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The first direct oxidative conversion of a selenol to a stable selenenic acid: Experimental demonstration of three processes included in the catalytic cycle of glutathione peroxidase
ORGANIC LETTERS
The biochemistry of selenium and the glutathione system
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Malondialdehyde, glutathione peroxidase and superoxide dismutase in peripheral blood erythrocytes of patients with acute cerebral ischemia
EUROPEAN JOURNAL OF NEUROLOGY
The selenoorganic compound ebselen suppresses liver injury induced by Propionibacterium acnes and lipopolysaccharide in rats
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Structure-activity correlation between natural glutathione peroxidase (GPx) and mimics: A biomimetic concept for the design and synthesis of more efficient GPx mimics
CHEMISTRY-A EUROPEAN JOURNAL
Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice
PHARMACOLOGY & TOXICOLOGY
2-(chloroseleno)benzoyl chloride: A tandem reagent for selenenylation-acylation of C-H acids
CHEMISTRY LETTERS
Oxidative and nitrosative stress in acute renal ischemia
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons
NEUROSCIENCE LETTERS
Cloning and expression of a single-chain catalytic antibody that acts as aglutathione peroxidase mimic with high catalytic efficiency
BIOCHEMICAL JOURNAL
Bisbenzisoselenazol-3(2H)-ones, a new group of ebselen analogues
POLISH JOURNAL OF CHEMISTRY
Nucleophilic and radical chemistry of benzylselenides: preparation of novel selenocephems and selenopenams
TETRAHEDRON LETTERS
Selective oxidation of aromatic aldehydes to arenecarboxylic acids using ebselen-tert-butyl hydroperoxide catalytic system
TETRAHEDRON
Intracisternal increase of superoxide anion production in a canine subarachnoid hemorrhage model
STROKE
The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site
JOURNAL OF NEUROCHEMISTRY
One - Pot synthesis of novel sulfur and selenium heterocycles by directed ortho-lithiation
JOURNAL OF HETEROCYCLIC CHEMISTRY
Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo
GUT
Preventive effect of ebselen on acute gastric mucosal lesion development in rats treated with compound 48/80
EUROPEAN JOURNAL OF PHARMACOLOGY
Electrochemical behaviour of seleno-organic compounds Part 5. [2H] Benziso-1,2-selenazol-3-one, [3H] benzo-2,1-thiaselenol-3-one and [3H] benzo-1,2-dithiol-3-one
ELECTROCHIMICA ACTA
The mechanism of reaction of ebselen with superoxide in aprotic solvents as examined by cyclic voltammetry and ESR
CHEMICAL & PHARMACEUTICAL BULLETIN
Mitochondrial membrane potential in density-separated trout erythrocytes exposed to oxidative stress in vitro
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Generation of three selenium-containing catalytic antibodies with high catalytic efficiency using a novel hapten design method
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
A novel glutathione peroxidase mimic with antioxidant activity
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Glutathione peroxidase-like antioxidant activity of diaryl diselenides: A mechanistic study
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Effect of three diaryl tellurides, and an organoselenium compound in trouterythrocytes exposed to oxidative stress in vitro
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Ebselen: prospective therapy for cerebral ischaemia
EXPERT OPINION ON INVESTIGATIONAL DRUGS
A novel selenocystine-beta-cyclodextrin conjugate that acts as a glutathione peroxidase mimic
BIOCONJUGATE CHEMISTRY
Water-soluble organotellurium compounds: Catalytic protection against peroxynitrite and release of zinc from metallothionein
CHEMICAL RESEARCH IN TOXICOLOGY
Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics
FREE RADICAL BIOLOGY AND MEDICINE
Selenoorganic compound, ebselen, inhibits nitric oxide and tumor necrosis factor-alpha production by the modulation of Jun-N-terminal kinase and the NF-kappa B signaling pathway in rat Kupffer cells
JOURNAL OF CELLULAR BIOCHEMISTRY
Effects of peroxynitrite on rabbit cornea
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
PKA and arachidonic acid activation of human recombinant ClC-2 chloride channels
