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La ricerca find articoli where soggetti phrase all words 'DIFFERENTIAL DISPLAY' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 1338 riferimenti
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    1. Safadi, FF; Xu, J; Smock, SL; Rico, MC; Owen, TA; Popoff, SN
      Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts

      JOURNAL OF CELLULAR BIOCHEMISTRY
    2. Lobler, M; Sass, M; Kunze, C; Schmitz, KP; Hopt, UT
      Biomaterial patches sutured onto the rat stomach induce a set of genes encoding pancreatic enzymes

      BIOMATERIALS
    3. Hadjiargyrou, M; Rightmire, EP; Ando, T; Lombardo, FT
      The E11 osteoblastic lineage marker is differentially expressed during fracture healing

      BONE
    4. Duluc, I; Hoff, C; Kedinger, M; Freund, JN
      Differentially expressed endoderm and mesenchyme genes along the fetal ratintestine

      GENESIS
    5. Wang, JF; Bown, CD; Chen, B; Young, LT
      Identification of mood stabilizer-regulated genes by differential-display PCR

      INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
    6. Strakhova, MI; Skolnick, P
      Can 'differential display' methodologies make an impact on biological psychiatry?

      INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
    7. Johnston-Wilson, NL; Bouton, CMLS; Pevsner, J; Breen, JJ; Torrey, EF; Yolken, RH
      Emerging technologies for large-scale screening of human tissues and fluids in the study of severe psychiatric disease

      INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
    8. Fujimoto, S; Yano, Y; Nishiguchi, S; Koh, N; Tamori, A; Shiomi, S; Kuroki, T; Otani, S
      Identification of genes differentially expressed by putrescine in HepG2 hepatoblastoma cells

      HEPATOLOGY RESEARCH
    9. Rhodes, JC; Oliver, BG; Askew, DS; Amlung, TW
      Identification of genes of Aspergillus fumigatus upregulated during growthon endothelial cells

      MEDICAL MYCOLOGY
    10. Zhao, XJ; Calderone, RA; Krueger, KE; Chol, G; Cihlar, RL
      Isolation and characterization of the Candida albicans MOT2 gene

      MEDICAL MYCOLOGY
    11. Takayama, I; Diago, Y; Ward, SM; Sanders, KM; Yamanaka, T; Fujino, MA
      Differential gene expression in the small intestines of wildtype and W/W-Vmice

      NEUROGASTROENTEROLOGY AND MOTILITY
    12. Yamamoto, T; Matsuda, Y; Hikino, T; Nakayama, Y; Abe, S
      Cloning of dynein intermediate chain cDNA of the newt Cynops pyrrhogaster

      DNA RESEARCH
    13. Rindi, L; Lari, N; Garzelli, C
      Genes of Mycobacterium tuberculosis H37Rv downregulated in the attenuated strain H37Ra are restricted to M-tuberculosis complex species

      MICROBIOLOGICA
    14. Denslow, ND; Lee, HS; Bowman, CJ; Hemmer, MJ; Folmar, LC
      Multiple responses in gene expression in fish treated with estrogen

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    15. Fujimoto, S; Toshimori-Tsuda, I; Kishimoto, K; Yamano, Y; Morishima, I
      Protein purification, cDNA cloning and gene expression of lysozyme from eri-silkworm, Samia cynthia ricini

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    16. Li, HS; Zhang, JY; Thompson, BS; Deng, XY; Ford, ME; Wood, PG; Stolz, DB; Eagon, PK; Whitcomb, DC
      Rat mitochondrial ATP synthase ATP5G3: cloning and upregulation in pancreas after chronic ethanol feeding

