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La ricerca find articoli where soggetti phrase all words 'FAMILIAL ALZHEIMERS-DISEASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 731 riferimenti
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    1. Chen, FS; Yu, G; Arawaka, S; Nishimura, M; Kawarai, T; Yu, H; Tandon, A; Supala, A; Song, YQ; Rogaeva, E; Milman, P; Sato, C; Yu, C; Janus, C; Lee, J; Song, LX; Zhang, LL; Fraser, PE; St George-Hyslop, PH
      Nicastrin binds to membrane tethered Notch

      NATURE CELL BIOLOGY
    2. De Strooper, B; Annaert, W
      Presenilins and the intramembrane proteolysis of proteins: facts and fiction

      NATURE CELL BIOLOGY
    3. Martin, LJ
      Neuronal cell death in nervous system development, disease, and injury (Review)

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    4. Sklar, P
      The genomic approach to candidate genes

      HARVARD REVIEW OF PSYCHIATRY
    5. Datar, RH
      Nucleic acids in diagnosis (Part II): Genetic testing and screening

      NATIONAL MEDICAL JOURNAL OF INDIA
    6. Lesuisse, C; Xu, GL; Anderson, J; Wong, M; Jankowsky, J; Holtz, G; Gonzalez, V; Wong, PCY; Price, DL; Tang, F; Wagner, S; Borchelt, DR
      Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice

      HUMAN MOLECULAR GENETICS
    7. Faham, M; Baharloo, S; Tomitaka, S; DeYoung, J; Freimer, NB
      Mismatch repair detection (MRD): high-throughput scanning for DNA variations

      HUMAN MOLECULAR GENETICS
    8. De Jonghe, C; Esselens, C; Kumar-Singh, S; Craessaerts, K; Serneels, S; Checler, F; Annaert, W; Van Broeckhoven, C; De Strooper, B
      Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability

      HUMAN MOLECULAR GENETICS
    9. Goedert, M; Spillantini, MG; Serpell, LC; Berriman, J; Smith, MJ; Jakes, R; Crowther, RA
      From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    10. Hernandez, D; Sugaya, K; Qu, TY; McGowan, E; Duff, K; McKinney, M
      Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes

      NEUROREPORT
    11. Zill, P; Engel, R; Hampel, H; Behrens, S; Burger, K; Padberg, F; Stubner, S; Moller, HJ; Ackenheil, M; Bondy, B
      Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients

      EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
    12. Annaert, WG; Esselens, C; Baert, V; Boeve, C; Snellings, G; Cupers, P; Craessaerts, K; De Strooper, B
      Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

      NEURON
    13. Gunawardena, S; Goldstein, LSB
      Disruption of axonal transport and neuronal viability by amyloid precursorprotein mutations in Drosophila

      NEURON
    14. Yu, HK; Saura, CA; Choi, SY; Sun, LD; Yang, XD; Handler, M; Kawarabayashi, T; Younkin, L; Fedeles, B; Wilson, MA; Younkin, S; Kandel, ER; Kirkwood, A; Shen, J
      APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

      NEURON
    15. Wolfe, MS
      gamma-secretase inhibitors as molecular probes of presenilin function

      JOURNAL OF MOLECULAR NEUROSCIENCE
    16. Wong, PC; Cai, HB; Borchelt, DR; Price, DL
      Genetically engineered models relevant to neurodegenerative disorders - Their value for understanding disease mechanisms and designing/testing experimental therapeutics

      JOURNAL OF MOLECULAR NEUROSCIENCE
    17. Hedera, P
      Ethical principles and pitfalls of genetic testing for dementia

      JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
    18. Kumar, VB; Vyas, K; Franko, M; Choudhary, V; Buddhiraju, C; Alvarez, J; Morley, JE
      Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8)

      BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
    19. Massart, F; Reginster, JY; Brandi, ML
      Genetics of menopause-associated diseases

      MATURITAS
    20. Phiel, CJ; Klein, PS
      Molecular targets of lithium action

      ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
    21. Eckert, A; Steiner, B; Marques, C; Leutz, S; Romig, H; Haass, C; Muller, WE
      Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

