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La ricerca find articoli where soggetti phrase all words 'ENGINEERED BIOSYNTHESIS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 94 riferimenti
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    1. Thomas, R
      A biosynthetic classification of fungal and streptomycete fused-ring aromatic polyketides

      CHEMBIOCHEM
    2. Staunton, J; Wilkinson, B
      Combinatorial biosynthesis of polyketides and nonribosomal peptides

      CURRENT OPINION IN CHEMICAL BIOLOGY
    3. Floss, HG
      Antibiotic biosynthesis: from natural to unnatural compounds

      JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
    4. Pfeifer, BA; Khosla, C
      Biosynthesis of polyketides in heterologous hosts

      MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
    5. Staunton, J; Weissman, KJ
      Polyketide biosynthesis: a millennium review

      NATURAL PRODUCT REPORTS
    6. Cornish, K
      Biochemistry of natural rubber, a vital raw material, emphasizing biosynthetic rate, molecular weight and compartmentalization, in evolutionarily divergent plant species

      NATURAL PRODUCT REPORTS
    7. Yu, TW; Muller, R; Muller, M; Zhang, XH; Draeger, G; Kim, CG; Leistner, E; Floss, HG
      Mutational analysis and reconstituted expression of the biosynthetic genesinvolved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in Amycolatopsis mediterranei S699

      JOURNAL OF BIOLOGICAL CHEMISTRY
    8. Brunker, P; Sterner, O; Bailey, JE; Minas, W
      Heterologous expression of the naphthocyclinone hydroxylase gene from Streptomyces arenae for production of novel hybrid polyketides

      ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
    9. Taguchi, T; Ebizuka, Y; Hopwood, DA; Ichinose, K
      A new mode of stereochemical control revealed by analysis of the biosynthesis of dihydrogranaticin in Streptomyces violaceoruber Tu22

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    10. Wu, N; Tsuji, SY; Cane, DE; Khosla, C
      Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    11. Kwon, HJ; Smith, WC; Xiang, LK; Shen, B
      Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    12. Hertweck, C
      The multiplasmid approach: A new perspective for combinatorial biosynthesis

      CHEMBIOCHEM
    13. Ziermann, R; Betlach, MC
      A two-vector system for the production of recombinant polyketides in Streptomyces

      JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
    14. Mankelow, DP; Neilan, BA
      Non-ribosomal peptide antibiotics

      EXPERT OPINION ON THERAPEUTIC PATENTS
    15. Kantola, J; Kunnari, T; Hautala, A; Hakala, J; Ylihonko, K; Mantsala, P
      Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.

      MICROBIOLOGY-UK
    16. Tang, L; Fu, H; McDaniel, R
      Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases

      CHEMISTRY & BIOLOGY
    17. Piel, J; Hertweck, C; Shipley, PR; Hunt, DM; Newman, MS; Moore, BS
      Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase

      CHEMISTRY & BIOLOGY
    18. Volchegursky, Y; Hu, ZH; Katz, L; McDaniel, R
      Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea

      MOLECULAR MICROBIOLOGY
    19. Shen, B
      Biosynthesis of aromatic polyketides

      BIOSYNTHESIS: AROMATIC POLYKETIDES, ISOPRENOIDS, ALKALOIDS
    20. Lal, R; Kumari, R; Kaur, H; Khanna, R; Dhingra, N; Tuteja, D
      Regulation and manipulation of the gene clusters encoding type-I PKSs

      TRENDS IN BIOTECHNOLOGY
    21. Burson, KK; Khosla, C
      Dissecting the chain length specificity in bacterial aromatic polyketide synthases using chimeric genes

      TETRAHEDRON
    22. Tang, L; Shah, S; Chung, L; Carney, J; Katz, L; Khosla, C; Julien, B
      Cloning and heterologous expression of the epothilone gene cluster

      SCIENCE
    23. Cordell, GA
      Biodiversity and drug discovery - a symbiotic relationship

      PHYTOCHEMISTRY
    24. Khosla, C
      Natural product biosynthesis: A new interface between enzymology and medicine

      JOURNAL OF ORGANIC CHEMISTRY
    25. Marti, T; Hu, ZH; Pohl, NL; Shah, AN; Khosla, C
      Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist - Insights into an unusual priming mechanism

      JOURNAL OF BIOLOGICAL CHEMISTRY
    26. Doi-Katayama, Y; Yoon, YJ; Choi, CY; Yu, TW; Floss, HG; Hutchinson, CR
      Thioesterases and the premature termination of polyketide chain elongationin rifamycin B biosynthesis by Amycolatopsis mediterranei S699

