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Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzed aryl-aryl coupling reaction
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Quantitation of camptothecin and related compounds
JOURNAL OF CHROMATOGRAPHY B
Separation methods for camptothecin and related compounds
JOURNAL OF CHROMATOGRAPHY B
Spatial expression of DNA topoisomerase I genes during cell proliferation in Daucus carota
EUROPEAN JOURNAL OF HISTOCHEMISTRY
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
NATURE MEDICINE
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts
CLINICAL CANCER RESEARCH
Phase I and pharmacological study of a new camptothecin derivative, exatecan mesylate (DX-8951f), infused over 30 minutes every three weeks
CLINICAL CANCER RESEARCH
Weekly irinotecan and cisplatin in advanced non-small cell lung cancer: A multicenter phase II study
CLINICAL CANCER RESEARCH
Polymethylene derivatives of nucleic bases with omega-functional groups: II. Adenine and hypoxanthine derivatives
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changesin protein interactions
MOLECULAR BIOLOGY OF THE CELL
Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo
ANTI-CANCER DRUGS
The potential of alkaloids in drug discovery
PHYTOTHERAPY RESEARCH
A phase II trial of irinotecan (CPT-11) for unresectable biliary tree carcinoma
ANNALS OF ONCOLOGY
Camptothecin schedule and timing of administration with irradiation
ONCOLOGY-NEW YORK
Human rDNA: Evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes
GENOMICS
Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): A novelcamptothecin analog
JOURNAL OF CLINICAL ONCOLOGY
Irinotecan in the treatment of colorectal cancer: Clinical overview
JOURNAL OF CLINICAL ONCOLOGY
Phase I trial of the combination of irinotecan, paclitaxel, and carboplatin in patients with advanced non-small-cell lung cancer
JOURNAL OF CLINICAL ONCOLOGY
Phase I study of topotecan plus cranial radiation for glioblastoma multiforme: Results of Radiation Therapy Oncology Group Trial 9507
JOURNAL OF CLINICAL ONCOLOGY
Ground and excited-state ionization behavior of 9-aminocamptothecin: An absorption and fluorescence spectral study
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY
Clinical effect of irinotecan in advanced and metastatic breast cancer patients previously treated with doxorubicin- and docetaxel-containing regimens
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Naphthazarin derivatives (VIII): Synthesis, inhibitory effect on DNA topoisomerase-I, and antiproliferative activity of 6-(1-acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinones
ARCHIV DER PHARMAZIE
Synergistic interaction between topotecan and microtubule-interfering agents
CANCER CHEMOTHERAPY AND PHARMACOLOGY
A phase I and pharmacologic study of 9-aminocamptothecin administered as a120-h infusion weekly to adult cancer patients
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Association of HLA class II genes with systemic sclerosis in Koreans
JOURNAL OF RHEUMATOLOGY
Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33
CANCER LETTERS
Distinctive features of Drosophila alternative splicing factor RS domain: Implication for specific phosphorylation, shuttling, and splicing activation
MOLECULAR AND CELLULAR BIOLOGY
DNA topoisomerases as targets for anticancer drugs
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Naphthazarin derivatives (VII): Antitumor action against ICR mise bearing ascitic S-180 cells
ARCHIVES OF PHARMACAL RESEARCH
Naphthazarin derivatives (VII): Antitumor action against ICR mice bearing ascitic S-180 cells
ARCHIVES OF PHARMACAL RESEARCH
Antibodies against DNA topoisomerase I in blood serum of patients with pathologies of pancreas
EXPERIMENTAL ONCOLOGY
A theoretical study on camptothecin-AM1 treatment
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
Hoechst 33342-induced apoptosis is associated with decreased immunoreactive topoisomerase I and topoisomerase I-DNA complex formation
