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Stage-specific expression of Gadd45 induced by X-irradiation in rat spermatogenesis
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis
NEURO-ONCOLOGY
The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating
GENES TO CELLS
The epidermal growth factor receptor as a target for cancer therapy
ENDOCRINE-RELATED CANCER
Staurosporine-induced apoptosis of HPV positive and negative human cervical cancer cells from different points in the cell cycle
CELL DEATH AND DIFFERENTIATION
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
CLINICAL CANCER RESEARCH
A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor
CLINICAL CANCER RESEARCH
Differences in activation of G2/M checkpoint in keratinocytes after genotoxic stress induced by hydrogen peroxide and ultraviolet a radiation
FREE RADICAL RESEARCH
Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide
MOLECULAR BIOLOGY OF THE CELL
TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines
GENES CHROMOSOMES & CANCER
Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas
SEMINARS IN CANCER BIOLOGY
Epidermal growth factor receptor biology (IMC-C225)
CURRENT OPINION IN ONCOLOGY
DNA damage and cell cycle checkpoints in hyperoxic lung injury: braking tofacilitate repair
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G(0)/G(1) arrest only in serum starved cells
INTERNATIONAL JOURNAL OF ONCOLOGY
Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect
EUROPEAN JOURNAL OF CANCER
Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV
ONCOGENE
G2 phase cell cycle arrest in human skin following UV irradiation
ONCOGENE
Protection against chemotherapy-induced cytotoxicity by cyclin-dependent kinase inhibitors (CKI) in CKI-responsive cells compared with CKI-unresponsive cells
ONCOGENE
Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
ONCOGENE
Differential post-translational modification of the tumour suppressor proteins Rb and p53 modulate the rates of radiation-induced apoptosis in vivo
ONCOGENE
The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway
ONCOGENE
Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody
ONCOGENE
Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720
JAPANESE JOURNAL OF CANCER RESEARCH
UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery
JAPANESE JOURNAL OF CANCER RESEARCH
From cells to organisms: can we learn about aging from cells in culture?
EXPERIMENTAL GERONTOLOGY
Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Sensitivity to topoisomerase I inhibitors and cisplatin is associated withepidermal growth factor receptor expression in human cervical squamous carcinoma ME180 sublines
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Inhibition of normal human lung fibroblast growth by beryllium
TOXICOLOGY
AMF1 (GPS2) modulates p53 transactivation
MOLECULAR AND CELLULAR BIOLOGY
Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells
PROSTATE
Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G(1) block
EMBO JOURNAL
Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and vinca alkaloids of human ovarian cancer cells
ANTICANCER RESEARCH
Complex regulation of CDK2 and g1 arrest during neuronal differentiation of human prostatic cancer TSU-Pr1 cells by staurosporine
ANTICANCER RESEARCH
Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells
INVESTIGATIONAL NEW DRUGS
TP53 gene mutations, nuclear p53 accumulation, expression of waf/p21, bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme
JOURNAL OF NEURO-ONCOLOGY
Inhibitory effects of sodium butyrate on proliferation and invasiveness ofhuman glioma cells
NEUROSURGERY
Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N-omega-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines
CARCINOGENESIS
Positive effect of the induction of p21(WA1/CIP1) on the course of ischemic acute renal failure
KIDNEY INTERNATIONAL
Senescent cells are resistant to death despite low Bcl-2 level
MECHANISMS OF AGEING AND DEVELOPMENT
Permanent growth arrest in irradiated human fibroblasts
RADIATION RESEARCH
Molecular events in radiation transformation
RADIATION RESEARCH
Myc represses the p21((WAF1/CIP1)) promoter and interacts with Sp1/Sp3
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2 '-deoxycytidine
MOLECULAR PHARMACOLOGY
Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells
JOURNAL OF VIROLOGY
The Willet F. Whitmore, Jr., lectureship: Blockade of epidermal growth factor receptors as anticancer therapy
JOURNAL OF UROLOGY
Characterization of DNA damage-stimulated self-interaction of Saccharomyces cerevisiae checkpoint protein Rad17p
JOURNAL OF BIOLOGICAL CHEMISTRY
Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition
INTERNATIONAL JOURNAL OF CANCER
Involvement of the MAP kinase pathways in induction of GADD45 following UVradiation
EXPERIMENTAL CELL RESEARCH
Retinoic acid- and bone morphogenetic protein 4-induced apoptosis in P19 embryonal carcinoma cells requires p27
EXPERIMENTAL CELL RESEARCH
Ablation of p21waf1cip1 expression enhances the capacity of p53-deficient human tumor cells to repair UVB-induced DNA damage
CANCER RESEARCH
Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by ravopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity
CANCER RESEARCH
Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanomacells
CANCER RESEARCH
A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells
CANCER RESEARCH
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice
CANCER RESEARCH
Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225
BRITISH JOURNAL OF DERMATOLOGY
