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La ricerca find articoli where soggetti phrase all words 'CHRONIC EXPOSURE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 419 riferimenti
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    1. Tanaka, Y; Nakanishi, J
      Effect of linear alkylbenzene sulfonate on population growth of Daphnia galeata: A life table evaluation

      ENVIRONMENTAL TOXICOLOGY
    2. Ben-David, M; Kondratyuk, T; Woodin, BR; Snyder, PW; Stegeman, JJ
      Induction of cytochrome P450 1A1 expression in captive river otters fed Prudhoe Bay crude oil: evaluation by immunohistochemistry and quantitative RT-PCR

      BIOMARKERS
    3. Bouchard, M; Brunet, RC; Droz, PO; Carrier, G
      A biologically based dynamic model for predicting the disposition of methanol and its metabolites in animals and humans

      TOXICOLOGICAL SCIENCES
    4. Borghoff, SJ; Prescott, JS; Janszen, DB; Wong, BA; Everitt, JI
      alpha 2u-globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats

      TOXICOLOGICAL SCIENCES
    5. Liu, T; Liu, J; LeCluyse, EL; Zhou, YS; Cheng, ML; Waalkes, MP
      Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China

      TOXICOLOGICAL SCIENCES
    6. Satarug, S; Baker, JR; Reilly, PEB; Moore, MR; Williams, DJ
      Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium

      HUMAN & EXPERIMENTAL TOXICOLOGY
    7. Kiriyama, MT; Oka, M; Takehana, M; Kobayashi, S
      Expression of a small heat shock protein 27 (HSP27) in mouse skin tumors induced by UVB-irradiation

      BIOLOGICAL & PHARMACEUTICAL BULLETIN
    8. Tanaka, Y; Nakanishi, J
      Life history elasticity and the population-level effect of p-nonylphenol on Daphnia galeata

      ECOLOGICAL RESEARCH
    9. Sunyer, J
      Urban air pollution and chronic obstructive pulmonary disease: a review

      EUROPEAN RESPIRATORY JOURNAL
    10. Wyde, ME; Wong, VA; Kim, AH; Lucier, GW; Walker, NJ
      Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent

      CHEMICAL RESEARCH IN TOXICOLOGY
    11. Fok, TF; Chui, KKM; Cheung, R; Ng, PC; Cheung, KL; Hjelm, M
      Manganese intake and cholestatic jaundice in neonates receiving parenteralnutrition: a randomized controlled study

      ACTA PAEDIATRICA
    12. Wiegman, S; van Vlaardingen, PLA; Bleeker, EAJ; de Voogt, P; Kraak, MHS
      Phototoxicity of azaarene isomers to the marine flagellate Dunaliella tertiolecta

      ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
    13. Baussant, T; Sanni, S; Skadsheim, A; Jonsson, G; Borseth, JF; Gaudebert, B
      Bioaccumulation of polycyclic aromatic compounds: 2. Modeling, bioaccumulation in marine organisms chronically exposed to dispersed oil

      ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
    14. Jones, PD; Kannan, K; Newsted, JL; Tillitt, DE; Williams, LL; Giesy, JP
      Accumulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin by rainbow trout (Onchorhynchus mykiss) at environmentally relevant dietary concentrations

      ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
    15. Nagy, J; Muller, F; Laszlo, L
      Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones

      DRUG AND ALCOHOL DEPENDENCE
    16. Christova, T; Duridanova, D; Braykova, A; Setchenska, M; Bolton, T
      Heme oxygenase is the main protective enzyme in rat liver upon 6-day administration of cobalt chloride

      ARCHIVES OF TOXICOLOGY
    17. Pedraza-Chaverri, J; Granados-Silvestre, MD; Medina-Campos, ON; Maldonado, PD; Olivares-Corichi, IM; Ibarra-Rubio, ME
      Post-transcriptional control of catalase expression in garlic-treated rats

      MOLECULAR AND CELLULAR BIOCHEMISTRY
    18. Haines, MM; Stansfeld, SA; Job, RS; Berglund, B; Head, J
      A follow-up study of effects of chronic aircraft noise exposure on child stress responses and cognition

      INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
    19. Kohn, MC; Walker, NJ; Kim, AH; Portier, CJ
      Physiological modeling of a proposed mechanism of enzyme induction by TCDD