      PHYSIOLOGICAL GENOMICS
    17. Harrington, JJ; Sherf, B; Rundlett, S; Jackson, PD; Perry, R; Cain, S; Leventhal, C; Thornton, M; Ramachandran, R; Whittington, J; Lerner, L; Costanzo, D; McElligott, K; Boozer, S; Mays, R; Smith, E; Veloso, N; Klika, A; Hess, J; Cothren, K; Lo, K; Offenbacher, J; Danzig, J; Ducar, M
      Creation of genome-wide protein expression libraries using random activation of gene expression

      NATURE BIOTECHNOLOGY
    18. Chen, J; Bender, TP
      A novel system to identify Myb target promoters in friend murine erythroleukemia cells

      BLOOD CELLS MOLECULES AND DISEASES
    19. Yang, Y; Duan, ZJ; Skarpidi, E; Li, QL; Papayannopoulou, T; Stamatoyannopoulos, G
      Cloning and characterization of a potential transcriptional activator of human gamma-globin genes

      BLOOD CELLS MOLECULES AND DISEASES
    20. Mitchell, T; Plonczynski, M; McCollum, A; Hardy, CL; Safaya, S; Steinberg, MH
      Gene expression profiling during erythroid differentiation of K562 cells

      BLOOD CELLS MOLECULES AND DISEASES
    21. Miele, G; Manson, J; Clinton, M
      A novel erythroid-specific marker of transmissible spongiform encephalopathies

      NATURE MEDICINE
    22. Ghadersohi, A; Sood, AK
      Prostate epithelium-derived ets transcription factor mRNA is overexpressedin human breast tumors and is a candidate breast tumor marker and a breasttumor antigen

      CLINICAL CANCER RESEARCH
    23. Yamamoto, Y; Sakamoto, M; Fujii, G; Kanetaka, K; Asaka, M; Hirohashi, S
      Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma

      CLINICAL CANCER RESEARCH
    24. Russo, J; Hu, YF; Silva, IDCG; Russo, IH
      Cancer risk related to mammary gland structure and development

      MICROSCOPY RESEARCH AND TECHNIQUE
    25. Shimizu-Nishikawa, K; Tsuji, S; Yoshizato, K
      Identification and characterization of newt rad (ras associated with diabetes), a gene specifically expressed in regenerating limb muscle

      DEVELOPMENTAL DYNAMICS
    26. Bucherna, N; Szabo, E; Heszky, LE; Nagy, I
      DNA methylation and gene expression differences during alternative in vitro morphogenetic processes in eggplant (Solanum melongena L.)

      IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
    27. Boudinot, P; Salhi, S; Blanco, M; Benmansour, A
      Viral haemorrhagic septicaemia virus induces vig-2, a new interferon-responsive gene in rainbow trout

      FISH & SHELLFISH IMMUNOLOGY
    28. Stanton, LW
      Methods to profile gene expression

      TRENDS IN CARDIOVASCULAR MEDICINE
    29. Kool, J; van Zaane, W; van der Eb, AJ; Terleth, C
      Down-regulation of T-STAR, a growth inhibitory protein, after SV40-mediated immortalization

      CELL GROWTH & DIFFERENTIATION
    30. Wu, R; Jurek, M; Sundarababu, S; Weinstein, DE
      The POU gene Brn-5 is induced by neuregulin and is restricted to myelinating Schwann cells

      MOLECULAR AND CELLULAR NEUROSCIENCE
    31. Verca, MSB; Widmer, DAJ; Wagner, GC; Dreyer, JL
      Cocaine-induced expression of the tetraspanin CD81 and its relation to hypothalamic function

      MOLECULAR AND CELLULAR NEUROSCIENCE
    32. Santhanam, R; Naz, RK
      Novel human testis-specific cDNA: Molecular cloning, expression and immunobiological effects of the recombinant protein

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    33. Brunet-Simon, A; Henrion, G; Renard, JP; Duranthon, V
      Onset of zygotic transcription and maternal transcript legacy in the rabbit embryo

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    34. Lewohl, JM; Dodd, PR; Mayfield, RD; Harris, RA
      Application of DNA microarrays to study human alcoholism