ANNALS OF CLINICAL AND LABORATORY SCIENCE
Partial synthesis of camptothecin analogs. Part 3: Easy approach to a quinoline-lactone system
TETRAHEDRON LETTERS
Total synthesis of benzo[c]phenanthridine alkaloids, chelerythrine and 12-methoxydihydrochelerythrine, by a palladium-assisted internal biaryl coupling reaction
SYNTHESIS-STUTTGART
Interaction of topotecan, DNA tapoisomerase I inhibitor, with double-stranded polydeoxyribonucleotides. 1. Topotecan dimerization in solution
MOLECULAR BIOLOGY
Quantitative structure-antitumor activity relationships of camptothecin analogues: Cluster analysis and genetic algorithm-based studies
JOURNAL OF MEDICINAL CHEMISTRY
Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity
JOURNAL OF MEDICINAL CHEMISTRY
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues
JOURNAL OF MEDICINAL CHEMISTRY
Autoantibodies to the amino-terminal fragment of beta-fodrin expressed in glandular epithelial cells in patients with Sjogren's syndrome
JOURNAL OF IMMUNOLOGY
Systemic sclerosis (scleroderma): Specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts
JOURNAL OF IMMUNOLOGY
Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors
EUROPEAN JOURNAL OF IMMUNOLOGY
Unusual potency of BN 80915, a novel fluorinated E-ring modified camptothecin, toward human colon carcinoma cells
CANCER RESEARCH
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistanceprotein-mediated drug efflux
CANCER RESEARCH
Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin
CANCER RESEARCH
Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506
CANCER RESEARCH
Effect of P-glycoprotein modulators on the pharmacokinetics of camptothecin using microdialysis
BRITISH JOURNAL OF PHARMACOLOGY
Autoreactive CD4(+) T-cell clones to beta 2-glycoprotein I in patients with antiphospholipid syndrome: preferential recognition of the major phospholipid-binding site
BLOOD
Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura
BLOOD
Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan
BIOCHEMICAL PHARMACOLOGY
c-Fos is surface active and interacts differentially with phospholipid monolayers
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Lack of efficacy of 9-aminocamptothecin in adults with newly diagnosed glioblastoma multiforme and recurrent high-grade astrocytoma
NEURO-ONCOLOGY
Death, autoantigen modifications, and tolerance
ARTHRITIS RESEARCH
To be or not to be in the nucleolus
NATURE CELL BIOLOGY
Simple and rapid determination of irinotecan and its metabolite SN-38 in plasma by high-performance liquid-chromatography: application to clinical pharmacokinetic studies
JOURNAL OF CHROMATOGRAPHY B
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Evidence that camptothecin-induced aberrations in the G(2) phase of cell cycle of Chinese hamster ovary (CHO) cell lines is associated with transcription
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Cytotoxic mechanism of flavonoid from Temu Kunci (Kaempferia pandurata) incell culture of human mammary carcinoma
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules
CELL DEATH AND DIFFERENTIATION
In vivo studies of the non-transcribed spacer region of rDNA in Saccharomyces cerevisiae
FOOD TECHNOLOGY AND BIOTECHNOLOGY
Hepatotoxicity of camptothecin derivatives in a primary culture system of rat hepatocytes
JOURNAL OF CHEMOTHERAPY
Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans
CLINICAL CANCER RESEARCH
B-cell epitopes of intracellular autoantigens: Myth and reality
MOLECULAR MEDICINE
Genetic factors in the etiology of systemic sclerosis and Raynaud phenomenon
CURRENT OPINION IN RHEUMATOLOGY
Analysis of stereoelectronic properties of camptothecin analogues in relation to biological activity
BIOORGANIC & MEDICINAL CHEMISTRY
Pyrrolo-quinoline derivatives as potential antineoplastic drugs
BIOORGANIC & MEDICINAL CHEMISTRY
Chromosome cohesion: A polymerase for chromosome bridges