      JOURNAL OF NEUROSCIENCE RESEARCH
    22. Martins, RN; Taddei, K; Kendall, C; Evin, G; Bates, KA; Harvey, AR
      Altered expression of apolipoprotein E, amyloid precursor protein and presenilin-1 is associated with chronic reactive gliosis in rat cortical tissue

      NEUROSCIENCE
    23. Petegnief, V; Saura, J; De Gregorio-Rocasolano, N; Paul, SM
      Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: Nuclear factor kappa B inhibitors reduce basal and lesion-induced secretion of apolipoprotein E

      NEUROSCIENCE
    24. Kostyszyn, B; Cowburn, RF; Seiger, A; Kjaeldgaard, A; Sundstrom, E
      Expression of presenilin-1 and notch-1 receptor in human embryonic CNS

      NEUROSCIENCE
    25. Hardy, J; Crook, R
      Presenilin mutations line up along transmembrane alpha-helices

      NEUROSCIENCE LETTERS
    26. Tehranian, R; Hasanvan, H; Iverfeldt, K; Post, C; Schultzberg, M
      Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576

      NEUROSCIENCE LETTERS
    27. Mehler, MF; Gokhan, S
      Developmental mechanisms in the pathogenesis of neurodegenerative diseases

      PROGRESS IN NEUROBIOLOGY
    28. Pigino, G; Pelsman, A; Mori, H; Busciglio, J
      Presenilin-1 mutations reduce cytoskeletal association, deregulate neuritegrowth, and potentiate neuronal dystrophy and tau phosphorylation

      JOURNAL OF NEUROSCIENCE
    29. Mudher, A; Chapman, S; Richardson, J; Asuni, A; Gibb, G; Pollard, C; Killick, R; Iqbal, T; Raymond, L; Varndell, I; Sheppard, P; Makoff, A; Gower, E; Soden, PE; Lewis, P; Murphy, M; Golde, TE; Rupniak, HT; Anderton, BH; Lovestone, S
      Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase

      JOURNAL OF NEUROSCIENCE
    30. Fitzjohn, SM; Morton, RA; Kuenzi, F; Rosahl, TW; Shearman, M; Lewis, H; Smith, D; Reynolds, DS; Davies, CH; Collingridge, GL; Seabrook, GR
      Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant formof amyloid precursor protein

      JOURNAL OF NEUROSCIENCE
    31. Mattson, MP; Chan, SL; Camandola, S
      Presenilin mutations and calcium signaling defects in the nervous and immune systems

      BIOESSAYS
    32. Ishii, K; Lippa, C; Tomiyama, T; Miyatake, F; Ozawa, K; Tamaoka, A; Hasegawa, T; Fraser, PE; Shoji, S; Nee, LE; Pollen, DA; St George-Hyslop, PH; Ii, K; Ohtake, T; Kalaria, RN; Rossor, MN; Lantos, PL; Cairns, NJ; Farrer, LA; Mori, H
      Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition

      NEUROBIOLOGY OF AGING
    33. Shoji, M; Kanai, M; Matsubara, E; Tomidokoro, Y; Shizuka, M; Ikeda, Y; Ikeda, M; Harigaya, Y; Okamoto, K; Hirai, S
      The levels of cerebrospinal fluid A beta 40 and A beta 42(43) are regulated age-dependently

      NEUROBIOLOGY OF AGING
    34. Fernandez-Novoa, L; Cacabelos, R
      Histamine function in brain disorders

      BEHAVIOURAL BRAIN RESEARCH
    35. Sisodia, SS; Annaert, W; Kim, SH; De Strooper, B
      gamma-secretase: Never more enigmatic

      TRENDS IN NEUROSCIENCES
    36. Lendon, C; Craddock, N
      Susceptibility gene(s) forAlzheimer's disease on chromosome 10

      TRENDS IN NEUROSCIENCES
    37. Radant, A; Tsuang, D; Peskind, ER; McFall, M; Raskind, W
      Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder

      PSYCHIATRY RESEARCH
    38. Sobin, C; Blundell, ML; Conry, A; Weiller, F; Gavigan, C; Haiman, C; Karayiorgou, M
      Early, non-psychotic deviant behavior in schizophrenia: a possible endophenotypic marker for genetic studies

      PSYCHIATRY RESEARCH
    39. Lee, VMY
      Biomedicine - Tauists and beta aptists united - Well almost!

