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La ricerca find articoli where soggetti phrase all words 'DISULFIDE BOND' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 786 riferimenti
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    1. Lisowsky, T; Lee, JE; Polimeno, L; Francavilla, A; Hofhaus, G
      Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase

      DIGESTIVE AND LIVER DISEASE
    2. Sun, Y; Lu, GS; Tam, JP
      A thioester ligation approach to amphipathic bicyclic peptide library

      ORGANIC LETTERS
    3. Miyashita, Y; Hamajima, M; Yamada, Y; Fujisawa, K; Okamoto, K
      Synthesis, characterization and reactivity of linear-type S-bridged trinuclear complexes containing vanadium(III) ion. Crystal structures of [V-III{M(aet)(3)}(2)](ClO4)(3) (M = Rh-III, Ir-III; aet=2-aminoethanethiolate)

      JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
    4. Scigelova, M; Green, PS; Giannakopulos, AE; Rodger, A; Crout, DHG; Derrick, PJ
      A practical protocol for the reduction of disulfide bonds in proteins prior to analysis by mass spectrometry

      EUROPEAN JOURNAL OF MASS SPECTROMETRY
    5. Kadokura, H; Beckwith, J
      The expanding world of oxidative protein folding

      NATURE CELL BIOLOGY
    6. Guo, ZY; Feng, YM
      Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin

      BIOLOGICAL CHEMISTRY
    7. Harada, T; Kurimoto, E; Tokuhiro, K; Asami, O; Sakai, T; Nohara, D; Kato, K
      Disulfide bond formation in refolding of thermophilic fungal protein disulfide isomerase

      JOURNAL OF BIOSCIENCE AND BIOENGINEERING
    8. Scozzafava, A; Mastrolorenzo, A; Supuran, CT
      Agents that target cysteine residues of biomolecules and their therapeuticpotential

      EXPERT OPINION ON THERAPEUTIC PATENTS
    9. MacLellan, SR; Forsberg, CW
      Properties of the major non-specific endonuclease from the strict anaerobeFibrobacter succinogenes and evidence for disulfide bond formation in vivo

      MICROBIOLOGY-UK
    10. Cumming, RC; Lightfoot, J; Beard, K; Youssoufian, H; O'Brien, PJ; Buchwald, M
      Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1

      NATURE MEDICINE
    11. Kim, SJ; Jeong, DG; Chi, SW; Lee, JS; Ryu, SE
      Crystal structure of proteolytic fragments of the redox-sensitive Hsp33 with constitutive chaperone activity

      NATURE STRUCTURAL BIOLOGY
    12. Petrovskaya, LE; Kryukova, EA; Kayushin, AL; Korobko, VG
      Chaperone Caf1M stabilizes hybrid proteins containing sequences of F1 antigen subunit from Yersinia pestis

      RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
    13. Zhmak, MN; Kasheverov, IE; Utkin, YN; Tsetlin, VI; Vol'pina, OM; Ivanov, VT
      An efficient synthetic scheme for natural alpha-conotoxins and their analogues

      RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
    14. Sijwali, PS; Brinen, LS; Rosenthal, PJ
      Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2

      PROTEIN EXPRESSION AND PURIFICATION
    15. Takahashi, K; Takai, T; Yasuhara, T; Yokota, T; Okumura, Y
      Effects of site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der f 1 on secretion and protease activity

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    16. Graumann, J; Lilie, H; Tang, XL; Tucker, KA; Hoffmann, JT; Vijayalakshmi, J; Saper, M; Bardwell, JCA; Jakob, U
      Activation of the redox-regulated molecular chaperone Hsp33 - A two-step mechanism

      STRUCTURE
    17. Jones, G; Ronk, M; Mori, F; Zhang, ZQ
      Disulfide structure of alfimeprase: A recombinant analog of fibrolase

      PROTEIN SCIENCE
    18. Xu, J; Baase, WA; Quillin, ML; Baldwin, EP; Matthews, BW
      Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme

      PROTEIN SCIENCE
    19. Zhang, YH; Yan, XG; Maier, CS; Schimerlik, MI; Deinzer, ML
      Structural comparison of recombinant human macrophage colony stimulating factor beta and a partially reduced derivative using hydrogen deuterium exchange and electrospray ionization mass spectrometry

      PROTEIN SCIENCE
    20. Hofmann, BA; Sydow, S; Jahn, O; Van Werven, L; Liepold, T; Eckart, K; Spiess, J
      Functional and protein chemical characterization of the N-terminal domain of the rat corticotropin-releasing factor receptor 1