      JOURNAL OF ANTIBIOTICS
    27. Taguchi, T; Itou, K; Ebizuka, Y; Malpartida, F; Hopwood, DA; Surti, CM; Booker-Milburn, KI; Stephenson, GR; Ichinose, K
      Chemical characterisation of disruptants of the Streptomyces coelicolor A3(2) actVI genes involved in actinorhodin biosynthesis

      JOURNAL OF ANTIBIOTICS
    28. Mirjalili, N; Zormpaidis, V; Leadlay, PF; Ison, AP
      The effect of rapeseed oil uptake on the production of erythromycin and triketide lactone by Saccharopolyspora erythraea

      BIOTECHNOLOGY PROGRESS
    29. Hu, ZH; Hunziker, D; Hutchinson, CR; Khosla, C
      A host-vector system for analysis and manipulation of rifamycin polyketidebiosynthesis in Amycolatopsis mediterranei

      MICROBIOLOGY-UK
    30. Zawada, RJX; Khosla, C
      Heterologous expression, purification, reconstitution and kinetic analysisof an extended type II polyketide synthase

      CHEMISTRY & BIOLOGY
    31. Tang, L; Fu, H; Betlach, MC; McDaniel, R
      Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase

      CHEMISTRY & BIOLOGY
    32. Gokhale, RS; Hunziker, D; Cane, DE; Khosla, C
      Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

      CHEMISTRY & BIOLOGY
    33. Fujii, I; Mori, Y; Watanabe, A; Kubo, Y; Tsuji, G; Ebizuka, Y
      Heterologous expression and product identification of Colletotrichum lagenarium polyketide synthase encoded by the PKS1 gene involved in melanin biosynthesis

      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
    34. Brunker, P; McKinney, K; Sterner, O; Minas, W; Bailey, JE
      Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes

      GENE
    35. Lowe, G
      Oligomeric and biogenetic combinatorial libraries

      NATURAL PRODUCT REPORTS
    36. Bender, CL; Rangaswamy, V; Loper, J
      Polyketide production by plant-associated pseudomonads

      ANNUAL REVIEW OF PHYTOPATHOLOGY
    37. Khosla, C; Gokhale, RS; Jacobsen, JR; Cane, DE
      Tolerance and specificity of polyketide synthases

      ANNUAL REVIEW OF BIOCHEMISTRY
    38. Rohr, J; Mendez, C; Salas, JA
      The biosynthesis of aureolic acid group antibiotics

      BIOORGANIC CHEMISTRY
    39. Bisang, C; Long, PF; Cortes, J; Westcott, J; Crosby, J; Matharu, AL; Cox, RJ; Simpson, TJ; Staunton, J; Leadlay, PF
      A chain initiation factor common to both modular and aromatic polyketide synthases

      NATURE
    40. Hutchinson, CR
      Microbial polyketide synthases: More and more prolific

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    41. Shen, YM; Yoon, P; Yu, TW; Floss, HG; Hopwood, D; Moore, BS
      Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    42. McDaniel, R; Thamchaipenet, A; Gustafsson, C; Fu, H; Betlach, M; Betlach, M; Ashley, G
      Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    43. Petkovic, H; Thamchaipenet, A; Zhou, LH; Hranueli, D; Raspor, P; Waterman, PG; Hunter, IS
      Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths

      JOURNAL OF BIOLOGICAL CHEMISTRY
    44. Dreier, J; Shah, AN; Khosla, C
      Kinetic analysis of the actinorhodin aromatic polyketide synthase

      JOURNAL OF BIOLOGICAL CHEMISTRY
    45. Lau, J; Fu, H; Cane, DE; Khosla, C
      Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

      BIOCHEMISTRY
    46. Kendrew, SG; Katayama, K; Deutsch, E; Madduri, K; Hutchinson, CR
      DnrD cyclase involved in the biosynthesis of doxorubicin: Purification andcharacterization of the recombinant enzyme

      BIOCHEMISTRY
    47. Kulowski, K; Wendt-Pienkowski, E; Han, L; Yang, KQ; Vining, LC; Hutchinson, CR
      Functional characterization of the jadI gene as a cyclase forming angucyclinones

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    48. HUTCHINSON CR
      COMBINATORIAL BIOSYNTHESIS FOR NEW DRUG DISCOVERY

