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La ricerca find articoli where soggetti phrase all words 'ESTROGEN-RECEPTORS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 966 riferimenti
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    1. McEwen, BS
      Genome and hormones: Gender differences in physiology - Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms

      JOURNAL OF APPLIED PHYSIOLOGY
    2. Bowser, C; Riederer, A
      Detection of progesterone receptors in connective tissue cells of the lower nasal turbinate of women.

      LARYNGO-RHINO-OTOLOGIE
    3. Rider, V; Abdou, NI
      Gender differences in autoimmunity: molecular basis for estrogen effects in systemic lupus erythematosus

      INTERNATIONAL IMMUNOPHARMACOLOGY
    4. Greenstein, B; Roa, R; Dhaher, Y; Nunn, E; Greenstein, A; Khamashta, M; Hughes, GRV
      Estrogen and progesterone receptors in murine models of systemic lupus erythematosus

      INTERNATIONAL IMMUNOPHARMACOLOGY
    5. Jenkins, JK; Suwannaroj, S; Elbourne, KB; Ndebele, K; McMurray, RW
      17-beta-estradiol alters Jurkat lymphocyte cell cycling and induces apoptosis through suppression of Bcl-2 and cyclin A

      INTERNATIONAL IMMUNOPHARMACOLOGY
    6. Vermeirsch, H; Simoens, P; Coryn, M; Van den Broeck, W
      Immunolocalization of androgen receptors in the canine ovary and their relation to sex steroid hormone concentrations

      REPRODUCTION
    7. Vermeirsch, H; Simoens, P; Coryn, M; Van den Broeck, W
      Immunolocalization of progesterone receptors in the canine ovary and theirrelation to sex steroid hormone concentrations

      REPRODUCTION
    8. Wise, PM
      The 'menopause' and the aging brain: causes and repercussions of hypoestrogenicity

      BIOGERONTOLOGY
    9. Stygar, D; Wang, H; Vladic, YS; Ekman, G; Eriksson, H; Sahlin, L
      Co-localization of oestrogen receptor beta and leukocyte markers in the human cervix

      MOLECULAR HUMAN REPRODUCTION
    10. Cutolo, M; Villaggio, B; Bisso, A; Sulli, A; Coviello, D; Dayer, JM
      Presence of estrogen receptors in human myeloid monocytic cells (THP-1 cell line)

      EUROPEAN CYTOKINE NETWORK
    11. Maruyama, S; Nagasue, N; Dhar, DK; Yamanoi, A; El-Assal, ON; Satoh, K; Okita, K
      Preventive effect of FK143, a 5 alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats

      CLINICAL CANCER RESEARCH
    12. Ferrero-Pous, M; Trassard, M; Le Doussal, V; Hacene, K; Tubiana-Hulin, M; Spyratos, F
      Comparison of enzyme immunoassay and immunohistochemical measurements of estrogen and progesterone receptors in breast cancer patients

      APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
    13. Gahr, M
      Distribution of sex steroid hormone receptors in the avian brain: Functional implications for neural sex differences and sexual behaviors

      MICROSCOPY RESEARCH AND TECHNIQUE
    14. Aste, N; Cozzi, B; Stankov, B; Panzica, G
      Sexual differences and effect of photoperiod on melatonin receptor in avian brain

      MICROSCOPY RESEARCH AND TECHNIQUE
    15. Panzica, G; Viglietti-Panzica, C; Balthazart, J
      Sexual dimorphism in the neuronal circuits of the quail preoptic and limbic regions

      MICROSCOPY RESEARCH AND TECHNIQUE
    16. Mankoff, DA; Bellon, JR
      Positron-emission tomographic imaging of cancer: Glucose metabolism and beyond

      SEMINARS IN RADIATION ONCOLOGY
    17. Goldstein, JM; Seidman, LJ; Horton, NJ; Makris, N; Kennedy, DN; Caviness, VS; Faraone, SV; Tsuang, MT
      Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging

      CEREBRAL CORTEX
    18. Ooga, T; Itoh, M; Miyamoto, K; Takeuchi, Y; Nishioka, M
      Image analysis of the effects of gonadectomy on colloidal carbon uptake invivo by sinusoidal cells in liver and spleen of the mouse

      AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
    19. Verthelyi, D; Petri, M; Ylamus, M; Klinman, DM
      Disassociation of sex hormone levels and cytokine production in SLE patients

      LUPUS
    20. Hassan, HI; Walker, RA
      Altered expression of epidermal growth factor receptor in non-involved tissue of cancer-containing breasts

      BREAST
    21. Koerner, F; Oyama, T; Kurosumi, M; Maluf, H
      Ovarian hormone receptors in human mammary stromal cells

      JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
    22. Verheijen, FM; Sprong, M; Jacobs, HM; Donker, GH; Amelink, GJ; Thijssen, JHH; Blankenstein, MA
      Progesterone receptor isoform expression in human meningiomas

      EUROPEAN JOURNAL OF CANCER
    23. Woolcott, CG; Aronson, KJ; Hanna, WM; SenGupta, SK; McCready, DR; Sterns, EE; Miller, AB
      Organochlorines and breast cancer risk by receptor status, tumor size, andgrade (Canada)

      CANCER CAUSES & CONTROL
    24. Clarke, IJ; Pompolo, S; Scott, CJ; Rawson, JA; Caddy, D; Jakubowska, AE; Pereira, AM
      Cells of the arcuate nucleus and ventromedial nucleus of the ovariectomized ewe that respond to oestrogen: A study using Fos immunohistochemistry

      JOURNAL OF NEUROENDOCRINOLOGY
    25. Del Negro, C; Edeline, JM
      Differences in auditory and physiological properties of HVc neurons between reproductively active male and female canaries (Serinus canaria)

      EUROPEAN JOURNAL OF NEUROSCIENCE
    26. Bernard-Poenaru, O; Roux, C; Blanque, R; Gardner, C; de Vernejoul, MC; Cohen-Solal, ME
      Bone-resorbing cytokines from peripheral blood mononuclear cells after hormone replacement therapy: A longitudinal study

      OSTEOPOROSIS INTERNATIONAL
    27. Berclaz, G; Altermatt, HJ; Rohrbach, V; Kieffer, I; Dreher, E; Andres, AC
      Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast

      ANNALS OF ONCOLOGY
    28. Vang, R; Medeiros, LJ; Warnke, RA; Higgins, JP; Deavers, MT
      Ovarian non-Hodgkin's lymphoma: A clinicopathologic study of eight primarycases

      MODERN PATHOLOGY
    29. Dhaher, YY; Greenstein, BD; Khamashta, MA; Hughes, GRV
      Effects of oestradiol and the oestrogen antagonist Ici 182,780 on the delayed type hypersensitivity (DTH) index and on serum levels of IgM and IgG inovariectomised Balb/C and MRL/Mp-Lpr/Lpr mice, a model of systemic lupus erythematosus (SLE)

      AUTOIMMUNITY
    30. Nagao, T; Yoshimura, S; Saito, Y; Nakagomi, M; Usumi, K; Ono, H
      Reproductive effects in male and female rats of neonatal exposure to genistein

      REPRODUCTIVE TOXICOLOGY
    31. Hosli, E; Jurasin, K; Ruhl, W; Luthy, R; Hosli, L
      Colocalization of androgen, estrogen and cholinergic receptors on culturedastrocytes of rat central nervous system

      INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
    32. Cutolo, M; Carruba, G; Villaggio, B; Coviello, DA; Dayer, JM; Campisi, I; Miele, M; Stefano, R; Castagnetta, LAM
      Phorbol diester 12-O-tetradecanoylphorbol 13-acetate (TPA) up-regulates the expression of estrogen receptors in human THP-1 leukemia cells