      PROTEIN SCIENCE
    21. Zavodszky, M; Chen, CW; Huang, JK; Zolkiewski, M; Wen, L; Krishnamoorthi, R
      Disulfide bond effects on protein stability: Designed variants of Cucurbita maxima trypsin inhibitor-V

      PROTEIN SCIENCE
    22. Paget, MSB; Molle, V; Cohen, G; Aharonowitz, Y; Buttner, MJ
      Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the sigma(R) regulon

      MOLECULAR MICROBIOLOGY
    23. Herbig, AF; Helmann, JD
      Roles of metal ions and hydrogen peroxide in modulating the interaction ofthe Bacillus subtilis PerR peroxide regulon repressor with operator DNA

      MOLECULAR MICROBIOLOGY
    24. Sandkvist, M
      Biology of type II secretion

      MOLECULAR MICROBIOLOGY
    25. Fernandez, LA; de Lorenzo, V
      Formation of disulphide bonds during secretion of proteins through the periplasmic-independent type I pathway

      MOLECULAR MICROBIOLOGY
    26. Paget, MSB; Bae, JB; Hahn, MY; Li, W; Kleanthous, C; Roe, JH; Buttner, MJ
      Mutational analysis of RsrA, a zinc-binding anti-sigma factor with a thiol-disulphide redox switch

      MOLECULAR MICROBIOLOGY
    27. Grant, CM
      Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions

      MOLECULAR MICROBIOLOGY
    28. Campos, A; Zhang, RG; Alkire, RW; Matsumura, P; Westbrook, EM
      Crystal structure of the global regulator FlhD from Escherichia coli at 1.8 angstrom resolution

      MOLECULAR MICROBIOLOGY
    29. MacIntyre, S; Zyrianova, IM; Chernovskaya, TV; Leonard, M; Rudenko, EG; Zav'yalov, VP; Chapman, DAG
      An extended hydrophobic interactive surface of Yersinia pestis Caf1M chaperone is essential for subunit binding and F1 capsule assembly

      MOLECULAR MICROBIOLOGY
    30. Kobayashi, T; Takahashi, Y; Ito, K
      Identification of a segment of DsbB essential for its respiration-coupled oxidation

      MOLECULAR MICROBIOLOGY
    31. Moran, LK; Gutteridge, JMC; Quinlan, GJ
      Thiols in cellular redox signalling and control

      CURRENT MEDICINAL CHEMISTRY
    32. de Crouy-Chanel, A; Richarme, G
      Amount and redox state of cytoplasmic, membrane and periplasmic proteins in Escherichia coli redox mutants

      RESEARCH IN MICROBIOLOGY
    33. Hossain, MI; Itoh, Y; Morioka, K; Obatake, A
      Contribution of the polymerization of protein by disulfide bonding to increased gel strength of walleye pollack surimi gel with preheating time

      FISHERIES SCIENCE
    34. Matsumoto, M; Misawa, S; Chiba, N; Takaku, H; Hayashi, H
      Selective nonpeptidic inhibitors of herpes simplex virus type 1 and human cytomegalovirus proteases

      BIOLOGICAL & PHARMACEUTICAL BULLETIN
    35. Katayama, H; Ohira, T; Nagata, K; Nagasawa, H
      A recombinant molt-inhibiting hormone of the kuruma prawn has a similar secondary structure to a native hormone: Determination of disulfide bond arrangement and measurements of circular dichroism spectra

      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
    36. Edeling, MA; Guddat, LW; Fabianek, RA; Halliday, JA; Jones, A; Thony-Meyer, L; Martin, JL
      Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE)

      ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
    37. Antunes, F; Cadenas, E
      Cellular titration of apoptosis with steady state concentrations of H2O2: Submicromolar levels of H2O2 induce apoptosis through Fenton chemistry independent of the cellular thiol state

      FREE RADICAL BIOLOGY AND MEDICINE
    38. Inaka, K; Kanaya, E; Kikuchi, M; Miki, K
      Crystal structure of a mutant human lysozyme with a substituted disulfide bond

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    39. Guo, RT; Chou, LJ; Chen, YC; Chen, CY; Pari, K; Jen, CYJ; Lo, SZJ; Huang, SL; Lee, CY; Chang, TW; Chaung, WJ
      Expression in Pichia pastoris and characterization by circular dichroism and NMR of rhodostomin

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    40. Nakanishi, H; Nakayama, K; Yokota, A; Tachikawa, H; Takahashi, N; Jigami, Y
      Hut1 proteins identified in Saccharomyces cerevisiae and Schizosaccharomyces pombe are functional homologues involved in the protein-folding process at the endoplasmic reticulum

      YEAST
    41. Elez, D; Dundjerski, J; Matic, G
      Cadmium affects the redox state of rat liver glucocorticoid receptor

