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La ricerca find articoli where soggetti phrase all words 'CELL RECEPTORS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 628 riferimenti
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    1. Nielsen, LB; Pedersen, FS; Pedersen, L
      Expression of type III sodium-dependent phosphate transporters/retroviral receptors mRNAs during osteoblast differentiation

      BONE
    2. Pfeiffer, KA; Fimmers, R; Engels, G; van der Ven, H; van der Ven, K
      The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion

      MOLECULAR HUMAN REPRODUCTION
    3. Larocca, D; Baird, A
      Receptor-mediated gene transfer by phage-display vectors: applications in functional genomics and gene therapy

      DRUG DISCOVERY TODAY
    4. Heinz, D; Peters, M; Prange, R; Gerken, G; Rose-John, S
      Possible role of human interleukin-6 and soluble interleukin-6 receptor inhepatitis B virus infection

      JOURNAL OF VIRAL HEPATITIS
    5. Alonso, R; Llopis, I; Flores, C; Murgui, A; Timoneda, J
      Different adhesins for type IV collagen on Candida albicans: identification of a lectin-like adhesin recognizing the 7S(IV) domain

      MICROBIOLOGY-SGM
    6. Le Bouteiller, P; Solier, C
      Is antigen presentation the primary function of HLA-G?

      MICROBES AND INFECTION
    7. Carfi, A; Willis, SH; Whitbeck, JC; Krummenacher, C; Cohen, GH; Eisenberg, RJ; Wiley, DC
      Herpes simplex virus glycoprotein D bound to the human receptor HveA

      MOLECULAR CELL
    8. Trowsdale, J
      Genetic and functional relationships between MHC and NK receptor genes

      IMMUNITY
    9. Marchalonis, JJ; Adelman, MK; Robey, IF; Schluter, SF; Edmundson, AB
      Exquisite specificity and peptide epitope recognition promiscuity, properties shared by antibodies from sharks to humans

      JOURNAL OF MOLECULAR RECOGNITION
    10. Tateshita, T; Ono, I; Kaneko, F
      Effects of collagen matrix containing transforming growth factor (TGF)-beta 1 on wound contraction

      JOURNAL OF DERMATOLOGICAL SCIENCE
    11. Giannoukos, G; Szapary, D; Smith, CL; Meeker, JEW; Simons, SS
      New antiprogestins with partial agonist activity: Potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties

      MOLECULAR ENDOCRINOLOGY
    12. Van Broekhoven, CL; Altin, JG
      A novel system for convenient detection of low-affinity receptor-ligand interactions: Chelator-lipid liposomes engrafted with recombinant CD4 bind tocells expressing MHC class II

      IMMUNOLOGY AND CELL BIOLOGY
    13. Mannie, MD; Walker, MR
      Feedback activation of T-cell antigen-presenting cells during interactionswith T-cell responders

      JOURNAL OF LEUKOCYTE BIOLOGY
    14. Eisen, HN
      Specificity and degeneracy in antigen recognition: Yin and Yang in the immune system

      ANNUAL REVIEW OF IMMUNOLOGY
    15. Benezra, M; Vogel, T; Ben-Sasson, SA; Panet, A; Sehayek, E; Al-Haideiri, M; Decklbaum, RJ; Vlodavsky, I
      A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation

      JOURNAL OF CELLULAR BIOCHEMISTRY
    16. Montesano, C; Gioia, C; Martini, F; Agrati, C; Cairo, C; Pucillo, LP; Colizzi, V; Poccia, F
      Antiviral activity and anergy of gamma delta T lymphocytes in cord blood and immuno-compromised host

      JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
    17. Ariga, K
      Information conversion devices based on molecular recognition on nano-sized ultrathin films

      KOBUNSHI RONBUNSHU
    18. Meves, A; Stock, SN; Beyerle, A; Pittelkow, MR; Peus, D
      H2O2 mediates oxidative stress-induced epidermal growth factor receptor phosphorylation

      TOXICOLOGY LETTERS
    19. Vandenbark, AA; Morgan, E; Bartholomew, R; Bourdette, D; Whitham, R; Carlo, D; Gold, D; Hashim, G; Offner, H
      TCR peptide therapy in human autoimmune diseases

      NEUROCHEMICAL RESEARCH
    20. Korzick, DH; Holiman, DA; Boluyt, MO; Laughlin, MH; Lakatta, EG
      Diminished alpha(1)-adrenergic-mediated contraction and translocation of PKC in senescent rat heart