      JOURNAL OF BIOMEDICAL SCIENCE
    35. Zhu, YF; Lin, H; Wang, M; Li, Z; Wiggins, RC; Luo, J
      Up-regulation of transcription of smooth muscle myosin alkali light chain by ethanol in human breast cancer cells

      INTERNATIONAL JOURNAL OF ONCOLOGY
    36. Hu, ED; Chen, ZX; Fredrickson, TA; Spurr, N; Gentle, S; Sims, M; Zhu, Y; Halsey, W; Van Horn, S; Mao, J; Sathe, GM; Brooks, DP
      Rapid isolation of tissue-specific genes from rat kidney

      EXPERIMENTAL NEPHROLOGY
    37. Hong, ST; Lee, MY; Kim, SR
      Molecular cloning of the anther-preferential nonspecific lipid transfer protein cDNA in hot pepper by mRNA differential display

      MOLECULES AND CELLS
    38. Park, CJ; Shin, R; Park, JM; Lee, GJ; Yoo, TH; Paek, KH
      A hot pepper cDNA encoding a pathogenesis-related protein 4 is induced during the resistance response to tobacco mosaic virus

      MOLECULES AND CELLS
    39. Zhang, KM; Chen, BS; Wu, G; Xue, H; Zeng, WW; Zhang, J
      Molecular cloning and identification of naturally occurring human antisense angiopoietin-1: Gna-1

      SCIENCE IN CHINA SERIES C-LIFE SCIENCES
    40. Gao, ZH; Xue, YB; Dai, JR
      cDNA-AFLP analysis reveals that maize resistance to Bipolaris maydis is associated with the induction of multiple defense-related genes

      CHINESE SCIENCE BULLETIN
    41. Masmoudi, K; Brini, F; Hassairi, A; Ellouz, R
      Isolation and characterization of a differentially expressed sequence tag from Triticum darum salt-stressed roots

      PLANT PHYSIOLOGY AND BIOCHEMISTRY
    42. Luo, Z; Geschwind, DH
      Microarray applications in neuroscience

      NEUROBIOLOGY OF DISEASE
    43. Nakabachi, A; Ishikawa, H
      Expression of host S-adenosylmethionine decarboxylase gene and polyamine composition in aphid bacteriocytes

      INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
    44. Oka, R; Sasagawa, T; Ninomiya, I; Miwa, K; Tanii, H; Saijoh, K
      Reduction in the local expression of complement component 6 (Cd) and 7 (C7) mRNAs in oesophageal carcinoma

      EUROPEAN JOURNAL OF CANCER
    45. Kim, DS; Lee, SJ; Park, SY; Yoo, HJ; Kim, SH; Kim, KJ; Cho, HJ
      Differentially expressed genes in rat dorsal root ganglia following peripheral nerve injury

      NEUROREPORT
    46. Sayler, GS; Fleming, JT; Nivens, DE
      Gene expression monitoring in soils by mRNA analysis and gene lux fusions

      CURRENT OPINION IN BIOTECHNOLOGY
    47. Tochitani, S; Liang, FY; Watakabe, A; Hashikawa, T; Yamamori, T
      The occ1 gene is preferentially expressed in the primary visual cortex in an activity-dependent manner: a pattern of gene expression related to the cytoarchitectonic area in adult macaque neocortex

      EUROPEAN JOURNAL OF NEUROSCIENCE
    48. Schlichter, U; Burk, O; Worpenberg, S; Klempnauer, KH
      The chicken Pdcd4 gene is regulated by v-Myb

      ONCOGENE
    49. Paivarinne, H; Kainulainen, H
      DAPIT, a novel protein down-regulated in insulin-sensitive tissues in streptozotocin-induced diabetes

      ACTA DIABETOLOGICA
    50. Kang, YR; Nasrallah, JB
      Use of genetically ablated stigmas for the isolation of genes expressed specifically in the stigma epidermis

      SEXUAL PLANT REPRODUCTION
    51. Buysse, JM
      The role of genomics in antibacterial target discovery

      CURRENT MEDICINAL CHEMISTRY
    52. Ludwig, AA; Tenhaken, R
      A new cell wall located n-rich protein is strongly induced during the hypersensitive response in Glycine max L.