      CELL BIOLOGY AND TOXICOLOGY
    42. Tsuge, S; Okuno, T; Furusawa, I; Kubo, Y; Horino, O
      Stabilization of cauliflower mosaic virus P3 tetramer by covalent linkage

      MICROBIOLOGY AND IMMUNOLOGY
    43. Phillips, ZEV; Strauch, MA
      Role of Cys54 in AbrB multimerization and DNA-binding activity

      FEMS MICROBIOLOGY LETTERS
    44. Pfend, G; Matthieu, JM; Garin, N; Tosic, M
      Implication of the extracellular disulfide bond on myelin protein zero expression

      NEUROCHEMICAL RESEARCH
    45. Crognale, MA; Nolan, JB; Webster, MA; Neitz, M; Neitz, J
      Color vision and genetics in a case of cone dysfunction syndrome

      COLOR RESEARCH AND APPLICATION
    46. Berezhkovskiy, LM; Deshpande, SV
      On the requirement of oxidizing reagent for the formation of a disulfide bond

      BIOPHYSICAL CHEMISTRY
    47. Wu, PF; Chang, LS
      Expression of A chain and B chain of beta-bungarotoxin from Taiwan banded krait: The functional implication of the interchain disulfide bond between A chain and B chain

      JOURNAL OF PROTEIN CHEMISTRY
    48. Kurokawa, Y; Koganesawa, N; Kobashigawa, Y; Koshiba, T; Demura, M; Nitta, K
      Oxidative folding of human lysozyme: Effects of the loss of two disulfide bonds and the introduction of a calcium-binding site

      JOURNAL OF PROTEIN CHEMISTRY
    49. Reid, E; Cole, J; Eaves, DJ
      The Escherichia coli CcmG protein fulfils a specific role in cytochrome c assembly

      BIOCHEMICAL JOURNAL
    50. Bader, MW; Hiniker, A; Regeimbal, J; Goldstone, D; Haebel, PW; Riemer, J; Metcalf, P; Bardwell, JCA
      Turning a disulfide isomerase into an oxidase: DsbC mutants that imitate DsbA

      EMBO JOURNAL
    51. Mezghrani, A; Fassio, A; Benham, A; Simmen, T; Braakman, I; Sitia, R
      Manipulation of oxidative protein folding and PDI redox state in mammaliancells

      EMBO JOURNAL
    52. Kimple, ME; Siderovski, DP; Sondek, J
      Functional relevance of the disulfide-linked complex of the N-terminal PDZdomain of InaD with NorpA

      EMBO JOURNAL
    53. Schembri, MA; Klemm, P
      Coordinate gene regulation by fimbriae-induced signal transduction

      EMBO JOURNAL
    54. Behrens, S; Maier, R; de Cock, H; Schmid, FX; Gross, CA
      The SurA periplasmic PPlase lacking its parvulin domains functions in vivoand has chaperone activity

      EMBO JOURNAL
    55. Kurimoto, A; Tanabe, T; Tachibana, A; Yamauchi, K
      Thiolated dermal bovine collagen as a novel support for bioactive substances - conjugation with lysozyme

      JOURNAL OF BIOTECHNOLOGY
    56. Katiyar, S; Till, EA; Lennarz, WJ
      Studies on the function of yeast protein disulfide isomerase in renaturation of proteins

      BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    57. Kabashima, T; Li, Y; Kanada, N; Ito, K; Yoshimoto, T
      Enhancement of the thermal stability of pyroglutamyl peptidase I by introduction of an intersubunit disulfide bond

      BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    58. Krnajski, Z; Gilberger, TW; Walter, RD; Muller, S
      The malaria parasite Plasmodium falciparum possesses a functional thioredoxin system

      MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    59. Yamauchi, K; Takeuchi, N; Kurimoto, A; Tanabe, T
      Films of collagen crosslinked by S-S bonds: preparation and characterization

      BIOMATERIALS
    60. Ritz, D; Beckwith, J
      Roles of thiol-redox pathways in bacteria

      ANNUAL REVIEW OF MICROBIOLOGY
    61. Raivio, TL; Silhavy, TJ
      Periplasmic stress and ECF sigma factors

      ANNUAL REVIEW OF MICROBIOLOGY
    62. Eckert, DM; Kim, PS
      Mechanisms of viral membrane fusion and its inhibition

      ANNUAL REVIEW OF BIOCHEMISTRY
    63. Endo, K; Bu, HB
      Electrochemical polymerization of 1,10-decanedithiol in CH3CN