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    21. Wu, GY; Walton, CM; Wu, CH
      Targeted polynucleotides for inhibition of hepatitis B and C viruses

      CROATIAN MEDICAL JOURNAL
    22. Yamada, K; Nishida, K; Hibi, M; Hirano, T; Matsuda, Y
      Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat

      CYTOGENETICS AND CELL GENETICS
    23. von Zastrow, M
      Role of endocytosis in signalling and regulation of G-protein-coupled receptors

      BIOCHEMICAL SOCIETY TRANSACTIONS
    24. Hubert, GW; Paquet, M; Smith, Y
      Differential subcellular localization of mGluR1a and mGluR5 in the rat andmonkey substantia nigra

      JOURNAL OF NEUROSCIENCE
    25. Oltz, EM
      Regulation of antigen receptor gene assembly in lymphocytes

      IMMUNOLOGIC RESEARCH
    26. Nikitin, EA; Leniva, EA; Sudarikov, AB
      Role of molecular methods in the diagnosis and monitoring of lympho proliferative diseases

      GEMATOLOGIYA I TRANSFUZIOLOGIYA
    27. Sales, MGF; Nasciutti, LE; Lorena, DE; Muzzi, M; Porto, LC
      Differential expression of laminin isoform (alpha 2), integrins (alpha 3 beta 1 and alpha 6 beta 4) and cytokeratin 20 in H-pylori gastritis

      HISTOLOGY AND HISTOPATHOLOGY
    28. Singh, B; Rawlings, N; Kaur, A
      Expression of integrin alpha v beta 3 in pig, dog and cattle

      HISTOLOGY AND HISTOPATHOLOGY
    29. Iype, T; Jayasree, K; Sudhakaran, PR
      Modulation of alpha(2)beta(1) integrin changes during mammary gland development by beta-oestradiol

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
    30. Schaecher, KE; Goust, JM; Banik, NL
      The effects of calpain inhibition upon IL-2 and CD25 expression in human peripheral blood mononuclear cells

      JOURNAL OF NEUROIMMUNOLOGY
    31. Fikri, Y; Denis, O; Pastoret, PP; Nyabenda, J
      Purified bovine WC1(+) gamma delta T lymphocytes are activated by staphylococcal enterotoxins and toxic shock syndrome toxin-1 superantigens: proliferation response, TCR V gamma profile and cytokines expression

      IMMUNOLOGY LETTERS
    32. Dixon, B; Stet, RJM
      The relationship between major histocompatibility receptors and innate immunity in teleost fish

      DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
    33. Solem, ST; Hordvik, I; Killie, JEA; Warr, GW; Jorgensen, TO
      Diversity of the immunoglobulin heavy chain in the Atlantic salmon (Salmo salar L.) is contributed by genes from two parallel IgH isoloci.

      DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
    34. Milne, RSB; Connolly, SA; Krummenacher, C; Eisenberg, RJ; Cohen, GH
      Porcine HveC, a member of the highly conserved HveC/Nectin 1 family, is a functional alphaherpesvirus receptor

      VIROLOGY
    35. Connolly, SA; Whitbeck, JC; Rux, AH; Krummenacher, C; Littel-van den Hurk, SV; Cohen, GH; Eisenberg, RJ
      Glycoprotein D homologs in herpes simplex virus type 1, pseudorabies virus, and bovine herpes virus type 1 bind directly to human HveC (nectin-1) with different affinities

      VIROLOGY
    36. Escuder, B; Rowan, AE; Feiters, MC; Nolte, RJM
      Aggregation behaviour and binding properties of an L-lysine appended glycoluril receptor

      TETRAHEDRON LETTERS
    37. Schwartz, JA; Lium, EK; Silverstein, SJ
      Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96

      JOURNAL OF VIROLOGY
    38. Lu, CW; Roth, MJ
      Functional characterization of the N termini of murine leukemia virus envelope proteins

      JOURNAL OF VIROLOGY
    39. Nixdorf, R; Klupp, BG; Mettenleiter, TC
      Restoration of function of carboxy-terminally truncated pseudorabies virusglycoprotein B by point mutations in the ectodomain

      JOURNAL OF VIROLOGY
    40. Jia, QM; Hogle, JM; Hashikawa, T; Nomoto, A
      Molecular genetic analysis of revertants from a poliovirus mutant that is specifically adapted to the mouse spinal cord

