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    1. Mattiello, L; Rampazzo, L
      Electrochemistry of a spirolactone

      JOURNAL OF ELECTROANALYTICAL CHEMISTRY
    2. Rapta, P; Dunsch, L
      Dimerisation of organic radical ions and redox reactions of dimers as studied by temperature-dependent in situ ESR/UV-vis-NIR spectroelectrochemistry

      JOURNAL OF ELECTROANALYTICAL CHEMISTRY
    3. Darfeuille, F; Cazenave, C; Gryaznov, S; Duconge, F; Di Primo, C; Toulme, JJ
      RNA and N3 -> P5 ' kissing aptamers targeted to the trans-activation responsive (TAR) RNA of the human immunodeficiency virus-1

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    4. Blackwell, HE; Clemons, PA; Schreiber, SL
      Exploiting site-site interactions on solid support to generate dimeric molecules

      ORGANIC LETTERS
    5. Carlsson, F; Malmsten, M; Linse, P
      Monte Carlo simulations of lysozyme self-association in aqueous solution

      JOURNAL OF PHYSICAL CHEMISTRY B
    6. Boffey, RJ; Whittingham, WG; Kilburn, JD
      Diastereoselective SmI2 mediated cascade radical cyclisations of methylenecyclopropane derivatives - syntheses of paeonilactone B and 6-epi-paeonilactone A

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    7. Alder, RW; Blake, ME; Bufali, S; Butts, CP; Orpen, AG; Schutz, J; Williams, SJ
      Preparation of tetraalkylformamidinium salts and related species as precursors to stable carbenes

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    8. Ghosh, AK; Peng, SM; Paul, RL; Ward, MD; Goswami, S
      Synthesis and structure of tris(1,2-benzoquinone diimine)osmium(II) perchlorate, and its redox and spectroelectrochemical series

      JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
    9. Webster, RD; Heath, GA; Bond, AM
      Voltammetric, EPR and UV-VIS-NIR spectroscopic studies associated with thecharacterisation of electrochemically generated tris(dithiocarbamato)cobalt(IV) complexes in dichloromethane

      JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
    10. Llusar, R; Uriel, S; Vicent, C
      Transition metal incorporation into seleno-bridged cubane type clusters ofmolybdenum and tungsten. X-Ray crystal structures of the first [Mo3CuSe4] derivatives

      JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
    11. Degterev, A; Lugovskoy, A; Cardone, M; Mulley, B; Wagner, G; Mitchison, T; Yuan, JY
      Identification of small-molecule inhibitors of interaction between the BH3domain and Bcl-x(L)

      NATURE CELL BIOLOGY
    12. Slanina, Z; Uhlik, F; Saito, AT; Osawa, E
      Computing molecular complexes in Earth's and other atmospheres

      PHYSICS AND CHEMISTRY OF THE EARTH PART C-SOLAR-TERRESTIAL AND PLANETARY SCIENCE
    13. de Paz, JL; Angulo, J; Lassaletta, JM; Nieto, PM; Redondo-Horcajo, M; Lozano, RM; Gimenez-Gallego, G; Martin-Lomas, M
      The activation of fibroblast growth factors by heparin: Synthesis, structure, and biological activity of heparin-like oligosaccharides

      CHEMBIOCHEM
    14. Zschau, W
      Bleaching of edible fats and oils - Cooperative work of the German Societyfor Fat Science (DGF)

      EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
    15. Zschau, W
      Bleaching of edible fats and oils IX - Legal and analytical aspects of bleaching - From the working group "Technologies of industrial extraction and processing of edible fats"

      EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
    16. Hopf, H; Wolff, J
      Thermal pericyclic tandem reactions

      EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
    17. Lin, HN; Cornish, VW
      In vivo protein-protein interaction assays: Beyond proteins

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    18. Valente, S; Gobbo, M; Licini, G; Scarso, A; Scrimin, P
      Allosteric regulation of an HIV-1 protease inhibitor by Zn-II ions

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    19. Burrows, AD; Dransfeld, A; Green, M; Jeffery, JC; Jones, C; Lynam, JM; Nguyen, MT
      Mononuclear eta(2)(4e)-bonded phosphaalkyne complexes; Selective formationof a 1,2-diphosphacyclobutadiene tantalum complex

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    20. Heinze, J; Willmann, C; Bauerle, P
      Evidence for a dimerization during anodic redox switching of 1,3,5-tripyrrolidinobenzene: A new molecular switch