      POLYMER JOURNAL
    64. Endo, K; Bu, HB
      Synthesis of disulfide polymer by electrochemical polymerization of alpha,omega-alkanedithiols

      POLYMER
    65. Yano, H; Wong, JH; Cho, MJ; Buchanan, BB
      Redox changes accompanying the degradation of seed storage proteins in germinating rice

      PLANT AND CELL PHYSIOLOGY
    66. Tamamura, H
      Development of selective antagonists against an HIV second receptor

      YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
    67. Goldstone, D; Haebel, PW; Katzen, F; Bader, MW; Bardwell, JCA; Beckwith, J; Metcalf, P
      DsbC activation by the N-terminal domain of DsbD

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    68. Branza-Nichita, N; Durantel, D; Carrouee-Durantel, S; Dwek, RA; Zitzmann, N
      Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers

      JOURNAL OF VIROLOGY
    69. Parker, CE; Deterding, LJ; Hager-Braun, C; Binley, JM; Schulke, N; Katinger, H; Moore, JP; Tomer, KB
      Fine definition of the epitope on the gp41 glycoprotein of human immunodeficiency virus type 1 for the neutralizing monoclonal antibody 2F5

      JOURNAL OF VIROLOGY
    70. Cormier, EG; Tran, DNH; Yukhayeva, L; Olson, WC; Dragic, T
      Mapping the determinants of the CCRS amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes

      JOURNAL OF VIROLOGY
    71. Davies, A; Gowen, BE; Krebs, AM; Schertler, GFX; Saibil, HR
      Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane

      JOURNAL OF MOLECULAR BIOLOGY
    72. Tachibana, H; Oka, T; Akasaka, K
      Native-like tertiary structure formation in the alpha-domain of a hen lysozyme two-disulfide variant

      JOURNAL OF MOLECULAR BIOLOGY
    73. Zahn, R; Damberger, F; Ortenzi, C; Luporini, P; Wuthrich, K
      NMR structure of the Euplotes raikovi pheromone Er-23 and identification of its five disulfide bonds

      JOURNAL OF MOLECULAR BIOLOGY
    74. Capitani, G; Rossmann, R; Sargent, DF; Grutter, MG; Richmond, TJ; Hennecke, H
      Structure of the soluble domain of a membrane-anchored thioredoxin-like protein from Bradyrhizobium japonicum reveals unusual properties

      JOURNAL OF MOLECULAR BIOLOGY
    75. Chapon, V; Czjzek, M; El Hassouni, M; Py, B; Juy, M; Barras, F
      Type II protein secretion in gram-negative pathogenic bacteria: The study of the structure/secretion relationships of the cellulase CeI5 (formerly EGZ) from Erwinia chrysanthemi

      JOURNAL OF MOLECULAR BIOLOGY
    76. Foloppe, N; Sagemark, J; Nordstrand, K; Berndt, KD; Nilsson, L
      Structure, dynamics and electrostatics of the active site of glutaredoxin 3 from Escherichia coli: Comparison with functionally related proteins

      JOURNAL OF MOLECULAR BIOLOGY
    77. DeLozier, JA; Parks, JS; Shelness, GS
      Vesicle-binding properties of wild-type and cysteine mutant forms of oil domain of apolipoprotein B

      JOURNAL OF LIPID RESEARCH
    78. Harris, MR; Lybarger, L; Yu, YYL; Myers, NB; Hansen, TH
      Association of ERp57 with mouse MHC class I molecules is tapasin dependentand mimics that of calreticulin and not calnexin

      JOURNAL OF IMMUNOLOGY
    79. Purcell, AW; Gorman, JJ
      The use of post-source decay in matrix-assisted laser desorption/ionisation mass spectrometry to delineate T cell determinants

      JOURNAL OF IMMUNOLOGICAL METHODS
    80. Woo, BH; Lee, JT; Na, DH; Lee, KC
      Sepharose-unbinding ricin E as a source for ricin A chain immunotoxin

      JOURNAL OF IMMUNOLOGICAL METHODS
    81. Gomez, A; Wellbrock, C; Gutbrod, H; Dimitrijevic, N; Schartl, M
      Ligand-independent dimerization and activation of the oncogenic Xmrk receptor by two mutations in the extracellular domain

      JOURNAL OF BIOLOGICAL CHEMISTRY
    82. Krupp, R; Chan, C; Missiakas, D
      DsbD-catalyzed transport of electrons across the membrane of Escherichia coli

      JOURNAL OF BIOLOGICAL CHEMISTRY
    83. Chen, Q; Nussbaum-Shochat, A; Amster-Choder, O
      A novel sugar-stimulated covalent switch in a sugar sensor

