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La ricerca find articoli where soggetti phrase all words 'EPILEPTIFORM DISCHARGES' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 122 riferimenti
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    1. Nicolai, J; van Putten, MJAM; Tavy, DLJ
      BIPLEDs in akinetic mutism caused by bilateral anterior cerebral artery infarction

      CLINICAL NEUROPHYSIOLOGY
    2. Holmes, MD; Dodrill, CB; Kutsy, RL; Ojemann, GA; Miller, JW
      Is the left cerebral hemisphere more prone to epileptogenesis than the right?

      EPILEPTIC DISORDERS
    3. Krakow, K; Lemieux, L; Messina, D; Scott, CA; Symms, MR; Duncan, JS; Fish, DR
      Spatio-temporal imaging of focal interictal epileptiform activity using EEG-triggered functional MRI

      EPILEPTIC DISORDERS
    4. Assal, F; Papazyan, JP; Slosman, DO; Jallon, P; Goerres, GW
      SPECT in periodic lateralized epileptiform discharges (PLEDs): a form of partial status epilepticus?

      SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
    5. Engstrom, ER; Hillered, L; Flink, R; Kihlstrom, L; Lindquist, C; Nie, JX; Olsson, Y; Silander, HC
      Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection

      EPILEPSY RESEARCH
    6. Mendez, M; Radtke, RA
      Interactions between sleep and epilepsy

      JOURNAL OF CLINICAL NEUROPHYSIOLOGY
    7. Shah, GD; Hirsch, LJ
      Bitemporal epileptiform discharges induced by bupropion: A case report

      CLINICAL NEUROPHARMACOLOGY
    8. Chuang, SC; Bianchi, R; Kim, D; Shin, HS; Wong, RKS
      Group I metabotropic glutamate receptors elicit epileptiform discharges inthe hippocampus through PLC beta 1 signaling

      JOURNAL OF NEUROSCIENCE
    9. Pal, S; Sun, D; Limbrick, D; Rafiq, A; DeLorenzo, RJ
      Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture modelof epilepsy

      CELL CALCIUM
    10. Parsons, JT; Churn, SB; DeLorenzo, RJ
      Chronic inhibition of cortex microsomal Mg2+/Ca2+ ATPase-mediated Ca2+ uptake in the rat pilocarpine model following epileptogenesis

      JOURNAL OF NEUROCHEMISTRY
    11. Eiris-Punal, J; Rodriguez-Nunez, A; Fernandez-Martinez, N; Fuster, M; Castro-Gago, M; Martinon, JM
      Usefulness of the head-upright tilt test for distinguishing syncope and epilepsy in children

      EPILEPSIA
    12. Stuve, O; Dodrill, CB; Holmes, MD; Miller, JW
      The absence of interictal spikes with documented seizures suggests extratemporal epilepsy

      EPILEPSIA
    13. Blume, WT; Ociepa, D; Kander, V
      Frontal lobe seizure propagation: Scalp and subdural EEG studies

      EPILEPSIA
    14. Sam, MC; So, EL
      Significance of epileptiform discharges in patients without epilepsy in the community

      EPILEPSIA
    15. Kramer, G
      Epilepsy in the elderly: Some clinical and pharmacotherapeutic aspects

      EPILEPSIA
    16. Otto, FG; Kozian, R
      Subacute encephalopathy with epileptic seizures in alcoholism (SESA): Casereport

      CLINICAL ELECTROENCEPHALOGRAPHY
    17. Rothmeier, J; Friese, M; Willemsen, F; Froescher, W
      Subacute encephalopathy with seizures in chronic alcoholism (SESA syndrome)

      CLINICAL ELECTROENCEPHALOGRAPHY
    18. Raza, M; Pal, S; Rafiq, A; DeLorenzo, RJ
      Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy

      BRAIN RESEARCH
    19. Rosenow, F; Luders, H
      Presurgical evaluation of epilepsy

      BRAIN
    20. Vakkuri, A; Yli-Hankala, A; Sarkela, M; Lindgren, L; Mennander, S; Korttila, K; Saarnivaara, L; Jantti, V
      Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children