      JOURNAL OF CELLULAR BIOCHEMISTRY
    33. Larsson, D; Nemere, I; Sundell, K
      Putative basal lateral membrane receptors for 24,25-dihydroxyvitamin D-3 in carp and Atlantic cod enterocytes: Characterization of binding and effects on intracellular calcium regulation

      JOURNAL OF CELLULAR BIOCHEMISTRY
    34. Petursdottir, V; Moslemi, AR; Persson, M; Nordborg, E; Nordborg, C
      Estrogen receptor alpha in giant cell arteritis: A molecular genetic study

      CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
    35. Miliaras, D; Papaemmanouil, S; Blatzas, G
      Ovarian capillary hemangioma and stromal luteinization: a case study with hormonal receptor evaluation

      EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
    36. Katzburg, S; Ornoy, A; Hendel, D; Lieberherr, M; Kaye, AM; Somjen, D
      Age and gender specific stimulation of creatine kinase specific activity by gonadal steroids in human bone-derived cells in culture

      JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
    37. Kanashiro, CA; Khalil, RA
      Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    38. Cerda-Reverter, JM; Zanuy, S; Munoz-Cueto, JA
      Cytoarchitectonic study of the brain of a perciform species, the sea bass (Dicentrarchus labrax). II. The Diencephalon

      JOURNAL OF MORPHOLOGY
    39. Gonzalez-Aguero, G; Ondarza, R; Gamboa-Dominguez, A; Cerbon, MA; Camacho-Arroyo, I
      Progesterone receptor isoforms expression pattern in human astrocytomas

      BRAIN RESEARCH BULLETIN
    40. Wrobel, KH; Schimmel, M
      Establishment of the urogenital junction in the male bovine embryo: an ultrastructural study

      ANATOMY AND EMBRYOLOGY
    41. Aloisi, AM; Seta, DD; Ceccarelli, I; Farabollini, F
      Bisphenol-A differently affects estrogen receptors-alpha in estrous-cycling and lactating female rats

      NEUROSCIENCE LETTERS
    42. Pasquali, D; Staibano, S; Prezioso, D; Franco, R; Esposito, D; Notaro, A; De Rosa, G; Bellastella, A; Sinisi, AA
      Estrogen receptor beta expression in human prostate tissue

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    43. Bilinska, B; Schmalz-Fraczek, B; Kotula, M; Carreau, S
      Photoperiod-dependent capability of androgen aromatization and the role ofestrogens in the bank vole testis visualized by means of immunohistochemistry

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    44. Kassam, A; Capone, JP; Rachubinski, RA
      The short heterodimer partner receptor differentially modulates peroxisomeproliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomalbeta-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    45. Ferret, S; Dockery, P; Harvey, BJ
      17 beta-Oestradiol stimulates capacitative Ca2+ entry in human endometrialcells

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    46. Appeltants, D; Ball, GF; Balthazart, J
      The distribution of tyrosine hydroxylase in the canary brain: demonstration of a specific and sexually dimorphic catecholaminergic innervation of thetelencephalic song control nuclei

      CELL AND TISSUE RESEARCH
    47. Hermann, B; Vollmer, I; Holsboer, F; Rupprecht, R
      Antidepressants do not modulate estrogen receptor alpha-mediated gene expression

      JOURNAL OF NEURAL TRANSMISSION
    48. Halperin, R; Zehavi, S; Hadas, E; Habler, L; Bukovsky, I; Schneider, D
      Immunohistochemical comparison of primary peritoneal and primary ovarian serous papillary carcinoma

      INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
    49. Arnold, JT; Kaufman, DG; Seppala, M; Lessey, BA
      Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model

      HUMAN REPRODUCTION
    50. Olsen, NJ; Kovacs, WJ
      Effects of androgens on T and B lymphocyte development