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Ebselen decreases ozone-induced pulmonary inflammation in rats
LUNG
Synthetic organoselenium compounds as antioxidants: glutathione peroxidaseactivity
CHEMICAL SOCIETY REVIEWS
The anti-oxidant ebselen antagonizes the release of the apoptogenic factorcytochrome c induced by Fe2+/citrate in rat liver mitochondria
NEUROSCIENCE LETTERS
Role of inducible nitric oxide synthase in dextran sulphate sodium-inducedcolitis
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Synthesis and superoxide dismutase activity studies of beta-cyclodextrin derivatives containing 1,2-benzisoselenazol-3 (2H)-one
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
Effect of protective agents against cisplatin ototoxicity
AMERICAN JOURNAL OF OTOLOGY
Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
Helicobacter pylori reduces intracellular glutathione in gastric epithelial cells
DIGESTIVE DISEASES AND SCIENCES
Oxidative stress developed during open heart surgery induces apoptosis: Reduction of apoptotic cell death by ebselen, a glutathione peroxidase mimic
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Effect of an antioxidant, Ebselen, on development of chronic cerebral vasospasm after subarachnoid hemorrhage in primates
SURGICAL NEUROLOGY
Prevention of nephrotoxicity of cisplatin by repeated oral administration of ebselen in rats
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Preparation of 5-selenopentopyranose sugars from pentose starting materials by samarium(II) iodide or (phenylseleno)formate mediated ring closures
TETRAHEDRON
Synthesis of 2-substituted pyrrolidine nitroxide radicals
SYNTHESIS-STUTTGART
Evaluation of the kinetics of beta-elimination reactions of selenocysteineSe-conjugates in human renal cytosol: possible implications for the use askidney selective prodrugs
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copper(I)-assisted mild and convenient synthesis of new Se-N heterocycles:Access to a promising class of GPx mimics
JOURNAL OF ORGANIC CHEMISTRY
4-Hydroxynonenal induces oxidative stress and death of cultured spinal cord neurons
JOURNAL OF NEUROCHEMISTRY
Antioxidant actions of ovothiol-derived 4-mercaptoimidazoles: glutathione peroxidase activity and protection against peroxynitrite-induced damage
FEBS LETTERS
The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease
EXPERIMENTAL NEUROLOGY
Prevention of nitrogen mustard-induced apoptosis in normal and transformedlymphocytes by ebselen
BIOCHEMICAL PHARMACOLOGY
Reaction of phenylaminoethyl selenides with peroxynitrite and hydrogen peroxide
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Synthesis of organoselenium sulfonamides as new potential cytokine inducers: 2,2 '-diselenobis(benzenesulfonamides) and 1,3,2-benzothiaselenazolone 1,1-dioxides
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Role of peroxynitrite in airway microvascular hyperpermeability during late allergic phase in guinea pigs
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Synthesis and crystal structure of 2-phosphonoalkyl-1,2-benzisoselenazol-3(2H)-ones and their antitumor activities
HETEROATOM CHEMISTRY
Ebselen in acute middle cerebral artery occlusion: A placebo-controlled, double-blind clinical trial
CEREBROVASCULAR DISEASES
Ebselen as protection against ethanol-induced toxicity in rat stomach
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
4-hydroxynonenal inhibits glutathione peroxidase: Protection by glutathione
FREE RADICAL BIOLOGY AND MEDICINE
An acute intratracheal selenium study: Immediate effects on respiration inguinea pigs
TOXICOLOGY LETTERS
Effects of ebselen on cerebral ischemia and reperfusion evaluated by microdialysis
NEUROLOGICAL RESEARCH
Effect of ebselen on contractile responses in perfused rabbit basilar artery
NEUROSURGERY
Defenses against peroxynitrite
NITRIC OXIDE, PT C
Samarium(II) iodide mediated intramolecular homolytic substitution at selenium: Preparation of 5-seleno-D-pentopyranose sugars from common pentose starting materials
TETRAHEDRON LETTERS
Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Novel water-soluble diorganyl tellurides with thiol peroxidase and antioxidant activity
