Le informazioni sugli articoli di fonte ISI sono coperte da copyright

Per ulteriori informazioni selezionare i riferimenti di interesse.

1. Anzenbacher, P; Anzenbacherova, E
   Cytochromes P450 and metabolism of xenobiotics
   CELLULAR AND MOLECULAR LIFE SCIENCES
   
   P. Anzenbacher e E. Anzenbacherova, "Cytochromes P450 and metabolism of xenobiotics", CELL MOL L, 58(5-6), 2001, pp. 737-747
2. Smith, WA; Freeman, JW; Gupta, RC
   Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l] pyrene in the human breast cells MCF-7
   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
   
   W.A. Smith et al., "Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l] pyrene in the human breast cells MCF-7", MUT RES-F M, 480, 2001, pp. 97-108
3. Saranko, CJ; Meyer, KG; Pluta, LJ; Henderson, RF; Recio, L
   Lung-specific mutagenicity and mutational spectrum in B6C3F1 lacI transgenic mice following inhalation exposure to 1,2-epoxybutene
   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
   
   C.J. Saranko et al., "Lung-specific mutagenicity and mutational spectrum in B6C3F1 lacI transgenic mice following inhalation exposure to 1,2-epoxybutene", MUT RES-F M, 473(1), 2001, pp. 37-49
4. Hauford, V; Buchet, JP; Gardinal, S; Ghittori, S; Imbriani, M; Hirvonen, A; Lison, D
   Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene
   BIOMARKERS
   
   V. Hauford et al., "Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene", BIOMARKERS, 6(3), 2001, pp. 236-249
5. Licata, AC; Dekant, W; Smith, CE; Borghoff, SJ
   A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: Implementing sensitivity and variability analyses
   TOXICOLOGICAL SCIENCES
   
   A.C. Licata et al., "A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: Implementing sensitivity and variability analyses", TOXICOL SCI, 62(2), 2001, pp. 191-204
6. Zepnik, H; Pahler, A; Schauer, U; Dekant, W
   Ochratoxin A-induced tumor formation: Is there a role of reactive ochratoxin A metabolites?
   TOXICOLOGICAL SCIENCES
   
   H. Zepnik et al., "Ochratoxin A-induced tumor formation: Is there a role of reactive ochratoxin A metabolites?", TOXICOL SCI, 59(1), 2001, pp. 59-67
7. Caro, AA; Cederbaum, AL; Stoyanovsky, DA
   Oxidation of the ketoxime acetoxime to nitric oxide by oxygen radical-generating systems
   NITRIC OXIDE-BIOLOGY AND CHEMISTRY
   
   A.A. Caro et al., "Oxidation of the ketoxime acetoxime to nitric oxide by oxygen radical-generating systems", NITRIC OXID, 5(4), 2001, pp. 413-424
8. Sieber, V; Martinez, CA; Arnold, FH
   Libraries of hybrid proteins from distantly related sequences
   NATURE BIOTECHNOLOGY
   
   V. Sieber et al., "Libraries of hybrid proteins from distantly related sequences", NAT BIOTECH, 19(5), 2001, pp. 456-460
9. Synold, TW; Dussault, I; Forman, BM
   The orphan nuclear receptor SXR coordinately regulates drug metabolism andefflux
   NATURE MEDICINE
   
   T.W. Synold et al., "The orphan nuclear receptor SXR coordinately regulates drug metabolism andefflux", NAT MED, 7(5), 2001, pp. 584-590
10. Ekins, S; Wrighton, SA
    Application of in silico approaches to predicting drug-drug interactions
    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
    
    S. Ekins e S.A. Wrighton, "Application of in silico approaches to predicting drug-drug interactions", J PHARM TOX, 45(1), 2001, pp. 65-69
11. Wen, Z; Scott, JG
    Cloning of two novel P450 cDNAs from German cockroaches, Blattella germanica (L.): CYP6K1 and CYP6J1
    INSECT MOLECULAR BIOLOGY
    
    Z. Wen e J.G. Scott, "Cloning of two novel P450 cDNAs from German cockroaches, Blattella germanica (L.): CYP6K1 and CYP6J1", INSEC MOL B, 10(2), 2001, pp. 131-137
12. Siegle, I; Fritz, P; Eckhardt, K; Zanger, UM; Eichelbaum, M
    Cellular localization and regional distribution of CYP2D6 mRNA and proteinexpression in human brain
    PHARMACOGENETICS
    
    I. Siegle et al., "Cellular localization and regional distribution of CYP2D6 mRNA and proteinexpression in human brain", PHARMACOGEN, 11(3), 2001, pp. 237-245
13. Corchero, J; Pimprale, S; Kimura, S; Gonzalez, FJ
    Organization of the CYP1A cluster on human chromosome 15: implications forgene regulation
    PHARMACOGENETICS
    