      IMMUNOLOGIC RESEARCH
    51. Beyer, ME; Yu, G; Hanke, H; Hoffmeister, HM
      Acute gender-specific hemodynamic and inotropic effects of 17 beta-estradiol on rats

      HYPERTENSION
    52. Alvarado-Cabrero, I; Candanedo-Gonzalez, F; Sosa-Romero, A
      Leiomyoma of the urethra in a Mexican woman: A rare neoplasm associated with the expression of estrogen receptors by immunohistochemistry

      ARCHIVES OF MEDICAL RESEARCH
    53. Becraft, PW
      Plant steroids recognized at the cell surface

      TRENDS IN GENETICS
    54. Day, JK; Besch-Williford, C; McMann, TR; Hufford, MG; Lubahn, DB; MacDonald, RS
      Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice

      NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
    55. Mankoff, DA; Peterson, LM; Tewson, TJ; Link, JM; Gralow, JR; Graham, MM; Krohn, KA
      [F-18]fluoroestradiol radiation dosimetry in human PET studies

      JOURNAL OF NUCLEAR MEDICINE
    56. Avril, N; Menzel, M; Dose, J; Schelling, M; Weber, W; Janicke, F; Nathrath, W; Schwaiger, M
      Glucose metabolism of breast cancer assessed by F-18-FDG PET: Histologic and immunohistochemical tissue analysis

      JOURNAL OF NUCLEAR MEDICINE
    57. Hendricks, JB
      Quantitative histology by laser scanning cytometry

      JOURNAL OF HISTOTECHNOLOGY
    58. Withanage, GSK; Murata, H; Koyama, T; Ishiwata, I
      Agonistic and antagonistic effects of zearalenone, an etrogenic mycotoxin,on SKN, HHUA, and HepG2 human cancer cell lines

      VETERINARY AND HUMAN TOXICOLOGY
    59. De Bosschere, H; Ducatelle, R; Vermeirsch, H; Van den Broeck, W; Coryn, M
      Cystic endometrial hyperplasia-pyometra complex in the bitch: Should the two entities be disconnected

      THERIOGENOLOGY
    60. Herbison, AE; Pape, JR
      New evidence for estrogen receptors in gonadotropin-releasing hormone neurons

      FRONTIERS IN NEUROENDOCRINOLOGY
    61. Witte, D; Chirala, M; Younes, A; Li, Y; Younes, M
      Estrogen receptor beta is expressed in human colorectal adenocarcinoma

      HUMAN PATHOLOGY
    62. Mittal, K; Demopoulos, RI
      MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors

      HUMAN PATHOLOGY
    63. Mann, S; Laucirica, R; Carlson, N; Younes, PS; Ali, N; Younes, A; Li, Y; Younes, M
      Estrogen receptor beta expression in invasive breast cancer

      HUMAN PATHOLOGY
    64. Zhao, XJ; McKerr, G; Dong, Z; Higgins, CA; Carson, J; Yang, ZQ; Hannigan, BM
      Expression of oestrogen and progesterone receptors by mast cells alone, but not lymphocytes, macrophages or other immune cells in human upper airways

      THORAX
    65. Wahl, RL
      Current status of PET in breast cancer imaging, staging, and therapy

      SEMINARS IN ROENTGENOLOGY
    66. Gaumy, JL; Bailly, JD; Burgat, V; Guerre, P
      Zearalenone: properties and experimental toxicity.

      REVUE DE MEDECINE VETERINAIRE
    67. Ikeguchi, M; Fukuda, K; Oka, S; Yamaguchi, K; Hisamitsu, K; Tsujitani, S; Sakatani, T; Ueda, T; Kaibara, N
      Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma

      ONCOLOGY
    68. Anderson, ST; Walsh, JP; Tillet, Y; Clarke, IJ; Curlewis, JD
      Dopaminergic input to the ventromedial hypothalamus facilitates the oestrogen-induced luteinizing hormone surge in ewes

      NEUROENDOCRINOLOGY
    69. Belvedere, P; Dalla Valle, L; Vianello, S; Carnevali, O; Colombo, L
      Hormonal steroidogenesis in liver and small intestine of the green frog, Rana esculenta L.