      JOURNAL OF VIROLOGY
    41. Anderson, MM; Lauring, AS; Robertson, S; Dirks, C; Overbaugh, J
      Feline Pit2 functions as a receptor for subgroup B feline leukemia viruses

      JOURNAL OF VIROLOGY
    42. Salaun, C; Rodrigues, P; Heard, JM
      Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor

      JOURNAL OF VIROLOGY
    43. Smirnova, IV; Citron, BA; Arnold, PM; Festoff, BW
      Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca2+ mobilization,and apoptosis

      JOURNAL OF NEUROBIOLOGY
    44. Ciatto, C; Tissot, AC; Tschopp, M; Capitani, G; Pecorari, F; Pluckthun, A; Grutter, MG
      Zooming in on the hydrophobic ridge of H-2D(b): Implications for the conformational variability of bound peptides

      JOURNAL OF MOLECULAR BIOLOGY
    45. Tsujimura, K; Obata, Y; Matsudaira, Y; Ozeki, S; Yoshikawa, K; Saga, S; Takahashi, T
      The binding of thymus leukemia (TL) antigen tetramers to normal intestinalintraepithelial lymphocytes and thymocytes

      JOURNAL OF IMMUNOLOGY
    46. Canavez, F; Young, NT; Guethlein, LA; Rajalingam, R; Khakoo, SI; Shum, BP; Parham, P
      Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes

      JOURNAL OF IMMUNOLOGY
    47. Chen, ZW; Li, YY; Zeng, XJ; Kuroda, MJ; Schmitz, JE; Shen, Y; Lai, XM; Shen, L; Letvin, NL
      The TCR repertoire of an immunodominant CD8(+) T lymphocyte population

      JOURNAL OF IMMUNOLOGY
    48. Wong, P; Barton, GM; Forbush, KA; Rudensky, AY
      Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands

      JOURNAL OF EXPERIMENTAL MEDICINE
    49. Rajalingam, R; Hong, M; Adams, EJ; Shum, BP; Guethlein, LA; Parham, P
      Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes

      JOURNAL OF EXPERIMENTAL MEDICINE
    50. Shukla, D; Spear, PG
      Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry

      JOURNAL OF CLINICAL INVESTIGATION
    51. Reyes-Reyes, M; Mora, N; Zentella, A; Rosales, C
      Phosphatidylinositol 3-kinase mediates integrin-dependent NF-kappa B and MARK activation through separate signaling pathways

      JOURNAL OF CELL SCIENCE
    52. Erb, L; Liu, J; Ockerhausen, J; Kong, QM; Garrad, RC; Griffin, K; Neal, C; Krugh, B; Santiago-Perez, LI; Gonzalez, FA; Gresham, HD; Turner, JT; Weisman, GA
      An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(0)-mediated signal transduction

      JOURNAL OF CELL BIOLOGY
    53. Maenaka, K; van der Merwe, PA; Stuart, DI; Jones, EY; Sondermann, P
      The human low affinity Fc gamma receptors IIa, IIb, and III bind IgG with fast kinetics and distinct thermodynamic properties

      JOURNAL OF BIOLOGICAL CHEMISTRY
    54. Kawahara, M; Ueda, H; Tsumoto, K; Kumagai, I; Mahoney, W; Nagamune, T
      A growth signal with an artificially induced erythropoietin receptor-gp130cytoplasmic domain heterodimer

      JOURNAL OF BIOCHEMISTRY
    55. Pinheiro, JP; van Leeuwen, HP
      Metal speciation dynamics and bioavailability. 2. Radial diffusion effectsin the microorganism range

      ENVIRONMENTAL SCIENCE & TECHNOLOGY
    56. Mannie, MD; Norris, MS
      MHC class-II-restricted antigen presentation by myelin basic protein-specific CD4(+) T cells causes prolonged desensitization and outgrowth of CD4(-)responders

      CELLULAR IMMUNOLOGY
    57. Xu, LK; Villain, M; Galin, FS; Araga, S; Blalock, JE
      Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T cells

      CELLULAR IMMUNOLOGY
    58. Yamamoto, T; Eckes, B; Krieg, T
      Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: Differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    59. Sun, BQ; Yi, GS; Zhao, SY; Chen, DP; Zhou, YX; Cheng, J
      Solid substrate phosphorescent immunoassay based on bioconjugated nanoparticles

      ANALYTICAL LETTERS
    60. Baulieu, EE
      Neurosteroids, a new function in the brain: neurotrophicity, memory, ageing...

      BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
    61. Chapman, JM; Guerin, M; Bruckert, E
      Quantitative and qualitative anomalies of LDL: relevance to atherosclerosis

      BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
    62. Fruchart, JC; Staels, B; Duriez, P
      New conceptions in the mechanism of action of fibrates and prospective therapeutics in atherosclerosis

      BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
    63. Tsao, P; Cao, T; von Zastrow, M
      Role of endocytosis in mediating downregulation of G-protein-coupled receptors

      TRENDS IN PHARMACOLOGICAL SCIENCES
    64. Kranz, DM
      Incompatible differences: view of an allogeneic pMHC-TCR complex

      NATURE IMMUNOLOGY
    65. Calogero, A; de Leij, YFMH; Mulder, NH; Hospers, GAP
      Recombinant T-cell receptors: An immunologic link to cancer therapy

      JOURNAL OF IMMUNOTHERAPY
    66. Serrano, D; Becker, K; Cunningham-Rundles, C; Mayer, L
      Characterization of the T cell receptor repertoire in patients with commonvariable immunodeficiency: Oligoclonal expansion of CD8(+) T cells

      CLINICAL IMMUNOLOGY
    67. Lagerholm, BC; Thompson, NL
      Temporal dependence of ligand dissociation and rebinding at planar surfaces

      JOURNAL OF PHYSICAL CHEMISTRY B
    68. Narayanaswami, V; Ryan, RO
      Molecular basis of exchangeable apolipoprotein function

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    69. Uings, IJ; Farrow, SN
      Cell receptors and cell signalling

      JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
    70. Lehours, P; Raher, S; Dubois, S; Guo, J; Godard, A; Jacques, Y
      Subunit structure of the high and low affinity human interleukin-15 receptors

      EUROPEAN CYTOKINE NETWORK
    71. de Wit, R; Hendrix, CMJ; Boonstra, J; Verkleij, AJ; Post, JA
      Large-scale screening assay to measure epidermal growth factor internalization

      JOURNAL OF BIOMOLECULAR SCREENING
    72. Paulsson, G; Zhou, XH; Tornquist, E; Hansson, GK
      Oligoclonal T cell expansions in atherosclerotic lesions of apolipoproteinE-deficient mice

      ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
    73. Colognato, H; Yurchenco, PD
      Form and function: The laminin family of heterotrimers

      DEVELOPMENTAL DYNAMICS
    74. McCormick, C; Duncan, G; Tufaro, F
      Herpes simplex virus: discovering the link between heparan sulphate and hereditary bone tumours

      REVIEWS IN MEDICAL VIROLOGY
    75. Boyington, JC; Raiz, AN; Brooks, AG; Patamawenu, A; Sun, PD
      Reconstitution of bacterial expressed human CD94: The importance of the stem region for dimer formation

      PROTEIN EXPRESSION AND PURIFICATION
    76. Vogt, RF; Whitfield, WE; Henderson, LO; Hannon, WH
      Fluorescence intensity calibration for immunophenotyping by flow cytometry

      METHODS-A COMPANION TO METHODS IN ENZYMOLOGY
    77. Uckert, W; Becker, C; Gladow, M; Klein, D; Kammertoens, T; Pedersen, L; Blankenstein, T
      Efficient gene transfer into primary human CD8(+) T lymphocytes by MuLV-10A1 retrovirus pseudotype

      HUMAN GENE THERAPY
    78. Suminoe, A; Matsuzaki, A; Takada, H; Hattori, H; Furuno, K; Takemoto, M; Maki, H; Kanaya, N; Ohnuma, K; Nishihira, H; Hara, T
      An infant with precursor natural killer (NK) cell leukemia successfully treated with an unrelated cord blood transplantation

      LEUKEMIA & LYMPHOMA
    79. Nie, GY; Li, Y; Hampton, AL; Salamonsen, LA; Clements, JA; Findlay, JK
      Identification of monoclonal nonspecific suppressor factor beta (MNSF beta) as one of the genes differentially expressed at implantation sites compared to interimplantation sites in the mouse uterus

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    80. Singh, B; Fu, CZ; Bhattacharya, J
      Vascular expression of the alpha(v)beta(3)-integrin in lung and other organs

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    81. Abdalla, SA; Pece-Barbara, N; Vera, S; Tapia, E; Paez, E; Bernabeu, C; Letarte, M
      Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2

      HUMAN MOLECULAR GENETICS
    82. Vihinen, P; Nikkola, J; Vlaykova, T; Hahka-Kemppinen, M; Talve, L; Heino, J; Pyrhonen, S
      Prognostic value of beta 1 integrin expression in metastatic melanoma