    J. Corchero et al., "Organization of the CYP1A cluster on human chromosome 15: implications forgene regulation", PHARMACOGEN, 11(1), 2001, pp. 1-6
14. Duetz, WA; van Beilen, JB; Witholt, B
    Using proteins in their natural environment: potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis
    CURRENT OPINION IN BIOTECHNOLOGY
    
    W.A. Duetz et al., "Using proteins in their natural environment: potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis", CURR OPIN B, 12(4), 2001, pp. 419-425
15. de Groot, FMH; Damen, EWP; Scheeren, HW
    Anticancer prodrugs for application in monotherapy: Targeting hypoxia, tumor-associated enzymes, and receptors
    CURRENT MEDICINAL CHEMISTRY
    
    F.M.H. de Groot et al., "Anticancer prodrugs for application in monotherapy: Targeting hypoxia, tumor-associated enzymes, and receptors", CURR MED CH, 8(9), 2001, pp. 1093-1122
16. Washio, T; Arisawa, H; Kohsaka, K; Yasuda, H
    Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011
    BIOLOGICAL & PHARMACEUTICAL BULLETIN
    
    T. Washio et al., "Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011", BIOL PHAR B, 24(11), 2001, pp. 1263-1266
17. Testai, E
    The drug-metabolizing enzymatic system and the experimental tools used forin vitro toxicology for metabolic studies
    CELL BIOLOGY AND TOXICOLOGY
    
    E. Testai, "The drug-metabolizing enzymatic system and the experimental tools used forin vitro toxicology for metabolic studies", CELL BIOL T, 17(4), 2001, pp. 271-285
18. Mihara, K; Matsumura, M; Yoshioka, E; Hanada, K; Nakasa, H; Ohmori, S; Kitada, M; Ogata, H
    Intestinal first-pass metabolism of eperisone in the rat
    PHARMACEUTICAL RESEARCH
    
    K. Mihara et al., "Intestinal first-pass metabolism of eperisone in the rat", PHARM RES, 18(8), 2001, pp. 1131-1137
19. Piver, B; Berthou, F; Dreano, Y; Lucas, D
    Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components
    TOXICOLOGY LETTERS
    
    B. Piver et al., "Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components", TOX LETT, 125(1-3), 2001, pp. 83-91
20. Ishii, M; Xu, BQ; Ding, LR; Fischer, NE; Inaba, T
    Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver microsomes of human, hamster and rat
    TOXICOLOGY LETTERS
    
    M. Ishii et al., "Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver microsomes of human, hamster and rat", TOX LETT, 119(3), 2001, pp. 219-225
21. Bournique, B; Lambert, N; Boukaiba, R; Martinet, M
    In vitro metabolism and drug interaction potential of a new highly potent anti-cytomegalovirus molecule, CMV423 (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine 1-carboxamide)
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    
    B. Bournique et al., "In vitro metabolism and drug interaction potential of a new highly potent anti-cytomegalovirus molecule, CMV423 (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine 1-carboxamide)", BR J CL PH, 52(1), 2001, pp. 53-63
22. Yoshimura, R; Ueda, N; Nakamura, J
    Possible relationship between combined plasma concentrations of risperidone plus 9-hydroxyrisperidone and extrapyramidal symptoms - Preliminary study
    NEUROPSYCHOBIOLOGY
    
    R. Yoshimura et al., "Possible relationship between combined plasma concentrations of risperidone plus 9-hydroxyrisperidone and extrapyramidal symptoms - Preliminary study", NEUROPSYCHB, 44(3), 2001, pp. 129-133
23. Walton, K; Dorne, JL; Renwick, AG
    Uncertainty factors for chemical risk assessment: interspecies differencesin the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates
    FOOD AND CHEMICAL TOXICOLOGY
    
    K. Walton et al., "Uncertainty factors for chemical risk assessment: interspecies differencesin the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates", FOOD CHEM T, 39(7), 2001, pp. 667-680
24. DeVane, CL; Nemeroff, CB
    An evaluation of risperidone drug interactions
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
    
    C.L. DeVane e C.B. Nemeroff, "An evaluation of risperidone drug interactions", J CL PSYCH, 21(4), 2001, pp. 408-416
25. Spina, E; Scordo, MG; Avenoso, A; Perucca, E
    Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
    
    E. Spina et al., "Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity", J CL PSYCH, 21(1), 2001, pp. 108-109
26. Bachrich, T; Thalhammer, T; Jager, W; Haslmayer, P; Alihodzic, B; Bakos, S; Hitchman, E; Senderowicz, AM; Penner, E
    Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases
    HEPATOLOGY
    