      EUROPEAN JOURNAL OF PLANT PATHOLOGY
    53. Hirate, Y; Mieda, M; Harada, T; Yamasu, K; Okamoto, H
      Identification of ephrin-A3 and novel genes specific to the midbrain-MHB in embryonic zebrafish by ordered differential display

      MECHANISMS OF DEVELOPMENT
    54. Christiansen, JH; Coles, EG; Robinson, V; Pasini, A; Wilkinson, DG
      Screening from a subtracted embryonic chick hindbrain cDNA library: identification of genes expressed during hindbrain, midbrain and cranial neural crest development

      MECHANISMS OF DEVELOPMENT
    55. Tanaka, K; Kondoh, N; Shuda, M; Matsubara, O; Imazeki, N; Ryo, A; Wakatsuki, T; Hada, A; Goseki, N; Igari, T; Hatsuse, K; Aihara, T; Horiuchi, S; Yamamoto, N; Yamamoto, M
      Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
    56. Vreugdenhil, E; de Kloet, ER; Schaaf, M; Datson, NA
      Genetic dissection of corticosterone receptor function in the rat hippocampus

      EUROPEAN NEUROPSYCHOPHARMACOLOGY
    57. Su, HY; Palmer, BR; Wellby, MP; Bickerstaffe, R; Hickford, JGH
      Differential expression of a gene homologous to a G-alpha protein gene in neonatal mouse skin during development of hair follicles

      JOURNAL OF DERMATOLOGICAL SCIENCE
    58. Hill, JM; Lukiw, WJ; Gebhardt, BM; Higaki, S; Loutsch, JM; Myles, ME; Thompson, HW; Kwon, BS; Bazan, NG; Kaufman, HE
      Gene expression analyzed by microarrays in HSV-1 latent mouse trigeminal ganglion following heat stress

      VIRUS GENES
    59. Kimura, T; Nakano, T; Taki, N; Ishikawa, M; Asami, T; Yoshida, S
      Cytokinin-induced gene expression in cultured green cells of Nicotiana tabacum identified by fluorescent differential display

      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
    60. Takechi, T; Koizumi, K; Tsujimoto, H; Fukushima, M
      Screening of differentially expressed genes in 5-fluorouracil-resistant human gastrointestinal tumor cells

      JAPANESE JOURNAL OF CANCER RESEARCH
    61. Leffers, H; Naesby, M; Vendelbo, B; Skakkebaek, NE; Jorgensen, M
      Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters

      APMIS
    62. Bals, R; Jany, B
      Identification of disease genes by expression profiling

      EUROPEAN RESPIRATORY JOURNAL
    63. Gromova, I; Gromov, P; Celis, JE
      A novel member of the glycosyltransferase family, beta 3Gn-T2, highly downregulated in invasive human bladder transitional cell carcinomas

      MOLECULAR CARCINOGENESIS
    64. Rae, FK; Hooper, JD; Nicol, DL; Clements, JA
      Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors

      MOLECULAR CARCINOGENESIS
    65. van Laar, T; Schouten, T; van der Eb, AJ; Terleth, C
      Induction of the SAPK activator MIG-6 by the alkylating agent methyl methanesulfonate

      MOLECULAR CARCINOGENESIS
    66. Kettenhofen, R; Hoppe, J; Eberhard, G; Seul, C; Ko, Y; Sachinidis, A
      Regulation of Gadd45a mRNa expression in vascular smooth muscle under growth and stress conditions

      CELLULAR SIGNALLING
    67. Harris, LK; Black, RT; Golden, KM; Reeves, TM; Povlishock, JT; Phillips, LL
      Traumatic brain injury-induced changes in gene expression and functional activity of mitochondrial cytochrome c oxidase

