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Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels
JOURNAL OF APPLIED PHYSIOLOGY
Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography
JOURNAL OF CHROMATOGRAPHY B
Hplc of (+/-)-fenfluramine and phentermine in plasma after derivatization with dansyl chloride
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ASHP therapeutic position statement on the safe use of pharmacotherapy forobesity management in adults
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
Pharmacologic options for the treatment of obesity
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
Lifestyle treatments in randomized clinical trials of pharmacotherapies for obesity
OBESITY RESEARCH
Long-term impairment of anterograde axonal transport along fiber projection originating in the rostral raphe nuclei after treatment with fenfluramineor methylenedioxymethamphetamine
SYNAPSE
Additive effects on rat brain 5HT release of combining phentermine with dexfenfluramine
INTERNATIONAL JOURNAL OF OBESITY
High performance liquid chromatography with UV detection for the simultaneous determination of sympathomimetic amines using 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride as a label
BIOMEDICAL CHROMATOGRAPHY
In situ metabolic and hemodynamic response to dexfenfluramine in white adipose tissue of rats
ANNALS OF NUTRITION AND METABOLISM
Low risk of significant echocardiographic valvulopathy in patients treatedwith anorectic drugs
INTERNATIONAL JOURNAL OF CARDIOLOGY
The effect of (R)-HA966 or ACEA 1021 on dexfenfluramine or (S)-MDMA-induced changes in temperature, activity, and neurotoxicity
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Operation for anorexigen-associated valvular heart disease
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Effects of anorexinogen agents on cloned voltage-gated K+ channel hKv1.5
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine
BRITISH JOURNAL OF PHARMACOLOGY
Evidence for the existence of adaptive thermogenesis during weight loss
BRITISH JOURNAL OF NUTRITION
Medial versus lateral parabrachial nucleus lesions in the rat: effects on cholecystokinin- and D-fenfluramine-induced anorexia
BRAIN RESEARCH
Echocardiographic examination of women previously treated with fenfluramine - Long-term follow-up of a randomized, double-blind, placebo-controlled trial
ARCHIVES OF INTERNAL MEDICINE
The progression of fenfluramine-associated valvular heart disease assessedby echocardiography
ANNALS OF INTERNAL MEDICINE
Silver lining to the cloud over anorexogen-related cardiac valvulopathy?
ANNALS OF INTERNAL MEDICINE
Rapid clot formation and abnormal fibrin structure in a symptomatic patient taking fenfluramine - A case report
ANGIOLOGY
Appetite suppressants and valvular heart disease
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
Anorectic drugs and pulmonary hypertension from the bedside to the bench
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
Association between selective serotonin-reuptake inhibitor therapy and heart valve regurgitation
AMERICAN JOURNAL OF CARDIOLOGY
Effects of amphetamine, dexfenfluramine, diazepam, and other pharmacological and dietary manipulations on food "seeking" and "taking" behavior in non-human primates
PSYCHOPHARMACOLOGY
Acute anorectic effect of single and combined drugs in mice using a non-deprivation protocol
PSYCHOPHARMACOLOGY
Antiobesity pharmacotherapy in the management of Type 2 diabetes
DIABETES-METABOLISM RESEARCH AND REVIEWS
Effects of diet and serotonergic agonist on hepatic apolipoprotein B-100 secretion and endothelial function in obese men
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity
ENDOCRINE
Drug therapy of obesity in type 2 diabetes mellitus.
