; Coles, JA
      Ammonium in nervous tissue: transport across cell membranes, fluxes from neurons to glial cells, and role in signalling

      PROGRESS IN NEUROBIOLOGY
    37. Davies, KJA
      Degradation of oxidized proteins by the 20S proteasome

      BIOCHIMIE
    38. Liu, LP; Bridges, RJ; Eyer, CL
      Effect of cytochrome P450 1A induction on oxidative damage in rat brain

      MOLECULAR AND CELLULAR BIOCHEMISTRY
    39. Astolfi, S; De Biasi, MG; Passera, C
      Effects of irradiance-sulphur interactions on enzymes of carbon, nitrogen,and sulphur metabolism in maize plants

      PHOTOSYNTHETICA
    40. Sharma, RK
      Expression of Bcl-2 during the development of rabbit retina

      CURRENT EYE RESEARCH
    41. Nishikawa, S; Tamai, M
      Muller cells in the human foveal region

      CURRENT EYE RESEARCH
    42. Soupene, E; Ramirez, RM; Kustu, S
      Evidence that fungal MEP proteins mediate diffusion of the uncharged species NH3 across the cytoplasmic membrane

      MOLECULAR AND CELLULAR BIOLOGY
    43. Petersen, MK; Sandstrom, JP
      Outcome of indirect competition between two aphid species mediated by responses in their common host plant

      FUNCTIONAL ECOLOGY
    44. Aslanian, AM; Kilberg, MS
      Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells

      BIOCHEMICAL JOURNAL
    45. Monedero, V; Poncet, S; Mijakovic, I; Fieulaine, S; Dossonnet, V; Martin-Verstraete, I; Nessler, S; Deutscher, J
      Mutations lowering the phosphatase activity of HPr kinase/phosphatase switch off carbon metabolism

      EMBO JOURNAL
    46. Trevisan, A; Giraldo, M; Borella, M; Maso, S
      Historical control data on urinary and renal tissue biomarkers in naive male Wistar rats

      JOURNAL OF APPLIED TOXICOLOGY
    47. Buniatian, GH; Hartmann, HJ; Traub, P; Weser, U; Wiesinger, H; Gebhardt, R
      Acquisition of blood-tissue barrier-supporting features by hepatic stellate cells and astrocytes of myofibroblastic phenotype. Inverse dynamics of metallothionein and glial fibrillary acidic protein expression

      NEUROCHEMISTRY INTERNATIONAL
    48. Kerokoski, P; Soininen, H; Pirttila, T
      beta-amyloid (1-42) affects MTT reduction in astrocytes: implications for vesicular trafficking and cell functionality

      NEUROCHEMISTRY INTERNATIONAL
    49. Raj, D; Langford, M; Krueger, S; Shelton, M; Welbourne, T
      Regulatory responses to an oral D-glutamate load: formation of D-pyrrolidone carboxylic acid in humans

      AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
    50. Nievola, CC; Mercier, H; Majerowicz, N
      Levels of nitrogen assimilation in bromeliads with different growth habits

      JOURNAL OF PLANT NUTRITION
    51. Fray, AE; Dempster, S; Williams, RE; Cookson, MR; Shaw, PJ
      Glutamine synthetase activity and expression are not affected by the development of motor neuronopathy in the G93A SOD-1/ALS mouse

      MOLECULAR BRAIN RESEARCH
    52. Lapouble, E; Hevor, TK; Pichon, JL
      A rapid semi-preparative synthesis of radioactive methionine sulfoximine, which retains full biological activity

      BIOGENIC AMINES
    53. Spijkers, JAA; van den Hoff, MJB; Hakvoort, TBM; Vermeulen, JLM; Tesink-Taekema, S; Lamers, WH
      Foetal rise in hepatic enzymes follows decline in c-met and hepatocyte growth factor expression

