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La ricerca find articoli where soggetti phrase all words 'DIHYDROFOLATE-REDUCTASE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 1401 riferimenti
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    1. Antoniou, D; Schwartz, SD
      Internal enzyme motions as a source of catalytic activity: Rate-promoting vibrations and hydrogen tunneling

      JOURNAL OF PHYSICAL CHEMISTRY B
    2. Charrier, JD; Duffy, JES; Hitchcock, PB; Young, DW
      Unusual stereoselectivity in the alkylation of pyroglutamate ester urethanes

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    3. Hyde, JE; Sims, PFG
      Sulfa-drug resistance in Plasmodium falciparum

      TRENDS IN PARASITOLOGY
    4. Carlton, JMR; Hayton, M; Cravo, PVL; Walliker, D
      Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models

      TRENDS IN PARASITOLOGY
    5. Sibley, CH; Hyde, JE; Sims, PFG; Plowe, CV; Kublin, JG; Mberu, EK; Cowman, AF; Winstanley, PA; Watkins, WM; Nzila, AM
      Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

      TRENDS IN PARASITOLOGY
    6. Moritz, T; Williams, DA
      Marrow protection - transduction of hematopoietic cells with drug resistance genes

      CYTOTHERAPY
    7. Tropsha, A; Zhang, WF
      Identification of the descriptor pharmacophores using variable selection QSAR: Applications to database mining

      CURRENT PHARMACEUTICAL DESIGN
    8. Rodriguez, JB
      Specific molecular targets to control tropical diseases

      CURRENT PHARMACEUTICAL DESIGN
    9. Ouellette, M
      Biochemical and molecular mechanisms of drug resistance in parasites

      TROPICAL MEDICINE & INTERNATIONAL HEALTH
    10. Olliaro, P; Taylor, WRJ; Rigal, J
      Controlling malaria: challenges and solutions

      TROPICAL MEDICINE & INTERNATIONAL HEALTH
    11. Eberl, KJ; Jelinek, T; Aida, AO; Peyerl-Hoffmann, G; Heuschkel, C; el Valy, AO; Christophel, EM
      Prevalence of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparum isolates from southern Mauritania

      TROPICAL MEDICINE & INTERNATIONAL HEALTH
    12. Lowe, G; Carr, C; Quarrell, R
      Racemisation and rearrangement of 1,2-dihydro-1,3,5-triazines: a novel reversible thermal electrocyclic reaction

      CHEMICAL COMMUNICATIONS
    13. Nishikawa, NS; Izumi, M; Yokoi, M; Miyazawa, H; Hanaoka, F
      E2F regulates growth-dependent transcription of genes encoding both catalytic and regulatory subunits of mouse primase

      GENES TO CELLS
    14. Durand, R; Savel, J
      Dihydrofolate reductase inhibitors: new developments in antiparasitic chemotherapy

      EXPERT OPINION ON THERAPEUTIC PATENTS
    15. Lee, C; Schwartz, MP; Prakash, S; Iwakura, M; Matouschek, A
      ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal

      MOLECULAR CELL
    16. Peyret, P; Katinka, MD; Duprat, S; Duffieux, F; Barbe, V; Barbazanges, M; Weissenbach, J; Saurin, W; Vivares, CP
      Sequence and analysis of chromosome I of the amitochondriate intracellularparasite Encephalitozoon cuniculi (Microspora)

      GENOME RESEARCH
    17. Tucker, CL; Fields, S
      A yeast sensor of ligand binding

      NATURE BIOTECHNOLOGY
    18. Whetstine, JR; Gifford, AJ; Witt, T; Liu, XY; Flatley, RM; Norris, M; Haber, M; Taub, JW; Ravindranath, Y; Matherly, LH
      Single nucleotide polymorphisms in the human reduced folate carrier: Characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers

      CLINICAL CANCER RESEARCH
    19. Gourley, DG; Schuttelkopf, AW; Leonard, GA; Luba, J; Hardy, LW; Beverley, SM; Hunter, WN
      Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites

      NATURE STRUCTURAL BIOLOGY
    20. Evans, JT; Cravens, P; Gatlin, J; Kelly, PF; Lipsky, PE; Garcia, JV
      Pre-clinical evaluation of an in vitro selection protocol for the enrichment of transduced CD34(+) cell-derived human dendritic cells

      GENE THERAPY
    21. Ni, XH; Schachman, HK
      In vivo assembly of aspartate transcarbamoylase from fragmented and circularly permuted catalytic polypeptide chains

      PROTEIN SCIENCE
    22. Beernink, PT; Yang, YR; Graf, R; King, DS; Shah, SS; Schachman, HK
      Random circular permutation leading to chain disruption within and near alpha helices in the catalytic chains of aspartate transcarbamoylase: Effectson assembly, stability, and function

      PROTEIN SCIENCE
    23. Ojennus, DD; Fleissner, MR; Wuttke, DS
      Reconstitution of a native-like SH2 domain from disordered peptide fragments examined by multidimensional heteronuclear NMR

      PROTEIN SCIENCE
    24. Michnick, SW
      Exploring protein interactions by interaction-induced folding of proteins from complementary peptide fragments

      CURRENT OPINION IN STRUCTURAL BIOLOGY
    25. Gogonea, V; Suarez, D; van der Vaart, A; Merz, KW
      New developments in applying quantum mechanics to proteins

      CURRENT OPINION IN STRUCTURAL BIOLOGY
    26. Portugal, J; Martin, B; Vaquero, A; Ferrer, N; Villamarin, S; Priebe, W
      Analysis of the effects of daunorubicin and WP631 on transcription

      CURRENT MEDICINAL CHEMISTRY
    27. Beausejour, CM; Eliopoulos, N; Momparler, L; Le, NLO; Momparler, RL
      Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene

      CANCER GENE THERAPY
    28. Skold, O
      Resistance to trimethoprim and sulfonamides

      VETERINARY RESEARCH
    29. Marelius, J; Ljungberg, KB; Aqvist, J
      Sensitivity of an empirical affinity scoring function to changes in receptor-ligand complex conformations

      EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
    30. Osborne, MJ; Wright, PE
      Anisotropic rotational diffusion in model-free analysis for a ternary DHFRcomplex

      JOURNAL OF BIOMOLECULAR NMR
    31. Pitman, MC; Huber, WK; Horn, H; Kramer, A; Rice, JE; Swope, WC
      FLASHFLOOD: A 3D field-based similarity search and alignment method for flexible molecules

      JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    32. So, SS; Karplus, M
      Evaluation of designed ligands by a multiple screening method: Applicationto glycogen phosphorylase inhibitors constructed with a variety of approaches

      JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    33. Kellogg, GE; Burnett, JC; Abraham, DJ
      Very empirical treatment of solvation and entropy: a force field derived from Log P-o/w

      JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    34. King, RD; Srinivasan, A; Dehaspe, L
      Warmr: a data mining tool for chemical data

      JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    35. Santos, OA; Hopfinger, AJ
      A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors

      JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    36. Jansen, M; Bardenheuer, W; Sorg, UR; Seeber, S; Flasshove, M; Moritz, T
      Protection of hematopoietic cells from O-6-alkylation damage by O-6-methylguanine DNA methyltransferase gene transfer: studies with different O-6-alkylating agents and retroviral backbones

      EUROPEAN JOURNAL OF HAEMATOLOGY
    37. Bouvet, JP; Stahl, D; Rose, S; Quan, CP; Kazatchkine, MD; Kaveri, SV
      Induction of natural autoantibody activity following treatment of human immunoglobulin with dissociating agents

      JOURNAL OF AUTOIMMUNITY
    38. Chen, T; Mittelstaedt, RA; Shelton, SD; Dass, SB; Manjanatha, MG; Casciano, DA; Heflich, RH
      Gene- and tissue-specificity of mutation in Big Blue (R) rats treated withthe hepatocarcinogen N-hydroxy-2-acetylaminofluorene

