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    1. Tatebe, S; Unate, H; Sinicrope, FA; Sakatani, T; Sugamura, K; Makino, M; Ito, H; Savaraj, N; Kaibara, N; Kuo, MT
      Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma

      INTERNATIONAL JOURNAL OF CANCER
    2. Lipkin, EW; Aumann, CA; Newell-Morris, LL
      Evidence for common controls over inheritance of bone quantity and body size from segregation analysis in a pedigreed colony of nonhuman primates (Macaca nemestrina)

      BONE
    3. Seregni, E; Ferrari, L; Martinetti, A; Bombardieri, E
      Diagnostic and prognostic tumor markers in the gastrointestinal tract

      SEMINARS IN SURGICAL ONCOLOGY
    4. van Egmond-Frohlich, AWA; Paul, K; Eggert, W; Gaedicke, G; Wahn, U; Bauer, CP
      Familial dysautonomia: A diagnostic dilemma. Chronic lung disease with signs of an autoimmune disease

      PEDIATRIC PULMONOLOGY
    5. Hernandez, OM; Housmans, PR; Potter, JD
      Plasticity in skeletal cardiac, and smooth muscle - Invited review: Pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation

      JOURNAL OF APPLIED PHYSIOLOGY
    6. Meyer, TD; Salkow, K; Hautzinger, M
      Preliminary results refeering to the predictive validity of the Hypomanic Personality scale - 3 years later

      ZEITSCHRIFT FUR KLINISCHE PSYCHOLOGIE UND PSYCHOTHERAPIE
    7. Ilan, T; Shohat, T; Tobar, A; Magal, N; Yahav, M; Halpern, GJ; Rechavi, G; Shohat, M
      Autosomal dominant nephritis with renal failure of non-alport type: Clinical and molecular studies

      ISRAEL MEDICAL ASSOCIATION JOURNAL
    8. Mullerad, M; Falik, T; Madeb, R; Nativ, O
      Hereditary prostate cancer - the search for the gene

      ISRAEL MEDICAL ASSOCIATION JOURNAL
    9. Langevitz, P; Livneh, A; Neumann, L; Buskila, D; Shemer, J; Amolsky, D; Pras, M
      Prevalence of ischemic heart disease in patients with familial Mediterranean fever

      ISRAEL MEDICAL ASSOCIATION JOURNAL
    10. van der Put, NMJ; van Straaten, HWM; Trijbels, FJM; Blom, HJ
      Folate, homocysteine and neural tube defects: An overview

      EXPERIMENTAL BIOLOGY AND MEDICINE
    11. Klein, AP; Hruban, RH; Brune, KA; Petersen, GM; Goggins, M
      Familial pancreatic cancer

      CANCER JOURNAL
    12. Kere, J
      Human population genetics: Lessons from Finland

      ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
    13. Williams, CS; Sheng, HM; Brockman, JA; Armandla, R; Shao, JY; Washington, MK; Elkahloun, AG; Dubois, RN
      A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established humancolon cancer xenografts

      NEOPLASIA
    14. Skotheim, RI; Kraggerud, SM; Fossa, SD; Stenwig, AE; Gedde-Dahl, T; Danielsen, HE; Jakobsen, KS; Lothe, RA
      Familial/bilateral and sporadic testicular germ cell tumors show frequent genetic changes at loci with suggestive linkage evidence

      NEOPLASIA
    15. Huang, DR; Zhou, YH; Hoffman, GS
      Pathogenesis: immunogenetic factors

      BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
    16. Guindi, M; Riddell, RH
      The pathology of epithelial pre-malignancy of the gastrointestinal tract

      BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
    17. Kronborg, O
      Colonic screening and surveillance

      BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
    18. Thakker, RV
      Molecular genetics and patient management of multiple endocrine neoplasia type I

      BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
    19. Bhatnagar, D; Mackness, MI; Durrington, PN
      Treatment of mixed hyperlipidaemia using a combination of omega-3 fatty acids and HMG CoA reductase inhibitor

      EUROPEAN HEART JOURNAL SUPPLEMENTS
    20. Wasan, KM; Peteherych, KD; Najafi, S; Zamfir, C; Pritchard, PH
      Assessing the plasma pharmacokinetics, tissue distribution, excretion and effects on cholesterol pharmacokinetics of a novel hydrophilic compound, FM-VP4, following administration to rats.

      JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
    21. Hegele, RA
      Molecular basis of partial lipodystrophy and prospects for therapy

      TRENDS IN MOLECULAR MEDICINE
    22. Nadeau, JH
      Modifier genes in mice and humans

      NATURE REVIEWS GENETICS
    23. Goedert, M
      Alpha-synuclein and neurodegenerative diseases

      NATURE REVIEWS NEUROSCIENCE
    24. Gellera, C
      Genetics of ALS in Italian families

      AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
    25. Chen, FS; Yu, G; Arawaka, S; Nishimura, M; Kawarai, T; Yu, H; Tandon, A; Supala, A; Song, YQ; Rogaeva, E; Milman, P; Sato, C; Yu, C; Janus, C; Lee, J; Song, LX; Zhang, LL; Fraser, PE; St George-Hyslop, PH
      Nicastrin binds to membrane tethered Notch

      NATURE CELL BIOLOGY
    26. De Strooper, B; Annaert, W
      Presenilins and the intramembrane proteolysis of proteins: facts and fiction

      NATURE CELL BIOLOGY
    27. Berx, G; Van Roy, F
      The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

      BREAST CANCER RESEARCH
    28. Marsh, A; Spurdle, AB; Turner, BC; Fereday, S; Thorne, H; Pupo, GM; Mann, GJ; Hopper, JL; Sambrook, JF; Chenevix-Trench, G
      The intronic G13964C variant in p53 is not a high-risk mutation in familial breast cancer in Australia

      BREAST CANCER RESEARCH
    29. Hopper, JL
      More breast cancer genes?

      BREAST CANCER RESEARCH
    30. Salahshor, S; Lei, HX; Huo, HG; Kristensen, VN; Loman, N; Sjoberg-Margolin, S; Borg, A; Borresen-Dale, AL; Vorechovsky, I; Lindblom, A
      Low frequency of E-cadherin alterations in familial breast cancer

      BREAST CANCER RESEARCH
    31. Bonnin, F; Lottmann, H; Sauty, L; Garel, C; Archambaud, F; Beaudouin, V; El Ghoneimi, A; Loirat, C; Bok, BD; Aigrain, Y
      Scintigraphic screening for renal damage in siblings of children with symptomatic primary vesico-ureteric reflux

      BJU INTERNATIONAL
    32. Burnett, TR; Watts, GF
      Therapeutic considerations for postprandial dyslipidaemia

      DIABETES OBESITY & METABOLISM
    33. Frenkel, J; Houten, SM; Waterham, HR; Wanders, RJA; Rijkers, GT; Duran, M; Kuijpers, TW; van Luijk, W; Poll-The, BT; Kuis, W
      Clinical and molecular variability in childhood periodic fever with hyperimmunoglobulinaemia D

      RHEUMATOLOGY
    34. Stephan, JL; Kone-Paut, I; Galambrun, C; Mouy, R; Bader-Meunier, B; Prieur, AM
      Reactive haemophagocytic syndrome in children with inflammatory disorders.A retrospective study of 24 patients

      RHEUMATOLOGY
    35. Cavaco, BM; Barros, L; Pannett, AAJ; Ruas, L; Carvalheiro, M; Ruas, MMA; Krausz, T; Santos, MA; Sobrinho, LG; Leite, V; Thakker, RV
      The hyperparathyroidism-jaw tumour syndrome in a Portuguese kindred

      QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
    36. Hutchins, RR; Hani, AB; Kojodjojo, P; Ho, R; Snooks, SJ
      Adenocarcinoma of the small bowel

      ANZ journal of surgery
    37. Ooi, BS; Lee, CN; Ti, TK; Chachlani, N; Chua, ET
      Retroperitoneal fibromatosis presenting as acute duodenal obstruction

      ANZ journal of surgery
    38. Semsarian, C; Seidman, CE
      Molecular medicine in the 21st century

      INTERNAL MEDICINE JOURNAL
    39. Oleksiak, MF; Kolell, KJ; Crawford, DL
      Utility of natural populations for microarray analyses: Isolation of genesnecessary for functional genomic studies

      MARINE BIOTECHNOLOGY
    40. Esposito, I; Friess, H; Buchler, MW
      Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms

      LANGENBECKS ARCHIVES OF SURGERY
    41. Rukavina, AS; Topic, RZ; Ferencak, G; Sucic, M
      A novel missense mutation C127R (FH Zagreb) in the LDL-receptor gene