    T. Bachrich et al., "Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases", HEPATOLOGY, 33(5), 2001, pp. 1053-1059
27. Thatcher, NJ; Murray, S
    Analysis of the glutathione conjugate of paracetamol in human liver microsomal fraction by liquid chromatography mass spectrometry
    BIOMEDICAL CHROMATOGRAPHY
    
    N.J. Thatcher e S. Murray, "Analysis of the glutathione conjugate of paracetamol in human liver microsomal fraction by liquid chromatography mass spectrometry", BIOMED CHRO, 15(6), 2001, pp. 374-378
28. Lewis, DFV
    COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics
    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
    
    D.F.V. Lewis, "COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics", J CHEM TECH, 76(3), 2001, pp. 237-244
29. Stevenson, TH; Gutierrez, AF; Alderton, WK; Lian, LY; Scrutton, NS
    Kinetics of CO binding to the haem domain of murine inducible nitric oxidesynthase: differential effects of haem domain ligands
    BIOCHEMICAL JOURNAL
    
    T.H. Stevenson et al., "Kinetics of CO binding to the haem domain of murine inducible nitric oxidesynthase: differential effects of haem domain ligands", BIOCHEM J, 358, 2001, pp. 201-208
30. Ponsoda, X; Pareja, E; Gomez-Lechon, MJ; Fabra, R; Carrasco, E; Trullenque, R; Castell, JV
    Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor
    JOURNAL OF HEPATOLOGY
    
    X. Ponsoda et al., "Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor", J HEPATOL, 34(1), 2001, pp. 19-25
31. Vigano, L; Locatelli, A; Grasselli, G; Gianni, L
    Drug interactions of paclitaxel and docetaxel and their relevance for the design of combination therapy
    INVESTIGATIONAL NEW DRUGS
    
    L. Vigano et al., "Drug interactions of paclitaxel and docetaxel and their relevance for the design of combination therapy", INV NEW DR, 19(2), 2001, pp. 179-196
32. Spina, E; Avenoso, A; Facciola, G; Scordo, MG; Ancione, M; Madia, A
    Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine
    THERAPEUTIC DRUG MONITORING
    
    E. Spina et al., "Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine", THER DRUG M, 23(3), 2001, pp. 223-227
33. Le Ferrec, E; Ilyin, G; Maheo, K; Bardiau, C; Courtois, A; Guillouzo, A; Morel, F
    Differential effects of oltipraz on CYP1A and CYP2B in rat lung
    CARCINOGENESIS
    
    E. Le Ferrec et al., "Differential effects of oltipraz on CYP1A and CYP2B in rat lung", CARCINOGENE, 22(1), 2001, pp. 49-55
34. Dyck, LE; Davis, BA
    Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine
    DRUG METABOLISM AND DISPOSITION
    
    L.E. Dyck e B.A. Davis, "Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine", DRUG META D, 29(8), 2001, pp. 1156-1161
35. Lampen, A; Meyer, S; Nau, H
    Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cells
    DRUG METABOLISM AND DISPOSITION
    
    A. Lampen et al., "Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic acid in intestinal cells", DRUG META D, 29(5), 2001, pp. 742-747
36. Loadman, PM; Swaine, DJ; Bibby, MC; Welham, KJ; Patterson, LH
    A preclinical pharmacokinetic study of the bioreductive drug AQ4N
    DRUG METABOLISM AND DISPOSITION
    
    P.M. Loadman et al., "A preclinical pharmacokinetic study of the bioreductive drug AQ4N", DRUG META D, 29(4), 2001, pp. 422-426
37. Hesse, LM; Venkatakrishnan, K; Von Moltke, LL; Shader, RI; Greenblatt, DJ
    CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam
    DRUG METABOLISM AND DISPOSITION
    
    L.M. Hesse et al., "CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam", DRUG META D, 29(2), 2001, pp. 133-140
38. Yasui-Furukori, N; Hidestrand, M; Spina, E; Facciola, G; Scordo, MG; Tybring, G
    Different enantioselective 9-hydroxylation of risperidone by the two humanCYP2D6 and CYP3A4 enzymes
    DRUG METABOLISM AND DISPOSITION
    
    N. Yasui-Furukori et al., "Different enantioselective 9-hydroxylation of risperidone by the two humanCYP2D6 and CYP3A4 enzymes", DRUG META D, 29(10), 2001, pp. 1263-1268
39. Vickers, AEM; Zollinger, M; Dannecker, R; Tynes, R; Heitz, F; Fischer, V
    In vitro metabolism of tegaserod in human liver and intestine: Assessment of drug interactions
    DRUG METABOLISM AND DISPOSITION
    
