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Simvastatina. Una maggiorenne di belle speranze: tra clinica ed economia sanitaria
Farmeconomia e percorsi terapeutici
Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering
BIOTECHNOLOGY PROGRESS
Evaluation of theophylline-stimulated changes in carnitine palmitoyltransferase activity in skeletal muscle and liver of rats
JOURNAL OF ENZYME INHIBITION
Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle
JOURNAL OF APPLIED PHYSIOLOGY
Alterations in enzymes involved in fat metabolism after acute and chronic altitude exposure
JOURNAL OF APPLIED PHYSIOLOGY
The tetratricopeptide repeat domains of human, tobacco, and nematode PEX5 proteins are functionally interchangeable with the analogous native domain for peroxisomal import of PTS1-terminated proteins in yeast
MOLECULAR GENETICS AND GENOMICS
Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in melon (Cucumis melo L. reticulatus)
MOLECULAR GENETICS AND GENOMICS
The complex clinical and genetic classification of inherited ataxias. II. Autosomal recessive ataxias
NEUROLOGICAL SCIENCES
Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors
INTERNATIONAL IMMUNOPHARMACOLOGY
Mechanisms of acute coronary syndromes and the potential role of statins
ATHEROSCLEROSIS SUPPLEMENTS
Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
EXPERIMENTAL BIOLOGY AND MEDICINE
Enantioselective synthesis of spiropentanes from hydroxymethylallenes
ORGANIC LETTERS
Properties of firefly luciferase immobilized through a biotin carboxyl carrier protein domain
LUMINESCENCE
Emerging therapies in osteoporosis
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Unhealthy ageing: functional and socioeconomic impact
EUROPEAN HEART JOURNAL SUPPLEMENTS
Healthy ageing: ageing safely
EUROPEAN HEART JOURNAL SUPPLEMENTS
Healthy ageing: addressing acute coronary syndrome?
EUROPEAN HEART JOURNAL SUPPLEMENTS
Dementia at old age: a clinical end-point of atherosclerotic disease
EUROPEAN HEART JOURNAL SUPPLEMENTS
Vascular inflammation and activation: new targets for lipid lowering
EUROPEAN HEART JOURNAL SUPPLEMENTS
Distorted square planar nickel(II) carbonyl complexes containing terminal thiolate/selenolate ligands
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
Multidrug permeases and subcellular cholesterol transport
NATURE REVIEWS MOLECULAR CELL BIOLOGY
The life cycle of the peroxisome
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
NATURE CELL BIOLOGY
Therapeutic considerations for postprandial dyslipidaemia
DIABETES OBESITY & METABOLISM
Genetically engineered Pseudomonas: a factory of new bioplastics with broad applications
ENVIRONMENTAL MICROBIOLOGY
Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Catalysis by mutants of methylmalonyl-CoA mutase: A theoretical rationalization for a change in the rate-determining step
CHEMBIOCHEM
A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation
CHEMBIOCHEM
Biosynthesis and regulation of fatty acids and triglycerides in oil seed rape. Current status and future trends
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
Desaturases fused to their electron donor
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
Autocatalytic radical ring opening of N-cyclopropyl-N-phenylamines under aerobic conditions - Exclusive formation of the unknown oxygen adducts, N-(1,2-dioxolan-3-yl)-N-phenylamines
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Synthesis of fluorogypsetin and fluorobrevianamide E by a novel fluorination - Cyclization of cyclo-L-Trp-L-AAs
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Radical shuttling in a protein: Ribose pseudorotation controls alkyl-radical transfer in the coenzyme B-12 dependent enzyme glutamate mutase
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Comparison of magnetic and thermal properties of prismane and double-cubane [Fe6S6](4+) superclusters
THEORETICAL CHEMISTRY ACCOUNTS
An overview of endosymbiotic models for the origins of eukaryotes, their ATP-producing organelles (mitochondria and hydrogenosomes), and their heterotrophic lifestyle
BIOLOGICAL CHEMISTRY
PTS2 protein import into mammalian peroxisomes
TRAFFIC
Regulation of organelle membrane fusion by Pkc1p
TRAFFIC
A novel ATP regeneration system using polyphosphate-AMP phosphotransferaseand polyphosphate kinase
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Degradation of conjugated linoleic acid isomers in the yeast Saccharomycescerevisiae
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Acyl-CoA elongase expression during seed development in Brassica napus
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Production of acetate in the liver and its utilization in peripheral tissues
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
The use of Pseudomonas acyl-CoA synthetase to form acyl-CoAs from dicarboxylic fatty acids
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Active-site residues of a plant membrane-bound fatty acid elongase beta-ketoacyl-CoA synthase, FAE1 KCS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection
JOURNAL OF CHROMATOGRAPHY B
Clinical applications of tandem mass spectrometry: ten years of diagnosis and screening for inherited metabolic diseases
JOURNAL OF CHROMATOGRAPHY B
Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry
JOURNAL OF CHROMATOGRAPHY B
Headspace solid-phase microextraction profiling of volatile compounds in urine: application to metabolic investigations
JOURNAL OF CHROMATOGRAPHY B
Recent progress in the synthesis of zaragozic acids and analogs
CURRENT ORGANIC CHEMISTRY
Statins and bone formation
CURRENT PHARMACEUTICAL DESIGN
Lipase enhanced catalytic efficiency in lactonisation reactions
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
The apicoplast as an antimalarial drug target
DRUG RESISTANCE UPDATES
A cost-effectiveness model of alternative statins to achieve target LDL-cholesterol levels
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Is a statin a statin?