      JOURNAL OF HEPATOLOGY
    54. Gieche, J; Mehlhase, J; Licht, A; Zacke, T; Sitte, N; Grune, T
      Protein oxidation and proteolysis in RAW264.7 macrophages: effects of PMA activation

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
    55. Matsui, H; Lin, LR; Singh, DP; Shinohara, T; Reddy, VN
      Lens epithelium-derived growth factor: Increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress

      INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
    56. Matt, P; Geiger, M; Walch-Liu, P; Engels, C; Krapp, A; Stitt, M
      The immediate cause of the diurnal changes of nitrogen metabolism in leaves of nitrate-replete tobacco: a major imbalance between the rate of nitratereduction and the rates of nitrate uptake and ammonium metabolism during the first part of the light period

      PLANT CELL AND ENVIRONMENT
    57. Matt, P; Geiger, M; Walch-Liu, P; Engels, C; Krapp, A; Stitt, M
      Elevated carbon dioxide increases nitrate uptake and nitrate reductase activity when tobacco is growing on nitrate, but increases ammonium uptake andinhibits nitrate reductase activity when tobacco is growing on ammonium nitrate

      PLANT CELL AND ENVIRONMENT
    58. Oliveira, IC; Brenner, E; Chiu, J; Hsieh, MH; Kouranov, A; Lam, HM; Shin, MJ; Coruzzi, G
      Metabolite and light regulation of metabolism in plants: lessons from the study of a single biochemical pathway

      BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
    59. Merker, K; Stolzing, A; Grune, T
      Proteolysis, caloric restriction and aging

      MECHANISMS OF AGEING AND DEVELOPMENT
    60. Dhahbi, JM; Mote, PL; Wingo, J; Rowley, BC; Cao, SX; Walford, RL; Spindler, SR
      Caloric restriction alters the feeding response of key metabolic enzyme genes

      MECHANISMS OF AGEING AND DEVELOPMENT
    61. Hinz, HJ; Schwarz, FP
      Measurement and analysis of results obtained on biological substances withdifferential scanning calorimetry

      PURE AND APPLIED CHEMISTRY
    62. Riedel, J; Tischner, R; Mack, G
      The chloroplastic glutamine synthetase (GS-2) of tobacco is phosphorylatedand associated with 14-3-3 proteins inside the chloroplast

      PLANTA
    63. Pozuelo, M; MacKintosh, C; Galvan, A; Fernandez, E
      Cytosolic glutamine synthetase and not nitrate reductase from the green alga Chlamydomonas reinhardtii is phosphorylated and binds 14-3-3 proteins

      PLANTA
    64. Sauer, J; Schreiber, U; Schmid, R; Volker, U; Forchhammer, K
      Nitrogen starvation-induced chlorosis in Synechococcus PCC 7942. Low-levelphotosynthesis as a mechanism of long-term survival

      PLANT PHYSIOLOGY
    65. Kiyomiya, S; Nakanishi, H; Uchida, H; Tsuji, A; Nishiyama, S; Futatsubashi, M; Tsukada, H; Ishioka, NS; Watanabe, S; Ito, T; Mizuniwa, C; Osa, A; Matsuhashi, S; Hashimoto, S; Sekine, T; Mori, S
      Real time visualization of N-13-translocation in rice under different environmental conditions using positron emitting tracer imaging system

      PLANT PHYSIOLOGY
    66. Chandlee, JM
      Current molecular understanding of the genetically programmed process of leaf senescence

      PHYSIOLOGIA PLANTARUM
    67. Irmler, A; Forchhammer, K
      A PP2C-type phosphatase dephosphorylates the PII signaling protein in the cyanobacterium Synechocystis PCC 6803

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    68. Motohashi, K; Kondoh, A; Stumpp, MT; Hisabori, T
      Comprehensive survey of proteins targeted by chloroplast thioredoxin

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    69. Robertson, DL; Smith, GJ; Alberte, RS
      Glutamine synthetase in marine algae: New surprises from an old enzyme