    A.E.M. Vickers et al., "In vitro metabolism of tegaserod in human liver and intestine: Assessment of drug interactions", DRUG META D, 29(10), 2001, pp. 1269-1276
40. Weaver, RJ
    Assessment of drug-drug interactions concepts and approaches
    XENOBIOTICA
    
    R.J. Weaver, "Assessment of drug-drug interactions concepts and approaches", XENOBIOTICA, 31(8-9), 2001, pp. 499-538
41. Hoskins, J; Shenfield, G; Murray, M; Gross, A
    Characterization of moclobemide N-oxidation in human liver microsomes
    XENOBIOTICA
    
    J. Hoskins et al., "Characterization of moclobemide N-oxidation in human liver microsomes", XENOBIOTICA, 31(7), 2001, pp. 387-397
42. Renwick, AB; Lewis, DFV; Fulford, S; Surry, D; Williams, B; Worboys, PD; Cai, X; Wang, RW; Price, RJ; Lake, BG; Evans, DC
    Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4
    XENOBIOTICA
    
    A.B. Renwick et al., "Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4", XENOBIOTICA, 31(4), 2001, pp. 187-204
43. Bai, S; Brunner, LJ; Stepkowski, SM; Napoli, KL; Kahan, BD
    Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat
    TRANSPLANTATION
    
    S. Bai et al., "Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat", TRANSPLANT, 71(11), 2001, pp. 1585-1592
44. Kappers, WA; Edwards, RJ; Murray, S; Boobis, AR
    Diazinon is activated by CYP2C19 in human liver
    TOXICOLOGY AND APPLIED PHARMACOLOGY
    
    W.A. Kappers et al., "Diazinon is activated by CYP2C19 in human liver", TOX APPL PH, 177(1), 2001, pp. 68-76
45. Bak, S; Feyereisen, R
    The involvement of two P450 enzymes, CYP83B1 and CYP83A1, in auxin homeostasis and glucosinolate biosynthesis
    PLANT PHYSIOLOGY
    
    S. Bak e R. Feyereisen, "The involvement of two P450 enzymes, CYP83B1 and CYP83A1, in auxin homeostasis and glucosinolate biosynthesis", PLANT PHYSL, 127(1), 2001, pp. 108-118
46. Pauli-Magnus, C; Rekersbrink, S; Klotz, U; Fromm, MF
    Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
    
    C. Pauli-Magnus et al., "Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein", N-S ARCH PH, 364(6), 2001, pp. 551-557
47. Holla, VR; Adas, F; Imig, JD; Zhao, XY; Price, E; Olsen, N; Kovacs, WJ; Magnuson, MA; Keeney, DS; Breyer, MD; Falck, JR; Waterman, MR; Capdevila, JH
    Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    V.R. Holla et al., "Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension", P NAS US, 98(9), 2001, pp. 5211-5216
48. Yoshinari, K; Sueyoshi, T; Moore, R; Negishi, M
    Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYP2B1 gene by phenobarbital in rat livers
    MOLECULAR PHARMACOLOGY
    
    K. Yoshinari et al., "Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYP2B1 gene by phenobarbital in rat livers", MOLEC PHARM, 59(2), 2001, pp. 278-284
49. Vernia, S; Beaune, P; Coloma, J; Lopez-Garcia, MP
    Differential sensitivity of rat hepatocyte CYP isoforms to self-generated nitric oxide
    FEBS LETTERS
    
    S. Vernia et al., "Differential sensitivity of rat hepatocyte CYP isoforms to self-generated nitric oxide", FEBS LETTER, 488(1-2), 2001, pp. 59-63
50. Boek-Dohalska, L; Hodek, P; Sulc, M; Stiborova, M
    alpha-naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6
    CHEMICO-BIOLOGICAL INTERACTIONS
    
    L. Boek-Dohalska et al., "alpha-naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6", CHEM-BIO IN, 138(1), 2001, pp. 85-106
51. Himmelstein, MW; Carpenter, SC; Hinderliter, PM; Snow, TA; Valentine, R
    The metabolism of beta-chloroprene: preliminary in-vitro studies using liver microsomes
    CHEMICO-BIOLOGICAL INTERACTIONS
    
    M.W. Himmelstein et al., "The metabolism of beta-chloroprene: preliminary in-vitro studies using liver microsomes", CHEM-BIO IN, 135, 2001, pp. 267-284
52. Lu, C; Li, AP
    Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog
    CHEMICO-BIOLOGICAL INTERACTIONS
    
    C. Lu e A.P. Li, "Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog", CHEM-BIO IN, 134(3), 2001, pp. 271-281
53. Dupuy, J; Larrieu, G; Braun, J; Alvinerie, M; Galtier, P
    Differential effects of phenobarbital on the constitutive and inducible expression of P4502B and 3A subfamilies in sheep tissues
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
    