      JOURNAL OF NEUROTRAUMA
    68. Bao, B; Lee, DY; Prasad, AS
      Isolation and characterization of mammary cDNA differentially expressed inlethal milk mutation mice

      JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE
    69. Vercauteren, I; Van Der Schueren, E; Van Montagu, M; Gheysen, G
      Arabidopsis thaliana genes expressed in the early compatible interaction with root-knot nematodes

      MOLECULAR PLANT-MICROBE INTERACTIONS
    70. Vaghchhipawala, Z; Bassuner, R; Clayton, K; Lewers, K; Shoemaker, R; Mackenzie, S
      Modulations in gene expression and mapping of genes associated with cyst nematode infection of soybean

      MOLECULAR PLANT-MICROBE INTERACTIONS
    71. Hua, LV; Green, M; Wong, A; Warsh, JJ; Li, PP
      Tetraspan protein CD151: A common target of mood stabilizing drugs?

      NEUROPSYCHOPHARMACOLOGY
    72. Tononi, G; Cirelli, C
      Modulation of brain gene expression during sleep and wakefulness: A reviewof recent findings

      NEUROPSYCHOPHARMACOLOGY
    73. Hua, LV; Green, M; Warsh, JJ; Li, PP
      Molecular cloning of a novel isoform of diphosphoinositol polyphosphate phosphohydrolase: A potential target of lithium therapy

      NEUROPSYCHOPHARMACOLOGY
    74. Barsyte, D; Lovejoy, DA; Lithgow, GJ
      Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutantsof Caenorhabditis elegans

      FASEB JOURNAL
    75. Qiu, FH; Devchand, PR; Wada, K; Serhan, CN
      Aspirin-triggered lipoxin A(4) and lipoxin A(4) up-regulate transcriptional corepressor NAB1 in human neutrophils

      FASEB JOURNAL
    76. Carper, D; John, M; Chen, ZG; Subramanian, S; Wang, RR; Ma, WC; Spector, A
      Gene expression analysis of an H2O2-resistant lens epithelial cell line

      FREE RADICAL BIOLOGY AND MEDICINE
    77. Rae, FK; Hooper, JD; Eyre, HJ; Sutherland, GR; Nicol, DL; Clements, JA
      TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma

      GENOMICS
    78. Zhou, RH; Kokame, K; Tsukamoto, Y; Yutani, C; Kato, H; Miyata, T
      Characterization of the human NDRG gene family: A newly identified member,NDRG4, is specifically expressed in brain and heart

      GENOMICS
    79. Rutherford, MN; Bayly, GRL; Matthews, BP; Okuda, T; Dinjens, WMN; Kondoh, H; LeBrun, DP
      The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells

      LEUKEMIA
    80. Casanova, B; de la Fuente, MT; Garcia-Gila, M; Sanz, L; Silva, A; Garcia-Marco, JA; Garcia-Pardo, A
      The class II tumor-suppressor gene RARRES3 is expressed in B cell lymphocytic leukemias and down-regulated with disease progression

      LEUKEMIA
    81. Li, HS; Deng, XY; Thompson, BS; Zhang, JY; Wood, PG; Eagon, PK; Whitcomb, DC
      Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats

      PANCREAS
    82. Gill, KS; Sandhu, D
      Candidate-gene cloning and targeted marker enrichment of wheat chromosomalregions using RNA fingerprinting - differential display

      GENOME
    83. Prunet-Marcassus, B; Ambid, L; Viguerie-Bascands, N; Penicaud, L; Casteilla, L
      Evidence for a direct effect of melatonin on mitochondrial genome expression of Siberian hamster brown adipocytes

      JOURNAL OF PINEAL RESEARCH
    84. Menke, U; Mueller-Roeber, B
      RNA fingerprinting of specific plant cell types: Adaptation to plants and optimization of RNA arbitrarily primed PCR (RAP-PCR)