      LIFE SCIENCES
    70. Kuerer, HM; Buzdar, AU; Singletary, SE
      Biologic basis and evolving role of aromatase inhibitors in the managementof invasive carcinoma of the breast

      JOURNAL OF SURGICAL ONCOLOGY
    71. Wehrenberg, U; Prange-Kiel, J; Rune, GM
      Steroidogenic factor-1 expression in marmoset and rat hippocampus: co-localization with StAR and aromatase

      JOURNAL OF NEUROCHEMISTRY
    72. Bosma, PT; Blazquez, M; Fraser, EJ; Schulz, RW; Docherty, K; Trudeau, VL
      Sex steroid regulation of glutamate decarboxylase mRNA expression in goldfish brain is sexually dimorphic

      JOURNAL OF NEUROCHEMISTRY
    73. Dellovade, TL; Davis, AM; Ferguson, C; Sieghart, W; Homanics, GE; Tobet, SA
      GABA influences the development of the ventromedial nucleus of the hypothalamus

      JOURNAL OF NEUROBIOLOGY
    74. Fusani, L; Hutchison, JB; Gahr, M
      Testosterone regulates the activity and expression of aromatase in the canary neostriaturn

      JOURNAL OF NEUROBIOLOGY
    75. Wennstrom, KL; Reeves, BJ; Brenowitz, EA
      Testosterone treatment increases the metabolic capacity of adult avian song control nuclei

      JOURNAL OF NEUROBIOLOGY
    76. Azcoitia, I; Sierra, A; Veiga, S; Honda, S; Harada, N; Garcia-Segura, LM
      Brain aromatase is neuroprotective

      JOURNAL OF NEUROBIOLOGY
    77. Childs, GV; Unabia, G; Komak, S
      Differential expression of estradiol receptors alpha and beta by gonadotropes during the estrous cycle

      JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
    78. Katzenellenbogen, JA
      Steroids labeled with F-18 for imaging tumors by positron emission tomography

      JOURNAL OF FLUORINE CHEMISTRY
    79. Lawson, MA; Li, D; Glidewell-Kenney, CA; Lopez, FJ
      Androgen responsiveness of the pituitary gonadotrope cell line L beta T2

      JOURNAL OF ENDOCRINOLOGY
    80. Suzuki, T; Darnel, AD; Akahira, J; Ariga, N; Ogawa, S; Kaneko, C; Takeyama, J; Moriya, T; Sasano, H
      5 alpha-Reductases in human breast carcinoma: Possible modulator of in situ androgenic actions

      JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
    81. Apparao, KBC; Murray, MJ; Fritz, MA; Meyer, WR; Chambers, AF; Truong, PR; Lessey, BA
      Osteopontin and its receptor alpha v beta 3 integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially

      JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
    82. Lu, TT; Repa, JJ; Mangelsdorf, DJ
      Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism

      JOURNAL OF BIOLOGICAL CHEMISTRY
    83. Russo, LA; Calabro, SP; Filler, TA; Carey, DJ; Gardner, RM
      In vivo regulation of syndecan-3 expression in the rat uterus by 17 beta-estradiol

      JOURNAL OF BIOLOGICAL CHEMISTRY
    84. Uno, M; Otsuki, T; Kurebayashi, J; Sakaguchi, H; Isozaki, Y; Ueki, A; Yata, K; Fujii, T; Hiratsuka, J; Akisada, T; Harada, T; Imajo, Y
      Anti-HER2-antibody enhances irradiation-induced growth inhibition in head and neck carcinoma