JOURNAL OF ORGANIC CHEMISTRY
The involvement of protein kinase C in nitric oxide-induced damage to rat isolated colonic mucosal cells
BRITISH JOURNAL OF PHARMACOLOGY
Protective effect of ebselen against hydrogen peroxide-induced cytotoxicity and DNA damage in HepG(2) cells
BIOCHEMICAL PHARMACOLOGY
PROTECTION BY SELENOPROTEIN-P IN HUMAN PLASMA AGAINST PEROXYNITRITE-MEDIATED OXIDATION AND NITRATION
Biological chemistry
DIFERROCENYL DISELENIDES - EXCELLENT THIOL PEROXIDASE-LIKE ANTIOXIDANTS
Chemical communications
EFFECT OF EBSELEN ON IL-1-INDUCED ALTERATIONS IN CARTILAGE METABOLISM
Inflammation research
PROTECTION AGAINST PEROXYNITRITE BY SELENOPROTEINS
Zeitschrift fur Naturforschung. C, A journal of biosciences
Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors
BIOLOGICAL & PHARMACEUTICAL BULLETIN
REACTIONS OF 1-METHYL-2-PHENYLINDOLE WITH MALONDIALDEHYDE AND 4-HYDROXYALKENALS - ANALYTICAL APPLICATIONS TO A COLORIMETRIC ASSAY OF LIPID-PEROXIDATION
Chemical research in toxicology
Kinetic study of the reaction of glutathione peroxidase with peroxynitrite
CHEMICAL RESEARCH IN TOXICOLOGY
GLUTATHIONE-PEROXIDASE MIMICS PREVENT TNF-ALPHA-INDUCED AND NEUTROPHIL-INDUCED ENDOTHELIAL ALTERATIONS
Free radical biology & medicine
OXIDATIVE STRESS DEVELOPED DURING THE REPERFUSION OF ISCHEMIC MYOCARDIUM INDUCES APOPTOSIS
Free radical biology & medicine
PROTECTION BY EBSELEN AGAINST CISPLATIN-INDUCED NEPHROTOXICITY - ANTIOXIDANT SYSTEM
Molecular and cellular biochemistry
SELENIUM YEAST IS AN EFFECTIVE IN-VITRO AND IN-VIVO ANTIOXIDANT AND HYPOLIPEMIC AGENT IN NORMAL HAMSTERS
Nutrition research
NEUROPROTECTIVE EFFECT OF AN ANTIOXIDANT, EBSELEN, IN PATIENTS WITH DELAYED NEUROLOGICAL DEFICITS AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE
Neurosurgery
HYLPERHYDRO-4,7-METHANO-1,2-BENZISOSELENAZOL-3A-OL
Acta crystallographica. Section C, Crystal structure communications
EBSELEN IN ACUTE ISCHEMIC STROKE - A PLACEBO-CONTROLLED, DOUBLE-BLINDCLINICAL-TRIAL
Stroke
ALPHA-(PHENYLSELENENYL) KETONES - STRUCTURE, MOLECULAR MODELING AND RATIONALIZATION OF THEIR GLUTATHIONE PEROXIDASE-LIKE ACTIVITY
Journal of molecular structure
Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion
EUROPEAN JOURNAL OF PHARMACOLOGY
TOXICITY OF FOTEMUSTINE IN RAT HEPATOCYTES AND MECHANISM-BASED PROTECTION AGAINST IT
Chemico-biological interactions
DIFFERENTIAL EFFECT OF EBSELEN ON COMPOUND 48 80-INDUCED AND ANTI-IGE-INDUCED HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS/
Biochemical pharmacology
PROTECTION BY ORGANOTELLURIUM COMPOUNDS AGAINST PEROXYNITRITE-MEDIATED OXIDATION AND NITRATION REACTIONS
Biochemical pharmacology
INACTIVATION OF GLUTATHIONE-PEROXIDASE BY PEROXYNITRITE
Archives of biochemistry and biophysics
MODULATION OF CYTOKINE PRODUCTION BY A SELENOORGANIC COMPOUND (AE-22)IN HYPERREACTIVE OR HYPOREACTIVE BRONCHOALVEOLAR LEUKOCYTES OF ASTHMATICS OR LUNG-CANCER PATIENTS
Journal of interferon & cytokine research
CHIROPTICAL PROPERTIES OF 2-CARBOXYALKYL-1,2-BENZISOSELENAZO-3(2H)-ONES
Enantiomer
EBSELEN, A NOVEL ANTIOXIDANT COMPOUND, PROTECTS THE RAT-LIVER FROM ISCHEMIA-REPERFUSION INJURY
Transplant international
PEROXYNITRITE-MEDIATED OXIDATION OF D,L-SELENOMETHIONINE - KINETICS, MECHANISM AND THE ROLE OF CARBON-DIOXIDE
Free radical biology & medicine
CYTOTOXICITY OF PEROXYNITRITE IN RAT PANCREATIC ACINAR AR4-2J CELLS
Pancreas
SCAVENGING OF HYPOCHLOROUS ACID BY CARVEDILOL AND EBSELEN IN-VITRO
General pharmacology
GLUTATHIONE TRANSFERASE MIMICS - MICELLAR CATALYSIS OF AN ENZYMATIC-REACTION
Biochemical journal
PROTECTION OF EBSELEN AGAINST ANOXIC DAMA GE OF CULTURED NEURONS OF CEREBRAL-CORTEX
Zhongguo yaoli xuebao
EBSELEN (DR3305) AMELIORATES DELAYED CEREBRAL VASOSPASM IN A CANINE 2-HEMORRHAGE MODEL
Neurological research
BIS(2-CHLOROSULFONYLPHENYL) DISELENIDE - THE SUBSTRATE FOR ORGANOSELENIUM SULFONAMIDES
Synthetic communications
SYNTHESIS OF 2-ACYLBENZISOSELEN-AZOL-3(2H)-ONES AND 2-SULFONYLBENZISOSELEN-AZOL-3(2H)-ONES
Synthetic communications
GLUTATHIONE-PEROXIDASE PROTECTS AGAINST PEROXYNITRITE-MEDIATED OXIDATIONS - A NEW FUNCTION FOR SELENOPROTEINS AS PEROXYNITRITE REDUCTASE
The Journal of biological chemistry