    J. Dupuy et al., "Differential effects of phenobarbital on the constitutive and inducible expression of P4502B and 3A subfamilies in sheep tissues", CAN J PHYSL, 79(10), 2001, pp. 848-853
54. Miyata, N; Taniguchi, K; Seki, T; Ishimoto, T; Sato-Watanabe, M; Yasuda, Y; Doi, M; Kametani, S; Tomishima, Y; Ueki, T; Sato, M; Kameo, K
    HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme
    BRITISH JOURNAL OF PHARMACOLOGY
    
    N. Miyata et al., "HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme", BR J PHARM, 133(3), 2001, pp. 325-329
55. Gonzalez, MC; Marteau, C; Franchi, J; Migliore-Samour, D
    Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation
    BRITISH JOURNAL OF DERMATOLOGY
    
    M.C. Gonzalez et al., "Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation", BR J DERM, 145(5), 2001, pp. 749-757
56. Schoedel, KA; Sellers, EM; Tyndale, RF
    Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain
    BIOCHEMICAL PHARMACOLOGY
    
    K.A. Schoedel et al., "Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain", BIOCH PHARM, 62(8), 2001, pp. 1025-1036
57. Gilmore, J; Rotondo, F; Pelletier, AM; LaMarre, J; Alaoui-Jamali, M; Kirby, GM
    Identification of a 43-kDa protein in human liver cytosol that binds to the 3 '-untranslated region of CYP2A6 mRNA
    BIOCHEMICAL PHARMACOLOGY
    
    J. Gilmore et al., "Identification of a 43-kDa protein in human liver cytosol that binds to the 3 '-untranslated region of CYP2A6 mRNA", BIOCH PHARM, 62(6), 2001, pp. 669-678
58. Long, L; Moschel, RC; Dolan, ME
    Debenzylation of O-6-benzyl-8-oxoguanine in human liver: implications for O-6-benzylguanine metabolism
    BIOCHEMICAL PHARMACOLOGY
    
    L. Long et al., "Debenzylation of O-6-benzyl-8-oxoguanine in human liver: implications for O-6-benzylguanine metabolism", BIOCH PHARM, 61(6), 2001, pp. 721-726
59. Murray, BP; Correia, MA
    Ubiquitin-dependent 26S proteasomal pathway: A role in the degradation of native human liver CYP3A4 expressed in Saccharomyces cerevisiae?
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
    
    B.P. Murray e M.A. Correia, "Ubiquitin-dependent 26S proteasomal pathway: A role in the degradation of native human liver CYP3A4 expressed in Saccharomyces cerevisiae?", ARCH BIOCH, 393(1), 2001, pp. 106-116
60. Lobaccaro, JMA; Repa, JJ; Lu, TT; Caira, F; Henry-Berger, J; Volle, DH; Mangelsdorf, DJ
    Regulation of lipid metabolism by the orphan nuclear receptors
    ANNALES D ENDOCRINOLOGIE
    
    J.M.A. Lobaccaro et al., "Regulation of lipid metabolism by the orphan nuclear receptors", ANN ENDOCR, 62(4), 2001, pp. 239-247
61. Spina, E; Avenoso, A; Facciola, G; Salemi, M; Scordo, MG; Ancione, M; Madia, AG; Perucca, E
    Relationship between plasma risperidone and 9-hydroxyrisperidone concentrations and clinical response in patients with schizophrenia
    PSYCHOPHARMACOLOGY
    
    E. Spina et al., "Relationship between plasma risperidone and 9-hydroxyrisperidone concentrations and clinical response in patients with schizophrenia", PSYCHOPHAR, 153(2), 2001, pp. 238-243
62. Clemente, MG; De Virgiliis, S
    Autoantigen characterization in liver/kidney microsome positive hepatitis
    DIGESTIVE AND LIVER DISEASE
    
    M.G. Clemente e S. De Virgiliis, "Autoantigen characterization in liver/kidney microsome positive hepatitis", DIG LIVER D, 32(1), 2000, pp. 39-45
63. Amet, Y; Plee-Gautier, E; Berthou, F; Adas, F; French, SW
    Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes
    EUROPEAN JOURNAL OF NUTRITION
    
    Y. Amet et al., "Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes", EUR J NUTR, 39(6), 2000, pp. 270-276
64. Vadon-Le Goff, S; Boucher, JL; Mansuy, D
    Oxidation of arylamidoximes by various chemical and biomimetic systems: comparison with their oxidations by hemeproteins
    COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
    
