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Prospective study of diabetes mellitus and liver cancer in Japan
DIABETES-METABOLISM RESEARCH AND REVIEWS
A role for chemokine receptor transactivation in growth factor signaling
EMBO REPORTS
IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
The IGF system in thyroid cancer: new concepts
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
The IGF axis and hepatocarcinogenesis
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer
ENDOCRINE-RELATED CANCER
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS)
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
Inhibition of insulin-like growth factor signaling pathways in mammary gland by pure antiestrogen ICI 182,780
CLINICAL CANCER RESEARCH
Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors
CLINICAL CANCER RESEARCH
Combination cytokine therapy in rheumatoid arthritis: The next generation
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
Oncoprotein changes in the flat lesions with atypia and invasive neoplasmsof the urinary bladder
ONCOLOGY REPORTS
In utero radiation-induced changes in growth factor levels in the developing rat brain
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis
ONCOGENE
The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions
ONCOGENE
Crk family adaptors - signalling complex formation and biological roles
ONCOGENE
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
ONCOGENE
Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells
ONCOGENE
Molecular significance of excess body weight in postmenopausal breast cancer patients, in relation to expression of insulin-like growth factor I receptor and insulin-like growth factor II genes
JAPANESE JOURNAL OF CANCER RESEARCH
Nonandrogenic mediators of prostatic growth
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Human growth factor receptor bound 14 binds the activated insulin receptorand alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
Signaling pathways initiated in macrophages after engagement of type A scavenger receptors
JOURNAL OF LEUKOCYTE BIOLOGY
Insulin-like growth factors and prostate cancer
WORLD JOURNAL OF UROLOGY
Targeting protein kinases for tumor therapy
ONKOLOGIE
IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells
SPINE
Current prospects for controlling cancer growth with non-cytotoxic agents - nutrients, phytochemicals, herbal extracts, and available drugs
MEDICAL HYPOTHESES
Regulation of glutamine transport by the type I insulin-like growth factorreceptor in a human neuroblastoma cell line
CANCER LETTERS
STAT3 is constitutively active in some patients with Polycythemia rubra vera
EXPERIMENTAL HEMATOLOGY
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors
BIOCHEMICAL SOCIETY TRANSACTIONS
Scaffolding protein Gab2 mediates differentiation signaling downstream of fms receptor tyrosine kinase
MOLECULAR AND CELLULAR BIOLOGY
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling
MOLECULAR AND CELLULAR BIOLOGY
Altered expression of receptors for thyroid hormone and insulin-like growth factor-1 during reconstitution after allogeneic hematopoietic stem cell transplantation
BONE MARROW TRANSPLANTATION
Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors
BIOCHEMICAL JOURNAL
Activation of hypoxia-inducible factor 1 alpha by oxygen independent pathways
EXPERIMENTAL ONCOLOGY
Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression
JOURNAL OF NEURO-ONCOLOGY
Insulin treatment enhances expression of IGF-I in sural nerves of diabeticpatients
MUSCLE & NERVE
Interferon-alpha therapy increases type I insulin-like growth factor receptors expression on lymphoid cells from patients with chronic myelogenous leukemia
LEUKEMIA RESEARCH
Age-dependent IGF-1 regulation of gene transcription of Ca2+ channels in skeletal muscle
MECHANISMS OF AGEING AND DEVELOPMENT
Expression of protein tyrosine kinases and stem cell factor in chicken blastodermal cells
POULTRY SCIENCE
Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Pediatric heart transplantation: Improving results in high-risk patients
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation
JOURNAL OF NEUROCHEMISTRY
Inhibition of insulin-like growth factor-1 receptor and IRS-2 signaling byethanol in SH-SY5Y neuroblastoma cells
JOURNAL OF NEUROCHEMISTRY
Insulin-like growth factor binding protein 5 and type-1 insulin-like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells
JOURNAL OF NEUROCHEMISTRY
TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation
JOURNAL OF IMMUNOLOGY
Regulation of proliferation of prostate epithelial cells by 1,25-dihydroxyvitamin D-3 is accompanied by an increase in insulin-like growth factor binding protein-3
JOURNAL OF ENDOCRINOLOGY
IGF type 1 receptor ligand binding characteristics are altered in a subgroup of children with intrauterine growth retardation
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site
JOURNAL OF BIOLOGICAL CHEMISTRY
Four PSM/SH2-B alternative splice variants and their differential roles inmitogenesis