      JOURNAL OF PHYCOLOGY
    70. Alcaide, B; Almendros, P; Aragoncillo, C; Rodriguez-Acebes, R
      Metal-promoted allylation, propargylation, or allenylation of azetidine-2,3-diones in aqueous and anhydrous media. Application to the asymmetric synthesis of densely functionalized 3-substituted 3-hydroxy-beta-lactams

      JOURNAL OF ORGANIC CHEMISTRY
    71. Labow, BI; Souba, WW; Abcouwer, SF
      Mechanisms governing the expression of the enzymes of glutamine metabolism- Glutaminase and glutamine synthetase

      JOURNAL OF NUTRITION
    72. Medina, MA
      Glutamine and cancer

      JOURNAL OF NUTRITION
    73. Kruchkova, Y; Ben-Dror, I; Herschkovitz, A; David, M; Yayon, A; Vardimon, L
      Basic fibroblast growth factor: a potential inhibitor of glutamine synthetase expression in injured neural tissue

      JOURNAL OF NEUROCHEMISTRY
    74. Kobayashi, S; Millhorn, DE
      Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells

      JOURNAL OF NEUROCHEMISTRY
    75. Levine, MZ; Harrison, PJH; Walthall, WW; Tai, PC; Derby, CD
      A CUB-serine protease in the olfactory organ of the spiny lobster Panulirus argus

      JOURNAL OF NEUROBIOLOGY
    76. Kashiwagi, A; Noumachi, W; Katsuno, M; Alam, MT; Urabe, I; Yomo, T
      Plasticity of fitness and diversification process during an experimental molecular evolution

      JOURNAL OF MOLECULAR EVOLUTION
    77. Falke, S; Fisher, MT; Gogol, EP
      Structural changes in GroEL effected by binding a denatured protein substrate

      JOURNAL OF MOLECULAR BIOLOGY
    78. Obara, M; Kajiura, M; Fukuta, Y; Yano, M; Hayashi, M; Yamaya, T; Sato, T
      Mapping of QTLs associated with cytosolic glutamine synthetase and NADH-glutamate synthase in rice (Oryza sativa L.)

      JOURNAL OF EXPERIMENTAL BOTANY
    79. Stohr, C; Mack, G
      Diurnal changes in nitrogen assimilation of tobacco roots

      JOURNAL OF EXPERIMENTAL BOTANY
    80. Lim, CB; Chew, SF; Anderson, PM; Ip, YK
      Reduction in the rates of protein and amino acid catabolism to slow down the accumulation of endogenous ammonia: A strategy potentially adopted by mudskippers (Periophthalmodon schlosseri and Boleophthalmus boddaerti) duringaerial exposure in constant darkness

      JOURNAL OF EXPERIMENTAL BIOLOGY
    81. Steele, SL; Chadwick, TD; Wright, PA
      Ammonia detoxification and localization of urea cycle enzyme activity in embryos of the rainbow trout (Oncorhynchus mykiss) in relation to early tolerance to high environmental ammonia levels

      JOURNAL OF EXPERIMENTAL BIOLOGY
    82. Anezary, L; Medina, JI; Sanchez-Nogueiro, J; Lopez-Gallardo, M; Prada, C
      Shape diversity among chick retina miller cells and their postnatal differentiation

      JOURNAL OF COMPARATIVE NEUROLOGY
    83. Peterson, RE; Fadool, JM; McClintock, J; Linser, PJ
      Muller cell differentiation in the zebrafish neural retina: Evidence of distinct early and late stages in cell maturation

      JOURNAL OF COMPARATIVE NEUROLOGY
    84. Bulteau, AL; Verbeke, P; Petropoulos, I; Chaffotte, AF; Friguet, B
      Proteasome inhibition in glyoxal-treated fibroblasts and resistance of glycated glucose-6-phosphate dehydrogenase to 20 S proteasome degradation in vitro

