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Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Inhibitory effects of 9-anilinoacridines on Plasmodium falciparum gametocytes
TROPICAL MEDICINE & INTERNATIONAL HEALTH
Emerging mechanisms of fluoroquinolone resistance
EMERGING INFECTIOUS DISEASES
Characterization of drug resistance to VM-26 in A2780 ovarian carcinoma cells
ZOOLOGICAL STUDIES
Unique action determinants of double acting topoisomerase inhibitor, TAS-103
INTERNATIONAL JOURNAL OF ONCOLOGY
Comparative QSAR studies on bibenzimidazoles and terbenzimidazoles inhibiting topoisomerase I
BIOORGANIC & MEDICINAL CHEMISTRY
Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2 ':6 ',2 ''-, 2,2 ': 6 ',3 ''- and 2,2 : 6 ',4 ''-terpyridine derivatives
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Antitumor activity of XR5944, a novel and potent topoisomerase poison
ANTI-CANCER DRUGS
Altered topoisomerase II alpha and multidrug resistance-associated proteinlevels during drug selection: Adaptations to increasing drug pressure
JAPANESE JOURNAL OF CANCER RESEARCH
Aromatic extended bisamidines: Synthesis, inhibition of topoisomerases, and anticancer cytotoxicity in vitro
ARCHIV DER PHARMAZIE
Correlation between the expression of DNA topoisomerases I and II alpha and clinical parameters in kidney disease
AMERICAN JOURNAL OF KIDNEY DISEASES
Topoisomerase II can unlink replicating DNA by precatenane removal
EMBO JOURNAL
Topoisomerase II poisoning by indazole and imidazole complexes of ruthenium
JOURNAL OF BIOSCIENCES
Inhibition of human topoisomerase II by the antitumor metallocenes
JOURNAL OF INORGANIC BIOCHEMISTRY
Expression of topoisomerase II alpha in the G0/G1 cell cycle phase of fresh leukemic cells
LEUKEMIA RESEARCH
Topoisomerase V from Methanopyrus kandleri
HYPERTHERMOPHILIC ENZYMES, PT C
New advances in lung cancer chemotherapy: Topotecan and the role of topoisomerase I inhibitors
ONCOLOGY
Inhibition of cancer cell growth by ruthenium(II) arene complexes
JOURNAL OF MEDICINAL CHEMISTRY
Residues within the N-terminal domain of human topoisomerase I play a direct role in relaxation
JOURNAL OF BIOLOGICAL CHEMISTRY
Expression of stress response genes in germ cells during spermatogenesis
BIOLOGY OF REPRODUCTION
Green tea constituent (-)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The expression of the nuclear matrix proteins NuMA, topoisomerase II-alpha, and -beta in bone and osseous cell culture: Regulation by parathyroid hormone
BONE
Effect of the topoisomerase-II inhibitor etoposide on meiotic recombination in male mice
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex
CLINICAL CANCER RESEARCH
2 ''-substituted 5-phenylterbenzimidazoles as topoisomerase I poisons
BIOORGANIC & MEDICINAL CHEMISTRY
Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles
BIOORGANIC & MEDICINAL CHEMISTRY
Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16)
ONCOLOGY RESEARCH
Ex vivo activity of XR5000 against solid tumors
ANTI-CANCER DRUGS
Catalytic inhibition of topoisomerase II in Werner's syndrome cell lines enhances chromosomal damage induced by X-rays in the G2 phase of the cell cycle
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Induction of apoptosis by idarubicin: how important is the plasma peak?
