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Experimental regulation of STAT gene expression reveals an involvement of STAT5 in interleukin-4-driven cell proliferation
BIOLOGICAL CHEMISTRY
Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling
GENES TO CELLS
Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation
MOLECULAR BIOLOGY OF THE CELL
Effects of type 2 cytokines on glomerular epithelial cells
EXPERIMENTAL NEPHROLOGY
Direct transfection and activation of human cutaneous dendritic cells
GENE THERAPY
The structure and activity of a monomeric interferon-gamma :alpha-chain receptor signaling complex
STRUCTURE
IL-2-induced tumor necrosis factor (TNF)-beta expression: further analysisin the IL-2 knockout model, and comparison with TNF-alpha, lymphotoxin-beta, TNFR1 and TNFR2 modulation
INTERNATIONAL IMMUNOLOGY
Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression:IL-12 and tumor necrosis factor-alpha synergize for IL-12R expression at low antigen dose
INTERNATIONAL IMMUNOLOGY
Structural and functional hot spots in cytokine receptors
INTERNATIONAL JOURNAL OF HEMATOLOGY
Activation of the transcription factor NF-kappa B by the erythropoietin receptor - Structural requirements and biological significance
CELLULAR SIGNALLING
The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome
LEUKEMIA
Virulence of mousepox virus is independent of serpin-mediated control of cellular cytotoxicity
VIRAL IMMUNOLOGY
New approaches in the treatment of asthma
IMMUNOLOGY AND CELL BIOLOGY
Sulfhydryl-2 domain-containing protein tyrosine phosphatase-1 is not a negative regulator of interleukin-4 signaling in murine mast cells
JOURNAL OF LEUKOCYTE BIOLOGY
A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1 beta 2
JOURNAL OF LEUKOCYTE BIOLOGY
Cytokine receptors and signaling in hepatic stellate cells
SEMINARS IN LIVER DISEASE
Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases
MOLECULAR AND CELLULAR BIOLOGY
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization
MOLECULAR AND CELLULAR BIOLOGY
Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAR pathways
BIOCHEMICAL JOURNAL
Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells
BIOCHEMICAL JOURNAL
STAT1 from the cell membrane to the DNA
EMBO JOURNAL
Biochemical alteration of membrane-associated IL-6 RI (80-kDa) in adherentmacrophages and vascular endothelium
MOLECULAR IMMUNOLOGY
MHC class II beta-chain and alpha IIb beta 3 integrin are expressed on T-cell progenitors in embryonic bone marrow
MOLECULAR IMMUNOLOGY
Mechanisms of antipsychotic-induced weight gain
JOURNAL OF CLINICAL PSYCHIATRY
Genetic dissection of atypical antipsychotic-induced weight gain: Novel preliminary data on the pharmacogenetic puzzle
JOURNAL OF CLINICAL PSYCHIATRY
Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration
CELL
Molecular mechanisms of erythropoietin signaling
NEPHRON
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappa B signalling cascades
NATURE
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Stat1-independent regulation of gene expression in response to IFN-gamma
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Antiviral activities of the soluble extracellular domains of type I interferon receptors
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IL-10 and IL-4 regulate type-I and type-II IL-1 receptors expression on IL-1 beta-activated mouse primary astrocytes
JOURNAL OF NEUROCHEMISTRY
Identification of the domain in the human interleukin-11 receptor that mediates ligand binding
JOURNAL OF MOLECULAR BIOLOGY
High-dose leptin activates human leukocytes via receptor expression on monocytes
JOURNAL OF IMMUNOLOGY
Concomitant inhibition of janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts
JOURNAL OF IMMUNOLOGY
Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22
JOURNAL OF IMMUNOLOGY
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation
JOURNAL OF EXPERIMENTAL MEDICINE
Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of bcl-2
JOURNAL OF EXPERIMENTAL MEDICINE
Interaction of interleukin-6 on human granulosa cell steroid secretion
JOURNAL OF ENDOCRINOLOGY
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
JOURNAL OF CLINICAL INVESTIGATION
Divergent roles of SHP-2 in ERK activation by leptin receptors
JOURNAL OF BIOLOGICAL CHEMISTRY
The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3
JOURNAL OF BIOLOGICAL CHEMISTRY
CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling
JOURNAL OF BIOLOGICAL CHEMISTRY
Activation of estrogen receptor blocks interleukin-6-inducible cell growthof human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PLAS3
JOURNAL OF BIOLOGICAL CHEMISTRY
Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase C delta isrequired for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation
JOURNAL OF BIOLOGICAL CHEMISTRY
The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt
JOURNAL OF BIOLOGICAL CHEMISTRY
A growth signal with an artificially induced erythropoietin receptor-gp130cytoplasmic domain heterodimer
JOURNAL OF BIOCHEMISTRY
Detection of anaphylatoxin receptors on CD83(+) dendritic cells derived from human skin
IMMUNOLOGY
Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form
EUROPEAN JOURNAL OF BIOCHEMISTRY
Expression, crystallization and derivatization of the complete extracellular domain of the beta(c) subunit of the human IL-5, IL-3 and GM-CSF receptors
EUROPEAN JOURNAL OF BIOCHEMISTRY
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
EUROPEAN JOURNAL OF BIOCHEMISTRY