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Adenosylcobalamin-dependent isomerases: new insights into structure and mechanism
CURRENT OPINION IN CHEMICAL BIOLOGY
Using model-system genetics for drug-based target discovery
DRUG DISCOVERY TODAY
Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease
DRUG DISCOVERY TODAY
The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Incorporation of 1-C-14 linoleic acid in rat liver nuclei and chromatin fractions
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Dietary biotin requirement determined for Indian catfish, Heteropneustes fossilis (Bloch), fingerlings
AQUACULTURE RESEARCH
Statins: new drugs for treating osteoporosis?
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Novel agents for managing dyslipidaemia
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Statins and neuroprotection
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Glucose-6-phosphatase inhibitors for the treatment of Type 2 diabetes
EXPERT OPINION ON THERAPEUTIC PATENTS
Update on the role of acyl-CoA : cholesterol acyltransferase inhibitors inatherosclerosis
EXPERT OPINION ON THERAPEUTIC PATENTS
Effects of fluvastatin on cardiac events in renal transplant patients: ALERT (Assessment of Lescol (R) in Renal Transplantation) study design and baseline data
JOURNAL OF CARDIOVASCULAR RISK
The in-vitro influence of serum amyloid A isoforms on enzymes that regulate the balance between esterified and un-esterified cholesterol
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism
MICROBIOLOGY-SGM
cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG
MICROBIOLOGY-SGM
Pyruvate oxidase contributes to the aerobic growth efficiency of Escherichia coli
MICROBIOLOGY-SGM
A new simvastatin (mevinolin)-resistance marker from Haloarcula hispanica and a new Haloferax volcanii strain cured of plasmid pHV2
MICROBIOLOGY-UK
Myocardial energy metabolism and diabetes
DIABETES & METABOLISM
Insulin sensitivity and lipids
DIABETES & METABOLISM
Metabolism and the functions of myristic acid
OCL-OLEAGINEUX CORPS GRAS LIPIDES
Variable plasma/liver and tissue esterase hydrolysis of simvastatin in healthy volunteers after a single oral dose
CLINICAL DRUG INVESTIGATION
Comparison of the efficacy, safety and tolerability of policosanol versus fluvastatin in elderly hypercholesterolaemic women
CLINICAL DRUG INVESTIGATION
Do statins afford neuroprotection in patients with cerebral ischaemia and stroke?
CNS DRUGS
How well tolerated are lipid-lowering drugs?
DRUGS & AGING
Arginine 387 of human isovaleryl-CoA dehydrogenase plays a crucial role insubstrate/product binding
MOLECULAR GENETICS AND METABOLISM
Structure of the PCCA gene and distribution of mutations causing propionicacidemia
MOLECULAR GENETICS AND METABOLISM
Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy
MOLECULAR GENETICS AND METABOLISM
Impaired mitochondrial fatty acid oxidative flux in fibroblasts from a patient with malonyl-CoA decarboxylase deficiency
MOLECULAR GENETICS AND METABOLISM
Molecular and enzymatic characterization of a unique carnitine palmitoyltransferase 1A mutation in the Hutterite community
MOLECULAR GENETICS AND METABOLISM
Mutation analysis of the MCM gene in Israeli patients with mut(0) disease
MOLECULAR GENETICS AND METABOLISM
Impaired arachidonic (20 : 4n-6) and docosahexaenoic (22 : 6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria
MOLECULAR GENETICS AND METABOLISM
The clinical phenotype and outcome of mitochondrial acetoacetyl-CoA thiolase deficiency (beta-ketothiolase or T2 deficiency) in 26 enzymatically proved and mutation-defined patients
MOLECULAR GENETICS AND METABOLISM
A novel single-base substitution (380C > T) that activates a 5-base downstream cryptic splice-acceptor site within exon 5 in almost all transcripts in the human mitochondrial acetoacetyl-CoA thiolase gene
MOLECULAR GENETICS AND METABOLISM
Molecular and structural analysis of two novel mutations in a patient withMut(-) methylmalanyl-CoA deficiency
MOLECULAR GENETICS AND METABOLISM
Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22 : 6n-3) biosynthesis
MOLECULAR GENETICS AND METABOLISM
Repeated analysis of semen parameters in beagle dogs during a 2-year studywith the HMG-CoA reductase inhibitor, atorvastatin
TOXICOLOGICAL SCIENCES
Preclinical safety evaluation of avasimibe in beagle dogs: An ACAT inhibitor with minimal adrenal effects
TOXICOLOGICAL SCIENCES
Molecular cloning and sequence analysis of stearoyl-CoA desaturase in milkfish, Chanos chanos
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
Cloning, tissue distribution and nutritional regulation of a Delta 6-desaturase-like enzyme in rainbow trout
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
Characterization of microsomal diacylglycerol acyltransferase activity from bovine adipose and muscle tissue
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
Biodegradation of aromatic compounds by Escherichia coli
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Sodium ion cycle in bacterial pathogens: Evidence from cross-genome comparisons
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Biosynthesis of polyketides in heterologous hosts
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Sequence diversity in genes of lipid metabolism
GENOME RESEARCH
Should all patients with cardiovascular disease receive statin therapy?
AMERICAN JOURNAL OF MANAGED CARE