      SCIENCE
    40. Lewis, J; Dickson, DW; Lin, WL; Chisholm, L; Corral, A; Jones, G; Yen, SH; Sahara, N; Skipper, L; Yager, D; Eckman, C; Hardy, J; Hutton, M; McGowan, E
      Enhanced neurofibrillary degeneration in transgenic mice expressing mutanttau and APP

      SCIENCE
    41. Iwata, N; Tsubuki, S; Takaki, Y; Shirotani, K; Lu, B; Gerard, NP; Gerard, C; Hama, E; Lee, HJ; Saido, TC
      Metabolic regulation of brain A beta by neprilysin

      SCIENCE
    42. Lander, ES; Linton, LM; Birren, B; Nusbaum, C; Zody, MC; Baldwin, J; Devon, K; Dewar, K; Doyle, M; FitzHugh, W; Funke, R; Gage, D; Harris, K; Heaford, A; Howland, J; Kann, L; Lehoczky, J; LeVine, R; McEwan, P; McKernan, K; Meldrim, J; Mesirov, JP; Miranda, C; Morris, W; Naylor, J; Raymond, C; Rosetti, M; Santos, R; Sheridan, A; Sougnez, C; Stange-Thomann, N; Stojanovic, N; Subramanian, A; Wyman, D; Rogers, J; Sulston, J; Ainscough, R; Beck, S; Bentley, D; Burton, J; Clee, C; Carter, N; Coulson, A; Deadman, R; Deloukas, P; Dunham, A; Dunham, I; Durbin, R; French, L; Grafham, D; Gregory, S; Hubbard, T; Humphray, S; Hunt, A; Jones, M; Lloyd, C; McMurray, A; Matthews, L; Mercer, S; Milne, S; Mullikin, JC; Mungall, A; Plumb, R; Ross, M; Shownkeen, R; Sims, S; Waterston, RH; Wilson, RK; Hillier, LW; McPherson, JD; Marra, MA; Mardis, ER; Fulton, LA; Chinwalla, AT; Pepin, KH; Gish, WR; Chissoe, SL; Wendl, MC; Delehaunty, KD; Miner, TL; Delehaunty, A; Kramer, JB; Cook, LL; Fulton, RS; Johnson, DL; Minx, PJ; Clifton, SW; Hawkins, T; Branscomb, E; Predki, P; Richardson, P; Wenning, S; Slezak, T; Doggett, N; Cheng, JF; Olsen, A; Lucas, S; Elkin, C; Uberbacher, E; Frazier, M; Gibbs, RA; Muzny, DM; Scherer, SE; Bouck, JB; Sodergren, EJ; Worley, KC; Rives, CM; Gorrell, JH; Metzker, ML; Naylor, SL; Kucherlapati, RS; Nelson, DL; Weinstock, GM; Sakaki, Y; Fujiyama, A; Hattori, M; Yada, T; Toyoda, A; Itoh, T; Kawagoe, C; Watanabe, H; Totoki, Y; Taylor, T; Weissenbach, J; Heilig, R; Saurin, W; Artiguenave, F; Brottier, P; Bruls, T; Pelletier, E; Robert, C; Wincker, P; Rosenthal, A; Platzer, M; Nyakatura, G; Taudien, S; Rump, A; Yang, HM; Yu, J; Wang, J; Huang, GY; Gu, J; Hood, L; Rowen, L; Madan, A; Qin, SZ; Davis, RW; Federspiel, NA; Abola, AP; Proctor, MJ; Myers, RM; Schmutz, J; Dickson, M; Grimwood, J; Cox, DR; Olson, MV; Kaul, R; Raymond, C; Shimizu, N; Kawasaki, K; Minoshima, S; Evans, GA; Athanasiou, M; Schultz, R; Roe, BA; Chen, F; Pan, HQ; Ramser, J; Lehrach, H; Reinhardt, R; McCombie, WR; de la Bastide, M; Dedhia, N; Blocker, H; Hornischer, K; Nordsiek, G; Agarwala, R; Aravind, L; Bailey, JA; Bateman, A; Batzoglou, S; Birney, E; Bork, P; Brown, DG; Burge, CB; Cerutti, L; Chen, HC; Church, D; Clamp, M; Copley, RR; Doerks, T; Eddy, SR; Eichler, EE; Furey, TS; Galagan, J; Gilbert, JGR; Harmon, C; Hayashizaki, Y; Haussler, D; Hermjakob, H; Hokamp, K; Jang, WH; Johnson, LS; Jones, TA; Kasif, S; Kaspryzk, A; Kennedy, S; Kent, WJ; Kitts, P; Koonin, EV; Korf, I; Kulp, D; Lancet, D; Lowe, TM; McLysaght, A; Mikkelsen, T; Moran, JV; Mulder, N; Pollara, VJ; Ponting, CP; Schuler, G; Schultz, JR; Slater, G; Smit, AFA; Stupka, E; Szustakowki, J; Thierry-Mieg, D; Thierry-Mieg, J; Wagner, L; Wallis, J; Wheeler, R; Williams, A; Wolf, YI; Wolfe, KH; Yang, SP; Yeh, RF; Collins, F; Guyer, MS; Peterson, J; Felsenfeld, A; Wetterstrand, KA; Patrinos, A; Morgan, MJ
      Initial sequencing and analysis of the human genome