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    21. Lentz, D; Willemsen, S
      Fluorinated bis(enyl) ligands by metal-induced dimerization of fluorinatedallenes

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    22. Forsman, WC
      Gelation theory for solutions of polymers with loci of strong interaction

      MATERIALS RESEARCH INNOVATIONS
    23. von Strandmann, EP; Senkel, S; Ryffel, GU
      ERH (enhancer of rudimentary homologue), a conserved factor identical between frog and human, is a transcriptional repressor

      BIOLOGICAL CHEMISTRY
    24. Laage, R; Langosch, D
      Strategies for prokaryotic expression of eukaryotic membrane proteins

      TRAFFIC
    25. Ghosh, I; Bishop, P; Chmielewski, J
      DNA binding properties of basic helix-loop-helix fusion proteins of Tal and E47

      JOURNAL OF PEPTIDE RESEARCH
    26. Mizuguchi, H; Mizuno, H; Yasukawa, K; Ishiguro, T; Fukui, K; Imanaka, T; Takagi, M
      Enhanced signal transduction by a directly fused protein of interleukin-6 and its receptor

      JOURNAL OF BIOSCIENCE AND BIOENGINEERING
    27. Oyama, M; Higuchi, T; Okazaki, S
      Mechanistic discrimination of the reaction of l-aminopyrene cation radicalusing an electron transfer stopped-flow method. Decay reaction acceleratedby neutral molecules

      ELECTROCHEMISTRY COMMUNICATIONS
    28. Cochet, S; Volet, G; Cartron, JP; Bertrand, O
      New procedures for glycophorin A purification with high yield and high purity

      JOURNAL OF CHROMATOGRAPHY B
    29. Lensveld, DJ; Mesu, JG; van Dillen, AJ; de Jong, KP
      Synthesis and characterisation of MCM-41 supported nickel oxide catalysts

      MICROPOROUS AND MESOPOROUS MATERIALS
    30. Jong, SJ; Chen, CT; Fang, JM; Liu, YH; Lee, GH; Wang, Y
      Samarium diiodide-promoted sequential coupling-aldol-reduction reactions of ferrocene-substituted enones

      COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
    31. Wright, D; Usher, L
      Multivalent binding in the design of bioactive compounds

      CURRENT ORGANIC CHEMISTRY
    32. Landau, MV; Gutman, A; Herskowitz, M; Shuker, R; Bitton, Y; Mogilyansky, D
      The role and stability of Li2O2 phase in supported LiCl catalyst in oxidative dehydrogenation of n-butane

      JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
    33. Nishiwaki, K; Kobayashi, M; Takeuchi, T; Matuoto, K; Osakada, K
      Nieuwland catalysts: investigation of structure in the solid state and in solution and performance in the dimerization of acetylene

      JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
    34. Carlini, C; Marchionna, M; Galletti, AMR; Sbrana, G
      Olefin oligomerization by novel catalysts prepared by oxidative addition of carboxylic acids to nickel(0) precursors and modified by phosphine ancillary ligands and organoaluminum compounds

      JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
    35. Sheldon, R
      Catalytic reactions in ionic liquids

      CHEMICAL COMMUNICATIONS
    36. Suzuki, T; Higuchi, H; Ohkita, M; Tsuji, T
      Dual-mode electrochromism switched by proton transfer: dynamic redox properties of bis(diarylmethylenium)-type dyes

      CHEMICAL COMMUNICATIONS
    37. Nair, V; Balagopal, L; Sheeba, V; Panicker, SB; Rath, NP
      Oxidative cyclisation of cinnamyl ethers mediated by CAN: a stereoselective synthesis of 3,4-trans disubstituted tetrahydrofuran derivatives

      CHEMICAL COMMUNICATIONS
    38. Wasserscheid, P; Gordon, CM; Hilgers, C; Muldoon, MJ; Dunkin, IR
      Ionic liquids: polar, but weakly coordinating solvents for the first biphasic oligomerisation of ethene to higher alpha-olefins with cationic Ni complexes

      CHEMICAL COMMUNICATIONS
    39. Huthoff, H; Berkhout, B
      Two alternating structures of the HIV-1 leader RNA

      RNA-A PUBLICATION OF THE RNA SOCIETY
    40. Lindenboim, L; Borner, C; Stein, R
      Bcl-x(S) can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-x(S) to the mitochondria and its BH3 and loop domains

      CELL DEATH AND DIFFERENTIATION
    41. Zloh, M; Esposito, D; Gibbons, WA
      Docking of transmembrane helices into four helix bundles in the high affinity IgE receptor