      ACTA ANAESTHESIOLOGICA SCANDINAVICA
    21. Lawn, ND; Westmoreland, BF; Sharbrough, FW
      Multifocal periodic lateralized epileptiform discharges (PLEDs): EEG features and clinical correlations

      CLINICAL NEUROPHYSIOLOGY
    22. Hisada, K; Morioka, T; Nishio, S; Muraishi, M; Yamamoto, T; Yoshida, T; Fukui, M
      Magnetoencephalographic analysis of periodic lateralized epileptiform discharges (PLEDs)

      CLINICAL NEUROPHYSIOLOGY
    23. Parrino, L; Smerieri, A; Spaggiari, MC; Terzano, MG
      Cyclic alternating pattern (CAP) and epilepsy during sleep: how a physiological rhythm modulates a pathological event

      CLINICAL NEUROPHYSIOLOGY
    24. Baykan, B; Kinay, D; Gokyigit, A; Gurses, C
      Periodic lateralized epileptiform discharges: association with seizures

      SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
    25. Golomb, D; Ermentrout, GB
      Effects of delay on the type and velocity of travelling pulses in neuronalnetworks with spatially decaying connectivity

      NETWORK-COMPUTATION IN NEURAL SYSTEMS
    26. Krakow, K; Baxendale, SA; Maguire, EA; Krishnamoorthy, ES; Lemieux, L; Scott, CA; Smith, SJ
      Fixation-off sensitivity as a model of continuous epileptiform discharges:electroencephalographic, neuropsychological and functional MRI findings

      EPILEPSY RESEARCH
    27. Marrosu, F; Puligheddu, M; Giagheddu, M; Cossu, G; Piga, M
      Correlation between cerebral perfusion and hyperventilation enhanced focalspiking activity

      EPILEPSY RESEARCH
    28. Baumgartner, C; Pataraia, E; Lindinger, G; Deecke, L
      Neuromagnetic recordings in temporal lobe epilepsy

      JOURNAL OF CLINICAL NEUROPHYSIOLOGY
    29. So, EL; O'Brien, TJ; Brinkmann, BH; Mullan, BP
      The EEG evaluation of single photon emission computed tomography abnormalities in epilepsy

      JOURNAL OF CLINICAL NEUROPHYSIOLOGY
    30. Sadler, M; Desbiens, R
      Scalp EEG in temporal lobe epilepsy surgery

      CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
    31. Bijak, M
      Neuropeptide Y reduces epileptiform discharges and excitatory synaptic transmission in rat frontal cortex in vitro

      NEUROSCIENCE
    32. Straub, H; Hohling, JM; Kohling, R; Lucke, A; Tuxhorn, I; Ebner, A; Wolf, P; Pannek, H; Oppel, F; Speckmann, EJ
      Effects of nifedipine on rhythmic synchronous activity of human neocortical slices

      NEUROSCIENCE
    33. Witte, OW; Bidmon, HJ; Schiene, K; Redecker, C; Hagemann, G
      Functional differentiation of multiple perilesional zones after focal cerebral ischemia

      JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
    34. Laaris, N; Carlson, GC; Keller, A
      Thalamic-evoked synaptic interactions in barrel cortex revealed by opticalimaging

      JOURNAL OF NEUROSCIENCE
    35. Carlen, PL; Skinner, F; Zhang, L; Naus, C; Kushnir, M; Velazquez, JLP
      The role of gap junctions in seizures

      BRAIN RESEARCH REVIEWS
    36. Kurth, C; Gillam, F; Steinhoff, BJ
      EEG spike detection with a Kohonen feature map

      ANNALS OF BIOMEDICAL ENGINEERING
    37. Madeja, M; Muller, V; Musshoff, U; Speckmann, EJ
      Sensitivity of native and cloned hippocampal delayed-rectifier potassium channels to verapamil

      NEUROPHARMACOLOGY
    38. Thio, LL; Wong, M; Yamada, KA
      Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission

      NEUROLOGY
    39. Klodzinska, A; Bijak, M; Chojnacka-Wojcik, E; Kroczka, B; Swiader, M; Czuczwar, SJ; Pilc, A
      Roles of group II metabotropic glutamate receptors in modulation of seizure activity

      NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
    40. Meierkord, H; Grunig, F; Gutschmidt, U; Gutierrez, R; Pfeiffer, M; Draguhn, A; Bruckner, C; Heinemann, U
      Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition

      NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
    41. Ergene, E; Shih, JJ; Blum, DE; So, NK
      Frequency of bitemporal independent interictal epileptiform discharges in temporal lobe epilepsy

      EPILEPSIA
    42. Palmini, A
      Medical and surgical strategies for epilepsy care in developing countries

      EPILEPSIA
    43. Pijnenburg, YAL; Valk, J; Strijers, RLM; Jonkman, EJ; Scheltens, P
      Dementia in an elderly patient associated with extreme dilatation of the perivascular space

      ALZHEIMERS REPORTS
    44. Gross, DW; Wiebe, S; Blume, WT
      The periodicity of lateralized epileptiform discharges

      CLINICAL NEUROPHYSIOLOGY
    45. Torre, JLF; Alarcon, G; Binnie, CD; Polkey, CE
      Comparison of sphenoidal, foramen ovale and anterior temporal placements for detecting interictal epileptiform discharges in presurgical assessment for temporal lobe epilepsy

      CLINICAL NEUROPHYSIOLOGY
    46. Malow, BA; Carney, PR; Kushwaha, R; Bowes, RJ
      Hippocampal sleep spindles revisited: physiologic or epileptic activity?

      CLINICAL NEUROPHYSIOLOGY
    47. James, CJ; Jones, RD; Bones, PJ; Carroll, GJ
      Detection of epileptiform discharges in the EEG by a hybrid system comprising mimetic, self-organized artificial neural network, and fuzzy logic stages

      CLINICAL NEUROPHYSIOLOGY
    48. Maingueneau, F; Honnorat, J; Isnard, J; Tommasi-Davenas, C; Derex, L; Nighoghossian, N; Trouillas, P
      Partial non-convulsive status epilepsy in multiple sclerosis

      NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
    49. Husain, AM; Mebust, KA; Radtke, RA
      Generalized periodic epileptiform discharges: Etiologies, relationship to status epilepticus, and prognosis

      JOURNAL OF CLINICAL NEUROPHYSIOLOGY
    50. Shah, AK
      Cyclosporine A neurotoxicity among bone marrow transplant recipients

      CLINICAL NEUROPHARMACOLOGY
    51. Doczi, J; Banczerowski-Pelyhe, I; Barna, B; Vilagi, I
      Effect of a glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices

      BRAIN RESEARCH BULLETIN
    52. Stam, CJ; Vliegen, JHR; Nicolai, J
      Investigation of the dynamics underlying periodic complexes in the EEG

      BIOLOGICAL CYBERNETICS
    53. Boon, P; Michielsen, G; Goossens, L; Drieghe, C; D'Have, M; Buyle, M; Vonck, K; Naessens, B; De Paemeleere, F; Goethals, I; Thiery, E; Vandekerckhove, T; De Reuck, J
      Interictal and ictal video-EEG monitoring

      ACTA NEUROLOGICA BELGICA
    54. Avoli, M; Barbarosie, M
      Interictal-ictal interactions and limbic seizure generation

      REVUE NEUROLOGIQUE
    55. Frei, MG; Davidchack, RL; Osorio, I
      Least squares acceleration filtering for the estimation of signal derivatives and sharpness at extrema

      IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
    56. Sabau, A; Frahm, C; Pfeiffer, M; Breustedt, JM; Piechotta, A; Numberger, M; Engel, D; Heinemann, U; Draguhn, A
      Age-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro

      EUROPEAN JOURNAL OF PHARMACOLOGY
    57. Hamer, HM; Najm, I; Mohamed, A; Wyllie, E
      Interictal epileptiform discharges in temporal lobe epilepsy due to hippocampal sclerosis versus medial temporal lobe tumors

      EPILEPSIA
    58. Baumgartner, C
      Untitled - Reply

      EPILEPSIA
    59. Malow, BA; Selwa, LM; Ross, D; Aldrich, MS
      Lateralizing value of interictal spikes on overnight sleep-EEG studies in temporal lobe epilepsy

      EPILEPSIA
    60. Parrent, AG; Blume, WT
      Stereotactic amygdalohippocampotomy for the treatment of medial temporal lobe epilepsy

      EPILEPSIA
    61. Hughes, JR; Zialcita, ML
      EEG and epilepsy in the elderly compared to a younger group

      CLINICAL ELECTROENCEPHALOGRAPHY
    62. Hughes, JR; Fino, JJ; Melyn, MA
      Is there a chronic change of the "Mozart effect" on epileptiform activity?A case study

      CLINICAL ELECTROENCEPHALOGRAPHY
    63. Krakow, K; Woermann, FG; Symms, MR; Allen, PJ; Lemieux, L; Barker, GJ; Duncan, JS; Fish, DR
      EEG-triggered functional MRI of interictal epileptiform activity in patients with partial seizures

      BRAIN
    64. Witte, OW
      Lesion-induced plasticity as a potential mechanism for recovery and rehabilitative training

      CURRENT OPINION IN NEUROLOGY
    65. WESTENBROEK RE; BAUSCH SB; LIN RCS; FRANCK JE; NOEBELS JL; CATTERALL WA
      UP-REGULATION OF L-TYPE CA2+ CHANNELS IN REACTIVE ASTROCYTES AFTER BRAIN INJURY, HYPOMYELINATION, AND ISCHEMIA

      The Journal of neuroscience
    66. SERI S; CERQUIGLINI A; PISANI F
      SPIKE-INDUCED INTERFERENCE IN AUDITORY SENSORY PROCESSING IN LANDAU-KLEFFNER SYNDROME

      Electroencephalography and clinical neurophysiology. Evoked potentials
    67. SERLES W; PATARAIA E; BACHER J; OLBRICH A; AULL S; LEHRNER J; LEUTMEZER F; DEECKE L; BAUMGARTNER C
      CLINICAL SEIZURE LATERALIZATION IN MESIAL TEMPORAL-LOBE EPILEPSY - DIFFERENCES BETWEEN PATIENTS WITH UNITEMPORAL AND BITEMPORAL INTERICTAL SPIKES

      Neurology
    68. BOROOJERDI B; HUNGS M; BINIEK R; NOTH J
      A CASE OF SUBACUTE ENCEPHALOPATHY WITH SE IZURES IN ALCOHOLICS (SESA SYNDROME)

      Nervenarzt
    69. PATARAIA E; LURGER S; SERLES W; LINDINGER G; AULL S; LEUTMEZER F; BACHER J; OLBRICH A; CZECH T; NOVAK K; DEECKE L; BAUMGARTNER C
      ICTAL SCALP EEG IN UNILATERAL MESIAL TEMPORAL-LOBE EPILEPSY

      Epilepsia
    70. Malow, BA; Lin, XH; Kushwaha, R; Aldrich, MS
      Interictal spiking increases with sleep depth in temporal lobe epilepsy

      EPILEPSIA
    71. Gross, DW; Quesney, LF; Sadikot, AF
      Chronic periodic lateralized epileptiform discharges during sleep in a patient with caudate nucleus atrophy: insights into the anatomical circuitry of PLEDs

      ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
    72. KAPLAN PW
      REVERSIBLE HYPERCALCEMIC CEREBRAL VASOCONSTRICTION WITH SEIZURES AND BLINDNESS - A PARADIGM FOR ECLAMPSIA

      Clinical EEG electroencephalography
    73. STAM CJ; NICOLAI J; KEUNEN RWM
      NONLINEAR DYNAMICAL ANALYSIS OF PERIODIC LATERALIZED EPILEPTIFORM DISCHARGES