      PLANT MOLECULAR BIOLOGY REPORTER
    85. Morgan, MB; Vogelien, DL; Snell, TW
      Assessing coral stress responses using molecular biomarkers of gene transcription

      ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
    86. Austad, SN
      An experimental paradigm for the study of slowly aging organisms

      EXPERIMENTAL GERONTOLOGY
    87. Walters, DM; Russ, R; Knackmuss, HJ; Rouviere, PE
      High-density sampling of a bacterial operon using mRNA differential display

      GENE
    88. Fleischmann, J; Liu, H
      Polyadenylation of ribosomal RNA by Candida albicans

      GENE
    89. Modarressi, MH; Cameron, J; Taylor, KE; Wolfe, J
      Identification and characterisation of a novel gene, TSGA10, expressed in testis

      GENE
    90. Dong, QJ; Hyde, D; Herra, C; Kean, C; Murphy, P; O'Morain, CA; Buckley, M
      Identification of genes regulated by prolonged acid exposure in Helicobacter pylori

      FEMS MICROBIOLOGY LETTERS
    91. Chen, J; Brodsky, S; Li, H; Hampel, DJ; Miyata, T; Weinstein, T; Gafter, U; Norman, JT; Fine, LG; Goligorsky, MS
      Delayed branching of endothelial capillary-like cords in glycated collagenI is mediated by early induction of PAI-1

      AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
    92. Wrang, ML; Moller, F; Alsbo, CW; Diemer, NH
      Changes in gene expression following induction of ischemic tolerance in rat brain: Detection and verification

      JOURNAL OF NEUROSCIENCE RESEARCH
    93. Belloir, B; Kovari, E; Surini-Demiri, M; Savioz, A
      Altered apolipoprotein D expression in the brain of patients with Alzheimer disease

      JOURNAL OF NEUROSCIENCE RESEARCH
    94. Farquharson, C; Seawright, E; Jefferies, D
      Parathyroid hormone-related peptide expression in tibial dyschondroplasia

      AVIAN PATHOLOGY
    95. Medhurst, AD; Zeng, BY; Charles, KJ; Gray, J; Reavill, C; Hunter, AJ; Shale, JA; Jenner, P
      Up-regulation of secretoneurin immunoreactivity and secretogranin II mRNA in rat striatum following 6-hydroxydopamine lesioning and chronic L-dopa treatment

      NEUROSCIENCE
    96. Kuhn, E
      From library screening to microarray technology: Strategies to determine gene expression profiles and to identify differentially regulated genes in plants

      ANNALS OF BOTANY
    97. Uematsu, C; Nishida, J; Okano, K; Miura, F; Ito, T; Sakaki, Y; Kambara, H
      Multiplex polymerase chain reaction (PCR) with color-tagged module-shuffling primers for comparing gene expression levels in various cells

      NUCLEIC ACIDS RESEARCH
    98. Kim, JH; Kim, JE; Kim, HJ; Roh, GS; Yoo, YM; Kang, SS; Cho, YY; Cho, GJ; Choi, WS
      Ethanol decreases the expression of mitochondrial cytochrome c oxidase mRNA in the rat

      NEUROSCIENCE LETTERS
    99. Yamada, M; Yamada, M; Yamazaki, S; Takahashi, K; Nara, K; Ozawa, H; Yamada, S; Kiuchi, Y; Oguchi, K; Kamijima, K; Higuchi, T; Momose, K
      Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex

      NEUROSCIENCE LETTERS
    100. Yamamoto, K; Okamoto, A; Isonishi, S; Ochiai, K; Ohtake, Y
      Heat shock protein 27 was up-regulated in cisplatin resistant human ovarian tumor cell line and associated with the cisplatin resistance

      CANCER LETTERS


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Documento generato il 06/08/20 alle ore 04:24:28