      CURRENT OPINION IN MICROBIOLOGY
    49. ICHINOSE K; BEDFORD DJ; BIBB MJ; REVILL WP; HOPWOOD DA
      THE GRANATICIN BIOSYNTHETIC GENE-CLUSTER OF STREPTOMYCES VIOLACEORUBER TU22 - SEQUENCE-ANALYSIS AND EXPRESSION IN A HETEROLOGOUS HOST

      Chemistry & biology
    50. HITCHMAN TS; CROSBY J; BYROM KJ; COX RJ; SIMPSON TJ
      CATALYTIC SELF-ACYLATION OF TYPE-II POLYKETIDE SYNTHASE ACYL CARRIER PROTEINS

      Chemistry & biology
    51. ROWE CJ; CORTES J; GAISSER S; STAUNTON J; LEADLEY PF
      CONSTRUCTION OF NEW VECTORS FOR HIGH-LEVEL EXPRESSION IN ACTINOMYCETES

      Gene
    52. CANE DE; WALSH CT; KHOSLA C
      BIOCHEMISTRY - HARNESSING THE BIOSYNTHETIC CODE - COMBINATIONS, PERMUTATIONS, AND MUTATIONS

      Science
    53. KEALEY JT; LIU L; SANTI DV; BETLACH MC; BARR PJ
      PRODUCTION OF A POLYKETIDE NATURAL PRODUCT IN NONPOLYKETIDE-PRODUCINGPROKARYOTIC AND EUKARYOTIC HOSTS

      Proceedings of the National Academy of Sciences of the United Statesof America
    54. CARRERAS CW; KHOSLA C
      PURIFICATION AND IN-VITRO RECONSTITUTION OF THE ESSENTIAL PROTEIN-COMPONENTS OF AN AROMATIC POLYKETIDE SYNTHASE

      Biochemistry
    55. BAO WL; WENDTPIENKOWSKI E; HUTCHINSON CR
      RECONSTITUTION OF THE ITERATIVE TYPE-II POLYKETIDE SYNTHASE FOR TETRACENOMYCIN F2 BIOSYNTHESIS

      Biochemistry
    56. JACOBSEN JR; CANE DE; KHOSLA C
      SPONTANEOUS PRIMING OF A DOWNSTREAM MODULE IN 6-DEOXYERYTHRONOLIDE-B SYNTHASE LEADS TO POLYKETIDE BIOSYNTHESIS

      Biochemistry
    57. MCPHERSON M; KHOSLA C; CANE DE
      ERYTHROMYCIN BIOSYNTHESIS - THE BETA-KETOREDUCTASE DOMAINS CATALYZE THE STEREOSPECIFIC TRANSFER OF THE 4-PRO-S HYDRIDE OF NADPH

      Journal of the American Chemical Society
    58. KAO CM; MCPHERSON M; MCDANIEL RN; FU H; CANE DE; KHOSLA C
      ALCOHOL STEREOCHEMISTRY IN POLYKETIDE BACKBONES IS CONTROLLED BY THE BETA-KETOREDUCTASE DOMAINS OF MODULAR POLYKETIDE SYNTHASES

      Journal of the American Chemical Society
    59. LEADLAY PF
      COMBINATORIAL APPROACHES TO POLYKETIDE BIOSYNTHESIS

      CURRENT OPINION IN CHEMICAL BIOLOGY
    60. MEURER G; GERLITZ M; WENDTPIENKOWSKI E; VINING LC; ROHR J; HUTCHINSON CR
      ITERATIVE TYPE-II POLYKETIDE SYNTHASES, CYCLASES AND KETOREDUCTASES EXHIBIT CONTEXT-DEPENDENT BEHAVIOR IN THE BIOSYNTHESIS OF LINEAR AND ANGULAR DECAPOLYKETIDES

      Chemistry & biology
    61. CHUCK JA; MCPHERSON M; HUANG H; JACOBSEN JR; KHOSLA C; CANE DE
      MOLECULAR RECOGNITION OF DIKETIDE SUBSTRATES BY A BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE DOMAIN WITHIN A BIMODULAR POLYKETIDE SYNTHASE

      Chemistry & biology
    62. BYSTRYKH LV; HERREMA JK; KRUIZINGA W; KELLOGG RM
      5-HYDROXYALOESAPONARIN-II, A MINOR BLUE PIGMENT IN AN ACTINORHODIN-NEGATIVE MUTANT OF STREPTOMYCES-COELICOLOR A3(2)

      Biotechnology and applied biochemistry
    63. RAWLINGS BJ
      BIOSYNTHESIS OF POLYKETIDES