      JOURNAL OF BIOLOGICAL CHEMISTRY
    84. Bald, D; Noji, H; Yoshida, M; Hirono-Hara, Y; Hisabori, T
      Redox regulation of the rotation of F-1-ATP synthase

      JOURNAL OF BIOLOGICAL CHEMISTRY
    85. Zeidner, G; Sadja, R; Reuveny, E
      Redox-dependent gating of G protein-coupled inwardly rectifying K+ channels

      JOURNAL OF BIOLOGICAL CHEMISTRY
    86. Panse, VG; Beena, K; Philipp, R; Trommer, WE; Vogel, PD; Varadarajan, R
      Electron spin resonance and fluorescence studies of the bound-state conformation of a model protein substrate to the chaperone SecB

      JOURNAL OF BIOLOGICAL CHEMISTRY
    87. Mouchantaf, R; Kumar, U; Sulea, T; Patel, YC
      A conserved alpha-helix at the amino terminus of prosomatostatin serves asa sorting signal for the regulated secretory pathway

      JOURNAL OF BIOLOGICAL CHEMISTRY
    88. Tedford, HW; Fletcher, JI; King, GF
      Functional significance of the beta-hairpin in the insecticidal neurotoxinomega-atracotoxin-Hv1a

      JOURNAL OF BIOLOGICAL CHEMISTRY
    89. Gerber, J; Muhlenhoff, U; Hofhaus, G; Lill, R; Lisowsky, T
      Yeast Erv2p is the first microsomal FAD-linked sulfhydryl oxidase of the Erv1p/Alrp protein family

      JOURNAL OF BIOLOGICAL CHEMISTRY
    90. She, YM; Haber, S; Seifers, DL; Loboda, A; Chernushevich, I; Perreault, H; Ens, W; Standing, KG
      Determination of the complete amino acid sequence for the coat protein of brome mosaic virus by time-of-flight mass spectrometry - Evidence for mutations associated with change of propagation host

      JOURNAL OF BIOLOGICAL CHEMISTRY
    91. Benayoun, B; Esnard-Feve, A; Castella, S; Courty, Y; Esnard, F
      Rat seminal vesicle FAD-dependent sulfhydryl oxidase - Biochemical characterization and molecular cloning of a member of the new sulfhydryl oxidase/quiescin Q6 gene family

      JOURNAL OF BIOLOGICAL CHEMISTRY
    92. Labrecque, J; Deschenes, J; McNicoll, N; De Lean, A
      Agonistic induction of a covalent dimer in a mutant of natriuretic peptidereceptor-A documents a juxtamembrane interaction that accompanies receptoractivation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    93. Okuda, D; Morita, T
      Purification and characterization of a new RGD/KGD-containing dimeric disintegrin, piscivostatin, from the venom of Agkistrodon piscivorus piscivorus: The unique effect of piscivostatin on platelet aggregation

      JOURNAL OF BIOCHEMISTRY
    94. Odani, S; Baba, K; Tsuchida, Y; Aoyagi, Y; Wakui, S; Takahashi, Y
      Hepatic fatty acid-binding proteins of a teleost, Lateolabrax japonicus. The primary structures and location of a disulfide bond

      JOURNAL OF BIOCHEMISTRY
    95. Palacios, JL; Zaror, I; Martinez, P; Uribe, F; Opazo, P; Socias, T; Gidekel, M; Venegas, A
      Subset of hybrid eukaryotic proteins is exported by the type I secretion system of Erwinia chrysanthemi

      JOURNAL OF BACTERIOLOGY
    96. Bessette, PH; Qiu, J; Bardwell, JCA; Swartz, JR; Georgiou, G
      Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli

      JOURNAL OF BACTERIOLOGY
    97. Yamanaka, H; Izawa, H; Okamoto, K
      Carboxy-terminal region involved in activity of Escherichia coli TolC

      JOURNAL OF BACTERIOLOGY
    98. Burr, SE; Diep, DB; Buckley, JT
      Type II secretion by Aeromonas salmonicida: Evidence for two periplasmic pools of proaerolysin

      JOURNAL OF BACTERIOLOGY
    99. Urban, A; Leipelt, M; Eggert, T; Jaeger, KE
      DsbA and DsbC affect extracellular enzyme formation in Pseudomonas aeruginosa

      JOURNAL OF BACTERIOLOGY
    100. Zheng, M; Wang, X; Doan, B; Lewis, KA; Schneider, TD; Storz, G
      Computation-directed identification of OxyR DNA binding sites in Escherichia coli

      JOURNAL OF BACTERIOLOGY


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Documento generato il 08/08/20 alle ore 13:56:11