      CLINICAL CHEMISTRY AND LABORATORY MEDICINE
    42. Henriksen, FL; Petersen, PH; Beck-Nielsen, H; Horder, M
      Calibration, specificity and trueness of a postheparin plasma lipoprotein lipase assay

      CLINICAL CHEMISTRY AND LABORATORY MEDICINE
    43. Pallaud, C; Stranieri, C; Sass, C; Siest, G; Pignatti, F; Visvikis, S
      Candidate gene polymorphisms in cardiovascular disease: A comparative study of frequencies between a French and an Italian population

      CLINICAL CHEMISTRY AND LABORATORY MEDICINE
    44. Kaneko, K; Nagasaki, Y; Furukawa, T; Mizutamari, H; Sato, A; Masamune, A; Shimosegawa, T; Horii, A
      Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis

      JOURNAL OF HUMAN GENETICS
    45. Wang, DQ; Wu, BQ; Li, Y; Heng, WJ; Zhong, HH; Mu, Y; Wang, JJ
      A Chinese homozygote of familial hypercholesterolemia: identification of anovel C263R mutation in the LDL receptor gene

      JOURNAL OF HUMAN GENETICS
    46. Harada, H; Nagai, NH; Tsuneizumi, M; Mikami, I; Sugano, S; Emi, M
      Identification of DMC1, a novel gene in the TOC region on 17q25.1 that shows loss of expression in multiple human cancers

      JOURNAL OF HUMAN GENETICS
    47. Druck, T; Podolski, J; Byrski, T; Wyrwicz, L; Zajaczek, S; Kata, G; Borowka, A; Lubinski, J; Huebner, K
      The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation

      JOURNAL OF HUMAN GENETICS
    48. Kaiser, AM; Beart, RW
      Surgical management of ulcerative colitis

      SWISS MEDICAL WEEKLY
    49. Van Esch, H; Devriendt, K
      Transcription factor GATA3 and the human HDR syndrome

      CELLULAR AND MOLECULAR LIFE SCIENCES
    50. Kopp, P
      The TSH receptor and its role in thyroid disease

      CELLULAR AND MOLECULAR LIFE SCIENCES
    51. Hamilton, JA; Benson, MD
      Transthyretin: a review from a structural perspective

      CELLULAR AND MOLECULAR LIFE SCIENCES
    52. von Eyben, FE; von Eyben, R
      Smoking and other major coronary risk factors and acute myocardial infarction before 41 years of age - Two Danish case-control studies

      SCANDINAVIAN CARDIOVASCULAR JOURNAL
    53. Burke, B; Mounkes, LC; Stewart, C
      The nuclear envelope in muscular dystrophy and cardiovascular diseases

      TRAFFIC
    54. Kaufman, SS; Atkinson, JB; Bianchi, A; Goulet, OJ; Grant, D; Langnas, AN; McDiarmid, SV; Mittal, N; Reyes, J; Tzakis, AG
      Indications for pediatric intestinal transplantation: A position paper of the American Society of Transplantation

      PEDIATRIC TRANSPLANTATION
    55. Ferrillo, F; Plazzi, G; Nobili, L; Beelke, M; De Carli, F; Cortelli, P; Tinuper, P; Avoni, P; Vandi, S; Gambetti, P; Lugaresi, E; Montagna, P
      Absence of sleep EEG markers in fatal familial insomnia healthy carriers: a spectral analysis study

      CLINICAL NEUROPHYSIOLOGY
    56. Celesia, GG
      Disorders of membrane channels or channelopathies

      CLINICAL NEUROPHYSIOLOGY
    57. Murata, M; Miyoshi, Y; Ohsawa, M; Shibata, K; Ohta, T; Imai, Y; Nishikawa, M; Iwao, K; Tateishi, H; Shimano, T; Kobayashi, T; Nakamura, Y
      Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis

      HEPATOLOGY RESEARCH
    58. Surh, YJ; Chun, KS; Cha, HH; Han, SS; Keum, YS; Park, KK; Lee, SS
      Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppressionof NF-kappa B activation

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    59. Debruyne, PR; Bruyneel, EA; Li, XD; Zimber, A; Gespach, C; Mareel, MM
      The role of bile acids in carcinogenesis

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    60. Timmann, C; Muntau, B; Kuhne, K; Gelhaus, A; Horstmann, RD
      Two novel mutations R653H and E230K in the Mediterranean fever gene associated with disease

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    61. Deng, CX
      Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    62. Wierzbicki, AS
      Is a statin a statin?

      INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
    63. Houlston, RS
      What we could do now: molecular pathology of colorectal cancer

      JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
    64. Nakago, S; Hadfield, RM; Zondervan, KT; Mardon, H; Manek, S; Weeks, DE; Barlow, D; Kennedy, S
      Association between endometriosis and N-acetyl transferase 2 polymorphismsin a UK population

      MOLECULAR HUMAN REPRODUCTION
    65. Black, DA; Heyman, RE; Slep, AMS
      Risk factors for child sexual abuse

      AGGRESSION AND VIOLENT BEHAVIOR
    66. Patkar, AA; Berrettini, WH; Hoehe, M; Hill, KP; Sterling, RC; Gottheil, E; Weinstein, SP
      Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals

      ADDICTION BIOLOGY
    67. Komajda, M; Charron, P
      How will the human genome project change cardiovascular medicine?

      HEART
    68. Nakayama, T; Minato, M; Nakagawa, M; Soma, M; Tobe, H; Aoi, N; Kosuge, K; Sato, M; Ozawa, Y; Kanmatsuse, K; Kokubun, S
      A novel mutation in Ca2+-sensing receptor gene in familial hypocalciuric hypercalcemia

      ENDOCRINE
    69. Oram, JF
      Novel approaches to treating cardiovascular disease: lessons from Tangier disease

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    70. Slassi, A; Isaac, M; Arora, J
      Novel serotonergic and non-serotonergic migraine headache therapies

      EXPERT OPINION ON THERAPEUTIC PATENTS
    71. Pal, PK; Wszolek, ZK; Uitti, R; Markopoulou, K; Calne, SM; Stoessl, AJ; Calne, DB
      Positron emission tomography of dopamine pathways in familial Parkinsoniansyndromes

      PARKINSONISM & RELATED DISORDERS
    72. Kuopio, AM; Marttila, RJ; Helenius, H; Rinne, UK
      Familial occurrence of Parkinson's disease in a community-based case-control study

      PARKINSONISM & RELATED DISORDERS
    73. Ghosh, K; Shetty, S; Kulkarni, B; Nair, S; Pawar, A; Khare, A; Baindur, S; Mohanty, D
      Development of inhibitors in patients with haemophilia from India

      HAEMOPHILIA
    74. Ghosh, K; Shetty, S; Mohanty, D
      Milder clinical presentation of haemophilia A with severe deficiency of factor VIII as measured by one-stage assay

      HAEMOPHILIA
    75. Gasser, T; Dichgans, M; Finsterer, J; Hausmanowa-Petrusewicz, I; Jurkat-Rott, K; Klopstock, T; Leguern, E; Lehesjoki, AE; Lehmann-Horn, F; Lynch, T; Morris, H; Rossor, M; Steinlein, OK; Wood, N; Zaremba, J; Zeviani, M; Zoharn, A
      EFNS task force on molecular diagnosis of neurologic disorders - Guidelines for the molecular diagnosis of inherited neurologic diseases - Second of two parts

      EUROPEAN JOURNAL OF NEUROLOGY
    76. Kallela, M; Wessman, M; Havanka, H; Palotie, A; Farkkila, M
      Familial migraine with and without aura: clinical characteristics and co-occurrence

      EUROPEAN JOURNAL OF NEUROLOGY
    77. Howe, LR; Subbaramaiah, K; Brown, AMC; Dannenberg, AJ
      Cyclooxygenase-5: a target for the prevention and treatment of breast cancer

      ENDOCRINE-RELATED CANCER
    78. Evans, JR
      Risk factors for age-related macular degeneration

      PROGRESS IN RETINAL AND EYE RESEARCH
    79. Arvanitakis, Z; Wszolek, ZK
      Recent advances in the understanding of tau protein and movement disorders

      CURRENT OPINION IN NEUROLOGY
    80. Eneqvist, T; Sauer-Eriksson, AE
      Structural distribution of mutations associated with familial amyloidotic polyneuropathy in human transthyretin

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    81. Mochizuki, H; Kamakura, K; Masaki, T; Hirata, A; Tokuda, T; Yazaki, M; Motoyoshi, K; Ikeda, S
      Nodular cutaneous amyloidosis and carpal tunnel syndrome due to the amyloidogenic transthyretin His 114 variant

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    82. Munar-Ques, M; Dominguez, JML; Viader-Farre, C; Moreira, P; Saraiva, MJM
      Two Spanish sibs with familial amyloidotic polyneuropathy homozygous for the V30M-TTR gene