DIABETES & METABOLISM
The effects of drugs used to treat obesity on the autonomic nervous system
OBESITY RESEARCH
Diabetes disease stage predicts weight loss outcomes with long-term appetite suppressants
OBESITY RESEARCH
Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity
OBESITY RESEARCH
From the editor's desk .... Fenfluramines and heart valves
OBESITY SURGERY
An investigation of the serotonergic effects of fenfluramine, dexfenfluramine and dexnorfenfluramine using platelets as neuronal models
PLATELETS
Fluoxetine increases the anorectic and long-term dopamine-depleting effects of phentermine
SYNAPSE
Efficacy of fenfluramine and dexfenfluramine in the treatment of obesity: A meta-analysis
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
In obese individuals dexfenfluramine corrects molecular derangements reflecting insulin resistance
INTERNATIONAL JOURNAL OF OBESITY
One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor
INTERNATIONAL JOURNAL OF OBESITY
Adrenal responsiveness to high, low and very low ACTH 1-24 doses in obesity
CLINICAL ENDOCRINOLOGY
Physician prescribing of anorexigenics for weight loss in Salt Lake County, Utah
PHARMACOTHERAPY
Opportunities for medication development in obesity
DRUG DEVELOPMENT RESEARCH
Efficacy of dexfenfluramine in the treatment of alcohol dependence
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Sibutramine does not decrease the number of 5-HT re-uptake sites in rat brain and, like fluoxetine, protects against the deficits produced by dexfenfluramine
NEUROPHARMACOLOGY
Pharmacotherapy for obesity
MEDICAL CLINICS OF NORTH AMERICA
Diet drug-related cardiac valve disease: The Mayo Clinic EchocardiographicLaboratory experience
MAYO CLINIC PROCEEDINGS
Interaction between the serotoninergic and dopaminergic systems in d-fenfluramine-induced activation of c-fos and jun B genes in rat striatal neurons
JOURNAL OF NEUROCHEMISTRY
Dexfenfluramine-induced contraction of human and rat isolated pulmonary arteries
EUROPEAN JOURNAL OF PHARMACOLOGY
Fen/phen and valvular heart disease: The final link has now been established
CIRCULATION
Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
CIRCULATION
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin
AMERICAN JOURNAL OF CARDIOLOGY
Current efforts in the drug treatment of obesity
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
d-fenfluramine produces neuronal degeneration in localized regions of the cortex, thalamus, and cerebellum of the rat
TOXICOLOGICAL SCIENCES
Serial echocardiographic and clinical evaluation of valvular regurgitationbefore, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine
OBESITY RESEARCH
Histologic changes in three explanted native cardiac valves following use of fenfluramines
CARDIOVASCULAR PATHOLOGY
Determining exposure underreporting in pharmacoepidemiologic case-control studies: Methods and example
JOURNAL OF CLINICAL EPIDEMIOLOGY
Effects of antihistamines on fenfluramine-induced depletion of indoles in the brain of rats
SYNAPSE
Ethics and clinical trials
FUNDAMENTAL & CLINICAL PHARMACOLOGY
Three-month treatment with metformin or dexfenfluramine does not modify the effects of diet on anthropometric and endocrine-metabolic parameters in abdominal obesity
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: An autoradiographic study
NEUROCHEMICAL RESEARCH
Synergistic interactions between fenfluramine and phentermine
INTERNATIONAL JOURNAL OF OBESITY
The effect of sibutramine on resting energy expenditure and adrenaline-induced thermogenesis in obese females
INTERNATIONAL JOURNAL OF OBESITY
The impact of pharmacotherapy on weight management in type 2 diabetes
INTERNATIONAL JOURNAL OF OBESITY
Pharmacological treatment of obesity: present status
INTERNATIONAL JOURNAL OF OBESITY
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Pharmacologic induction of weight loss to treat type 2 diabetes
DIABETES CARE
A risk-benefit assessment of anti-obesity drugs
DRUG SAFETY
Surrogate end points, health outcomes, and the drug-approval process for the treatment of risk factors for cardiovascular disease
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Synergistic anorectic effect of dehydroepiandrosterone and d-fenfluramine on the obese Zucker rat
PHYSIOLOGY & BEHAVIOR
Simultaneous effects of local dexfenfluramine application on extracellularglutamate and serotonin levels in rat frontal cortex: a reverse microdialysis study
NEUROPHARMACOLOGY
The principle of precaution and drug treatment for obesity
MEDICINA CLINICA
Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine
MAYO CLINIC PROCEEDINGS
Hyperthermia-enhanced serotonin (5-HT) depletion resulting from D-fenfluramine exposure is preventable.