      JOURNAL OF BIOLOGICAL CHEMISTRY
    85. Tieman, BC; Johnston, MF; Fisher, MT
      A comparison of the GroE chaperonin requirements for sequentially and structurally homologous malate dehydrogenases - The importance of folding kinetics and solution environment

      JOURNAL OF BIOLOGICAL CHEMISTRY
    86. Abbott, JJ; Pei, JM; Ford, JL; Qi, Y; Grishin, VN; Phillips, MA; Grishin, NV
      Structure prediction and active site analysis of the metal binding determinants gamma-glutamyleysteine synthetase

      JOURNAL OF BIOLOGICAL CHEMISTRY
    87. Muro-Pastor, MI; Reyes, JC; Florencio, FJ
      Cyanobacteria perceive nitrogen status by sensing intracellular 2-oxoglutarate levels

      JOURNAL OF BIOLOGICAL CHEMISTRY
    88. Minic, Z; Simon, V; Penverne, B; Gaill, F; Herve, G
      Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila

      JOURNAL OF BIOLOGICAL CHEMISTRY
    89. Lasch, P; Petras, T; Ullrich, O; Backmann, J; Naumann, D; Grune, T
      Hydrogen peroxide-induced structural alterations of RNase A

      JOURNAL OF BIOLOGICAL CHEMISTRY
    90. Rudnick, PA; Arcondeguy, T; Kennedy, CK; Kahn, D
      glnD and mviN are genes of an essential operon in Sinorhizobium meliloti

      JOURNAL OF BACTERIOLOGY
    91. Kessler, PS; Daniel, C; Leigh, JA
      Ammonia switch-off of nitrogen fixation in the methanogenic archaeon Methanococcus maripaludis: Mechanistic features and requirement for the novel GLnB homologues, NifI(1) and NifI(2)

      JOURNAL OF BACTERIOLOGY
    92. Lopez-Garcia, SL; Vazquez, TEE; Favelukes, G; Lodeiro, AR
      Improved soybean root association of N-starved Bradyrhizobium japonicum

      JOURNAL OF BACTERIOLOGY
    93. Zhang, YP; Pohlmann, EL; Ludden, PW; Roberts, GP
      Functional characterization of three GlnB homologs in the photosynthetic bacterium Rhodospirillum rubrum: Roles in sensing ammonium and energy status

      JOURNAL OF BACTERIOLOGY
    94. Herrero, A; Muro-Pastor, AM; Flores, E
      Nitrogen control in cyanobacteria

      JOURNAL OF BACTERIOLOGY
    95. Reyes-Ramirez, F; Little, R; Dixon, R
      Role of Escherichia coli nitrogen regulatory genes in the nitrogen response of the Azotobacter vinelandii NifL-NifA complex

      JOURNAL OF BACTERIOLOGY
    96. Lorenzo, H; Siverio, JM; Caballero, M
      Salinity and nitrogen fertilization and nitrogen metabolism in rose plants

      JOURNAL OF AGRICULTURAL SCIENCE
    97. Nandula, VK; Westwood, JH; Foster, JG; Foy, CL
      Influence of glyphosate on amino acid composition of Egyptian broomrape [Orobanche aegyptiaca (Pers.)] and selected hosts

      JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
    98. Ochrietor, JD; Moroz, TM; Kadomatsu, K; Muramatsu, T; Linser, PJ
      Retinal degeneration following failed photoreceptor maturation in 5A11/Basigin null mice

      EXPERIMENTAL EYE RESEARCH
    99. Xu, YB; Carr, PD; Huber, T; Vasudevan, SG; Ollis, DL
      Th structure of the P-II-ATP complex

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    100. Krones, A; Jungermann, K; Kietzmann, T
      Cross-talk between the signals hypoxia and glucose at the glucose responseelement of the L-type pyruvate kinase gene

      ENDOCRINOLOGY


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Documento generato il 29/10/20 alle ore 15:02:48