JOURNAL OF BIOLOGICAL CHEMISTRY
G alpha(i2) enhances insulin signaling via suppression of protein-tyrosinephosphatase 1B
JOURNAL OF BIOLOGICAL CHEMISTRY
Synthesis and characterization of insulin-like growth factor (IGF)-1 photoprobes selective for the IGF-binding proteins (IGFBPs) - Photoaffinity labeling of the IGF-binding domain on IGFBP-2
JOURNAL OF BIOLOGICAL CHEMISTRY
Up-regulation of functionally impaired insulin-like growth factor-1 receptor in scrapie-infected neuroblastoma cells
JOURNAL OF BIOLOGICAL CHEMISTRY
A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Suppressors of cytokine signaling-1 and-6 associate with and inhibit the insulin receptor - A potential mechanism for cytokine-mediated insulin resistance
JOURNAL OF BIOLOGICAL CHEMISTRY
Proteomic analysis of macrophage differentiation - p46/52(Shc) tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation
JOURNAL OF BIOLOGICAL CHEMISTRY
Insulin-like growth factor 1 (IGF-1)-induced Twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase
JOURNAL OF BIOLOGICAL CHEMISTRY
Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal
JOURNAL OF BIOLOGICAL CHEMISTRY
The BPS domain of Grb10 inhibits the catalytic activity of the insulin andIGF1 receptors
FEBS LETTERS
Cytokine profile of serum and bronchoalveolar lavage fluids following thoracic esophageal cancer surgery
EUROPEAN SURGICAL RESEARCH
Surfing the insulin signaling web
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase
EUROPEAN JOURNAL OF BIOCHEMISTRY
Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and Evans blue
ENDOCRINOLOGY
Minireview: Tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology
ENDOCRINOLOGY
In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor grade
ENDOCRINOLOGY
Limited redundancy of survival signals from the type 1 insulin-like growthfactor receptor
ENDOCRINOLOGY
Insulin-like growth factor (IGF) binding protein-3 inhibits type 1 IGF receptor activation independently of its IGF binding affinity
ENDOCRINOLOGY
Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1
DIABETOLOGIA
Thrombin regulates insulin-like growth factor-1 receptor transcription in vascular smooth muscle - Characterization of the signaling pathway
CIRCULATION RESEARCH
Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest
CANCER RESEARCH
The 104-123 amino acid sequence of the beta-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion
CANCER RESEARCH
Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways
CANCER RESEARCH
Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth
CANCER RESEARCH
Insulin-like growth factor type 1 (IGF-1) and IGF binding protein-3 in patients with ewing sarcoma family of tumors
CANCER
Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts
BRITISH JOURNAL OF DERMATOLOGY
Tyrosine kinase signalling in breast cancer - Insulin-like growth factors and their receptors in breast cancer
BREAST CANCER RESEARCH
Structure and function of the type 1 insulin-like growth factor receptor
CELLULAR AND MOLECULAR LIFE SCIENCES
New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia
CELLULAR AND MOLECULAR LIFE SCIENCES
Progress in the development of inhibitors of SH2 domains
CURRENT PHARMACEUTICAL DESIGN
Real-time detection of insulin-like growth factor-1 stimulation of the MAC-T bovine mammary epithelial cell line
ENDOCRINE
Insulin-like growth factor-1 causes a switch-like reduction of endogenous growth hormone mRNA in rat MtT/S somatotroph cells
ENDOCRINE
Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review)
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Insulin-like growth factor (IGF) system in the bovine mammary gland and milk
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Function of the IGF-I receptor in breast cancer
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Crosstalk between the insulin-like growth factors and estrogens in breast cancer
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G(1) arrest and differentiation
CLINICAL CANCER RESEARCH
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression
MOLECULAR BIOLOGY OF THE CELL
Mouse submandibular gland morphogenesis: A paradigm for embryonic signal processing
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
Ewing sarcoma family of tumors
CURRENT OPINION IN ONCOLOGY
Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Cytogenetic and molecular abnormalities in astrocytic gliomas (Review)
ONCOLOGY REPORTS
Analysis of the ligand-binding domain of macrophage colony-stimulating receptor
CHINESE SCIENCE BULLETIN
The contradictions of the insulin-like growth factor 1 receptor
ONCOGENE
Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells
ONCOGENE
Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency
ONCOGENE
Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells
ONCOGENE
A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells
ONCOGENE
Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation
ONCOGENE
Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway
ONCOGENE