      Natural product reports
    64. ZAWADA RJX; KHOSLA C
      DOMAIN ANALYSIS OF THE MOLECULAR RECOGNITION FEATURES OF AROMATIC POLYKETIDE SYNTHASE SUBUNITS

      The Journal of biological chemistry
    65. SEOW KT; MEURER G; GERLITZ M; WENDTPIENKOWSKI E; HUTCHINSON CR; DAVIES J
      A STUDY OF ITERATIVE TYPE-II POLYKETIDE SYNTHASES, USING BACTERIAL GENES CLONED FROM SOIL DNA - A MEANS TO ACCESS AND USE GENES FROM UNCULTURED MICROORGANISMS

      Journal of bacteriology
    66. HONG ST; CARNEY JR; GOULD SJ
      CLONING AND HETEROLOGOUS EXPRESSION OF THE ENTIRE GENE CLUSTERS FOR PD-116740 FROM STREPTOMYCES STRAIN WP-4669 AND TETRANGULOL AND TETRANGOMYCIN FROM STREPTOMYCES-RIMOSUS NRRL-3016

      Journal of bacteriology
    67. KENDREW SG; HOPWOOD DA; MARSH ENG
      IDENTIFICATION OF A MONOOXYGENASE FROM STREPTOMYCES-COELICOLOR A3(2) INVOLVED IN BIOSYNTHESIS OF ACTINORHODIN - PURIFICATION AND CHARACTERIZATION OF THE RECOMBINANT ENZYME

      Journal of bacteriology
    68. HOPWOOD DA
      GENETIC CONTRIBUTIONS TO UNDERSTANDING POLYKETIDE SYNTHASES

      Chemical reviews
    69. FUJII I; EBIZUKA Y
      ANTHRACYCLINE BIOSYNTHESIS IN STREPTOMYCES-GALILAEUS

      Chemical reviews
    70. KATZ L
      MANIPULATION OF MODULAR POLYKETIDE SYNTHESES

      Chemical reviews
    71. KHOSLA C
      HARNESSING THE BIOSYNTHETIC POTENTIAL OF MODULAR POLYKETIDE SYNTHASES

      Chemical reviews
    72. STAUNTON J; WILKINSON B
      BIOSYNTHESIS OF ERYTHROMYCIN AND RAPAMYCIN

      Chemical reviews
    73. CARRERAS CW; GEHRING AM; WALSH CT; KHOSLA C
      UTILIZATION OF ENZYMATICALLY PHOSPHOPANTETHEINYLATED ACYL CARRIER PROTEINS AND ACETYL-ACYL CARRIER PROTEINS BY THE ACTINORHODIN POLYKETIDE SYNTHASE

      Biochemistry
    74. CRUMP MP; CROSBY J; DEMPSEY CE; PARKINSON JA; MURRAY M; HOPWOOD DA; SIMPSON TJ
      SOLUTION STRUCTURE OF THE ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN FROM STREPTOMYCES-COELICOLOR A3(2)

      Biochemistry
    75. MCDANIEL R; KAO CM; FU H; HEVEZI P; GUSTAFSSON C; BETLACH M; ASHLEY G; CANE DE; KHOSLA C
      GAIN-OF-FUNCTION MUTAGENESIS OF A MODULAR POLYKETIDE SYNTHASE

      Journal of the American Chemical Society
    76. FU H; KHOSLA C
      ANTIBIOTIC-ACTIVITY OF POLYKETIDE PRODUCTS DERIVED FROM COMBINATORIALBIOSYNTHESIS - IMPLICATIONS FOR DIRECTED EVOLUTION

      Molecular diversity
    77. YLIHONKO K; HAKALA J; KUNNARI T; MANTSALA P
      PRODUCTION OF HYBRID ANTHRACYCLINE ANTIBIOTICS BY HETEROLOGOUS EXPRESSION OF STREPTOMYCES NOGALATER NOGALAMYCIN BIOSYNTHESIS GENES

      Microbiology
    78. BLANCO G; FU H; MENDEZ C; KHOSLA C; SALAS JA
      DECIPHERING THE BIOSYNTHETIC ORIGIN OF THE AGLYCONE OF THE AUREOLIC ACID GROUP OF ANTITUMOR AGENTS

      Chemistry & biology
    79. BEDFORD D; JACOBSEN JR; LUO GL; CANE DE; KHOSLA C
      A FUNCTIONAL CHIMERIC MODULAR POLYKETIDE SYNTHASE GENERATED VIA DOMAIN REPLACEMENT