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    39. Lu, L; Zhang, HJ; Tower, J
      Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification

      GENES & DEVELOPMENT
    40. Frolov, MV; Huen, DS; Stevaux, O; Dimova, D; Balczarek-Strang, K; Elsdon, M; Dyson, NJ
      Functional antagonism between E2F family members

      GENES & DEVELOPMENT
    41. Joubert, F; Neitz, AWH; Louw, AI
      Structure-based inhibitor screening: A family of sulfonated dye inhibitorsfor malaria parasite triosephosphate isomerase

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    42. Jacobs, DJ; Rader, AJ; Kuhn, LA; Thorpe, MF
      Protein flexibility predictions using graph theory

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    43. Houry, WA
      Mechanism of substrate recognition by the chaperonin GroEL

      BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
    44. Hoyer, LL; Hecht, JE
      The ALS5 gene of Candida albicans and analysis of the Als5p N-terminal domain

      YEAST
    45. Kuschak, TI; Kuschak, BC; Smith, GM; Wright, JA; Mai, S
      Isolation of extrachromosomal elements by histone immunoprecipitation

      BIOTECHNIQUES
    46. Djeliova, V; Russev, G; Anachkova, B
      Distribution of DNA replication origins between matrix-attached and loop DNA in mammalian cells

      JOURNAL OF CELLULAR BIOCHEMISTRY
    47. Balatsos, NAA; Lallas, G; Havredaki, M; Tsiapalis, CM
      Drug action on poly(A) polymerase activity and isoforms during U937 cell apoptosis

      JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
    48. Longo-Sorbello, GSA; Bertino, JR
      Current understanding of methotrexate pharmacology and efficacy in acute leukemias. Use of newer antifolates in clinical trials

      HAEMATOLOGICA
    49. Skamrov, A; Feoktistova, E; Goldman, M; Beabealashvilli, R
      Gene re-arrangement and fusion in Mycoplasma gallisepticum thyA-nrdFEI locus

      FEMS MICROBIOLOGY LETTERS
    50. Djeliova, V; Russev, G; Anachkova, B
      Dynamics of association of origins of DNA replication with the nuclear matrix during the cell cycle

      NUCLEIC ACIDS RESEARCH
    51. Huang, D; Jokela, M; Tuusa, J; Skog, S; Poikonen, K; Syvaoja, JE
      E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2

      NUCLEIC ACIDS RESEARCH
    52. de Nonancourt-Didion, M; Gueant, JL; Adjalla, C; Chery, C; Hatier, R; Namour, F
      Overexpression of folate binding protein alpha is one of the mechanism explaining the adaptation of HT29 cells to high concentration of methotrexate

      CANCER LETTERS
    53. Santos-Filho, OA; de Alencastro, RB; Figueroa-Villar, JD
      Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance

      BIOPHYSICAL CHEMISTRY
    54. Groll, AH; Ritter, J; Muller, FMC
      Guidelines for prevention of Pneumocystis carinii pneumonitis in children and adolescents with cancer.

      KLINISCHE PADIATRIE
    55. Cavallo, R; Lembo, D; Gribaudo, G; Landolfo, S
      Murine cytomegalovirus infection induces cellular folylpolyglutamate synthetase activity in quiescent cells

      INTERVIROLOGY
    56. Meisinger, C; Ryan, MT; Hill, K; Model, K; Lim, JH; Sickmann, A; Muller, H; Meyer, HE; Wagner, R; Pfanner, N
      Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small Tom proteins, and import receptors

      MOLECULAR AND CELLULAR BIOLOGY
    57. Chang, YC; Illenye, S; Heintz, NH
      Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinesehamster dhfr gene

      MOLECULAR AND CELLULAR BIOLOGY
    58. Aita, T; Iwakura, M; Husimi, Y
      A cross-section of the fitness landscape of dihydrofolate reductase

      PROTEIN ENGINEERING
    59. Iwakura, M; Nakamura, D; Takenawa, T; Mitsuishi, Y
      An approach for protein to be completely reversible to thermal denaturation even at autoclave temperatures