      NATURE
    43. Nakajima, M; Miura, M; Aosaki, T; Shirasawa, T
      Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro

      JOURNAL OF NEUROCHEMISTRY
    44. Wolfe, MS
      Presenilin and gamma-secretase: structure meets function

      JOURNAL OF NEUROCHEMISTRY
    45. Parks, JK; Smith, TS; Trimmer, PA; Bennett, JP; Parker, WD
      Neurotoxic A beta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro

      JOURNAL OF NEUROCHEMISTRY
    46. Counts, SE; Lah, JJ; Levey, AI
      The regulation of presenilin-1 by nerve growth factor

      JOURNAL OF NEUROCHEMISTRY
    47. Skovronsky, DM; Fath, S; Lee, VMY; Milla, ME
      Neuronal localization of the TNF alpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

      JOURNAL OF NEUROBIOLOGY
    48. Ramelot, TA; Nicholson, LK
      Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR

      JOURNAL OF MOLECULAR BIOLOGY
    49. Tomita, M; Sugi, K; Ozawa, K; Tsong, TY; Yoshimura, T
      Targeting antigen-specific receptors on B lymphocytes to generate high yields of specific monoclonal antibodies directed against biologically active lower antigenic peptides within presenilin 1

      JOURNAL OF IMMUNOLOGICAL METHODS
    50. Kim, JW; Chang, TS; Lee, JE; Huh, SH; Yeon, SW; Yang, WS; Joe, CO; Mook-Jung, I; Tanzi, RE; Kim, TW; Choi, EJ
      Negative regulation of the SAPK/JNK signaling pathway by presenilin 1

      JOURNAL OF CELL BIOLOGY
    51. Soriano, S; Kang, DE; Fu, MF; Pestell, R; Chevallier, N; Zheng, H; Koo, EH
      Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein andNotch processing

      JOURNAL OF CELL BIOLOGY
    52. Wolfe, MS; Haass, C
      The role of presenilins in gamma-secretase activity

      JOURNAL OF BIOLOGICAL CHEMISTRY
    53. Ohkubo, N; Mitsuda, N; Tamatani, M; Yamaguchi, A; Lee, YD; Ogihara, T; Vitek, MP; Tohyama, M
      Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway

      JOURNAL OF BIOLOGICAL CHEMISTRY
    54. Beher, D; Wrigley, JDJ; Nadin, A; Evin, G; Masters, CL; Harrison, T; Castro, JL; Shearman, MS
      Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma-secretase inhibitor - Implications for presenilin biology

      JOURNAL OF BIOLOGICAL CHEMISTRY
    55. Kim, SH; Leem, JY; Lah, JJ; Slunt, HH; Levey, AI; Thinakaran, G; Sisodia, SS
      Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

      JOURNAL OF BIOLOGICAL CHEMISTRY
    56. Sato, N; Imaizumi, K; Manabe, T; Taniguchi, M; Hitomi, J; Katayama, T; Yoneda, T; Morihara, T; Yasuda, Y; Takagi, T; Kudo, T; Tsuda, T; Itoyama, Y; Makifuchi, T; Fraser, PE; St George-Hyslop, P; Tohyama, M
      Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2