      TOXICOLOGY
    20. Kuempel, ED; O'Flaherty, EJ; Stayner, LT; Smith, RJ; Green, FHY; Vallyathan, V
      A biomathematical model of particle clearance and retention in the lungs of coal miners - I. Model development

      REGULATORY TOXICOLOGY AND PHARMACOLOGY
    21. Gastel, JA
      Early indicators of response in biologically based risk assessment for nongenotoxic carcinogens

      REGULATORY TOXICOLOGY AND PHARMACOLOGY
    22. Cardoso, RS; Takahashi-Hyodo, S; Peitl, P; Ghilardi-Neto, T; Sakamoto-Hojo, ET
      Evaluation of chromosomal aberrations, micronuclei, and sister chromatid exchanges in hospital workers chronically exposed to ionizing radiation

      TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
    23. Bentley, KW
      beta-Phenylethylamines and the isoquinoline alkaloids

      NATURAL PRODUCT REPORTS
    24. Lasko, CM; Korytko, AI; Wehrenberg, WB; Cuttler, L
      Differential GH-releasing hormone regulation of GHRH receptor mRNA expression in the rat pituitary

      AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
    25. House, SD; Mao, X; Wu, GD; Espinelli, D; Li, WX; Chang, SLL
      Chronic morphine potentiates the inflammatory response by disrupting interleukin-1 beta modulation of the hypothalamic-pituitary-adrenal axis

      JOURNAL OF NEUROIMMUNOLOGY
    26. Slawecki, CJ; Betancourt, M; Cole, M; Ehlers, CL
      Periadolescent alcohol exposure has lasting effects on adult neurophysiological function in rats

      DEVELOPMENTAL BRAIN RESEARCH
    27. Ryan, PB; Scanlon, KA; MacIntosh, DL
      Analysis of dietary intake of selected metals in the NHEXAS-Maryland investigation

      ENVIRONMENTAL HEALTH PERSPECTIVES
    28. Hu, H
      Poorly controlled hypertension in a painter with chronic lead toxicity

      ENVIRONMENTAL HEALTH PERSPECTIVES
    29. Bernard, SM; Samet, JM; Grambsch, A; Ebi, KL; Romieu, I
      The potential impacts of climate variability and change on air pollution-related health effects in the United States

      ENVIRONMENTAL HEALTH PERSPECTIVES
    30. Wyde, ME; Eldridge, SR; Lucier, GW; Walker, NJ
      Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced tumor promotion by 17 beta-estradiol in female Sprague-Dawley rats

      TOXICOLOGY AND APPLIED PHARMACOLOGY
    31. Renwick, LC; Donaldson, K; Clouter, A
      Impairment of alveolar macrophage phagocytosis by ultrafine particles

      TOXICOLOGY AND APPLIED PHARMACOLOGY
    32. Lyons, HR; Land, MB; Gibbs, TT; Farb, DH
      Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels

      JOURNAL OF NEUROCHEMISTRY
    33. Carmignani, M; Volpe, AR; Botta, B; Espinal, R; De Bonnevaux, SC; De Luca, C; Botta, M; Corelli, F; Tafi, A; Sacco, R; Delle Monache, G
      Novel hypotensive agents from Verbesina caracasana. 8. Synthesis and pharmacology of (3,4-dimethoxycinnamoyl)-N-1-agmatine and synthetic analogues

      JOURNAL OF MEDICINAL CHEMISTRY
    34. Mitchell, DL; Volkmer, B; Breitbart, EW; Byrom, M; Lowery, MG; Greinert, R
      Identification of a non-dividing subpopulation of mouse and human epidermal cells exhibiting high levels of persistent ultraviolet photodamage

      JOURNAL OF INVESTIGATIVE DERMATOLOGY
    35. Kosofsky, BE; Hyman, SE
      No time for complacency: The fetal brain on drugs

      JOURNAL OF COMPARATIVE NEUROLOGY
    36. Harrington, RH; Sharma, A
      Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression

      JOURNAL OF BIOLOGICAL CHEMISTRY
    37. Bo, X; Broome, U; Remberger, M; Sumitran-Holgersson, S
      Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis

      GUT
    38. Yoshikawa, H; Tajiri, Y; Sako, Y; Hashimoto, T; Umeda, F; Nawata, H
      Effects of bezafibrate on beta-cell function of rat pancreatic islets

      EUROPEAN JOURNAL OF PHARMACOLOGY
    39. Bijl, M; Horst, G; Limburg, PC; Kallenberg, CGM
      Effects of smoking on activation markers, Fas expression and apoptosis of peripheral blood lymphocytes

      EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
    40. Maedler, K; Spinas, GA; Lehmann, R; Sergeev, P; Weber, M; Fontana, A; Kaiser, N; Donath, MY
      Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

      DIABETES
    41. Leibowitz, G; Ferber, S; Apelqvist, A; Edlund, H; Gross, DJ; Cerasi, E; Melloul, D; Kaiser, N
      IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes

      DIABETES
    42. Visviki, I; Palladino, J
      Growth and cytology of Chlamydomonas acidophila under acidic stress

      BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
    43. Shinozuka, Y; Okada, M; Oki, T; Sagane, K; Mizui, Y; Tanaka, I; Katayama, K; Murakami-Murofushi, K
      Altered expression of HES-1, BETA2/NeuroD, and PDX-1 is involved in impaired insulin synthesis induced by glucocorticoids in HIT-T15 cells

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    44. Legator, MS; Singleton, CR; Morris, DL; Philips, DL
      Health effects from chronic low-level exposure to hydrogen sulfide

      ARCHIVES OF ENVIRONMENTAL HEALTH
    45. Chhabra, SK; Chhabra, P; Rajpal, S; Gupta, RK
      Ambient air pollution and chronic respiratory morbidity in Delhi

      ARCHIVES OF ENVIRONMENTAL HEALTH
    46. Brown, KW
      Workers' health and colonial mercury mining at Huancavelica, Peru

      AMERICAS
    47. Duis, K; Oberemm, A
      Sensitivity of early life stages of vendace, Coregonus albula, to acid pH in postmining lakes: An experimental approach

      ENVIRONMENTAL TOXICOLOGY
    48. Kovalchuk, O; Arkhipov, A; Barylyak, I; Karachov, I; Titov, V; Hohn, B; Kovalchuk, I
      Plants experiencing chronic internal exposure to ionizing radiation exhibit higher frequency of homologous recombination than acutely irradiated plants

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    49. Morgan, WKC
      Meretricious mensuration

      JOURNAL OF EVALUATION IN CLINICAL PRACTICE
    50. Bischoff, FZ; Simpson, JL
      Heritability and molecular genetic studies of endometriosis

      HUMAN REPRODUCTION UPDATE
    51. Liu, YP; Liu, J; Habeebu, SM; Waalkes, MP; Klaassen, CD
      Metallothionein-I/II null mice are sensitive to chronic oval cadmium-induced nephrotoxicity

      TOXICOLOGICAL SCIENCES
    52. Habeebu, SS; Liu, J; Liu, YP; Klaassen, CD
      Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl2-induced bone injury

      TOXICOLOGICAL SCIENCES
    53. Flynn, KM; Ferguson, SA; Delclos, KB; Newbold, RR
      Effects of genistein exposure on sexually dimorphic behaviors in rats

      TOXICOLOGICAL SCIENCES
    54. Driscoll, KE; Costa, DL; Hatch, G; Henderson, R; Oberdorster, G; Salem, H; Schlesinger, RB
      Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations

      TOXICOLOGICAL SCIENCES
    55. Gauderman, WJ; McConnell, R; Gilliland, F; London, S; Thomas, D; Avol, E; Vora, H; Berhane, K; Rappaport, EB; Lurmann, F; Margolis, HG; Peters, J
      Association between air pollution and lung function growth in southern California children

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    56. MacIntosh, DL; Kabiru, C; Scanlon, KA; Ryan, PB
      Longitudinal investigation of exposure to arsenic, cadmium, chromium and lead via beverage consumption

      JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
    57. Umino, T; Wang, HJ; Zhu, YK; Liu, XD; Manouilova, LS; Spurzem, JR; Leuschen, MP; Rennard, SI
      Modification of type I collagenous gels by alveolar epithelial cells

      AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
    58. Jing, X; Wala, EP; Sloan, JW
      The effect of PK 11195, a specific antagonist of the peripheral benzodiazepine receptors, on body weight in rats chronically exposed to diazepam