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Expression of drug resistance-related genes in head and neck squamous cellcarcinoma and normal mucosa
JAPANESE JOURNAL OF CANCER RESEARCH
TAS-103 - Oncolytic topoisomerase inhibitor
DRUGS OF THE FUTURE
F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Mechanism of action of the dual topoisomerase-I and -II inhibitor TAS-103 and activity against (multi)drug resistant cells
CANCER CHEMOTHERAPY AND PHARMACOLOGY
High topoisomerase II alpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Rational tangle distances on knots and links
MATHEMATICAL PROCEEDINGS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY
Free energy and information contents of Conformons in proteins and DNA
BIOSYSTEMS
Novobiocin-induced VP-16 accumulation and MRP expression in human leukemiaand ovarian carcinoma cells
ANTI-CANCER DRUG DESIGN
Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase
BIOCHEMICAL JOURNAL
The 2-pyridone antibacterial agents: Bacterial topoisomerase inhibitors
MEDICINAL RESEARCH REVIEWS
Topoisomerase II alpha expression in ductal carcinoma in situ of the breast: A preliminary study
HUMAN PATHOLOGY
Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAsin lung tumor cells and normal and malignant lung tissue
LABORATORY INVESTIGATION
Relationship between expression of topoisomerase II isoforms and chemosensitivity in choroidal melanoma
JOURNAL OF PATHOLOGY
Cell cycle-coupled variation in topoisomerase II alpha mRNA is regulated by the 3 '-untranslated region - Possible role of redox-sensitive protein binding in mRNA accumulation
JOURNAL OF BIOLOGICAL CHEMISTRY
Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I
JOURNAL OF BIOLOGICAL CHEMISTRY
Reverse gyrase, the two domains intimately cooperate to promote positive supercoiling
JOURNAL OF BIOLOGICAL CHEMISTRY
Inhibition of Mycobacterium smegmatis topoisomerase I by specific oligonucleotides
FEBS LETTERS
Inhibition of topoisomerase II alpha expression by transforming growth factor-beta 1 is abrogated by the papillomavirus E7 protein
CANCER RESEARCH
ICBP90, a novel human CCAAT binding protein, involved in the regulation oftopoisomerase II alpha expression
CANCER RESEARCH
Cell density-dependent VP-16 sensitivity of leukaemic cells is accompaniedby the translocation of topoisomerase II alpha from the nucleus to the cytoplasm
BRITISH JOURNAL OF HAEMATOLOGY
Topoisomerase I inhibitors: selectivity and cellular resistance
DRUG RESISTANCE UPDATES
A target-specific cellular assay for screening of topoisomerase I inhibitors
JOURNAL OF BIOMOLECULAR SCREENING
Genetic recombination: Helicases and topoisomerases link up
CURRENT BIOLOGY
Differential in vitro interactions of a series of clinically useful topoisomerase-interacting compounds with the cleavage/religation activity of the human topoisomerase II alpha and II beta isoforms
ANTI-CANCER DRUGS
Topoisomerase activities and levels in irradiated Chinese hamster AA8 cells and in its radiosensitive mutant EM9
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
A dual topoisomerase inhibitor, TAS-103, induces apoptosis in human cancercells
JAPANESE JOURNAL OF CANCER RESEARCH
Carbamate analogues of amsacrine active against non-cycling cells: relative activity against topoisomerases II alpha and beta
CANCER CHEMOTHERAPY AND PHARMACOLOGY
A new human topoisomerase III that interacts with SGS1 protein
NUCLEIC ACIDS RESEARCH
Characterization of a Leishmania donovani gene encoding a protein that closely resembles a type IB topoisomerase
NUCLEIC ACIDS RESEARCH
Developmental toxicity of the topoisomerase inhibitor, etoposide, in rabbits after intravenous administration
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
Expression and relationship between topoisomerase I and II a genes in tumor and normal tissues in esophageal, gastric and colon cancers
ANTICANCER RESEARCH
The control of tuberculosis: a continuous game of snakes and ladders
JOURNAL OF BIOSCIENCES
Supramolecular topology
TETRAHEDRON
Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity
PLANTA MEDICA
Functional interaction between human topoisomerase II alpha and retinoblastoma protein
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Topoisomerases: Mechanisms of DNA topological alterations
MOLECULAR BIOLOGY
The topoisomerase II-associated protein, Pat1p, is required for maintenance of rDNA locus stability in Saccharomyces cerevisiae
MOLECULAR AND GENERAL GENETICS
DNA supercoiling and temperature adaptation: A clue to early diversification of life?