CURRENT BIOLOGY
Achievements and future of chemotherapy
EUROPEAN JOURNAL OF CANCER
Dramatic tumor response of bulky liver metastases following treatment withCPT-11 and a chronomodulated 4-day infusion of 5-fluorouracil, folinic acid and oxaliplatin every 2 weeks in a colorectal cancer patient
ANTI-CANCER DRUGS
Anti-neoplastic activity of topotecan versus cisplatin, etoposide and paclitaxel in four squamous cell cancer cell lines of the female genital tract using an ATP-Tumor Chemosensitivity Assay
ANTI-CANCER DRUGS
Stereocontrolled synthesis of 2-aryl tetralones. Application in the synthesis of B/C hexahydrobenzo[c]phenanthridine alkaloids
TETRAHEDRON-ASYMMETRY
Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
5-fluorouracil and folinic acid with or without CPT-11 in advanced colorectal cancer patients: A multicenter randomised phase II study of the Southern Italy Oncology Group
ANNALS OF ONCOLOGY
A dose escalating study of topotecan preceding cisplatin in previously untreated patients with small-cell lung cancer
ANNALS OF ONCOLOGY
Effects of global regulatory proteins and environmental conditions on fimbrial gene expression of F165(1) and F165(2) produced by Escherichia coli causing septicaemia in pigs
RESEARCH IN MICROBIOLOGY
Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma
JAPANESE JOURNAL OF CANCER RESEARCH
Irinotecan in esophageal cancer
ONCOLOGY-NEW YORK
Phase I study of irinotecan and concurrent radiation therapy for upper GI tumors
ONCOLOGY-NEW YORK
Phase I pharmacologic study of oral topotecan and intravenous cisplatin: Sequence-dependent hematologic side effects
JOURNAL OF CLINICAL ONCOLOGY
Phase I study of 3-week schedule of irinotecan combined with cisplatin in patients with advanced solid tumors
JOURNAL OF CLINICAL ONCOLOGY
Preclinical evaluation of irinotecan
ONKOLOGIE
Synthesis and evaluation of the antitumor activity of 2-substituted 1,4-dihydroxy-9,10-anthraquinones
ARCHIV DER PHARMAZIE
Pretreatment with ranitidine does not reduce the bioavailability of orallyadministered topotecan
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Studies of HLA-DR and DQ alleles in systemic sclerosis patients with autoantibodies to RNA polymerases and U3-RNP (fibrillarin)
JOURNAL OF RHEUMATOLOGY
HLA-DRB1 and DQB1 genes in Japanese patients with systemic sclerosis
JOURNAL OF RHEUMATOLOGY
A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth
MOLECULAR AND CELLULAR BIOLOGY
Isolation of camptothecin-sensitive Chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group
MUTAGENESIS
Functional characterization of SR and SR-related genes in Caenorhabditis elegans
EMBO JOURNAL
Chemosensitivity testing of irinotecan (CPT-11) in ovarian and endometrialcarcinomas: a comparison with cisplatin
ANTICANCER RESEARCH
Naphthazarin derivatives (IV): synthesis, inhibition of DNA topoisomerase I and cytotoxicity of 2-or 6-acyl-5,8-dimethoxy-1,4-naphahoquinones
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Poly(ADP-ribose) polymerase is affected early by thyroid state during liver regeneration in rats
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Cytotoxic effects of topotecan combined with various active G2/M-phase anticancer drugs in human tumor-derived cell lines
INVESTIGATIONAL NEW DRUGS
Use of COMPARE analysis to discover new natural product drugs: Isolation of camptothecin and 9-methoxycamptothecin from a new source
JOURNAL OF NATURAL PRODUCTS
Polymethylene derivatives of pyrimidine nucleic bases bearing omega-functional groups
BIOORGANICHESKAYA KHIMIYA
A phase II and pharmacokinetic study of weekly 72-h topotecan infusion in patients with platinum-resistant and paclitaxel-resistant ovarian carcinoma
GYNECOLOGIC ONCOLOGY
Expression of DNA topoisomerase I and DNA topoisomerase II-alpha in testicular seminomas
HUMAN PATHOLOGY
Expression of DNA topoisomerase I in neoplasms of the kidney: Correlation with histological grade, proliferation, and patient survival
HUMAN PATHOLOGY