      Clinical EEG electroencephalography
    74. HUGHES JR; TABER J; UPPAL H
      TRI-PLEDS - A CASE-REPORT

      Clinical EEG electroencephalography
    75. ROSS FM; BRODIE MJ; STONE TW
      ADENOSINE-MONOPHOSPHATE AS A MEDIATOR OF ATP EFFECTS AT P1 PURINOCEPTORS

      British Journal of Pharmacology
    76. KUCUKKAYA B; AKER R; YUKSEL M; ONAT F; YALCIN AS
      LOW-DOSE MK-801 PROTECTS AGAINST IRON-INDUCED OXIDATIVE CHANGES IN A RAT MODEL OF FOCAL EPILEPSY

      Brain research
    77. VONWEGERER J; VANCALKER D; BERGER M; WALDEN J
      AUGMENTATION OF GABA-B INDUCED FIELD POTENTIAL CHANGES BY CARBAMAZEPINE IN THE HIPPOCAMPUS

      Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology
    78. POHLMANNEDEN B; COCHIUS JI; HOCH DB; HENNERICI MG
      STROKE AND EPILEPSY - CRITICAL-REVIEW OF THE LITERATURE PART .2. RISK-FACTORS, PATHOPHYSIOLOGY AND OVERLAP SYNDROMES

      Cerebrovascular diseases
    79. ROPER SN; KING MA; ABRAHAM LA; BOILLOT MA
      DISINHIBITED IN-VITRO NEOCORTICAL SLICES CONTAINING EXPERIMENTALLY-INDUCED CORTICAL DYSPLASIA DEMONSTRATE HYPEREXCITABILITY

      Epilepsy research
    80. ONO S; CHIDA K; FUKAYA N; YOSHIHASHI H; TAKASU T
      DYSPHASIA ACCOMPANIED BY PERIODIC LATERALIZED EPILEPTIFORM DISCHARGES

      Internal medicine
    81. JAITLY R; SGRO JA; TOWNE AR; KO DJ; DELORENZO RJ
      PROGNOSTIC VALUE OF EEG MONITORING AFTER STATUS EPILEPTICUS - A PROSPECTIVE ADULT STUDY

      Journal of clinical neurophysiology
    82. MURIALDO G; GALIMBERTI CA; MAGRI F; SAMPAOLO P; COPELLO F; GIANELLI MV; GAZZERRO E; ROLLERO A; DEAGATONE C; MANNI R; FERRARI E; POLLERI A; TARTARA A
      MENSTRUAL-CYCLE AND OVARY ALTERATIONS IN WOMEN WITH EPILEPSY ON ANTIEPILEPTIC THERAPY

      Journal of endocrinological investigation
    83. BLUME WT; PARRENT AG; KAIBARA M
      STEREOTAXIC AMYGDALOHIPPOCAMPOTOMY AND MESIAL TEMPORAL SPIKES

      Epilepsia
    84. WOHLRAB G; SCHMITT B; BOLTSHAUSER E
      BENIGN FOCAL EPILEPTIFORM DISCHARGES IN CHILDREN AFTER SEVERE HEAD TRAUMA - PROGNOSTIC VALUE AND CLINICAL COURSE

      Epilepsia
    85. FUNAKAWA I; YASUDA T; TERAO A
      PERIODIC LATERALIZED EPILEPTIFORM DISCHARGES IN MITOCHONDRIAL ENCEPHALOMYOPATHY

      Electroencephalography and clinical neurophysiology
    86. MALOW BA; KUSHWAHA A; LIN XH; MORTON MJ; ALDRICH MS
      RELATIONSHIP OF INTERICTAL EPILEPTIFORM DISCHARGES TO SLEEP DEPTH IN PARTIAL EPILEPSY