      PHARMACOLOGICAL RESEARCH
    59. Szelenyi, I
      Animal models of bronchial asthma

      INFLAMMATION RESEARCH
    60. Ghanayem, BI; Ward, SM; Chanas, B; Nyska, A
      Comparison of the acute hematotoxicity of 2-butoxyethanol in male and female F344 rats

      HUMAN & EXPERIMENTAL TOXICOLOGY
    61. Nies, E; Blome, H; Bruggemann-Prieshoff, H
      Characterization of coloured toner powders and emissions from colour photocopiers/colour laser printers

      GEFAHRSTOFFE REINHALTUNG DER LUFT
    62. Kopp, MV; Bohnet, W; Frischer, T; Ulmer, C; Studnicka, M; Ihorst, G; Gardner, C; Forster, J; Urbanek, R; Kuehr, J
      Effects of ambient ozone on lung function in children over a two-summer period

      EUROPEAN RESPIRATORY JOURNAL
    63. Takahashi, H; Nomiyama, H; Nomiyama, K
      Mercury elevates systolic blood pressure in spontaneously hypertensive rats

      JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE
    64. Miller, FJ
      Dosimetry of particles in laboratory animals and humans in relationship toissues surrounding lung overload and human health risk assessment: A critical review

      INHALATION TOXICOLOGY
    65. Nikula, KJ
      Rat lung tumors induced by exposure to selected poorly soluble nonfibrous particles

      INHALATION TOXICOLOGY
    66. Gibson, MAS; Butters, NS; Reynolds, JN; Brien, JF
      Effects of chronic prenatal ethanol exposure on locomotor activity, and hippocampal weight, neurons, and nitric oxide synthase activity of the young postnatal guinea pig

      NEUROTOXICOLOGY AND TERATOLOGY
    67. Pi, JB; Kumagai, Y; Sun, GF; Yamauchi, H; Yoshida, T; Iso, H; Endo, A; Yu, LY; Yuki, KC; Miyauchi, T; Shimojo, N
      Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in Inner Mongolia

      FREE RADICAL BIOLOGY AND MEDICINE
    68. Butters, NS; Gibson, MAS; Reynolds, JN; Brien, JF
      Effects of chronic prenatal ethanol exposure on hippocampal glutamate release in the postnatal guinea pig

      ALCOHOL
    69. Collins, P; Wilkinson, LS; Everitt, BJ; Robbins, TW; Roberts, AC
      The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function

      BEHAVIORAL NEUROSCIENCE
    70. Kuhn, A; Munns, WR; Poucher, S; Champlin, D; Lussier, S
      Prediction of population-level response from mysid toxicity test data using population modeling techniques

      ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
    71. Roex, EWM; Van Gestel, CA; Van Wezel, AP; Van Straalen, NM
      Ratios between acute aquatic toxicity and effects on population growth rates in relation to toxicant mode of action

      ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
    72. Tanaka, Y; Nakanishi, J
      Mean extinction time of populations under toxicant stress and ecological risk assessment

      ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
    73. Purrello, F; Rabuazzo, AM
      Metabolic factors that affect beta-cell function and survival

      DIABETES NUTRITION & METABOLISM
    74. Bass, CE; Martin, BR
      Time course for the induction and maintenance of tolerance to Delta(9)-tetrahydrocannabinol in mice

      DRUG AND ALCOHOL DEPENDENCE
    75. Hungund, BL; Basavarajappa, BS
      Distinct differences in the cannabinoid receptor binding in the brain of C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption

      JOURNAL OF NEUROSCIENCE RESEARCH
    76. Villarroel, MJ; Ferrando, MD; Sancho, E; Andreu, E
      Population dynamics in Daphnia magna as modified by chronic tetradifon stress

      JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
    77. Nihlen, A; Droz, PO
      Toxicokinetic modelling of methyl formate exposure and implications for biological monitoring

      INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
    78. Kaplanski, J; Magazanik, A; Hadas, I; Sod-Moriah, U; Fraifeld, V
      Effects of lipopolysaccharide on body temperature and plasma zinc and ironconcentrations in rats exposed to different ambient temperatures