    S. Vadon-Le Goff et al., "Oxidation of arylamidoximes by various chemical and biomimetic systems: comparison with their oxidations by hemeproteins", CR AC S IIC, 3(10), 2000, pp. 785-792
65. Chiapella, C; Radovan, RD; Moreno, JA; Casares, L; Barbe, J; Llagostera, M
    Plant activation of aromatic amines mediated by cytochromes P450 and flavin-containing monooxygenases
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    
    C. Chiapella et al., "Plant activation of aromatic amines mediated by cytochromes P450 and flavin-containing monooxygenases", MUT RES-GTE, 470(2), 2000, pp. 155-160
66. Celander, MC; Moore, MJ; Stegeman, JJ
    Cellular localization of CYP3A proteins in various tissues from pilot whale (Globicephala melas)
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
    
    M.C. Celander et al., "Cellular localization of CYP3A proteins in various tissues from pilot whale (Globicephala melas)", ENV TOX PH, 8(4), 2000, pp. 245-253
67. Williams, TM; Borghoff, SJ
    Induction of testosterone biotransformation enzymes following oral administration of methyl tert-butyl ether to male Sprague-Dawley rats
    TOXICOLOGICAL SCIENCES
    
    T.M. Williams e S.J. Borghoff, "Induction of testosterone biotransformation enzymes following oral administration of methyl tert-butyl ether to male Sprague-Dawley rats", TOXICOL SCI, 57(1), 2000, pp. 147-155
68. Wu, D; Wang, XB; Chen, DF; Niu, TH; Ni, JT; Liu, X; Xu, XP
    Metabolic gene polymorphisms and risk of dysmenorrhea
    EPIDEMIOLOGY
    
    D. Wu et al., "Metabolic gene polymorphisms and risk of dysmenorrhea", EPIDEMIOLOG, 11(6), 2000, pp. 648-653
69. Sarmanova, J; Tynkova, L; Susova, S; Gut, I; Soucek, P
    Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic
    PHARMACOGENETICS
    
    J. Sarmanova et al., "Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic", PHARMACOGEN, 10(9), 2000, pp. 781-788
70. Paulussen, A; Lavrijsen, K; Bohets, H; Hendrickx, J; Verhasselt, P; Luyten, W; Konings, F; Armstrong, M
    Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans
    PHARMACOGENETICS
    
    A. Paulussen et al., "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans", PHARMACOGEN, 10(5), 2000, pp. 415-424
71. Nwankwo, JO; Tahnteng, JG; Emerole, GO
    Inhibition of aflatoxin B1 genotoxicity in human liver-derived HepG2 cellsby kolaviron biflavonoids and molecular mechanisms of action
    EUROPEAN JOURNAL OF CANCER PREVENTION
    
    J.O. Nwankwo et al., "Inhibition of aflatoxin B1 genotoxicity in human liver-derived HepG2 cellsby kolaviron biflavonoids and molecular mechanisms of action", EUR J CAN P, 9(5), 2000, pp. 351-361
72. De Rienzo, F; Fanelli, F; Menziani, MC; De Benedetti, PG
    Theoretical investigation of substrate specificity for cytochromes p450 IA2, p450 IID6 and p450 IIIA4
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    
    F. De Rienzo et al., "Theoretical investigation of substrate specificity for cytochromes p450 IA2, p450 IID6 and p450 IIIA4", J COMPUT A, 14(1), 2000, pp. 93-116
73. Ramirez, FC
    Diagnosis and treatment of gastroesophageal reflux disease in the elderly
    CLEVELAND CLINIC JOURNAL OF MEDICINE
    
    F.C. Ramirez, "Diagnosis and treatment of gastroesophageal reflux disease in the elderly", CLEV CLIN J, 67(10), 2000, pp. 755-765
74. Belle, DJ; Ring, BJ; Allerheiligen, SRB; Heathman, MA; O'Brien, LM; Sinha, V; Roskos, LK; Wrighton, SA
    A population approach to enzyme characterization and identification: Application to phenacetin O-deethylation
    PHARMACEUTICAL RESEARCH
    
    D.J. Belle et al., "A population approach to enzyme characterization and identification: Application to phenacetin O-deethylation", PHARM RES, 17(12), 2000, pp. 1531-1536
75. Boyle, SP; Craft, JA
    The effect of gender, sexual maturation and xenobiotic treatment on the formation of hydroxymethyl metabolites from 7,12-dimethylbenz[a]anthracene inrat liver microsomes
    TOXICOLOGY LETTERS
    
    S.P. Boyle e J.A. Craft, "The effect of gender, sexual maturation and xenobiotic treatment on the formation of hydroxymethyl metabolites from 7,12-dimethylbenz[a]anthracene inrat liver microsomes", TOX LETT, 117(1-2), 2000, pp. 1-9
76. Skaare, JU; Bernhoft, A; Derocher, A; Gabrielsen, GW; Goksoyr, A; Henriksen, E; Larsen, HJ; Lie, E; Wiig, O
    Organochlorines in top predators at Svalbard - occurrence, levels and effects
    TOXICOLOGY LETTERS
    