      Chemistry & biology
    80. OLIYNYK M; BROWN MJB; CORTES J; STAUNTON J; LEADLAY PF
      A HYBRID MODULAR POLYKETIDE SYNTHASE OBTAINED BY DOMAIN SWAPPING

      Chemistry & biology
    81. KUHSTOSS S; HUBER M; TURNER JR; PASCHAL JW; RAO RN
      PRODUCTION OF A NOVEL POLYKETIDE THROUGH THE CONSTRUCTION OF A HYBRIDPOLYKETIDE SYNTHASE

      Gene
    82. PIEPER R; KAO C; KHOSLA C; LUO GL; CANE DE
      SPECIFICITY AND VERSATILITY IN ERYTHROMYCIN BIOSYNTHESIS

      Chemical Society reviews
    83. KHOSLA C; ZAWADA RJX
      GENERATION OF POLYKETIDE LIBRARIES VIA COMBINATORIAL BIOSYNTHESIS

      Trends in biotechnology
    84. REVILL WP; BIBB MJ; HOPWOOD DA
      RELATIONSHIPS BETWEEN FATTY-ACID AND POLYKETIDE SYNTHASES FROM STREPTOMYCES-COELICOLOR A3(2) - CHARACTERIZATION OF THE FATTY-ACID SYNTHASE ACYL CARRIER PROTEIN

      Journal of bacteriology
    85. KHOSLA C; CAREN R; KAO CM; MCDANIEL R; WANG SW
      EVOLUTIONALLY GUIDED ENZYME DESIGN

      Biotechnology and bioengineering
    86. CARRERAS CW; PIEPER R; KHOSLA C
      EFFICIENT SYNTHESIS OF AROMATIC POLYKETIDES IN-VITRO BY THE ACTINORHODIN POLYKETIDE SYNTHASE

      Journal of the American Chemical Society
    87. TSOI CJ; KHOSLA C
      COMBINATORIAL BIOSYNTHESIS OF UNNATURAL NATURAL-PRODUCTS - THE POLYKETIDE EXAMPLE

      Chemistry & biology
    88. ROHR J
      COMBINATORIAL BIOSYNTHESIS - AN APPROACH IN THE NEAR FUTURE

      Angewandte Chemie, International Edition in English
    89. UDVARNOKI G; WAGNER C; MACHINEK R; ROHR J
      BIOSYNTHETIC ORIGIN OF THE OXYGEN-ATOMS OF TETRACENOMYCIN-C

      Angewandte Chemie, International Edition in English
    90. CROSBY J; SHERMAN DH; BIBB MJ; REVILL WP; HOPWOOD DA; SIMPSON TJ
      POLYKETIDE SYNTHASE ACYL CARRIER PROTEINS FROM STREPTOMYCES - EXPRESSION IN ESCHERICHIA-COLI, PURIFICATION AND PARTIAL CHARACTERIZATION

      Biochimica et biophysica acta. Protein structure and molecular enzymology
    91. MCDANIEL R; EBERTKHOSLA S; HOPWOOD DA; KHOSLA C
      RATIONAL DESIGN OF AROMATIC POLYKETIDE NATURAL-PRODUCTS BY RECOMBINANT ASSEMBLY OF ENZYMATIC SUBUNITS

      Nature
    92. BEDFORD DJ; SCHWEIZER E; HOPWOOD DA; KHOSLA C
      EXPRESSION OF A FUNCTIONAL FUNGAL POLYKETIDE SYNTHASE IN THE BACTERIUM STREPTOMYCES-COELICOLOR A3(2)

      Journal of bacteriology
    93. SHEN B; SUMMERS RG; WENDTPIENKOWSKI E; HUTCHINSON CR
      THE STREPTOMYCES-GLAUCESCENS TCMKL POLYKETIDE SYNTHASE AND TCMN POLYKETIDE CYCLASE GENES GOVERN THE SIZE AND SHAPE OF AROMATIC POLYKETIDES

      Journal of the American Chemical Society
    94. FU H; EBERTKHOSLA S; HOPWOOD DA; KHOSLA C
      RELAXED SPECIFICITY OF THE OXYTETRACYCLINE POLYKETIDE SYNTHASE FOR ANACETATE PRIMER IN THE ABSENCE OF A MALONAMYL PRIMER

      Journal of the American Chemical Society


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Documento generato il 10/08/20 alle ore 08:56:13