LIFE SCIENCES
A new national health agenda: Providing the public with accurate information
JOURNAL OF SOCIAL ISSUES
Prothrombotic mechanisms in primary pulmonary hypertension
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
Anorectic efficacy of the fenfluramine phentermine combination in rats: additivity or synergy?
EUROPEAN JOURNAL OF PHARMACOLOGY
The acute effects of dexfenfluramine on human and porcine pulmonary vascular tone and resistance
CHEST
Prevalence and determinants of valvulopathy in patients treated with dexfenfluramine
CIRCULATION
Measurement of human brain dexfenfluramine concentration by 19F magnetic resonance spectroscopy
BRAIN RESEARCH
Area postrema and the anorectic actions of dexfenfluramine and amylin
BRAIN RESEARCH
Appetite-suppressant drugs and heart valve abnormalities.
ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX
Long-term maintenance of weight loss after a very-low-calorie diet: A randomized blinded trial of the efficacy and tolerability of sibutramine
AMERICAN JOURNAL OF MEDICINE
Metabolic and weight-loss effects of a long-term dietary intervention in obese patients
AMERICAN JOURNAL OF CLINICAL NUTRITION
Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota
AMERICAN JOURNAL OF CARDIOLOGY
The clinical dilemma of anorectic drug use and valvular heart disease
AMERICAN JOURNAL OF CARDIOLOGY
Effects of dopamine and serotonin-releasing agents on methamphetamine discrimination and self-administration in rats
PSYCHOPHARMACOLOGY
AGGRESSIVE WEIGHT-REDUCTION TREATMENT IN THE MANAGEMENT OF TYPE-2 DIABETES
DIABETES & METABOLISM
OUTCOMES OF PHARMACOLOGICAL AND SURGICAL-TREATMENT FOR OBESITY
PharmacoEconomics
IS OBESITY WORTH TREATING IN THE ELDERLY
Drugs & aging
Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
SIBUTRAMINE REDUCES FOOD-INTAKE IN NON-DIETING WOMEN WITH OBESITY
Obesity research
THE PULMONARY HYPERTENSIVE FAWN-HOODED RAT HAS A NORMAL SEROTONIN TRANSPORTER CODING SEQUENCE
American journal of respiratory cell and molecular biology
METABOLISM OF DEXFENFLURAMINE IN HUMAN LIVER-MICROSOMES AND BY RECOMBINANT ENZYMES - ROLE OF CYP2D6 AND 1A2
Pharmacogenetics
THE APPETITE-SUPPRESSANT D-FENFLURAMINE INDUCES APOPTOSIS IN HUMAN SEROTONERGIC CELLS
NeuroReport
ANTIOBESITY DRUGS - WHAT DOES SIBUTRAMINE OFFER - AN ANALYSIS OF ITS POTENTIAL CONTRIBUTION TO OBESITY TREATMENT
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
PATTERNS OF C-FOS EXPRESSION INDUCED BY FLUVOXAMINE ARE DIFFERENT AFTER ACUTE VS. CHRONIC ORAL-ADMINISTRATION
European neuropsychopharmacology
HIGH-INCIDENCE OF PRIMARY PULMONARY-HYPERTENSION ASSOCIATED WITH APPETITE-SUPPRESSANTS IN BELGIUM
The European respiratory journal
NEUROTOXIC EFFECTS OF (+ -)FENFLURAMINE AND PHENTERMINE, ALONE AND INCOMBINATION, ON MONOAMINE NEURONS IN THE MOUSE-BRAIN/
Synapse
COMBINED PHENTERMINE FENFLURAMINE ADMINISTRATION AND CENTRAL SEROTONIN NEURONS/
Synapse
THE COMPARISON OF 4 WEIGHT-REDUCTION STRATEGIES AIMED AT OVERWEIGHT PATIENTS WITH DIABETES-MELLITUS - 4-YEAR FOLLOW-UP
Diabetic medicine