    J.U. Skaare et al., "Organochlorines in top predators at Svalbard - occurrence, levels and effects", TOX LETT, 112, 2000, pp. 103-109
77. Michalets, EL; Williams, CR
    Drug interactions with cisapride - Clinical implications
    CLINICAL PHARMACOKINETICS
    
    E.L. Michalets e C.R. Williams, "Drug interactions with cisapride - Clinical implications", CLIN PHARMA, 39(1), 2000, pp. 49-75
78. Caccia, S
    Biotransformation of post-clozapine antipsychotics - Pharmacological implications
    CLINICAL PHARMACOKINETICS
    
    S. Caccia, "Biotransformation of post-clozapine antipsychotics - Pharmacological implications", CLIN PHARMA, 38(5), 2000, pp. 393-414
79. Westphal, JF
    Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    
    J.F. Westphal, "Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin", BR J CL PH, 50(4), 2000, pp. 285-295
80. Hashemi, E; Till, C; Ioannides, C
    Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices
    TOXICOLOGY
    
    E. Hashemi et al., "Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices", TOXICOLOGY, 149(2-3), 2000, pp. 51-61
81. Lewis, DFV
    Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles
    TOXICOLOGY
    
    D.F.V. Lewis, "Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles", TOXICOLOGY, 144(1-3), 2000, pp. 197-203
82. Wiseman, A; Lewis, DFV; Ridgway, T; Wiseman, H
    Cytochromes P450 enzymes for clean food-processing: limitations of imitations!
    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
    
    A. Wiseman et al., "Cytochromes P450 enzymes for clean food-processing: limitations of imitations!", J CHEM TECH, 75(1), 2000, pp. 3-5
83. Genter, MB; Burman, DM; Dingeldein, MW; Clough, I; Bolon, B
    Evolution of alachlor-induced nasal neoplasms in the Long-Evans rat
    TOXICOLOGIC PATHOLOGY
    
    M.B. Genter et al., "Evolution of alachlor-induced nasal neoplasms in the Long-Evans rat", TOX PATHOL, 28(6), 2000, pp. 770-781
84. Spina, E; Avenoso, A; Facciola, G; Salemi, M; Scordo, MG; Giacobello, T; Madia, AG; Perucca, E
    Plasma concentrations of risperidone and 9-hydroxyrisperidone: Effect of comedication with carbamazepine or valproate
    THERAPEUTIC DRUG MONITORING
    
    E. Spina et al., "Plasma concentrations of risperidone and 9-hydroxyrisperidone: Effect of comedication with carbamazepine or valproate", THER DRUG M, 22(4), 2000, pp. 481-485
85. Tucker, GT
    Advances in understanding drug metabolism and its contribution to variability in patient response
    THERAPEUTIC DRUG MONITORING
    
    G.T. Tucker, "Advances in understanding drug metabolism and its contribution to variability in patient response", THER DRUG M, 22(1), 2000, pp. 110-113
86. Ma, B; Prueksaritanont, T; Lin, JH
    Drug interactions with calcium channel blockers: Possible involvement of metabolite-intermediate complexation with CYP3A
    DRUG METABOLISM AND DISPOSITION
    
    B. Ma et al., "Drug interactions with calcium channel blockers: Possible involvement of metabolite-intermediate complexation with CYP3A", DRUG META D, 28(2), 2000, pp. 125-130
87. Miksys, S; Rao, Y; Sellers, EM; Kwan, M; Mendis, D; Tyndale, RF
    Regional and cellular distribution of CYP2D subfamily members in rat brain
    XENOBIOTICA
    
    S. Miksys et al., "Regional and cellular distribution of CYP2D subfamily members in rat brain", XENOBIOTICA, 30(6), 2000, pp. 547-564
88. Henderson, MC; Miranda, CL; Stevens, JF; Deinzer, ML; Buhler, DR
    In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
    XENOBIOTICA
    
    M.C. Henderson et al., "In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus", XENOBIOTICA, 30(3), 2000, pp. 235-251
89. Moran, JH; Mitchell, LA; Bradbury, JA; Qu, W; Zeldin, DC; Schnellmann, RG; Grant, DF
    Analysis of the cytotoxic properties of linoleic acid metabolites producedby renal and hepatic P450s
    TOXICOLOGY AND APPLIED PHARMACOLOGY
    