      Electroencephalography and clinical neurophysiology
    87. ALARCON G; SEOANE JJG; BINNIE CD; MIGUEL MCM; JULER J; POLKEY CE; ELWES RDC; BLASCO JMO
      ORIGIN AND PROPAGATION OF INTERICTAL DISCHARGES IN THE ACUTE ELECTROCORTICOGRAM - IMPLICATIONS FOR PATHOPHYSIOLOGY AND SURGICAL-TREATMENT OF TEMPORAL-LOBE EPILEPSY

      Brain
    88. HUBSCHLE T; MADEJA M; MUSSHOFF U; SPECKMANN EJ
      MEMBRANE CURRENTS ELICITED BY THE ORGANIC CALCIUM-CHANNEL BLOCKER VERAPAMIL IN NATIVE AND RAT-BRAIN RNA-INJECTED OOCYTES OF XENOPUS-LAEVIS

      Arzneimittel-Forschung
    89. THOMAS RJ
      SEIZURES AND EPILEPSY IN THE ELDERLY

      Archives of internal medicine
    90. POTT W; REMSCHMIDT H
      FOCAL HYPERSYNCHRONOUS ACTIVITY IN CHILDR EN WITH SPECIFIC DEVELOPMENTAL DEFICITS - ARE THERE ANY CLINICAL IMPLICATIONS

      Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
    91. SHI HL; HIRAMATSU M; KOMATSU M; KAYAMA T
      ANTIOXIDANT PROPERTY OF FRUCTUS MOMORDICAE EXTRACT

      Biochemistry and molecular biology international
    92. KABUTO H; YOKOI I; HABU H; WILLMORE LJ; MORI A; OGAWA N
      REDUCTION IN NITRIC-OXIDE SYNTHASE ACTIVITY WITH DEVELOPMENT OF AN EPILEPTOGENIC FOCUS INDUCED BY FERRIC-CHLORIDE IN THE RAT-BRAIN

      Epilepsy research
    93. KOMATSU M; HIRAMATSU M; YOKOYAMA H; WILLMORE LJ
      EFFECT OF TJ-960 (A JAPANESE HERBAL MEDICINE) ON FREE-RADICAL CHANGESWITHIN AN IRON-INDUCED FOCAL EPILEPTOGENIC REGION IN RAT-BRAIN MEASURED BY IN-VIVO L-BAND ELECTRON-SPIN-RESONANCE

      Neuroscience letters
    94. AVOLI M; WILLIAMSON A
      FUNCTIONAL AND PHARMACOLOGICAL PROPERTIES OF HUMAN NEOCORTICAL NEURONS MAINTAINED IN-VITRO

      Progress in neurobiology
    95. PRIMAVERA A; GIANELLI MV; BANDINI F
      APHASIC STATUS EPILEPTICUS IN MULTIPLE-SCLEROSIS

      European neurology
    96. HOLMES MD; DODRILL CB; OJEMANN LM; OJEMANN GA
      5-YEAR OUTCOME AFTER EPILEPSY SURGERY IN NONMONITORED AND MONITORED SURGICAL CANDIDATES

      Epilepsia
    97. AVOLI M
      GABA-MEDIATED SYNCHRONOUS POTENTIALS AND SEIZURE GENERATION

      Epilepsia
    98. POLC P; JAHROMI SS; FACCIPONTE G; PELLETIER MR; ZHANG L; CARLEN PL
      BENZODIAZEPINE ANTAGONISTS REDUCE EPILEPTIFORM DISCHARGES IN RAT HIPPOCAMPAL SLICES

      Epilepsia
    99. SANTOSHKUMAR B; RADHAKRISHNAN K
      PERIODIC ELECTROENCEPHALOGRAPHIC PATTERN IN SUBACUTE SCLEROSING PANENCEPHALITIS MODIFIED BY PREEXISTING DAMAGED CEREBRAL HEMISPHERE

      Electroencephalography and clinical neurophysiology
    100. GABOR AJ; LEACH RR; DOWLA FU
      AUTOMATED SEIZURE DETECTION USING A SELF-ORGANIZING NEURAL-NETWORK

      Electroencephalography and clinical neurophysiology


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Documento generato il 31/05/20 alle ore 05:55:45