The relationship between radiation-induced G(1) arrest and chromosome aberrations in Li-Fraumeni fibroblasts with or without germline TP53 mutations
BRITISH JOURNAL OF CANCER
p53 missense but not truncation mutations ave associated with low levels of p21(CIP1/WAF1) mRNA expression in primary human sarcomas
BRITISH JOURNAL OF CANCER
Transcriptional activation of p21(WAF1/C1P1) by apicidin, a novel histone deacetylase inhibitor
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
p53 independent G(1) arrest induced by DL-alpha-difluoromethylomithine
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Overexpression of E2F1 in glioma-derived cell lines induces a p53-independent apoptosis that is further enhanced by ionizing radiation
NEURO-ONCOLOGY
Cell cycle and apoptosis
NEOPLASIA
The many substrates and functions of ATM
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Cell cycle progression and apoptosis after irradiation in an acidic environment
CELL DEATH AND DIFFERENTIATION
p53 accumulation due to down-regulation of ubiquitin: relevance for neuronal apoptosis
CELL DEATH AND DIFFERENTIATION
Role of p53 in cellular response to anticancer nucleoside analog-induced DNA damage
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
p53, p21(WAF1/CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smoothmuscle cells
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
p53, p21(WAF1/CIP1), and MDM2 involvement in proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Loss of p14(ARF) in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)
NATURE MEDICINE
Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cyclekinetics, and tumor angiogenesis
CLINICAL CANCER RESEARCH
Requirement for the von Hippel-Lindau tumor suppressor gene for functionalepidermal growth factor receptor blockade by monoclonal antibody C225 in renal cell carcinoma
CLINICAL CANCER RESEARCH
Blockade of receptors for growth factors: An anticancer therapy - The Fourth Annual Joseph H. Burchenal American Association for Cancer Research Clinical Research Award Lecture
CLINICAL CANCER RESEARCH
Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells
CLINICAL CANCER RESEARCH
Modulation of molecular targets to enhance radiation
CLINICAL CANCER RESEARCH
Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms
CLINICAL CANCER RESEARCH
Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21protein after the stabilization of p53 and the expression of p21
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Inactivation of p33(ING1) tumor suppressor affects the function of the cell cycle "checkpoints" and stability of the genome
RUSSIAN JOURNAL OF GENETICS
Prognostic value of simultaneous expression of p21 and mdm2 in breast carcinomas treated by adjuvant chemotherapy with antracyclin
ONCOLOGY REPORTS
Expression of cell cycle regulator genes in KB, a human squamous cell carcinoma cell line, after irradiation
INTERNATIONAL JOURNAL OF ONCOLOGY
Biological activity of all-trans-retinoic acid with and without tamoxifen and alpha-interferon 2a in breast cancer patients
INTERNATIONAL JOURNAL OF ONCOLOGY
Absence of p53-mediated G1 arrest with induction of MDM2 in sterigmatocystin-treated cells
INTERNATIONAL JOURNAL OF ONCOLOGY
A G2/M growth arrest response to low-dose intermittent H2O2 in normal uroepithelial cells
INTERNATIONAL JOURNAL OF ONCOLOGY
Effect of p16(INK4a) on chemosensitivity in nasopharyngeal carcinoma cells
INTERNATIONAL JOURNAL OF ONCOLOGY
p21 is associated with cyclin D1, p16INK4a and pRb expression in resectable non-small cell lung cancer
INTERNATIONAL JOURNAL OF ONCOLOGY
WAF1 accumulation by carbon-ion beam and alpha-particle irradiation in human glioblastoma cultured cells
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Effects of low dose irradiation on TK6 and U937 cells: induction of p53 and its role in cell-cycle delay and the adaptive response
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Loss of p21(WAF1/CIP1) accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model
ONCOGENE
Isolation and characterization of sixteen novel p53 response genes
ONCOGENE
Hepatitis B virus-X protein upregulates the expression of p21(waf1/cip1) and prolongs G1 -> S transition via a p53-independent pathway in human hepatoma cells
ONCOGENE
Sxa2 is a serine carboxypeptidase that degrades extracellular P-factor in the fission yeast Schizosaccharomyces pombe
MOLECULAR MICROBIOLOGY
Polymorphisms of p21 cyclin-dependent kinase inhibitor and malignant skin tumors
JOURNAL OF DERMATOLOGICAL SCIENCE
p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells
JAPANESE JOURNAL OF CANCER RESEARCH
The permissive effect of p21(Waf1/Cip1) on DNA synthesis is dependent on cell type: Effect is absent in p53-inactive cells
CELLULAR SIGNALLING
Oxidative stress and cell cycle checkpoint function
FREE RADICAL BIOLOGY AND MEDICINE
Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
FREE RADICAL BIOLOGY AND MEDICINE
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest
GENES & DEVELOPMENT
Cooperative effects of genes controlling the G(2)/M checkpoint
GENES & DEVELOPMENT
Induction of p53-independent p21 during ceramide-induced G1 arrest in human hepatocarcinoma cells
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
A transcriptional autoregulatory loop for KIN28-CCL1 and SRB10-SRB11, eachencoding RNA polymerase IICTD kinase-cyclin pair, stimulates the meiotic development of S-cerevisiae
YEAST
Overexpressed poly(ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(1) checkpoint
JOURNAL OF CELLULAR BIOCHEMISTRY
Epigenetic aspects of cellular senescence
EXPERIMENTAL GERONTOLOGY