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    83. Ovelgonne, JH; Landman, WJM; Gruys, E; Gielkens, ALJ; Peeters, BPH
      Identical amyloid precursor proteins in two breeds of chickens which differ in susceptibility to develop amyloid arthropathy

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    84. Apter, S; Zemer, D; Terhakopian, A; Gayer, G; Langevitz, P; Amitai, M; Schwartz, T; Atar, E; Hertz, M; Pras, M; Livneh, A
      Abdominal CT findings in nephropathic amyloidosis of familial Mediterranean fever

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    85. Frangione, B; Revesz, T; Vidal, R; Holton, J; Lashley, T; Houlden, H; Wood, N; Rostagno, A; Plant, G; Ghiso, J
      Familial cerebral amyloid angiopathy related to stroke and dementia

      AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
    86. Kamimura, R; Suzuki, S; Miyahara, K; Shiomi, M
      Arteriosclerosis in the influx and intravisceral arteries of the liver, kidney and lung of WHHL rabbits

      EXPERIMENTAL ANIMALS
    87. Shimizu, O; Inoue, Y; Takada, K; Nanba, K; Arai, H
      Aggregated occurrence of sleep apnea syndrome in a family

      PSYCHIATRY AND CLINICAL NEUROSCIENCES
    88. Walker, R; Dixon, S; Ruger, B; Davis, P; Hildebrant, F; Kremer, M; Eccles, M; Mcnoe, L; Watson, M; Reid, J
      Familial fibronectin glomerulopathy: analysis of chromosome 1q32 and uteroglobin gene loci in a large New Zealand family

      NEPHROLOGY
    89. Rostoker, G
      Schonlein-Henoch purpura in children and adults - Diagnosis, pathophysiology and management

      BIODRUGS
    90. Hankey, GJ; Eikelboom, JW
      Homocysteine levels in patients with stroke - Clinical relevance and therapeutic implications

      CNS DRUGS
    91. McGrath, DS; Goh, N; Foley, PJ; du Bois, RM
      Sarcoidosis: genes and microbes - soil or seed?

      SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
    92. Yildiz, A; Akkaya, V; Kilicaslan, I; Turkmen, A; Gorcin, B; Atilgan, D; Sever, MS
      Cardiac and intestinal amyloidosis in a renal transplant recipient with familial Mediterranean fever

      JOURNAL OF NEPHROLOGY
    93. Strippoli, P; Sarchielli, S; Santucci, R; Bagnara, GP; Brandi, G; Biasco, G
      Cold single-strand conformation polymorphism analysis: Optimization for detection of APC gene mutations in patients with familial adenomatous polyposis

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    94. Salahshor, S; Hou, H; Diep, CB; Loukola, A; Zhang, H; Liu, T; Chen, J; Iselius, L; Rubio, C; Lothe, RA; Aaltonen, L; Sun, XF; Lindmark, G; Lindblom, A
      A germline E-cadherin mutation in a family with gastric and colon cancer

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    95. Martin, LJ
      Neuronal cell death in nervous system development, disease, and injury (Review)

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    96. Li, FY; Szobor, A; Croxen, R; Anselmo, V; Yuan, QP; Lindblad, K; Schalling, M; Komoly, S; Beeson, D; Larsson, C
      Dominantly inherited familial myasthenia gravis as a separate genetic entity without involvement of defined candidate gene loci

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    97. Tonini, GP; McConville, C; Cusano, R; Rees, SA; Dagnino, M; Longo, L; De Bernardi, B; Conte, M; Garaventa, A; Romeo, G; Devoto, M; Seri, M
      Exclusion of candidate genes and chromosomal regions in familial neuroblastoma

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    98. Rios, A; Rodriguez, JM; Illana, J; Torregrosa, NM; Parrilla, P
      Familial papillary carcinoma of the thyroid: Report of three families

      EUROPEAN JOURNAL OF SURGERY
    99. Rutgeerts, P; Geboes, K
      Understanding inflammatory bowel disease - The clinician's perspective

      EUROPEAN JOURNAL OF SURGERY
    100. Kovach, MJ; Ruiz, J; Kimonis, K; Mueed, S; Sinha, S; Higgins, C; Elble, S; Elble, R; Kimonis, VE
      Genetic heterogeneity in autosomal dominant essential tremor

      GENETICS IN MEDICINE


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 14:42:38