      JOURNAL OF THERMAL BIOLOGY
    79. Sun, Z; Cade, R
      Cold-induced hypertension and diuresis

      JOURNAL OF THERMAL BIOLOGY
    80. Talan, MI; Roukoyatkina, NI
      Sustained shivering is necessary for development of cold-induced hypertension in rats

      JOURNAL OF THERMAL BIOLOGY
    81. Wang, YX; Gao, D; Pettus, M; Phillips, C; Bowersox, SS
      Interactions of intrathecally administered ziconotide, a selective blockerof neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats

      PAIN
    82. Liu, J; Liu, YP; Habeebu, SM; Waalkes, MP; Klaassen, CD
      Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice

      TOXICOLOGY
    83. Forbes, VE
      Is hormesis an evolutionary expectation?

      FUNCTIONAL ECOLOGY
    84. Tessier, L; Boisvert, JL; Vought, LBM; Lacoursiere, JO
      Anomalies on capture nets of Hydropsyche slossonae larvae (Trichoptera; Hydropsychidae) following a sublethal chronic exposure to cadmium

      ENVIRONMENTAL POLLUTION
    85. Crossley, SJ
      Joint FAO/WHO Geneva consultation - acute dietary intake methodology

      FOOD ADDITIVES AND CONTAMINANTS
    86. Gleason, CE; Gonzalez, M; Harmon, JS; Robertson, RP
      Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15

      AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
    87. Lionetto, MG; Giordano, ME; Vilella, S; Schettino, T
      Inhibition of eel enzymatic activities by cadmium

      AQUATIC TOXICOLOGY
    88. Cioli, I; Caricati, A; Nencini, P
      Quinpirole- and amphetamine-induced hyperdipsia: influence of fluid palatability and behavioral cost

      BEHAVIOURAL BRAIN RESEARCH
    89. Lippmann, M; Schlesinger, RB
      Toxicological bases for the setting of health-related atr pollution standards

      ANNUAL REVIEW OF PUBLIC HEALTH
    90. Lasley, SM; Gilbert, ME
      Glutamatergic components underlying lead-induced impairments in hippocampal synaptic plasticity

      NEUROTOXICOLOGY
    91. Masters, RD; Coplan, MJ; Hone, BT; Dykes, JE
      Association of silicofluoride treated water with elevated blood lead

      NEUROTOXICOLOGY
    92. Kuempel, ED
      Comparison of human and rodent lung dosimetry models for particle clearance and retention

      DRUG AND CHEMICAL TOXICOLOGY
    93. Tessier, L; Boisvert, JL; Vought, LBM; Lacoursiere, JO
      Effects of 2,4-dichlorophenol on the net-spinning behavior of Hydropsyche slossonae larvae (Trichoptera; Hydropsychidae), an early warning signal of chronic toxicity

      ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
    94. Irwin, M; Miller, C; Gillin, JC; Demodena, A; Ehlers, CL
      Polysomnographic and spectral sleep EEG in primary alcoholics: An interaction between alcohol dependence and African-American ethnicity

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    95. Slawecki, CJ; Betancourt, M; Li, TK; Ehlers, CL
      Neurophysiological findings and drinking levels in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    96. Ryan, PB; Huet, N; MacIntosh, DL
      Longitudinal investigation of exposure to arsenic, cadmium, and lead in drinking water

      ENVIRONMENTAL HEALTH PERSPECTIVES
    97. Croute, F; Beau, B; Arrabit, C; Gaubin, Y; Delmas, F; Murat, JC; Soleilhavoup, JP
      Pattern of stress protein expression in human lung cell-line A549 after short- or long-term exposure to cadmium

      ENVIRONMENTAL HEALTH PERSPECTIVES
    98. Barton, HA; Clewell, HJ
      Evaluating noncancer effects of trichloroethylene: Dosimetry, mode of action, and risk assessment

      ENVIRONMENTAL HEALTH PERSPECTIVES
    99. Visviki, I; Santikul, D
      The pH tolerance of Chlamydomonas applanata (Volvocales, Chlorophyta)

      ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
    100. Kondo, T; Kumagai, M; Ohta, Y; Bishop, B
      Ventilatory responses to hypercapnia and hypoxia following chronic hypercapnia in the rat

      RESPIRATION PHYSIOLOGY


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 15:59:35