      INTERNET JOURNAL OF CHEMISTRY
    42. Cheng, EHYA; Wei, MC; Weiler, S; Flavell, RA; Mak, TW; Lindsten, T; Korsmeyer, SJ
      BCL-2, BCL-X-L sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

      MOLECULAR CELL
    43. Waters, PJ; Scriver, CR; Parniak, MA
      Homomeric and heteromeric interactions between wild-type and mutant phenylalanine hydroxylase subunits: Evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia

      MOLECULAR GENETICS AND METABOLISM
    44. Baladron, V; Ruiz-Hidalgo, MJ; Gubina, E; Bonvini, E; Laborda, J
      Specific regions of the extracellular domain of dlk, an EGF-like homeotic protein involved in differentiation, participate in intramolecular interactions

      FRONTIERS IN BIOSCIENCE
    45. Renner, C; Moroder, L; Holak, TA
      Analytical solution to the Lipari-Szabo model based on the reduced spectral density approximation offers a novel protocol for extracting motional parameters

      JOURNAL OF MAGNETIC RESONANCE
    46. Engelke, R; Blais, NC; Sheffield, SA; Sander, RK
      Production of a chemically-bound dimer of 2,4,6-TNT by transient high pressure

      JOURNAL OF PHYSICAL CHEMISTRY A
    47. Erdem, SS
      A computational study on heterodimerization of charged porphyrins

      JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
    48. Aviezer, D; Seddon, AP; Wildey, MJ; Bohlen, P; Yayon, A
      Development of a high throughput screening assay for inhibitors of fibroblast growth factor-receptor-heparin interactions

      JOURNAL OF BIOMOLECULAR SCREENING
    49. Matsumura, ME; Li, F; Berthoux, L; Wei, BY; Lobe, DR; Jeon, C; McNamara, CA
      Vascular injury induces posttranscriptional regulation of the Id3 gene - Cloning of a novel Id3 isoform expressed during vascular lesion formation inrat and human atherosclerosis

      ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
    50. Morrison, TE; Mauser, A; Wong, A; Ting, JPY; Kenney, SC
      Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-earlyprotein

      IMMUNITY
    51. Kuznetsov, NY; Khrustalev, VN; Terentiev, AB; Belokon, YN
      Stereoselective dimerization of chiral alpha-bromoamides promoted by Fe(CO)(5)

      RUSSIAN CHEMICAL BULLETIN
    52. Suo, ZY; Wei, XW; Mei, YH; Lin, K; Xu, Z
      Group transfer and dimerization processes of C-60(CN)(2) under atmosphericpressure ionization conditions

      FULLERENE SCIENCE AND TECHNOLOGY
    53. Rumlova, M; Benedikova, J; Cubinkova, R; Pichova, I; Ruml, T
      Comparison of classical and affinity purification techniques of Mason-Pfizer monkey virus capsid protein: The alteration of the product by an affinity tag

      PROTEIN EXPRESSION AND PURIFICATION
    54. Holmes, WD; Consler, TG; Dallas, WS; Rocque, WJ; Willard, DH
      Solution studies of recombinant human stromal-cell-derived factor-1

      PROTEIN EXPRESSION AND PURIFICATION
    55. Bovenkamp, DE; Greer, PA
      Degenerate PCR-Based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature

      DNA AND CELL BIOLOGY
    56. Eissa, NT; Haggerty, CM; Palmer, CD; Patton, W; Moss, J
      Identification of residues critical for enzymatic activity in the domain encoded by exons 8 and 9 of the human inducible nitric oxide synthase

      AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
    57. Broudy, VC; Lin, NL; Sabath, DF
      The fifth immunoglobulin-like domain of the Kit receptor is required for proteolytic cleavage from the cell surface

      CYTOKINE
    58. Zotti, G; Destri, S; Porzio, W; Pasini, M; Rizzo, S; Benincori, T
      Polymers, dimers and radical cations from electrochemical oxidation of interring-bridged thiophene and thiophene-phenylene tetramers

      MACROMOLECULAR CHEMISTRY AND PHYSICS
    59. Ahn, BH; Kim, TH; Bae, YS
      Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins

      MOLECULES AND CELLS
    60. Park, H; Seong, C; Jang, J; Yoon, J; Han, K; Cho, NY; Baek, K
      Promoter analysis of the Drosophila melanogaster gene encoding the pterin 4 alpha-carbinolamine dehydratase