      PROTEIN ENGINEERING
    60. Hoyer-Hansen, G; Pessara, U; Holm, A; Pass, J; Weidle, U; Dano, K; Behrendt, N
      Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor

      BIOCHEMICAL JOURNAL
    61. Lim, JH; Martin, F; Guiard, B; Pfanner, N; Voos, W
      The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation

      EMBO JOURNAL
    62. de Borja, PF; Collins, NK; Du, P; Azizkhan-Clifford, J; Mudryj, M
      Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription

      EMBO JOURNAL
    63. Barrow, WW
      Treatment of mycobacterial infections

      REVUE SCIENTIFIQUE ET TECHNIQUE DE L OFFICE INTERNATIONAL DES EPIZOOTIES
    64. Reynolds, RC; Johnson, CA; Piper, JR; Sirotnak, FM
      Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring

      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    65. Ververidis, P; Davrazou, F; Diallinas, G; Georgakopoulos, D; Kanellis, AK; Panopoulos, N
      A novel putative reductase (Cpd1p) and the multidrug exporter Snq2p are involved in resistance to cercosporin and other singlet oxygen-generating photosensitizers in Saccharomyces cerevisae

      CURRENT GENETICS
    66. Wu, BN; Park, YD; Tian, WX; Zhou, HM
      Unfolding and inactivation of fatty acid synthase from chicken liver during urea denaturation

      BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    67. Hara, H; Yoshimura, H; Uchida, S; Toyoda, Y; Aoki, M; Sakai, Y; Morimoto, S; Shiokawa, K
      Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity

      BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
    68. de Koning-Ward, TF; Waters, AP; Crabb, BS
      Puromycin-N-acetyltransferase as a selectable marker for use in Plasmodiumfalciparum

      MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    69. Hankins, EG; Warhurst, DC; Sibley, CH
      Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210

      MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    70. Fox, BA; Belperron, AA; Bzik, DJ
      Negative selection of herpes simplex virus thymidine kinase in Toxoplasma gondii

      MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    71. Cunningham, ML; Beverley, SM
      Pteridine salvage throughout the Leishmania infectious cycle: implicationsfor antifolate chemotherapy

      MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    72. Sultan, AA; Thathy, V; de Koning-Ward, TF; Nussenzweig, V
      Complementation of Plasmodium berghei TRAP knockout parasites using human dihydrofolate reductase gene as a selectable marker

      MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    73. Bredel, M
      Anticancer drug resistance in primary human brain tumors

      BRAIN RESEARCH REVIEWS
    74. Olliaro, P
      Mode of action and mechanisms of resistance for antimalarial drugs

      PHARMACOLOGY & THERAPEUTICS
    75. Dybala-Defratyka, A; Paneth, P
      Theoretical evaluation of the hydrogen kinetic isotope effect on the firststep of the methylmalonyl-CoA mutase reaction

      JOURNAL OF INORGANIC BIOCHEMISTRY
    76. Mutabingwa, T; Nzila, A; Mberu, E; Nduati, E; Winstanley, P; Hills, E; Watkins, W
      Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania

      LANCET
    77. Iyer, JK; Milhous, WK; Cortese, JF; Kublin, JG; Plowe, CV
      Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine

      LANCET
    78. Kovacs, JA; Gill, VJ; Meshnick, S; Masur, H
      New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia

      JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
    79. Viswanadhan, VN; Mueller, GA; Basak, SC; Weinstein, JN
      Comparison of a neural net-based QSAR algorithm (PCANN) with hologram- andmultiple linear regression-based QSAR approaches: Application to 1,4-dihydropyridine-based calcium channel antagonists

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    80. Matherly, LH
      Molecular and cellular biology of the human reduced folate carrier

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 67
    81. Toteja, R; Nair, L; Bhasin, VK
      Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone

      MEMORIAS DO INSTITUTO OSWALDO CRUZ
    82. Hochhut, B; Lotfi, Y; Mazel, D; Faruque, SM; Woodgate, R; Waldor, MK
      Molecular analysis of antibiotic resistance gene clusters in Vibrio cholerae O139 and O1SXT constins

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    83. Imwong, M; Pukrittakayamee, S; Looareesuwan, S; Pasvol, G; Poirriez, J; White, NJ; Snounou, G
      Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: Geographical and clinical correlates

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    84. Cunningham, ML; Titus, RG; Turco, SJ; Beverley, SM
      Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin

      SCIENCE
    85. Thanh, NV; Cowman, AF; Hipgrave, D; Kim, TB; Phuc, BQ; Cong, LD; Biggs, BA
      Assessment of susceptibility of Plasmodium falciparum to chloroquine, quinine, mefloquine, sulfadoxine-pyrimethamine and artemisinin in southern VietNam

      TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
    86. Omar, SA; Adagu, IS; Warhurst, DC
      Can pretreatment screening for dhps and dhfr point mutations in Plasmodiumfalciparum infections be used to predict sulfadoxine-pyrimethamine treatment failure?

      TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
    87. Nagesha, HS; Din-Syafruddin; Casey, GJ; Susanti, AI; Fryauff, DJ; Reeder, JC; Cowman, AF
      Mutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in-vivo drug resistance in West Papua, Indonesia

      TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
    88. Robert, A; Benoit-Vical, F; Dechy-Cabaret, O; Meunier, B
      From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin

      PURE AND APPLIED CHEMISTRY
    89. Paget-McNicol, S; Saul, A
      Mutation rates in the dihydrofolate reductase gene of Plasmodium falciparum

      PARASITOLOGY
    90. Remy, I; Michnick, SW
      Visualization of biochemical networks in living cells

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    91. Sharina, IG; Zhao, RB; Wang, YH; Babani, S; Goldman, ID
      Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier

      MOLECULAR PHARMACOLOGY
    92. Nagakubo, J; Tomimatsu, T; Kitajima, M; Takayama, H; Aimi, N; Horie, T
      Characteristics of transport of fluoresceinated methotrexate in rat small intestine

      LIFE SCIENCES
    93. Rosowsky, A; Chen, H
      A novel method of synthesis of 2,4-diamino-6-arylmethylquinazolines using palladium(0)-catalyzed organozinc chemistry

      JOURNAL OF ORGANIC CHEMISTRY
    94. Feng, ZY; Butler, MC; Alam, SL; Loh, SN
      On the nature of conformational openings: Native and unfolded-state hydrogen and thiol-disulfide exchange studies of ferric aquomyoglobin

      JOURNAL OF MOLECULAR BIOLOGY
    95. Kel, AE; Kel-Margoulis, OV; Farnham, PJ; Bartley, SM; Wingender, E; Zhang, MQ
      Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors

      JOURNAL OF MOLECULAR BIOLOGY
    96. Huang, YT; Liaw, YC; Gorbatyuk, VY; Huang, TH
      Backbone dynamics of Escherichia coli thioesterase/protease I: Evidence ofa flexible active-site environment for a serine protease

      JOURNAL OF MOLECULAR BIOLOGY
    97. Turcotte, M; Muggleton, SH; Sternberg, MJE
      Automated discovery of structural signatures of protein fold and function

      JOURNAL OF MOLECULAR BIOLOGY
    98. Kalra, P; Redd, TV; Jayaram, B
      Free energy component analysis for drug design: A case study of HIV-1 protease-inhibitor binding

      JOURNAL OF MEDICINAL CHEMISTRY
    99. Mastropaolo, D; Camerman, A; Camerman, N
      Crystal structure of the hydrated strontium salt of methotrexate: Two independent molecules with different conformations

      JOURNAL OF MEDICINAL CHEMISTRY
    100. Loukas, YL
      Adaptive neuro-fuzzy inference system: An instant and architecture-free predictor for improved QSAR studies

      JOURNAL OF MEDICINAL CHEMISTRY


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Documento generato il 25/05/20 alle ore 07:25:35