Protein tyrosine phosphatase epsilon C selectively inhibits interleukin-6-and interleukin-10-induced JAK-STAT signaling
BLOOD
Novel targets for interleukin 18 binding protein
ANNALS OF THE RHEUMATIC DISEASES
gamma chain required for naive CD4(+) T cell survival but not for antigen proliferation
NATURE IMMUNOLOGY
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
NATURE IMMUNOLOGY
Interleukin 2 leads to dose-dependent expression of the alpha chain of theIL-2 receptor on CD25-negative T lymphocytes in the absence of exogenous antigenic stimulation
CLINICAL IMMUNOLOGY
The clinical usefulness of the measurement of cytokines
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Cell receptors and cell signalling
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
In vitro analysis of STAT5 activation by granulocyte-macrophage colony-stimulating factor
GENES TO CELLS
Stimulation by interleukin-6 and inhibition by tumor necrosis factor of cortisol release from bovine adrenal zona fasciculata cells through their receptors
ENDOCRINE
Soluble cytokine receptors: novel immunotherapeutic agents
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Mice unresponsive to GM-CSF are unexpectedly resistant to cutaneous Leishmania major infection
MICROBES AND INFECTION
Hematopoietic growth factors and cytokines
JOURNAL OF CLINICAL LIGAND ASSAY
Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6
CLINICAL CANCER RESEARCH
Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function
IMMUNITY
Technical aspects and clinical impact of hematopoietic progenitor subset quantification
STEM CELLS
Expression, purification, and characterization of human recombinant thrombopoietin in Chinese hamster ovary cells
PROTEIN EXPRESSION AND PURIFICATION
Role of the cytoplasmic domains of the type I interferon receptor subunitsin signalling
SEMINARS IN CANCER BIOLOGY
Tumour necrosis factor receptor I (p55) is upregulated on endothelial cells by exposure to the tumour-derived cytokine endothelial monocyte-activating polypeptide II (EMAP-II)
CYTOKINE
Interleukin 8, neutrophil-activating peptide-2 and GRO-alpha bind to and elicit cell activation via specific and different amino acid residues of CXCR2
CYTOKINE
Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): Gene and soluble form of LIF-R, and cytoplasmic domain of LIF-Rrequired for differentiation and growth arrest of myeloid leukemic cells
LEUKEMIA & LYMPHOMA
Genetic and environmental factors contributing to the onset of allergic disorders
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells
MOLECULES AND CELLS
Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation
INTERNATIONAL IMMUNOLOGY
A conditionally-active form of MEK1 results in autocrine transformation ofhuman and mouse hematopoietic cells
ONCOGENE
Control of myeloid differentiation and survival by Stats
ONCOGENE
Serum-soluble c-kit levels during mobilization of peripheral blood stem cells correlate with stem cell yield
INTERNATIONAL JOURNAL OF HEMATOLOGY
STAT-signalling through the cytoplasmic compartment - Consideration of a new paradigm
CELLULAR SIGNALLING
Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway
MOLECULAR ENDOCRINOLOGY
Gene expression profile and identification of differentially expressed transcripts during human intrathymic T-cell development by cDNA sequencing analysis
GENOMICS
The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced bygranulocyte colony-stimulating factor (G-CSF) and modulates signaling fromthe G-CSF receptor
LEUKEMIA
The distribution of receptors for the pro-inflammatory cytokines interleukin (IL)-6 and IL-8 in the developing human fetus
EARLY HUMAN DEVELOPMENT
Exon-intron organization of the human gp130 gene
GENE
Dose-dependent effects of endotoxin on human sleep
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Immunologic therapies in allergic disorders - current aspects
ALLERGOLOGIE
Serum levels of soluble interleukin 6 receptor and soluble gp130 are elevated in patients with localized scleroderma
JOURNAL OF RHEUMATOLOGY
Increased soluble tumor necrosis factor receptor levels in the serum of elderly people
GERONTOLOGY
Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissue
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Signaling mechanisms of cytokine receptors and their perturbances in disease
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Disrupted cortisol-ACTH relationships in elderly women given corticotrophin-releasing hormone two weeks after proximal femur fracture
CLINICAL ENDOCRINOLOGY
The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6
MOLECULAR AND CELLULAR BIOLOGY
The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors
MOLECULAR AND CELLULAR BIOLOGY
Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines
PROSTATE
Flow cytometric detection of growth factor receptors in autografts and analysis of growth factor concentrations in autologous stem cell transplantation: possible significance for platelet recovery
BONE MARROW TRANSPLANTATION
Cross-talk between interleukin 1 beta (IL-1 beta) and IL-6 signalling pathways: IL-1 beta selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism
BIOCHEMICAL JOURNAL
A single amino acid substitution (Trp(666) -> Ala) In the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction
BIOCHEMICAL JOURNAL
Role of growth factors in the regulation of hemopoiesis.
GEMATOLOGIYA I TRANSFUZIOLOGIYA
Increased serum-soluble interleukin-2 receptor in burn patients: Characterization and effects on the immune system
HUMAN IMMUNOLOGY