      INTERNATIONAL JOURNAL OF CANCER
    85. Erlandsson, MC; Ohlsson, C; Gustafsson, JA; Carlsten, H
      Role of oestrogen receptors alpha and beta in immune organ development andin oestrogen-mediated effects on thymus

      IMMUNOLOGY
    86. Kuppers, E; Ivanova, T; Karolczak, M; Lazarov, N; Fohr, K; Beyer, C
      Classical and nonclassical estrogen action in the developing midbrain

      HORMONES AND BEHAVIOR
    87. Gardener, HE; Clark, AS
      Systemic ICI 182,780 alters the display of sexual behavior in the female rat

      HORMONES AND BEHAVIOR
    88. Sarkar, S; Subhedar, N
      Seasonal changes in beta-endorphin-like immunoreactivity in the olfactory system of the female catfish, Clarias batrachus (Linn.)

      GENERAL AND COMPARATIVE ENDOCRINOLOGY
    89. Stavreus-Evers, A; Nikas, G; Sahlin, L; Eriksson, H; Landgren, BM
      Formation of pinopodes in human endometrium is associated with the concentrations of progesterone and progesterone receptors

      FERTILITY AND STERILITY
    90. Hoffman, GE; Le, WW; Murphy, AZ; Koski, CL
      Divergent effects of ovarian steroids on neuronal survival during experimental allergic encephalitis in Lewis rats

      EXPERIMENTAL NEUROLOGY
    91. Gollapudi, L; Oblinger, MM
      Estrogen effects on neurite outgrowth and cytoskeletal gene expression in ER alpha-transfected PC12 cell lines

      EXPERIMENTAL NEUROLOGY
    92. Benten, WPM; Stephan, C; Lieberherr, M; Wunderlich, F
      Estradiol signaling via sequestrable surface receptors

      ENDOCRINOLOGY
    93. Gale, EAM; Gillespie, KM
      Diabetes and gender

      DIABETOLOGIA
    94. Navas, JM; Segner, H
      Estrogen-mediated suppression of cytochrome P4501A (CYP1A) expression in rainbow trout hepatocytes: role of estrogen receptor

      CHEMICO-BIOLOGICAL INTERACTIONS
    95. Pierga, JY; Asselain, B; Jouve, M; Dieras, V; Carton, M; Laurence, V; Girre, V; Beuzeboc, P; Palangie, T; Dorval, T; Pouillart, P
      Effect of adjuvant chemotherapy on outcome in patients with metastatic breast carcinoma treated with first-line doxorubicin-containing chemotherapy

      CANCER
    96. Miyasaka, Y; Enomoto, N; Nagayama, K; Izumi, N; Marumo, F; Watanabe, M; Sato, C
      Analysis of differentially expressed genes in human hepatocellular carcinoma using suppression subtractive hybridization

      BRITISH JOURNAL OF CANCER
    97. Harukuni, I; Hurn, PD; Crain, BJ
      Deleterious effect of beta-estradiol in a rat model of transient forebrainischemia

      BRAIN RESEARCH
    98. Fujita, T; Kawata, T; Tokimasa, C; Tanne, K
      Influence of oestrogen and androgen on modelling of the mandibular condylar bone in ovariectomized and orchiectomized growing mice

      ARCHIVES OF ORAL BIOLOGY
    99. Taniguchi; Yang; Tang; Nakamura; Shan; Nakamura; Sato; Mori; Sakurai; Kakudo
      Cytologic grading of breast carcinoma - Reply

      ACTA CYTOLOGICA
    100. Rhodes, A; Jasani, B; Balaton, AJ; Barnes, DM; Anderson, E; Bobrow, LG; Miller, KD
      Study of interlaboratory reliability and reproducibility of estrogen and progesterone receptor assays in Europe - Documentation of poor reliability and identification of insufficient microwave antigen retrieval time as a major contributory element of unreliable assays

      AJCP. American journal of clinical pathology


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Documento generato il 16/01/21 alle ore 20:05:13