JOURNAL OF MOLECULAR EVOLUTION
Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures
JOURNAL OF MOLECULAR BIOLOGY
Antisense-mediated repression of RNA topoisomerase II expression leads to an impairment of HIV-1 replicative cycle
JOURNAL OF MOLECULAR BIOLOGY
Synthesis and antimicrobial activity of 4H-4-Oxoquinolizine derivatives: Consequences of structural modification at the C-8 position
JOURNAL OF MEDICINAL CHEMISTRY
The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin
JOURNAL OF BIOLOGICAL CHEMISTRY
Topoisomerase I is essential in Cryptococcus neoformans: Role in pathobiology and as an antifungal target
GENETICS
Diarylsemicarbazones: synthesis, antineoplastic activity and topoisomeraseI inhibition assay
FARMACO
Mode of action of fluoroquinolones
DRUGS
THE EXPRESSION AND LOCALIZATION OF SCL-70 DNA TOPOISOMERASE-I VARY THROUGHOUT THE CELL-CYCLE/
Revue du rhumatisme
SYNTHESIS AND INHIBITORY ACTIVITY OF NOVEL TRICYCLIC AND TETRACYCLIC QUINOLINES AGAINST TOPOISOMERASES
Bioorganic & medicinal chemistry
QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS ON 5-SUBSTITUTED TERBENZIMIDAZOLES AS TOPOISOMERASE-I POISONS AND ANTITUMOR AGENTS
Bioorganic & medicinal chemistry
EFFECTS OF 1,2-NAPHTHOQUINONES ON HUMAN TUMOR-CELL GROWTH AND LACK OFCROSS-RESISTANCE WITH OTHER ANTICANCER AGENTS
Anti-cancer drugs
HIGHER SENSITIVITY IN LEC RAT-CELLS TO A TOPOISOMERASE-II INHIBITOR, ELLIPTICINE
Journal of veterinary medical science
AMSACRINE-INDUCED MUTATIONS IN AS52 CELLS
Environmental and molecular mutagenesis
COMBINATION OF IRINOTECAN AND ETOPOSIDE FOR TREATMENT OF REFRACTORY OR RELAPSED SMALL-CELL LUNG-CANCER
Journal of clinical oncology
DRUG-RESISTANCE TO TOPOISOMERASE-II INHIBITORS
Biochimie
Topoisomerase I inhibitors from the Streptomyces sp. strain KM86-9B isolated from a marine sponge
ARCHIVES OF PHARMACAL RESEARCH
The cytotoxicity of copper(II) complexes of 2-acetyl-pyridyl-N-4-substituted thiosemicarbazones
ANTICANCER RESEARCH
BACTERIAL AND ARCHEAL TYPE-I TOPOISOMERASES
Biochimica et biophysica acta, N. Gene structure and expression
MUTAGENIC PROPERTIES OF TOPOISOMERASE-TARGETED DRUGS
Biochimica et biophysica acta, N. Gene structure and expression
USE OF A RAPID THROUGHPUT IN-VIVO SCREEN TO INVESTIGATE INHIBITORS OFEUKARYOTIC TOPOISOMERASE-II ENZYMES
Antimicrobial agents and chemotherapy
PROTEIN-STRUCTURE - TOPOLOGICAL NUTS AND BOLTS
Science
SYMBIOSIS BETWEEN METHANOGENIC ARCHAEA AND DELTA-PROTEOBACTERIA AS THE ORIGIN OF EUKARYOTES - THE SYNTROPHIC HYPOTHESIS
Journal of molecular evolution
SUPPRESSION OF LEU-500 MUTATION IN TOPA-TYPHIMURIUM STRAINS - THE PROMOTER RELAY AT WORK( SALMONELLA)
The Journal of biological chemistry
A MUTANT YEAST TOPOISOMERASE-II (TOP2G437S) WITH DIFFERENTIAL SENSITIVITY TO ANTICANCER DRUGS IN THE PRESENCE AND ABSENCE OF ATP
The Journal of biological chemistry
A PROMOTER RELAY MECHANISM FOR SEQUENTIAL GENE ACTIVATION
Journal of bacteriology
IONIC CONTROL OF CHROMOSOME ARCHITECTURE IN LIVING AND PERMEABILIZED CELLS
Experimental cell research
Mapping of topoisomerase II alpha epitopes recognized by autoantibodies inidiopathic pulmonary fibrosis
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
PREDICTIVE VALUE OF TOPOISOMERASE II-ALPHA AND OTHER PROGNOSTIC FACTORS FOR EPIRUBICIN CHEMOTHERAPY IN ADVANCED BREAST-CANCER
British Journal of Cancer
DIFFERENTIAL SENSITIVITIES OF RECOMBINANT HUMAN TOPOISOMERASE-II-ALPHA AND TOPOISOMERASE-II-BETA TO VARIOUS CLASSES OF TOPOISOMERASE-II INTERACTING AGENTS
Biochemical pharmacology
MUTATION-RATE OF AVIAN INTESTINAL COLIFORM BACTERIA WHEN PRESSURED WITH FLUOROQUINOLONES
Avian diseases
DNA TOPOISOMERASES AS REPAIR ENZYMES - MECHANISM(S) OF ACTION AND REGULATION BY P53
Acta Biochimica Polonica
THE TOPOISOMERASE-I GENE FROM CANDIDA-ALBICANS
Microbiology