    J.H. Moran et al., "Analysis of the cytotoxic properties of linoleic acid metabolites producedby renal and hepatic P450s", TOX APPL PH, 168(3), 2000, pp. 268-279
90. Gu, J; Su, T; Chen, Y; Zhang, QY; Ding, XX
    Expression of biotransformation enzymes in human fetal olfactory mucosa: Potential roles in developmental toxicity
    TOXICOLOGY AND APPLIED PHARMACOLOGY
    
    J. Gu et al., "Expression of biotransformation enzymes in human fetal olfactory mucosa: Potential roles in developmental toxicity", TOX APPL PH, 165(2), 2000, pp. 158-162
91. Sinclair, PR; Gorman, N; Walton, HS; Bement, WJ; Dalton, TP; Sinclair, JF; Smith, AG; Nebert, DW
    CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene andiron
    TOXICOLOGY AND APPLIED PHARMACOLOGY
    
    P.R. Sinclair et al., "CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene andiron", TOX APPL PH, 162(1), 2000, pp. 60-67
92. Ahmad, M; Nicholls, PJ; Smith, HJ; Ahmadi, M
    Effect of P450 isozyme-selective inhibitors on in-vitro metabolism of retinoic acid by rat hepatic microsomes
    JOURNAL OF PHARMACY AND PHARMACOLOGY
    
    M. Ahmad et al., "Effect of P450 isozyme-selective inhibitors on in-vitro metabolism of retinoic acid by rat hepatic microsomes", J PHARM PHA, 52(3), 2000, pp. 311-314
93. Katiyar, SK; Matsui, MS; Mukhtar, H
    Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1
    JOURNAL OF INVESTIGATIVE DERMATOLOGY
    
    S.K. Katiyar et al., "Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1", J INVES DER, 114(2), 2000, pp. 328-333
94. Noguchi, S; Jianmongkol, S; Bender, AT; Kamada, Y; Demady, DR; Osawa, Y
    Guanabenz-mediated inactivation and enhanced proteolytic degradation of neuronal nitric-oxide synthase
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    S. Noguchi et al., "Guanabenz-mediated inactivation and enhanced proteolytic degradation of neuronal nitric-oxide synthase", J BIOL CHEM, 275(4), 2000, pp. 2376-2380
95. Huel, G; Campagna, D; Girard, F; Moreau, T; Blot, P
    Does selenium reduce the risk of threatened preterm delivery associated with placental cytochrome P450-1A1 activity?
    ENVIRONMENTAL RESEARCH
    
    G. Huel et al., "Does selenium reduce the risk of threatened preterm delivery associated with placental cytochrome P450-1A1 activity?", ENVIR RES, 84(3), 2000, pp. 228-231
96. Skalova, L; Nobilis, M; Szotakova, B; Wsol, V; Kubicek, V; Baliharova, V; Kvasnickova, E
    Effect of substituents on microsomal reduction of benzo(c)fluorene N-oxides
    CHEMICO-BIOLOGICAL INTERACTIONS
    
    L. Skalova et al., "Effect of substituents on microsomal reduction of benzo(c)fluorene N-oxides", CHEM-BIO IN, 126(3), 2000, pp. 185-200
97. Longo, V; Amato, G; Salvetti, A; Gervasi, PG
    Heterogenous effects of anthraquinones on drug-metabolizing enzymes in theliver and small intestine of rat
    CHEMICO-BIOLOGICAL INTERACTIONS
    
    V. Longo et al., "Heterogenous effects of anthraquinones on drug-metabolizing enzymes in theliver and small intestine of rat", CHEM-BIO IN, 126(1), 2000, pp. 63-77
98. Silva, ID; Gaspar, J; da Costa, GG; Rodrigues, AS; Laires, A; Rueff, J
    Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents
    CHEMICO-BIOLOGICAL INTERACTIONS
    
    I.D. Silva et al., "Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents", CHEM-BIO IN, 124(1), 2000, pp. 29-51
99. Borek-Dohalska, L; Stiborova, M
    Texanes - Anticancer drug with unique mechanism of action
    CHEMICKE LISTY
    
    L. Borek-Dohalska e M. Stiborova, "Texanes - Anticancer drug with unique mechanism of action", CHEM LISTY, 94(4), 2000, pp. 226-229
100. Zalma, A; von Moltke, LL; Granda, BW; Harmatz, JS; Shader, RI; Greenblatt, DJ
     In vitro metabolism of trazodone by CYP3A: Inhibition by ketoconazole and human immunodeficiency viral protease inhibitors
     BIOLOGICAL PSYCHIATRY
     
     A. Zalma et al., "In vitro metabolism of trazodone by CYP3A: Inhibition by ketoconazole and human immunodeficiency viral protease inhibitors", BIOL PSYCHI, 47(7), 2000, pp. 655-661