      JOURNAL OF BIOLOGICAL CHEMISTRY
    57. Chishti, MA; Yang, DS; Janus, C; Phinney, AL; Horne, P; Pearson, J; Strome, R; Zuker, N; Loukides, J; French, J; Turner, S; Lozza, G; Grilli, M; Kunicki, S; Morissette, C; Paquette, J; Gervais, F; Bergeron, C; Fraser, PE; Carlson, GA; St George-Hyslop, P; Westaway, D
      Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695

      JOURNAL OF BIOLOGICAL CHEMISTRY
    58. Schneider, I; Reverse, D; Dewachter, I; Ris, L; Caluwaerts, N; Kuiperi, C; Gilis, M; Geerts, H; Kretzschmar, H; Godaux, E; Moechars, D; Van Leuven, F; Herms, J
      Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitatinglong-term potentiation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    59. Mitsuda, N; Ohkubo, N; Tamatani, M; Lee, YD; Taniguchi, M; Namikawa, K; Kiyama, H; Yamaguchi, A; Sato, N; Sakata, K; Ogihara, T; Vitek, MP; Tohyama, M
      Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1

      JOURNAL OF BIOLOGICAL CHEMISTRY
    60. Steiner, H; Revesz, T; Neumann, M; Romig, H; Grim, MG; Pesold, B; Kretzschmar, HA; Hardy, J; Holton, JL; Baumeister, R; Houlden, H; Haass, C
      A pathogenic presenilin-1 deletion causes abberrant A beta 42 production in the absence of congophilic amyloid plaques

      JOURNAL OF BIOLOGICAL CHEMISTRY
    61. Pinnix, I; Musunuru, U; Tun, H; Sridharan, A; Golde, T; Eckman, C; Ziani-Cherif, C; Onstead, L; Sambamurti, K
      A novel gamma-secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor

      JOURNAL OF BIOLOGICAL CHEMISTRY
    62. Benussi, L; Alberici, A; Mayhaus, M; Langer, U; Ghidoni, R; Mazzoli, F; Nicosia, F; Barbiero, L; Frisoni, G; Zanetti, O; Gasparini, L; Nitsch, RM; Binetti, G
      Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: A release enhanced by apoptosis

      EXPERIMENTAL CELL RESEARCH
    63. Kawamura, Y; Kikuchi, A; Takada, R; Takada, S; Sudoh, S; Shibamoto, S; Yanagisawa, K; Komano, H
      Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathwayby enhancement of beta-catenin phosphorylation

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    64. Heyn, SN; Vulliet, PR
      Presenilin 1 mutations increase amyloid precursor protein production and proteolysis in Xenopus laevis oocytes

      BRAIN RESEARCH
    65. Arendash, GW; King, DL; Gordon, MN; Morgan, D; Hatcher, JM; Hope, CE; Diamond, DM
      Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

      BRAIN RESEARCH
    66. Westlind-Danielsson, A; Arnerup, G
      Spontaneous in vitro formation of supramolecular beta-amyloid structures, "beta amy balls", by beta-amyloid 1-40 peptide

      BIOCHEMISTRY
    67. Sun, J; Li, MT; Han, JH; Gu, J
      Sensitization of differentiated PC12 cells to apoptosis by presenilin-2 ismediated by p38

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    68. Hashimoto, Y; Ito, Y; Niikura, T; Shao, Z; Hata, M; Oyama, F; Nishimoto, I
      Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    69. Sudo, H; Hashimoto, Y; Niikura, T; Shao, ZJ; Yasukawa, T; Ito, Y; Yamada, M; Hata, M; Hiraki, T; Kawasumi, M; Kouyama, K; Nishimoto, I
      Secreted A beta does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    70. Clarke, NJ; Crow, FW; Younkin, S; Naylor, S
      Analysis of in vivo-derived amyloid-beta polypeptides by on-line two-dimensional chromatography-mass spectrometry

      ANALYTICAL BIOCHEMISTRY
    71. Puglielli, L; Ingano, LAM; Tanzi, RE; Kovacs, DM
      The amyloid precursor protein V717I mutation increases susceptibility to cell death in a cholesterol-dependent manner

      ALZHEIMER'S DISEASE
    72. Grimm, HS; Lichtenthaler, SF; Beyreuther, K; Hartmann, T
      Intracellular and secreted A beta(42/40) ratios are differently influencedby APP mutations

      ALZHEIMER'S DISEASE
    73. Song, WH; Yankner, BA
      Presenilins and notch signaling pathway

      ALZHEIMER'S DISEASE
    74. Steiner, H; Haass, C
      A novel protease active site motif conserved in presenilins and polytopic bacterial aspartyl proteases?