      MOLECULES AND CELLS
    61. Fasi, A; Gomory, A; Palinko, I; Kiricsi, I
      Cyclodimerisation and cyclotrimerisation during the ring-opening reactionsof ethylene sulfide (thiirane) over acidic molecular sieves and alumina

      CATALYSIS LETTERS
    62. Sohn, JR; Ryu, SG
      Redox and catalytic behaviors of chromium oxide supported on zirconia

      CATALYSIS LETTERS
    63. Lu, Q; Liu, MH
      Molecular arrangement and photochemistry of a bolaamphiphilic anthracene derivative in Langmuir-Blodgett film

      JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
    64. Sun, L; Zhang, YM; Feng, WG
      Variational study on missing bond-charge repulsion on the extended Hubbardmodel: Effects on polyacetylene

      CHINESE PHYSICS
    65. Wang, YL; Wu, YJ
      Isokinetic correlation analysis of the series of electrophilic substitution reactions of o-substituted phenylmercurials

      SCIENCE IN CHINA SERIES B-CHEMISTRY
    66. Huang, DB; Chen, YQ; Ruetsche, M; Phelps, CB; Ghosh, G
      X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2

      STRUCTURE
    67. Vijayalakshmi, J; Mukhergee, MK; Graumann, J; Jakob, U; Saper, MA
      The 2.2 angstrom crystal structure of Hsp33: A heat shock protein with redox-regulated chaperone activity

      STRUCTURE
    68. Graumann, J; Lilie, H; Tang, XL; Tucker, KA; Hoffmann, JT; Vijayalakshmi, J; Saper, M; Bardwell, JCA; Jakob, U
      Activation of the redox-regulated molecular chaperone Hsp33 - A two-step mechanism

      STRUCTURE
    69. Kohler, JJ; Schepartz, A
      Effects of nucleic acids and polyanions on dimer formation and DNA bindingby bZIP and bHLHZip transcription factors

      BIOORGANIC & MEDICINAL CHEMISTRY
    70. Cochran, JR; Aivazian, D; Cameron, TO; Stern, LJ
      Receptor clustering and transmembrane signaling in T cells

      TRENDS IN BIOCHEMICAL SCIENCES
    71. Wu, CK; Hu, B; Rose, JP; Liu, ZJ; Nguyen, TL; Zheng, CS; Breslow, E; Wang, BC
      Structures of an unliganded neurophysin and its vasopressin complex: Implications for binding and allosteric mechanisms

      PROTEIN SCIENCE
    72. Kim, DH; Nam, GH; Jang, DS; Yun, S; Choi, G; Lee, HC; Choi, KY
      Roles of dimerization in folding and stability of ketosteroid isomerase from Pseudomonas putida biotype B

      PROTEIN SCIENCE
    73. Moll, JR; Ruvinov, SB; Pastan, I; Vinson, C
      Designed heterodimerizing leucine zippers with a range of pIs and stabilities up to 10(-15) M

      PROTEIN SCIENCE
    74. Stevens, TJ; Arkin, IT
      Substitution rates in alpha-helical transmembrane proteins

      PROTEIN SCIENCE
    75. Morikis, D; Elcock, AH; Jennings, PA; McCammon, JA
      Proton transfer dynamics of GART: The pH-dependent catalytic mechanism examined by electrostatic calculations

      PROTEIN SCIENCE
    76. Snijder, HJ; Van Eerde, JH; Kingma, RL; Kalk, KH; Dekker, N; Egmond, MR; Dijkstra, BW
      Structural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: Function of the Asn-His interaction in the catalytictriad

      PROTEIN SCIENCE
    77. Zhu, H; Celinski, SA; Scholtz, JM; Hu, JC
      An engineered leucine zipper a position mutant with an unusual three-stateunfolding pathway

      PROTEIN SCIENCE
    78. Kubatzky, KF; Ruan, WM; Gurezka, R; Cohen, J; Ketteler, R; Watowich, SS; Neumann, D; Langosch, D; Klingmuller, U
      Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

      CURRENT BIOLOGY
    79. Truong, K; Ikura, M
      The use of FRET imaging microscopy to detect protein-protein interactions and protein conformational changes in vivo

      CURRENT OPINION IN STRUCTURAL BIOLOGY
    80. Pellegrini, L
      Role of heparan sulfate in fibroblast growth factor signalling: a structural view

      CURRENT OPINION IN STRUCTURAL BIOLOGY
    81. Griffiths, GJ; Corfe, BM; Savory, P; Leech, S; Esposti, MD; Hickman, JA; Dive, C
      Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak

      ONCOGENE
    82. Monaco, C; Visconti, R; Barone, MV; Pierantoni, GM; Berlingieri, MT; De Lorenzo, C; Mineo, A; Vecchio, G; Fusco, A; Santoro, M
      The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane

      ONCOGENE
    83. Sorby, M; Sandstrom, J; Ostman, A
      An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1

      ONCOGENE
    84. Wert, M; Kennedy, S; Palfrey, HC; Hay, N
      Myc drives apoptosis in PC12 cells in the absence of Max

      ONCOGENE
    85. Vogt, PK
      Jun, the oncoprotein

      ONCOGENE
    86. Arevalo, JC; Conde, B; Hempstead, BI; Chao, MV; Martin-Zanca, D; Perez, P
      A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation

      ONCOGENE
    87. Scheidt, WR
      Structural deformations and bond length alternation in porphyrin pi-cationradicals

      JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
    88. Shivanyuk, A; Paulus, EF; Rissanen, K; Kolehmainen, E; Bohmer, V
      Resorcarenes in the boat conformation as building blocks for hydrogen-bonded assemblies including two ammonium cations

      CHEMISTRY-A EUROPEAN JOURNAL
    89. Wang, WF; Schuchmann, MN; Schuchmann, HP; von Sonntag, C
      The importance of mesomerism in the termination of alpha-carboxymethyl radicals from aqueous malonic and acetic acids

      CHEMISTRY-A EUROPEAN JOURNAL
    90. Flyunt, R; Schuchmann, MN; von Sonntag, C
      A common carbanion intermediate in the recombination and proton-catalysed disproportionation of the carboxyl radical anion, CO2,.- in aqueous solution

      CHEMISTRY-A EUROPEAN JOURNAL
    91. Heck, AJR; Bonnici, PJ; Breukink, E; Morris, D; Wills, M
      Modification and inhibition of vancomycin group antibiotics by formaldehyde and acetaldehyde

      CHEMISTRY-A EUROPEAN JOURNAL
    92. Hilgeroth, A; Baumeister, U
      Formation of novel photodimers from 4-aryl-1,4-dihydropyridines

      CHEMISTRY-A EUROPEAN JOURNAL
    93. Bray, KL; Charmant, JPH; Fairlamb, IJS; Lloyd-Jones, GC
      Structural and mechanistic studies on the activation and propagation of a cationic allylpalladium procatalyst in 1,6-diene cycloisomerization

      CHEMISTRY-A EUROPEAN JOURNAL
    94. Mahammed, A; Giladi, I; Goldberg, I; Gross, Z
      Synthesis and structural characterization of a novel covalently-bound corrole dimer

      CHEMISTRY-A EUROPEAN JOURNAL
    95. de Meijere, A; von Seebach, M; Zollner, S; Kozhushkov, SI; Belov, VN; Boese, R; Haumann, T; Benet-Buchholz, J; Yufit, DS; Howard, JAK
      Spirocyclopropanated bicyclopropylidenes: Straightforward preparation, physical properties, and chemical transformations

      CHEMISTRY-A EUROPEAN JOURNAL
    96. Nicolaou, KC; Hughes, R; Cho, SY; Winssinger, N; Labischinski, H; Endermann, R
      Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorialsynthesis

      CHEMISTRY-A EUROPEAN JOURNAL
    97. Turowska-Tyrk, I
      Structural transformations in a crystal during the photochemical reaction of 2-benzyl-5-benzylidenecyclopentanone

      CHEMISTRY-A EUROPEAN JOURNAL
    98. Burgstein, MR; Berberich, H; Roesky, PW
      Homoleptic lanthanide amides as homogeneous catalysts for alkyne hydroamination and the Tishchenko reaction

      CHEMISTRY-A EUROPEAN JOURNAL
    99. Hunig, S; Briehn, CA; Bauerle, P; Emge, A
      Electrochromics by intramolecular redox switching of single bonds

      CHEMISTRY-A EUROPEAN JOURNAL
    100. Cabeza, JA; del Rio, I; Garcia-Granda, S; Lavigne, G; Lugan, N; Moreno, M; Nombel, P; Perez-Priede, M; Riera, V; Rodriguez, A; Suarez, M; van der Maelen, JF
      Formation of cyclopentadienyl and ruthenacyclopentadienyl derivatives through ynenyl-diyne and ynenyl-alkyne couplings onto a triruthenium cluster core

      CHEMISTRY-A EUROPEAN JOURNAL


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 14:12:16