      MELANOMA RESEARCH
    83. Heinzmann, A; Blattmann, S; Forster, J; Kuehr, J; Deichmann, KA
      Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy

      EUROPEAN JOURNAL OF IMMUNOGENETICS
    84. Patel, SD; Moskalenko, M; Tian, T; Smith, D; McGuinness, R; Chen, LL; Winslow, GA; Kashmiri, S; Schlom, J; Stanners, CP; Finer, MH; McArthur, JG
      T-cell killing of heterogenous tumor or viral targets with bispecific chimeric immune receptors

      CANCER GENE THERAPY
    85. Alvarez-Vallina, L; Yanez, R; Blanco, B; Gil, M; Russell, SJ
      Pharmacologic suppression of target cell recognition by engineered T cellsexpressing chimeric T-cell receptors

      CANCER GENE THERAPY
    86. Muniappan, A; Banapour, B; Lebkowski, J; Talib, S
      Ligand-mediated cytolysis of tumor cells: Use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes

      CANCER GENE THERAPY
    87. Pharr, PN; Hofbauer, A; Worthington, RE; Longmore, GD
      Residual erythroid progenitors in W/W mice respond to erythropoietin in the absence of steel factor signals

      INTERNATIONAL JOURNAL OF HEMATOLOGY
    88. Johansson, I; Bratt, P; Hay, DI; Schluckebier, S; Stromberg, N
      Adhesion of Candida albicans, but not Candida krusei, to salivary statherin and mimicking host molecules

      ORAL MICROBIOLOGY AND IMMUNOLOGY
    89. Natah, SS; Hayrinen-Immonen, R; Hietanen, J; Patinen, P; Malmstrom, M; Savilahti, E; Konttinen, YT
      Increased density of lymphocytes bearing gamma/delta T-cell receptors in recurrent aphthous ulceration (RAU)

      INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
    90. Steinman, L
      Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed [with a hedge on this bet]

      JOURNAL OF AUTOIMMUNITY
    91. O'Hanlon, TP; Lawless, OJ; Katzin, WE; Feng, LJ; Miller, FW
      Restricted and shaved patterns of TCR beta-chain gene expression in silicone breast implant capsules and remote sites of tissue inflammation

      JOURNAL OF AUTOIMMUNITY
    92. Renedo, M; Arce, I; Montgomery, K; Roda-Navarro, P; Lee, E; Kucherlapati, R; Fernandez-Ruiz, E
      A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2

      GENOMICS
    93. Bowen, MA; Aruffo, AA; Bajorath, J
      Cell surface receptors and their ligands: In vitro analysis of CD6-CD166 interactions

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    94. Ahluwalia, B; Wesley, B; Adeyiga, O; Smith, DM; Da-Silva, A; Rajguru, S
      Alcohol modulates cytokine secretion and synthesis in human fetus: an in vivo and in vitro study

      ALCOHOL
    95. Makrigiannis, AP; Etzler, J; Winkler-Pickett, R; Mason, A; Ortaldo, JR; Anderson, SK
      Identification of the Ly49L protein: evidence for activating counterparts to inhibitory Ly49 proteins

      JOURNAL OF LEUKOCYTE BIOLOGY
    96. Khalil-Daher, I; Rouas-Freiss, N; Carosella, ED; Dausset, JB
      Human leukocyte antigen-G: Immunotolerant major histocompatibility complexmolecule in transplantation

      WORLD JOURNAL OF SURGERY
    97. van der Pluijm, G; Lowik, C; Papapoulos, S
      Tumour progression and angiogenesis in bone metastasis from breast cancer:new approaches to an old problem

      CANCER TREATMENT REVIEWS
    98. D'Andrea, RJ; Gonda, TJ
      A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: Insights from activated mutants of the common beta subunit

      EXPERIMENTAL HEMATOLOGY
    99. Spiegel, AM
      G protein defects in signal transduction

      HORMONE RESEARCH
    100. Eiras, P; Leon, F; Camarero, C; Lombardia, M; Roldan, E; Bootello, A; Roy, G
      Intestinal intraepithelial lymphocytes contain a CD3(-) CD7(+) subset expressing natural killer markers and a singular pattern of adhesion molecules

      SCANDINAVIAN JOURNAL OF IMMUNOLOGY


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Documento generato il 16/01/21 alle ore 11:13:13