      ALZHEIMER'S DISEASE
    75. Takashima, A; Tanemura, K
      Formation of neurofibrillary tangles in mouse brain

      ALZHEIMER'S DISEASE
    76. Esler, WP; Kimberly, WT; Ostaszewski, BL; Xia, WM; Selkoe, DJ; Wolfe, MS
      Toward the identification of gamma-secretase: Using transition state analog inhibitors

      ALZHEIMER'S DISEASE
    77. Gardell, SJ; Li, YM; Xu, M; Lai, MT; Huang, Q; Castro, JL; DiMuzio-Mower, J; Harrison, T; Lellis, C; Nadin, A; Neduvelil, JG; Register, RB; Sardana, MK; Shearman, MS; Shi, XP; Smith, AL; Yin, KC; Shafer, JA
      Photoactivated, active-site-directed gamma-secretase inhibitors covalentlylabel presenilin 1

      ALZHEIMER'S DISEASE
    78. Steiner, H; Haass, C
      Intramembrane proteolysis by presenilins

      NATURE REVIEWS MOLECULAR CELL BIOLOGY
    79. Esler, WP; Kimberly, WT; Ostaszewski, BL; Diehl, TS; Moore, CL; Tsai, JY; Rahmati, T; Xia, WM; Selkoe, DJ; Wolfe, MS
      Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1

      NATURE CELL BIOLOGY
    80. Zhang, ZH; Nadeau, P; Song, WH; Donoviel, D; Yuan, ML; Bernstein, A; Yankner, BA
      Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

      NATURE CELL BIOLOGY
    81. Capell, A; Steiner, H; Romig, H; Keck, S; Baader, M; Grim, MG; Baumeister, R; Haass, C
      Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

      NATURE CELL BIOLOGY
    82. Sato, N; Urano, F; Leem, JY; Kim, SH; Li, MQ; Donoviel, D; Bernstein, A; Lee, AS; Ron, D; Veselits, ML; Sisodia, SS; Thinakaran, G
      Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression

      NATURE CELL BIOLOGY
    83. Steiner, H; Kostka, M; Romig, H; Basset, G; Pesold, B; Hardy, J; Capell, A; Meyn, L; Grim, ML; Baumeister, R; Fechteler, K; Haass, C
      Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

      NATURE CELL BIOLOGY
    84. Christie, G; Hussain, I; Smith, L; Mansfield, F; Bresciani, L; Davis, JB; Gray, CW; Markwell, R; Wadsworth, H; King, R; McLaughlin, M; Cooper, DG; Karran, E; Ward, RV
      Peptidyl boronic acids inhibit the degradation of presenilin-l in presenilin-l transfected cells

      ALZHEIMERS REPORTS
    85. Howlett, DR
      Association of JNK immunoreactivity with B-amyloid/tau deposits in transgenic mouse brain

      ALZHEIMERS REPORTS
    86. Emilien, G; Ponchon, M; Caldas, C; Isacson, O; Maloteaux, JM
      Impact of genomics on drug discovery and clinical medicine

      QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
    87. Pang, CP; Baum, L; Lam, DSC
      Hunting for disease genes in multi-functional diseases

      CLINICAL CHEMISTRY AND LABORATORY MEDICINE
    88. Yamaguchi, F; Yamaguchi, K; Tokuda, M
      Presenilin-1 protein specifically expressed in Leydig cells with its expression level increased during rat testis development

      INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
    89. Larner, AJ
      Neuronal apoptosis as a therapeutic target in neurodegenerative disease

      EXPERT OPINION ON THERAPEUTIC PATENTS
    90. Chan, HYE; Bonini, NM
      Drosophila models of human neurodegenerative disease

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ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/10/20 alle ore 18:44:30